| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T40111 | ||||
| Target Name | Inosine-5'-monophosphate dehydrogenase | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Ribavirin | Drug Info | IC50 = 500000 nM | [535038] | |
| Action against Disease Model | Ribavirin | IC50 on h uMan adenovirus species C: 77000nM | [552517] | Drug Info | |
| Mizoribine | IC50 on severe acute respiratory syndrome-associated coronavirus Frankfurt-1: 3500 ng/mL | [552522] | Drug Info | ||
| References | |||||
| Ref 552517 | In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther. 2005;10(2):225-9. | ||||
| Ref 535038 | ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy. Acta Biochim Pol. 2000;47(1):173-80. | ||||
| Ref 552522 | Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus. Antiviral Res. 2005 Jun;66(2-3):159-63. Epub 2005 Feb 19. | ||||
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