| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T41666 | ||||
| Target Name | Hypoxanthine-guanine phosphoribosyltransferase | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine | Drug Info | Ki = 100 nM | [530305] | |
| 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine | Drug Info | Ki = 300 nM | [530305] | ||
| 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine | Drug Info | Ki = 10000 nM | [530305] | ||
| References | |||||
| Ref 530305 | Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | ||||
| Ref 530305 | Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | ||||
| Ref 530305 | Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. Epub 2009 Jul 25.Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | ||||
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