Target Validation Information
Target ID T58589
Target Name B1 bradykinin receptor
Target Type
Clinical Trial
Drug Potency against Target Des-Arg10-Leu9-Kallidin Drug Info Ki < 0.2 nM [527294]
H-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1669) Drug Info Ki = 0.22 nM [525817]
H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1431) Drug Info Ki = 83 nM [525817]
H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1638) Drug Info Ki = 5.6 nM [525817]
Des-Arg10-Kallidin Drug Info Ki < 0.2 nM [527294]
References
Ref 527294Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8.Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.
Ref 525817J Med Chem. 2000 Jun 15;43(12):2382-6.Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Ref 525817J Med Chem. 2000 Jun 15;43(12):2382-6.Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Ref 525817J Med Chem. 2000 Jun 15;43(12):2382-6.Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Ref 527294Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8.Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.

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