TTD - Therapeutic Targets Databse Version 4.3.02 (2013.09.14) File Name: List of 1008 FDA approved nature-derived drugs and their species origins. Following the seminal works of Newman and Cragg (J Nat Prod. 2007 Mar;70(3):461-77), the drug types are defined as follows: "B" Biological, a peptide or protein either isolated from an organism/cell line or produced by biotechnological means in a surrogate host; "N" Natural product; "ND" Derived from a natural product and is usually a semisynthetic modification; "NM" Natural product mimic; "S*" Made by total synthesis based on the pharmacophore from a natural product; "V" Vaccine. Reference: Zhu F, Qin C, Tao L, Liu X, Shi Z, Ma X, Jia J, Tan Y, Cui C, Lin J, Tan C, Jiang Y, Chen Y. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (PNAS). 2011 Aug 2;108(31):12943-8. Generic Name Trade Name Company Targeted Diseases Drug Type Source Approved Year IncobotulinumtoxinA Xeomin Merz Cervical dystonia and blepharospasm B Clostridium botulinum serotype A 2010 Digoxin fab DigiFab . Digoxin toxicity B Digitalis purpurea (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%) 2000 Aflibercept Eylea Regeneron Neovascular (wet) age-related macular degeneration B Homo sapian 2011 Rexin-g Not Available . Anticancer B Homo sapiens 2007 Tasonermin Beromun . Anticancer B Homo sapiens (17309302) 1999 Etanercept Enbrel . Antiarthritic B Homo sapiens (15673801) 1998 Rasburicase Fasturtec . Antihyperuricemia B Homo sapiens (17309302) 2001 Pegloticase Krystexxa Savient Gout B Homo sapian 2010 Asparaginase Erwinia chrysanthemi Erwinaze EUSA Pharma (USA) Acute lymphoblastic leukaemia B Homo sapian 2011 Pegaspargase Oncaspar . Anticancer B Erwinia chrysanthemi (17554375); Escherichia coli (17554375) 1994 Pegademase bovine Adagen . Immunostimulant B Bos taurus (17309302) 1991 Galsulfase Aryplase . Mucopolysaccharidosis B Homo sapiens (16128602) 2005 Rh-alphaglucosidase Pompase . Pompe's disease B Homo sapiens (17309302) 2006 Alglucosidase alfa* Lumizyme Genzyme Pompe's disease B Homo sapian 2010 RHuPH20 Hylenex . Reproduction B Homo sapiens (17309302) 2005 Laronidase Aldurazyme . Mucopolysaccharidosis B Homo sapiens (17309302) 2003 Imiglucerase Cerezyme . Gaucher's disease B Homo sapiens (17309302) 1978 Velaglucerase alfa Vpriv Shire Gaucher's disease B Homo sapiens 2010 Agalsidase alfa Replagal . Fabry disease B Homo sapiens (17309302) 2001 Agalsidase beta Fabrazyme . Fabry disease B Homo sapiens (17309302) 2001 Alglucerase Ceredase . Enzyme B Homo sapiens (17309302) 1991 Taliglucerase alfa Elelyso Pfizer Gaucher's disease B Homo sapian 2012 Choriogonadotropin alfa Ovidrel . Hormone B Homo sapiens (17697491) 2001 Follitropin beta Puregon . Hormone B Homo sapiens (9828905) 1998 Follitropin alfa Gonal-F . Hormone B Homo sapiens (7542980) 1995 Urofollitrophin Metrodin HP . Infertility; female B Homo sapiens (17309302) 1982 Corifollitropin alfa Elonva B 2010 RhPTH Preos . Osteoporosis B Homo sapiens (17309302) 2006 Glucagon rDNA GlucaGen . Hormone B Homo sapiens (10812186) 2000 Teduglutide Gattex NPS Short bowel syndrome B Homo sapian 2012 Pegfilgastrim Neulasta . Hematopoiesis B Homo sapiens (17309302) 2002 Nartograstim Neu-Up . Hematopoiesis B Homo sapiens (17309302) 1994 Filgrastim Neupogen . Immunostimulant B Homo sapiens (9679526) 1992 Lenogastrim Neutrogin . Hematopoiesis B Homo sapiens (10735900) 1991 Tbo-Filgrastim Neutroval Sicor Biotech Severe neutropaenia in patients with non-myeloid malignancies B Homo sapian 2012 Molgramostim Leucomax . Hematopoiesis B Homo sapiens (16883311) 1992 Sargramostim Leukine . Immunostimulant B Homo sapiens (17309302) 1991 Epidermal growth factor Gentel . Vulnerary B Homo sapiens (3553146) 1987 Mecasermin Increlex . Pituitary disorders B Homo sapiens (17309302) 2005 Mecasermin rinfabate IPLEX; Somazon . Antidiabetic B Homo sapiens (17309302) 1994 Somatomedin-1 Igef . Hormone B Homo sapiens (17309302) 1994 Palifermin Kepivance . Mucositis B Homo sapiens (17309302) 2005 Becaplermin Regranex . Diabetic foot ulcers B Homo sapiens (17309302) 1998 Rh-bmp-2/acs Infuse B 2002 Op-1 Novos B 2001 Linaclotide Linzess Forest Laboratories Irritable bowel syndrome with constipation; chronic idiopathic constipation B Homo sapian 2012 Hemoglobin glutamer Hemopure . Anemia B Homo sapiens (12783619) 2003 Belatacept Nulojix Bristol-Myers Squibb Organ rejection in kidney transplant B 2011 Brentuximab vedotin Adcetris Seattle Genetics Hodgkin's lymphoma; systemic anaplastic large cell lymphoma B 2011 Abatacept Orencia . Antiarthritic B Homo sapiens (17309302) 2006 Iv human immunoglobulin Gamunex . Immunomodulator B Homo sapiens (17309302) 2003 Alefacept Amevive . Antipsoriatic B Homo sapiens (17309302) 2003 Immunoglobulin intravenous Gammagard Liquid . Antiviral B Homo sapiens (17309302) 2002 Resp syncytial virus IG RespiGam . Antiviral B Human respiratory syncytial virus 1996 Immune globulin subcutaneous, 20% liquid Hizentra CSL Primary immunodeficiencies B Homo sapian 2010 Rilonacept Arcalyst Regeneron Cryopyrin-associated periodic syndromes including familial cold autoinflammatory syndrome and Muckle¨CWells syndrome B Homo sapian 2008 Crotalidae fab CroFab . Rattlesnake antivenom B Agkistrodon piscivorus (12447339); Crotalus adamanteus (12447339); Ovis aries (12447339); Crotalus atrox (12447339); Crotalus scutulatus (12447339) 2001 Igiv-hb Niuliva B 2009 Human immune globulin Privigen B 2007 Insulin glulisine Apidra . Antidiabetic B Homo sapiens (17309302) 2005 Oral insulin Oral-lyn . Antidiabetic B Homo sapiens (17309302) 2005 Pulmonary insulin Exubera Antidiabetic B Homo sapiens (17309302) 2003 Insulin aspart NovoRapid . Antidiabetic B Homo sapiens (17309302) 2002 Insulin determir Levemir . Antidiabetic B Homo sapiens (17309302) 2001 Insulin glargine Lantus . Antidiabetic B Homo sapiens (17309302) 2001 Human insulin zinc suspension Humulin Zn . Antidiabetic B Homo sapiens (17309302) 1999 Human neutral insulin Novolin R . Antidiabetic B Homo sapiens (17309302) 1999 Porcine neutral insulin Pork Actrapid . Antidiabetic B Sus scrofa (17309302) 1998 Insulin aspart; IA protamine NovoMix 30 . Antidiabetic B Homo sapiens (17309302) 1997 Insulin lispro Humalog . Antidiabetic B Homo sapiens (17309302) 1996 Soluble insulin Velosulin BR . Antidiabetic B Homo sapiens (17309302) 1986 Porcine isophane insulin Pork Insulatard . Antidiabetic B Sus scrofa (17309302) 1985 Isophane insulin Humulin N . Antidiabetic B Homo sapiens (17309302) 1982 Oralgen B 2007 Hu neutral insulin Insuman B 1992 Human insulin zn suspension Humulin l B 1985 Biphasic porcine insulin Pork mixtard 30 B 1982 Peginterferon alfa-2a Pegasys Antiviral B Homo sapiens 2001 Peginterferon alfa-2b Pegintron Antiviral B Homo sapiens 2000 Interferon alfacon-1 Infergen Antiviral B Homo sapiens 1997 Interferon gamma-n1 OGamma100 Antifungal B Homo sapiens 1996 Interferon beta-1a Avonex Multiple sclerosis B Homo sapiens 1996 Interferon b-1b Betaseron Multiple sclerosis B Homo sapiens 1993 Interferon gamma-1a Biogamma Anticancer B Homo sapiens 1992 Interferon gamma-1b Actimmune Immunostimulant B Homo sapiens 1991 Interferon alfa-n3 Alferon N Antiviral B Homo sapiens 1990 Interferon gamma Polyferon Biogen, Rentschler Inflammatory disease (rheumatoid arthritis, nasopharyngeal carcinoma, basal cell carcinoma, chronic hepatitis and adjunct immunotherapy for cancer) B Homo sapiens 1989 Interferon alfa Alfaferone Antiviral B Homo sapiens 1987 Interferon alfa2b Intron-A Anticancer B Homo sapiens 1986 Interferon alfa2a Roferon-A Anticancer B Homo sapiens 1986 Interferon alfa-n1 Wellferon Antiviral B Homo sapiens 1986 Interferon beta Frone Antiviral B Homo sapiens 1985 Interferon alfa-2b Viraferon Antiviral B Homo sapiens 1985 Mobenakin Octin . Anticancer B Homo sapiens (17309302) 1999 Denileukin diftitox Ontak . Anticancer B Homo sapiens (Clinical Lymphoma, Myeloma & Leukemia Volume 1, Supplement 1 s33-S36 2008) 2000 Celmoleukin Celeuk . Anticancer B Homo sapiens (1586600) 1992 Teceleukin Imumace . Anticancer B Homo sapiens (17309302) 1992 Aldesleukin Not Available . Anticancer (metastatic renal cell carcinoma) B Homo sapiens 1992 Interleukin-2 Proleukin . Anticancer B Homo sapiens (17309302) 1989 Epoietin delta Dynepo . Hematopoiesis B Homo sapiens (17825688) 2007 Darbepoietin alfa Aranesp . Erythropoiesis B Homo sapiens (11308267) 2001 Erythropoietin beta Epogin . Erythropoiesis B Homo sapiens (8808169) 1990 Erythropoietin alfa Epogen . Erythropoiesis B Homo sapiens (17575216) 1988 Rh-erythropoietin-alfa Hexal B 2007 Oprelvekin Neumega . Thrombocytopenia B Homo sapiens (17309302) 1998 Ziv-aflibercept Zaltrap Sanofi Metastatic colorectal cancer B Homo sapian 2012 Lutropin alfa Luveris . Hormone B Homo sapiens (17309302) 2001 Raxibacumab . HGS Anthrax B Homo sapian 2012 Belimumab Benlysta Human Genome Sciences Active, autoantibody-positive, systemic lupus erythematosus B Homo sapian 2011 Ipilimumab Yervoy Bristol-Myers Squibb Unresectable or metastatic melanoma B Homo sapian 2011 Tocilizumab Actemra Genentech Rheumatoid arthritis B Homo sapian 2010 Denosumab Prolia Amgen Postmenopausal osteoporosis? B Homo sapian 2010 Golimumab Simponi Centocor Ortho Biotech (a subsidiary of J&J) Rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis B Homo sapian 2009 Canakinumab Ilaris Novartis Cryopyrin-associated periodic syndromes B Homo sapian 2009 Ustekinumab Stelara Centocor Ortho Biotech (a subsidiary of J&J) Moderate-to-severe plaque psoriasis B Homo sapian 2009 Ofatumumab Arzerra GlaxoSmithKline (developed with Genmab) Chronic lymphocytic leukaemia B Homo sapian 2009 Certolizumab pegol Cimzia UCB Crohn's disease B Homo sapian 2008 131i-chtnt Not Available . Anticancer B Homo sapiens 2007 Ranibizumab Lucentis . Macular degeneration B Mus musculus 2006 Panitumumab Not Available . Anticancer (metastatic colorectal cancer) B Homo sapiens 2006 Nimotuzumab Not Available . Anticancer (squamous cell carcinomas of the head and neck, recurrent/refractory high grade malignant astrocytoma and glioma) B Mus musculus 2006 Bevacizumab Avastin . Anticancer B Mus musculus 2004 Natalizumab Tysabri . Multiple sclerosis B Mus musculus 2004 Efalizumab Raptiva . Antipsoriatic B Mus musculus 2003 Omalizumab Xolair . Antiasthmatic B Mus musculus 2003 Adalimumab Humira . Antiarthritic B Homo sapiens 2003 Cetuximab Erbitux . Anticancer B Homo sapiens 2003 Tositumomab Bexxar . Anticancer B Homo sapiens 2003 Ibritumomab Zevalin . Anticancer B Homo sapiens 2002 Alemtuzumab Campath . Anticancer B Mus musculus 2001 Trastuzumab Herceptin Genentech Oncological disease (for treatment of HER2-positive metatsatic breast cancer) B Mus musculus (17309302) 1998 Palivizumab Synagis . Antiviral B Mus musculus 1998 Basiliximab Simulect . Immunosuppressant B Homo sapiens 1998 Infliximab Remicade . Crohn's disease B Homo sapiens 1998 Daclizumab Zenapax . Immunosuppressant B Mus musculus 1997 Rituximab Rituxan . Anticancer B Homo sapiens 1997 Mab17-1a Panorex . Adjuvant/colorectal cancer B Mus musculus (17309302) 1995 Abciximab ReoPro . Antithrombotic B Homo sapiens 1994 HA-1A Centoxin . Antisepsis B Homo sapiens (1578120) 1992 Anti-thymocyte globulin Thymoglobuline . Immunosuppressant B Homo sapiens (17309302) 1984 Muromonab-CD3 Orthoclone OKT3 . Immunosuppressant B Homo sapiens (17309302) 1986 Pertuzumab Perjeta Genentech HER2-positive metastatic breast cancer B Homo sapian 2012 Catumaxomab Removab B 2009 Eculizumab Soliris B 2007 Mirimostim Leukoprol . Hematopoiesis B Homo sapiens (17309302) 1991 Collagenase Santyl Ointment . Enzyme B Homo sapiens (17309302) 1986 Glucarpidase Voraxaze BTG International Toxic plasma methotrexate concentrations in patients with delayed methotrexate clearance B Homo sapian 2012 Dornase alfa Pulmozyme . Cyctic fibrosis B Homo sapiens (8017432) 1994 Defibrotide Noravid . Antithrombotic B Bos primigenius (7681375); Sus scrofa (7681375) 1986 Rec-antihemophilic factor Advate . Antihemophilia B Homo sapiens (17309302) 2003 Drotrecogin alfa Xigris . Antisepsis B Homo sapiens (11445735) 2001 Activated protein C concn Anact C . DVT; anticoagulant B Homo sapiens (17309302) 2001 Pamiteplase Solinase . Antithrombotic B Homo sapiens (17309302) 2000 Tenecteplase TNKase . Antithrombotic B Homo sapiens (17309302) 2000 Moroctocog alfa Refacto . Hemophilia B Homo sapiens (17309302) 1999 Protein C concentrate Ceprotin . Purpura fulminans B Homo sapiens (17309302) 1999 Monteplase Cleactor . Antithrombotic B Homo sapiens (17309302) 1998 Factor VIIa NovoSeven . Hemophilia B Homo sapiens (15328151) 1996 Nateplase Milyzer . Antithrombotic B Homo sapiens (17309302) 1996 Reteplase Retavase . Antithrombotic B Homo sapiens (17309302) 1996 Recombinant factor VIII Kogenate . Hemophilia B Homo sapiens (17309302) 1993 Duteplase Solclot . Antithrombotic B Homo sapiens (1575179) 1992 Factor IX Novact M . Hemophilia B Homo sapiens (12694528) 1992 Factor Vlll Recombinate . Hemophilia B Homo sapiens (1421823) 1992 Pro-urokinase Thrombolyse . Antithrombotic B Homo sapiens (17309302) 1992 Silteplase Plasminer . Antithrombotic B Homo sapiens (17309302) 1991 Factor IX human AlphaNine . Hemophilia B Homo sapiens (20618876) 1990 Human factor VIII Haemate HS . Hemophilia B Homo sapiens (2498393) 1989 Factor VIII Monoclate-P . Hemophilia B Homo sapiens (Haemophilia Volume 5, Issue 2, pages 143¨C144, March 1999) 1987 Alteplase Activase . Antithrombotic B Homo sapiens (17309302) 1987 Anistreolase; Anistreplase Eminase . Antithrombotic B Streptococcus; Homo sapiens (17309302) 1987 Ocriplasmin Jetrea Thrombogenics Symptomatic vitreomacular adhesion B Homo sapian 2012 Coagulation factor ix Haemonine B 2009 Rh-thrombin Recothrom B 2008 Human thrombin Evithrom B 2007 Tisokinase Plasvata B 1990 Alpha1-proteinase inhibitor Glassia Baxter Emphysema B Homo sapian 2010 Ecallantide Kalbitor Dyax Corporation Hereditary angioedema B bovine 2009 Alpha-1 proteinase inhibitor Aralast . Antiemphysemic B Homo sapiens (17309302) 2003 Alpha-1 antitrypsin Prolastin . Antiemphysemic B Homo sapiens (17309302) 1988 Ulinastatin Miracid . Pancreatic disorders B Homo sapiens (17309302) 1985 Antithrombin III Thrombate III . Anticoagulant B Homo sapiens (17309302) 1983 Aprotinin Trasylol Bayer Ischemia B Bos taurus (14282026) 1960 Antithrombin alfa Atryn B 2006 Somatropin Asellacrin 2 || Asellacrin . Growth hormone deficiency B Homo sapiens 1976 Somatotropin Nutropin . Hormone B Homo sapiens (17309302) 1994 RecDNA somatotropin Saizen . Hormone B Homo sapiens (17309302) 1989 Somatrem Protropin . Hormone B Homo sapiens (17309302) 1985 Somatotropin rdna original Accretropin B 2008 Idursulfase Elaprase B 2006 Sulglycotide Gliptide B 1985 Calfactant Infasurf . RDS B Bos primigenius (9934915) 1999 Porcine lung surfactant Curoserf . RDS B Sus scrofa (17309302) 1994 Surfactant ta Surfacten B 1987 Tesamorelin Egrifta Theratechnologies HIV lipodystrophy B Homo sapiens 2010 Thymalfasin Zadaxin . Hepatitis B Homo sapiens (17309302) 1996 Factor 8 Wilate . Hemophilia B Homo sapiens (16363263) 2005 H-101 H-101 Shanghai Sunway Biotech Anticancer B Human adenovirus 5 (16507823) 2004 von Willebrand factor Wilfactin . Hemostatic B Homo sapiens (17309302) 2004 Anakinra Kineret . Antiarthritic B Homo sapiens (17309302) 2001 Pegvisomant Somavert . Acromelagy B Homo sapiens (17309302) 2000 Collagenase clostridium histolyticum Xiaflex Auxilium Dupuytren's contracture B Clostridium histolyticum 2010 Abobotulinum-toxin A Dysport Ipsen Cervical dystonia and glabellar lines B Clostridium botulinum type A 2009 Romiplostim Nplate Amgen Thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura B Homo sapian 2008 Orthokine Orthokine . Antiarthritic B Homo sapiens (17309302) 2005 Salmon calcitonin Osteotonina Not Available Osteoporosis B Salmonidae (17309302) 1985 Chondrocelect B 2009 Sf-1019 R-1818 B 2008 Rh-thrombomodulin Recomodulin B 2008 Methoxy polyethylene glycol-epoetin beta Mircera B 2007 Celacade B 2007 Colostrinin B 2007 Rfsh/rhfsh Follitrope B 2007 Follitropin alfa/lutropin alfa Pergoveris B 2007 Botulinum toxin type a Oculinium B 1990 Ru-41740 Biostim B 1985 Thymol Not Available Not Available Antifungal - Chemotherapy: Antifungal (topical) N Thymus vulgaris (3879679) 1978 Nordihydroguaiaretic acid Not Available Not Available Antioxidant (lard) N Larrea divaricata (3879679) 1978 Aminolevulinic acid HCI Levulan Not Available Actinic keratoses N Homo sapiens (17309302) 2000 Betain anhydrous Cystadane . Homocystinuria N Triticum 1996 Micronomicin sulfate Sagamicin Kyowa Antibacterial (Bacterial infections of the respiratory tract) N Micromonospora sagamiensis (6674537) 1982 Paromomycin sulfate Humatin King Pharmaceutical, The Institute of OneWorld Health Antibacterial (visceral leishmaniasis) N Streptomyces rimosus subsp. Paromomycinus (15806196); Streptomyces rimosus (1612424) 1981 Gentamicin Garamycin Lek Antibacterial N Micromonospora echinospora (18247396) 1979 Tobramycin sulfate Tobrex; Nebcin; Aktob; Distobram; Gernebcin; Sybryx; Tobramycetin Alcon Antibacterial N Streptomyces tenebrarius (18486398) 1975 Neomycin Mycifradin; Neo-Fradin; Biosol; Bykomycin; Endomixin; Fradiomycin Swiss Pharma Antibacterial N Streptomyces fradiae (3027020) 1964 Spectinomycin Not Available . Antibiotic N Streptomyces spectabilis 1961 Streptomycin Sulfate Streptomycin Merck & Co. under George W. Merck Antibacterial (tuberculosis, anti-plague Yersinia pestis) N Streptomyces griseus (7934895) 1946 Nicotine Not Available Not Available Insecticide N Asclepias syriaca (12008000); Lycopodium spp. (12008000); Nicotiana tabacum (3879679) 1984 Rifamycin B Not Available Lepetit Antibacterial N Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1958 Trabectedin; ecteinascidin; ecteinascidin-743; ET-743 Yondelis PharmaMar, Johnson and Johnson Oncological disease (advanced soft tissue sarcoma) N Ecteinascidia turbinata (18497896) 2007 Aclarubicin Aclacin Not Available Oncological disease N Streptomyces galilaeus (8407584) 1981 Daunorubicin; daunomycin; rubomycin C Cerubidine Not Available Oncological disease (for remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults, Leukemia (acute myeloid leukemia and acute lymphocytic leukemia) and other neoplasms) N Streptomyces coeruleorubidus (8967800); Streptomyces peucetius (15273252) 1967 Doxorubicin; doxorubicin hydrochloride; hydroxydaunorubicin Doxil; Adriamycin Johnson & Johnson Oncological disease (for the treatment of leukemia, various sarcomas, practically every type of cancer, neuroblastomas, leukoses, and lymphomas) N Streptomyces peucetius (16545946) 1966 Sennoside B Not Available Not Available Cardiovascular disease (laxative) N Cassia (3879679); Cassia senna (15137997) 1978 Chromomycin A3 (none given) Not Available Oncological disease N Streptomyces griseus (15255901) 1961 Griseofulvin; grisovin Fulvicin-U/F; Grifulvin V; Gris-PEG Not Available Antifungal (skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails) N Penicillium soppii (16311630); Penicillium griseofulvum (16311630); Penicillium raistrickii (16311630); Penicillium aethiopicum (16311630); Penicillium coprophilum (16311630); Penicillium canescens; Penicillium lanosum (16311630); Penicillium persicinum (16311630); Penicillium dipodomyicola (16311630); Penicillium sclerotigenum (16311630); Aspergillus lanosus (16311630); Penicillium jamesonlandense (16311630); Penicillium (16311630); Penicillium janczewskii (16311630) 1962 Hydrastine Not Available Not Available Haemostatic, Astringent N Hydrastis canadensis (3879679) 1978 Noscapine (narcotine) Anarcotine Paris Ecole de Pharmacie and Academie Royale des Sciences Antitussive (cough suppressant) N Papaver somniferum (3879679) 1895 Bucillamine Rimatil . Immunomodulator N Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1987 Aztreonam Azactam Squibb Antibacterial (Susceptible gram-negative bacteria, including Pseudomonas aeruginosa) N Chromobacterium violaceum (3168426) 1986 Benzylpenicillin; penicillin G Benpen; Crystapen Glaxo. Pharmaceuticals, Ltd. Antibacterial (Sensitive bacterial infections including gram-positive and some gram-negative organisms) N Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1942 THC-CBD; Dronabinol; cannabidiol; GW-1000-02 Sativex GW Pharmaceuticals Neurological disease (neuropathic pain in multiple sclerosis, MS pain) N Cannabis sativa (18275914) 2005 THC; dronabinol; Delta9-tetrahydrocannabinol Marinol Solvay Pharmaceuticals, Roxane Neurological disease (antinauseant, AIDS, antiemetic, decrease ocular tension) N Cannabis sativa (18751909) 1986 Digitoxin Crystodigin; Tardigal; Unidigin Pharm Weekbl Cardiovascular disease (for the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure) N Digitalis purpurea (13127018) 1996 Ouabain; g-strophanthin Not Available Not Available Cardiovascular disease (increased blood pressure and heart rate without changing the contractile response) N Acokanthera (DukeDB-22); Acokanthera oppositifolia (DukeDB-22); Acokanthera oblongifolia (DukeDB-22); Strophanthus gratus (DukeDB-975) 1978 Convallatoxin Not Available Not Available Cardiovascular disease (Cardiotonic) N Convallaria majalis (3879679) 1978 Deslanoside Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis lanata (3879679) 1978 Digitalin Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis purpurea (3879679) 1978 Lanatoside A Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis lanata (3879679) 1978 Lanatoside B Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis lanata (3879679) 1978 Lanatoside C Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis lanata (3879679) 1978 Neocarzinostatin (none given) Not Available Oncological disease N Streptomyces carzinostaticus (6236220) 1976 Carzinophilin (none given) Not Available Oncological disease N Streptomyces sahachiroi (CID 3032396) 1954 Epinephrine Bitartrate Bronitin; Adrenalin; EpiPen; Epipen Jr. Not Available Immunological, inflammatory and related disease - Inflammatory disease (anaphylaxis and sepsis) N Ephedra sinica (9014353) 1967 Agrimophol Not Available . Anthelmintic - Chemotherapy N Agrimonia eupatoria (3879679) 1978 Colchiceine amide Not Available Not Available Oncological disease - Chemotherapy: Antitumor agent N Colchicum autumnale (3879679) 1978 Demecolcine Not Available Not Available Oncological disease - Chemotherapy: Antitumor agent N Colchicum autumnale (3879679) 1978 Ivermectin Stromectol; Mectizan Merck & Co Antiparasitic (onchocerciasis (river blindness) in humans, a debilitating disease caused by the parasitic worm Onchocerca volvulus) N Streptomyces avermitilis (18824353) 1987 Neoandrographolide Not Available Not Available Antibacterial - Chemotherapy: Bacillary dysentery N Andrographis paniculata (3879679) 1978 Ingenol mebutate Picato Leo Pharma Actinic keratosis N Euphorbia peplus 2012 Asparaginase Elspar Merck & Co. Inc Oncological disease (for treatment of acute lympocytic leukemia and non-Hodgkins lymphoma) N Escherichia coli (18678946) 1969 Yohimbine Not Available Not Available Aphrodisiac N Pausinystalia (3879679) 1980 Vincamine Not Available Not Available Cerebral stimulant N Vinca minor (3879679) 1978 Ajmalicine Not Available . Circulatory disorders N Rauvolfia serpentina (3879679); Catharanthus roseus (%Needs for new plant-derived pharmaceuticals in the post-genome era, 2008 by Ying Wang%) 1978 Ergotamine Gynergen Not Available Neurological disease (for use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia") N Claviceps purpurea (15806196) 1960 Gamolenic acid Epogam Not Available Antiallergic N Homo sapiens (17309302) 1988 Hesperidin Not Available Not Available Capillary fragility N Citrus (3879679) 1978 Rutin Not Available Not Available Capillary fragility N Citrus (3879679) 1978 Hesperetin Hesperin Vydac Cardiovascular disease (for lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again) N Citrus bergamia (16390199); Citrus limon (18035532) 1997 Silymarin Not Available Not Available Antihepatotoxic N Silybum marianum (3879679) 1980 Xanthotoxin; ammoidin; 8-methoxypsoralen Not Available Not Available Leukoderma, Vitiligo N Ammi majus (3879679) 1980 Khellin Not Available Not Available Bronchodilator N Ammi (3879679) 1978 Rotenone Not Available Not Available Piscicide N Lonchocarpus (3879679) 1978 Eupatilin Not Available Korean traditional medicine Immunological, inflammatory and related disease (chronic diarrhoea) N Artemisia argyi (18497896) 1975 Betamethasone dipropionate Not Available . Anti-inflammatory N Homo sapiens 1975 Betamethasone sodium phosphate Not Available . Anti-inflammatory N Homo sapiens 1974 Testosterone (none given) Not Available Anticancer N Homo sapiens (17309302) 1965 Teicoplanin Targocid Sanofi-Aventis Antibacterial N Actinoplanes teichomyceticus (18712518) 1988 Vancomycin Vancocin; Vancoled; Vancor; Vancocyn; Lyphocin Eli Lilly Antibacterial N Amycolatopsis orientalis (3733518) 1958 Dermatan sulfate Mistral . DVT; anticoagulant N Homo sapiens (12213784) 1999 Hyaluronate sodium Suvenyl . Joint lubricant N Homo sapiens (17309302) 1987 Heparin sodium Not Available . Anticoagulant N Homo sapiens 1972 Gitalin Not Available Not Available Cardiovascular disease (Cardiotonic) N Digitalis purpurea (3879679) 1978 Menotropins Not Available . Growth hormone deficiency N Homo sapiens 1975 Angiotensin II Delivert Not Available Anticancer N Homo sapiens (17309302) 1994 Fusafungine Not Available . Antibiotic N Fusarium lateritium 1963 Galantamine hydrobromide; galanthamine Reminyl; Razadyne; Razadyne ER; Memeron; Nivalin Johnson & Johnson (Trad. Med. From Eastern Europe), Janssen Pharmaceuticals, Shire (U.K.) Neurological disease (Alzheimer¡¯s disease) N Lycoris squamigera (3879679); Narcissus pseudonarcissus (15620274); Lycoris radiata (%Needs for new plant-derived pharmaceuticals in the post-genome era an industrial view in drug research and development, 2008 by Ying Wang%); Galanthus elwesii (15620274); Leucojum aestivum (%Plants, medicines and man, 2006 by Michael W Fowler%); Galanthus nivalis (18497896); Galanthus woronowii (16198377) 2002 Capsaicin; ALGRX 4975 Not Available . Neurological disease (pain relieval) N Zingiber officinale (DukeDB-1078); Capsicum frutescens (DukeDB-208); Capsicum annuum (DukeDB-207) 1990 (+-)-Tetrahydropalmatine; rotundine Levo-THP Not Available Immunological, inflammatory and related disease - Analgesic; Sedative; Tranquillizer N Stephania rotunda (5706494); Stephania (3879679); Corydalis ambigua (3879679) 1978 Glaucine Not Available Not Available Antitussive N Glaucium flavum (3879679) 1978 Fumagillin; SR-90144 Flisint Sanofi-Aventis Antiparasitic (intestinal microsporidiosis) N Aspergillus fumigatus (15806196) 2005 Andrographolide Not Available Not Available Antibacterial - Chemotherapy: Bacillary dysentery N Andrographis paniculata (3879679) 1992 Omega-conotoxin MVIIA; SNX-III; SNX-111; C1002; Ziconotide Prialt Elan Pharmaceuticals, Neurex Neurological disease (chronic pain relief, neuropathic pain) N Conus magus (18497896); Conus geographus (10888010) 2005 Carperitide Hanp Not Available Congestive heart failure N Homo sapiens (17309302) 1995 Fidaxomicin Dificid Optimer Clostridium difficile-associated diarrhoea N actinomycete Dactylosporangium aurantiacum subspecies hamdenesis 2011 Tacrolimus; FK-506; Fujimycin Prograf; Advagraf and Protopic Astellas Pharma Inc, Fujisawa Immunological, inflammatory and related disease (liver transplantation) N Streptomyces tsukubaensis (11548050) 1993 Josamycin Josacine; Kitasamycin A3; Turimycin A5 Not Available Antibacterial N Streptomyces narbonensis (1576948) 1988 Midecamycin Not Available . Antibiotic N Streptomyces mycarofaciens 1988 Natamycin; pimaricin Pimafucin Not Available Antifungal (treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium) N Streptomyces natalensis (18045406) 1978 Amphotericin Abelcet; AmB; AmBisome; Ampho-Moronal; Amphocin; Amphotec; Amphotericin; Fungisome NeXstar Pharmaceuticals, Gilead Sciences Antibacterial N Streptomyces nodosus (18824121) 1966 Erythromycin Abboticin; Abomacetin; E-mycin; Ery-tab; Benzamycin Eli Lilly and Company Antibacterial (outbreaks of chlamydia, syphilis, acne, and gonorrhea, respiratory tract infections and outbreaks of chlamydia, syphilis, acne, and gonorrhea) N Saccharopolyspora erythraea (15806196) 1964 Nystatin Nystan Elizabeth Lee Hazen and Rachel Fuller Brown Antifungal (neonatal oral thrush) N Streptomyces noursei (17905880) 1964 Spiramycin Not Available . Antibiotic N Streptomyces ambofaciens 1955 Acemannan Acemannan hydrogel N 2001 Apomorphine hydrochloride Apokyn Mylan Bertek pharmaceuticals Neurological disease (Parkinson¡¯s disease) N Papaver somniferum (16796374) 2004 Morphine sulfate Avinza; DepoDur Elan, SkyePharma PLC, Endo Pharmaceuticals Neurological disease (for the relief and treatment of severe pain, post-surgical pain relief) N Asteraceae (12008000); Papaver somniferum (18497896); Poaceae (12008000) 2002 Pentazocine Talwin; Talwan Sterling Drug Company Neurological disease (for the relief of moderate to severe pain) N Papaver somniferum (18497896) 1967 Methylmorphine Codeine Not Available Neurological disease (for treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant, Analgesic and Antitussive) N Papaver bracteatum (3879679); Papaver somniferum (15806196) 1954 Heroin; diacetylmorphine Diamorphine Bayer company Neurological disease (used in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain) N Papaver somniferum (18497896) 1898 Lisdexamfetamine dimesylate Not Available . ADHD N Ephedra sinica; Senegalia berlandieri 2007 Ubenimex Bestatin Not Available Immunological, inflammatory and related disease - Immunostimulant N Streptomyces olivoreticuli (3496857) 1987 Pseudoephedrine Not Available Not Available Immunological, inflammatory and related disease - Sympathomimetic N Ephedra sinica (3879679) 1975 Pseudoephedrine, nor- Not Available Not Available Immunological, inflammatory and related disease - Sympathomimetic N Ephedra sinica (3879679) 1975 Amphetamine Adderall; Vyvanse; Dexedrine; Benzedrine Texas A&M University Attention-deficit disorder (ADD) and attention-deficit hyperactivity disorder (ADHD) in adults and children N Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1971 Kawain Not Available Not Available Cardiovascular disease (Tranquillizer) N Piper methysticum (3879679) 1978 Polyphenon E Veregen MediGene AG and Bradley Pharmaceuticals Antiviral (genital and perianal warts) N Camellia sinensis (18275914) 2006 Mizoribine Bredinin Japanese Xuhuacheng Association, Toyo Jozo Immunological, inflammatory and related disease (rejection of kidney transplants) N Eupenicillium brefeldianum (10390602) 1984 Lincomycin Lincocin Wallace Pharmaceuticals Antibacterial N Streptomyces lincolnensis (1328813) 1964 Colistin Not Available . Antibiotic N Paenibacillus polymyxa 1958 Crofelemer Fulyzaq Salix HIV-associated diarrhoea N ton lechleri 2012 Chenodiol Chenix Rowell Anticholelithogenic (Radiolucent gallstones) N Homo sapiens (17309302) 1983 Pentostatin; deoxycoformycin Nipent Warner-Lambert (Parke-Davis) Oncological disease (hairy cell leukaemia refractory to alpha interferon) N Streptomyces antibioticus (14651224) 1992 Adenosine Adenocord Not Available Antiarrhythmic N Homo sapiens (17309302) 1989 Papaverine Kavrin Not Available Neurological disease (for the treatment of impotence, smooth muscle relaxant, and also spasms of the gastrointestinal tract, bile ducts and ureter, vasospasm) N Papaver somniferum (15806196) 1984 Sanguinarine Not Available Not Available Dental plaque inhibitor N Sanguinaria canadensis (3879679) 1980 Berberine Not Available . Antibacterial - Chemotherapy: Bacillary dysentery N Thalictrum (15277092); Berberis vulgaris (3879679) 1978 Palmatine; filiraurine Not Available Not Available Antipyretic, Detoxicant N Coptis japonica (3879679) 1978 Stevioside Not Available Not Available Sweetener N Stevia rebaudiana (3879679) 1980 Aescin Not Available Not Available Immunological, inflammatory and related disease - Inflammatory disease (antiinflammatory) N Aesculus hippocastanum (3879679) 1978 Asiaticoside Not Available . Vulnerary N Centella asiatica (3879679) 1978 Glycyrrhizin; Glycyrrhetic acid Not Available Not Available Sweetener, Addison's disease N Glycyrrhiza glabra (3879679) 1978 Artemisinin; qinghaosu Artemisin Baiyunshan, Traditional Chinese Medicine Antiparasitic (malaria) N Artemisia annua (18497896) 1987 Spinosad Natroba ParaPRO Head lice N Saccharopolyspora spinosa 2011 Alprostadil MUSE . Erectile dysfunction N Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1998 Pravastatin Mevalotin; Pravachol; Selektine Sankyo Cardiovascular disease (for the treatment of hypercholesterolemia to reduce the risk of myocardial infarction, atherosclerosis, lipidaemia) N Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374) 1989 Simvastatin; simvastin Zocor; Simvastatin; Simlup and Simcard Merck Cardiovascular disease (for the treatment of hypercholesterolemia) N Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374); Aspergillus terreus (18497896) 1988 Lovastatin; mevinolin Mevacor Merck Cardiovascular disease (for management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia, and for primary prevention of coronary heart disease, familial hypercholesterolemia) N Aspergillus terreus (18578535) 1987 Extract of serenoa repens Permixon Not Available Benign prostatic hypertrophy N Serenoa repens (17309302) 1982 Oxytetracycline Terramycin Pfizer Antibacterial N Streptomyces rimosus (16959966) 1965 Tetracycline Sumycin; Terramycin; Tetracyn; Panmycin; Actisite Pfizer, Bristol-Myers Squibb and Teva Pharmaceuticals Antibacterial N Streptomyces viridifaciens (18588016); Streptomyces aureofaciens (11677904) 1963 Demeclocycline Declomycin; Declostatin; Ledermycin Not Available Antibacterial (hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) when fluid restriction alone has been ineffective) N Streptomyces aureofaciens (826231) 1960 Chlortetracycline; chlorotetracycline Aureomycin Lederle Antibacterial N Streptomyces aureofaciens (11677904) 1950 Hemsleyadin Not Available Not Available Antibacterial - Chemotherapy: Bacillary dysentery, Antipyretic N Hemsleya (3879679) 1978 Scopolamine Not Available Not Available Immunological, inflammatory and related disease - Sedative N Datura metel (3879679) 1979 Anisodamine Not Available . Anticholinergic N Anisodus tanguticus (3879679) 1978 Anisodine Not Available . Anticholinergic N Anisodus tanguticus (3879679) 1978 Atropine Equipin Not Available Anticholinergic - For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides. N Atropa belladonna (11710734); Mandragora officinarum (11710734); Datura stramonium (11710734) 1973 Cocaine; benzoylmethyl ecgonine Cocaine Not Available Neurological disease (for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities) N Erythroxylum coca (15806196) 1884 Rescinnamine Not Available Not Available Cardiovascular disease (Antihypertensive, Tranquillizer) N Rauvolfia serpentina (3879679) 1978 Vincristine; VCR; leurocristine Oncovin; Vincasar Not Available Oncological disease (for treatment of acute leukaemia, malignant lymphoma, acute erythraemia, acute panmyelosis, non-Hodgkin lymphoma, Hodgkin¡¯s disease and paediatric solid tumours) N Catharanthus roseus (18053006) 1963 Deserpidine Enduronyl Not Available Cardiovascular disease (for the treatment of hypertension and tranquillizer) N Rauwolfia (3879679) 1961 Reserpine Serpasil; Banasil; Alserin; Raupoid Poet and Kelly Cardiovascular disease (for the treatment of hypertension, tranquillizer) N Rauvolfia serpentina (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Rauvolfia vomitoria (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%) 1955 Prezatide copper acetate Iamin gel Not Available Vulnerary N Homo sapiens (17309302) 1996 Theophylline Lanophyllin Lannett N Camellia sinensis 1976 Caffeine; Ergotamine tartrate Cafergot Novartis N Coffea arabica 1948 Lentinan Lentinan Ajinomoto Oncological disease (Immunostimulant, gastric cancer with UFT (tegafur and uracil mixture)) N Lentinula edodes (19010422) 1986 Schizophyllan Sonifilan Kaken Immunological, inflammatory and related disease - Immunostimulant N Schizophyllum commune (CID 24777) 1986 Adoniside Not Available Not Available Cardiovascular disease N Adonis vernalis (3879679) 1978 Romidepsin Istodax Gloucester Pharmaceuticals Anticacer N Chromobacterium violaceum 2009 Folic acid Not Available Folate deficiency N 1946 Fibrinogen Not Available . Deep vein thrombosis or pulmonary embolism N Homo sapiens 1976 Citrofen N 2007 NIX-0699 Hemoxin N 2006 Paclitaxel-albumin; ABI-007; paclitaxel nanoparticles Abraxane American Pharmaceuticals Partners, Inc., American Bioscience Oncological disease (metastatic breast cancer) N Taxus brevifolia (18690825); Taxus wallichiana (16129603) 2005 Ach-02 Acheflan Universidade Federal de Santa Catarina Immunological, inflammatory and related disease - Analgesic N Cordia verbenacea (18951339) 2005 Mycophenolate sodium; mycophenolic acid Myfortic Novartis Immunological, inflammatory and related disease (immunosuppression, prevent rejection in organ transplantation) N Penicillium fagi (16311630); Penicillium bialowiezense (16311630); Penicillium roqueforti (16311630); Penicillium carneum (16311630); Aspergillus unilateralis (16311630); Penicillium brevicompactum (16311630); Byssochlamys nivea (16311630) 2003 Daptomycin; A21978C Cubicin Cubist (Lilly) Antibacterial (skin and skin structure infections caused by Gram-positive organisms) N Streptomyces filamentosus (16796374) 2003 Arglabin (none given) Not Available Oncological disease N Artemisia (8374514) 1999 Sirolimus; rapamycin Rapamune Pfizer, Wyeth Immunological, inflammatory and related disease (immunosuppresive, anti-proliferative) N Streptomyces hygroscopicus (18497896) 1999 Ephedrine Ephedrine Plus DMD Pharmaceuticals Immunological, inflammatory and related disease - Inflammatory disease (asthma, sympathomimetic) N Ephedra sinica (15925954) 1997 Voglibose; AO-128 Basen Triton ChemTech and Takeda Pharmaceutical Cardiovascular and metabolic disease (type 2 diabetes) N Streptomyces hygroscopicus (9403289) 1994 Paclitaxel Taxol Bristol-Myers Squibb (BMS) Oncological disease (for refractory ovarian cancer and against breast, head and neck and non-small cell lung cancers and in advanced forms of Kaposi's sarcoma) N Taxus baccata (12008000); Corylus avellana (12008000); Taxus brevifolia (18690825); Taxus wallichiana (16129603); Seimatoantlerium tepuiense (12008000) 1993 Masoprocol Actinex Not Available Oncological disease N Larrea tridentata (9617755) 1992 Acarbose Glucobay; Precose; Prandase Bayer AG and Bayer Pharmaceuticals Cardiovascular and metabolic disease (type 2 diabetes mellitus) N Actinoplanes (15257419) 1990 Solamargine Curaderm Not Available Oncological disease N Solanum americanum (12672156); Solanum incanum (8954074); Solanum aculeatissimum (19003135) 1989 RV-11 Zalig Pierrel Antibacterial (Chronic bronchitis) N Saccharopolyspora erythraea (15806196) 1989 Fosfomycin trometamol Monuril Forest Pharmaceuticals, Inc. Antibacterial (for the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis) N Streptomyces fradiae (16289393) 1988 Ganglioside GM1 Sygen Not Available Antithrombotic N Homo sapiens (17309302) 1987 Guglipid Guglip Not Available Lipoprotein disorders N Commiphora wightii (12626688) 1987 Plaunotol Kelnac Not Available Antiulcer N Croton stellatopilosus (18451506); Croton sublyratus (17253243) 1987 Mupirocin Bactroban Beecham Antibacterial (primary and secondary skin disorders, nasal infections, and wound healing, especially those involving S. aureus and S. epidermidis) N Pseudomonas fluorescens (16290171) 1986 Miokamycin; miocamycin; MOM Miocamycin Meiji Seika, Toyo. Jozo. Company Antibacterial (Respiratory tract, dermatological and surgical infections due to gram-positive bacteria and mycoplasmas) N Streptomyces mycarofaciens (6334185) 1985 Podophyllotoxin; podofilox Condylox; Condyline Not Available Antiviral (genital warts, condylomata acuminata) N Dysosma pleiantha (16129603); Sinopodophyllum hexandrum (16673335); Podophyllum peltatum (18690825) 1985 astromycin sulfate Fortimicin antibacterial N Micromonospora sp. MK-70 1985 Ciclosporin; cyclosporine; cyclosporin; ciclosporin A; cyclosporine A Sandimmune Novartis Immunological, inflammatory and related disease N Cylindrocarpon lucidum (11548050); Tolypocladium inflatum (18239429); Claviceps purpurea (15806196) 1983 Cyclosporine; cyclosporin A Gengraf; Sandimmun Maas BiolAB, Abbott labs, Sandoz Neurological disease (for treatment of transplant rejection, rheumatoid arthritis, severe psoriasis. Immunosuppressant. Graft/host disease and the prevention of rejection following organ transplantation; prophylaxis of graft rejection in organ and tissue transplantation) N Cylindrocarpon lucidum (11548050); Tolypocladium inflatum (18239429); Claviceps purpurea (15806196) 1983 (+)-Catechin Polyphenon 100 Mitsui Norin Co. Ltd. Haemostatic N Acacia catechu (17887937); Potentilla fragarioides (3879679) 1983 Chloramphenicol Chloromycetin Not Available Antibacterial (used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.) N Streptomyces venezuelae (18646313) 1982 Isotretinoin; Isotrentoin Accutane . Antiacne N Daucus carota 1982 Peplomycin Pepleo Not Available Oncological disease (prostatic cancer) N Streptomyces verticillus (15939315) 1981 Huperzine; huperzine A Haperzine; Selagine National Institute on Aging Neurological disease (Alzheimer¡¯s disease) N Huperzia serrata (18497896) 1980 Santonin Not Available Not Available Anthelmintic - Ascaricide (Chemotherapy) N Artemisia (3879679) 1980 Theobromine Not Available Not Available Vasodilator, Diuretic N Theobroma cacao (3879679) 1980 Vasicine; peganine Not Available Not Available Oxytocic N Acanthaceae (3879679) 1980 Daunorubicin hydrochloride Not Available N 1979 Monocrotaline Not Available Not Available Oncological disease - Antitumor agent (topical) N Crotalaria (15137997) 1978 Sennoside A Not Available Not Available Cardiovascular disease (laxative) N Cassia (3879679); Cassia senna (15137997) 1978 Salicin Not Available Not Available Immunological, inflammatory and related disease - Analgesic N Salix alba (3879679) 1978 Strychnine Not Available Not Available Neurological disease (CNS stimulant) N Strychnos nux-vomica (3879679) 1978 Allantoin Not Available . Vulnerary N Symphytum officinale (15137997) 1978 Allyl isothiocyanate Not Available . Rubefacient N Brassica nigra (3879679) 1978 Arecoline Not Available . Anthelmintic - Chemotherapy N Areca catechu (3879679) 1978 Camphor Not Available Not Available Rubefacient N Cinnamomum camphora (3879679) 1978 Cissampeline Not Available Not Available Skeletal muscle relaxant N Cissampelos pareira (3879679) 1978 Cynarin Not Available Not Available Choleretic N Cynara scolymus (3879679) 1978 Danthron; 1,8-dihydroxy-anthraquinone Not Available Not Available Laxative N Cassia (3879679) 1978 Glaziovine; glasiovine Not Available Not Available Antidepressant N Ocotea cf. glaziovii FS402 (3879679) 1978 Hyoscyamine Not Available Not Available Anticholinergic N Hyoscyamus niger (3879679) 1978 Menthol Not Available Not Available Rubefacient N Mentha spicata (15137997) 1978 Pachycarpine; (+)-sparteine Not Available Not Available Oxytocic N Sophora pachycarpa (3879679) 1978 Picrotoxin Not Available Not Available Analeptic N Anamirta cocculus (3879679) 1978 Rorifone Not Available Not Available Antitussive N Rorippa indica (3879679) 1978 Candicidin Candicidin A; Candicidin D; FR-008-III; Vanobid Not Available Antifungal (used in the topical treatment of vulvovaginal candidiasis) N Streptomyces griseus (18035532) 1976 Digoxin; Digitalis Lanoxin; Digitek; and Lanoxicaps GlaxoSmithKline Cardiovascular disease (for the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure, various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication) N Digitalis lanata (3879679); Digitalis purpurea (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%) 1975 Triptolide Not Available China Immunological, inflammatory and related disease (rheumatoid arthritis and leprosy) N Tripterygium wilfordii (16796374) 1975 L-Dopa Not Available Not Available Neurological disease - AntiParkinsonism N Mucuna pruriens var. utilis (3879679) 1974 Dopamine hydrochloride Not Available . Neurological disease N Homo sapiens 1974 Kanamycin Kantrex; Bekanamycin; Kanamycin A; Kanamycin B; Kenamycin A; Klebcil Bristol-Banyu Research Institute Antibacterial N Streptomyces kanamyceticus (6690428) 1973 Acetylcholine chloride Not Available . Neurological disease N Homo sapiens 1973 Pristinamycin; pristinamycine Pyostacine Not Available Antibacterial (staphylococcal infections) N Streptomyces pristinaespiralis (18542945) 1972 Capreomycin Caprocin; Ogostal Not Available Antibacterial (used in the treatment of tuberculosis in combination with other drugs) N Saccharothrix mutabilis subsp. Capreolus (14700198) 1971 Spectinomycin hydrochloride Not Available . Antibiotic N Streptomyces spectabilis 1971 Streptozocin; streptozotocin; STZ Zanosar Pharmacia & Uphjon Oncological disease (for the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma)) N Streptomyces achromogenes (12464347) 1970 Plicamycin Not Available . Anticancer (testicular cancer) N Streptomyces plicatus 1970 Levodopa Not Available . Dietary supplement N Mucuna pruriens 1970 Viomycin sulfate Viocin Not Available Antibacterial (tuberculosis) N Streptomyces puniceus (14700198) 1968 Physostigmine; eserine Antilirium; Eserine Salicylate; Isopto Eserine; and Eserine Sulfate Not Available Neurological disease (for the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity) N Physostigma venenosum (18497896) 1968 Bleomycin; bleomycin A2; bleomycin B2) Blenoxane Not Available Oncological disease (for palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas) N Streptomyces verticillus (15939315) 1966 Vinblastine; VLB; Vinca leukoblastine sulfate; VBL Velban; Vinblastine Sulfate Injection (Mayne Pharma) Istituto Nazionale Tumori Oncological disease (for treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, head and neck cancer, cervico-uterine cancer, testicular cancer, bladder cancer, and Kaposi's sarcoma) N Catharanthus roseus (18053006) 1965 Dactinomycin; actinomycin D Cosmegen Lyovac; Cosmegen Stowe Oncological disease (for the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, gestational trophoblastic neoplasia, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen) N Streptomyces parvulus (1744035); Streptomyces sindenensis (18335813) 1964 Polymyxin B Sulfate Aerospin; Poly-RX; Aerosporin Burroughs Wellcome Co. Antibacterial N Paenibacillus polymyxa (12644229) 1964 Cycloserine Seromycin Not Available Antibacterial (used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis) N Streptomyces garyphalus (16289393) 1964 Fusidic Acid Fucidine; Fusidin LEO Leo Laboratories, Merck Antibacterial (for the treatment of bacterial infections) N Fusidium griseum (16290171) 1962 Colchicine ColBenemid Not Available Oncological disease (leukemia, antigout) N Colchicum autumnale (18425692) 1961 Mithramycin Not Available . Anticancer N Streptomyces argillaceus 1961 Mitomycin C; mitomycin Mutamycin Not Available Oncological disease (for treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder) N Streptomyces caespitosus (16526821); Streptomyces lavendulae (15696615) 1956 Novobiocin Robiocina Not Available Antibacterial (for the treatment of infections due to staphylococci and other susceptible organisms) N Streptomyces caeruleus (16289393) 1955 Pinitol Not Available Not Available Expectorant N Thuja occidentalis (DukeDB-1011); Cedrus deodara (DukeDB-228); Trifolium pratense (DukeDB-1022); Vachellia farnesiana (DukeDB-10); Tsuga canadensis (DukeDB-1028); Glycine max (DukeDB-449); Pinus sylvestris (DukeDB-749); Medicago sativa (DukeDB-606); Pisum sativum (DukeDB-759); Ceratonia siliqua (DukeDB-244) 1955 Warfarin Coumadin; DuPont Not Available Cardiovascular disease (for the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis.) N Melilotus officinalis (16787371) 1954 Sarkomycin Not Available . Anticancer N Streptomyces erythrochromogenes 1954 Quinidine Not Available Not Available Antiarrhythmic N Cinchona (3879679) 1950 Bacitracin Baci-IM Not Available Antibacterial N Bacillus subtilis (15056142); Bacillus licheniformis (12121761) 1948 Quinine Aflukin; Chinin; Chinine; Coco-Quinine; Quinine Dab Quechua Indians of Peru Antiparasitic (malaria prophylaxis) N Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Cinchona (18454580) 1940 Pilocarpine Diocarpine; Isopto Carpine; Miocarpine; Ocusert Pilo-20; Ocusert Pilo-40; Pilopine HS; Salagen; Scheinpharm Pilocarpine; Timpilo Schein Pharmaceutical Glaucoma. For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sj?grens syndrome. Parasympathomimetic. N Pilocarpus (3879679) 1900 Cotinine Not Available Not Available Insecticide N Nicotiana spp. (12008000) 1560 Oralair grasses NB 2008 Xp-828l Dermylex NB 2007 Curemisinin NB 2007 Cladribine Leustatin . Anticancer ND Homo sapiens (17309302) 1993 Vigabatrin Sabril Merrell Dow Antiepileptic (Spasms and seizures, Intractable seizures unresponsive to currently available therapy) ND Homo sapiens (17309302) 2009 L-alanyl-L-glutamine Dipeptiven . Mucositis ND Homo sapiens (17309302) 2005 Hexyl aminolevulinate Hexvix Not Available Anticancer ND Homo sapiens (17309302) 2004 Pregabalin Lyrica Pfizer Antiepileptic (Epilepsy and neuropathic pain) ND Homo sapiens (17309302) 2004 Aminolevulinic acid me ester Metvix Not Available Actinic keratoses ND Homo sapiens (17309302) 2001 Tiopronin Thiota Santeen Urolithiasis (Cystine urolithiasis in children) ND Homo sapiens (17309302) 1989 Levacecarnine HCI Nicetile . Nootropic ND Homo sapiens (17309302) 1986 Framycetin Soframycin; Sofra-Tulle Chemia-Elektromet Rzesz¨®w Antibacterial ND Streptomyces fradiae (3027020) 2000 Arbekacin Habekacin Meiji Seika Antibacterial (bacterial infections) ND Streptomyces kanamyceticus (17661025) 1990 Isepamicin Isepacin Schering Antibacterial (Urinary and respiratory tract infections) ND Micromonospora echinospora (18533111) 1988 Amikacin Amikin Bristol-Myers Squibb Antibacterial ND Streptomyces kanamyceticus (6690428) 1981 Netilmicin sulfate Netromycin; Netromicine Schering-Plough Antibacterial (serious infections particularly those resistant to gentamicin) ND Micromonospora inyonensis (6376062) 1981 Amodiaquine; SQ Camoquin; Flavoquine Sanofi/Aventis Antiparasitic (malaria) ND Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Cinchona (18454580) 1996 Rocuronium bromide Zemuron . Muscle relaxant ND Homo sapiens (17309302) 1994 Dromostanolone Masterone Injection Syntex Oncological disease (advanced breast neoplasms, postmenopausal women with recurrent breast cancer) ND Homo sapiens (17309302) 1964 Rifabutin; Rfb Mycobutin Pfizer and Farmitalia Carlo Erba Antibacterial (mycobacterium avium complex (MAC) in AIDS) ND Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1992 Rifapentine Priftin; Rifampin Sanofi-Aventis and Merrell Dow Antibacterial (tuberculosis, gram-positive bacteria and Neisseria gonorrhoea infections) ND Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1988 Rifamixin Normix Alfa Antibacterial (Gastrointestinal infections and hepatic encephalopathy) ND Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1987 Rifaximin Xifaxan; Rifacol Salix Pharmaceuticals and Schiapparelli Antibacterial (wide spectrum of bacteria, including Salmonella spp., S. aureus, and E. coli) ND Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1985 Rifampicin; rifampin; rifaldazine; R/AMP; Rofact Rifadin Aventis Antibacterial ND Amycolatopsis mediterranei (17081297); Amycolatopsis rifamycinica (15280283) 1971 Amrubicin hydrochloride; SM-5887 Calsed; Cased Sumitomo Pharmaceuticals Oncological disease (lung cancer, bladder carcinoma and gastric cancer) ND Streptomyces peucetius (16796374) 2002 Amrubicin hcl Not Available . Anticancer (small-cell lung cancer) ND Streptomyces peucetius 2002 Gemtuzumab ozogamicin Mylotarg Wyeth and UCB Pharma Oncological disease (refractory acute myeloid leukaemia) ND Micromonospora echinospora (16796374) 2000 Valrubicin Valstar Anthra and Medeva Oncological disease (bladder cancer) ND Streptomyces peucetius (16545946) 1999 Idarubicin hydrochloride Zavedos Erbamont Oncological disease (acute non-lymphocytic leukemia, acute lymphocytic leukemia and acute myeloid leukemia; breast cancer; Hodgkin's and non-Hodgkin's lymphoma) ND Streptomyces coeruleorubidus (8967800); Streptomyces peucetius (15273252) 1990 Pirarubicin Pinorubicin; Therarubucin Sanraku and Meiji Seika Oncological disease (advanced bladder cancer) ND Streptomyces peucetius (16545946) 1988 Epirubicin HCI Farmorubicin Erbamont Oncological disease (for use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer, mammary, gastric, colorectal, pulmonary and ovarian carcinomas, as well as malignant lymphoma and melanoma and soft tissue sarcoma) ND Streptomyces peucetius (16545946) 1984 Bimatoprost Lumigan Allergan, Inc. Antiglaucoma (open angle glaucoma or ocular hypertension) ND Manduca sexta (11886778); Artemisia dracunculus (DukePED-123); Allium sativum (DukePED-54) 2001 Travoprost Travatan Alcon, Inc. Antiglaucoma (ocular hypertension and glaucoma) ND Manduca sexta (11886778); Artemisia dracunculus (DukePED-123); Allium sativum (DukePED-54) 2001 Methylnaltrexone bromide Relistor Progenics Opioid-induced constipation ND Papaver somniferum 2008 Ceftaroline fosamil Teflaro Cerexa Antibiotic ND Acremonium 2010 Ceftobiprole medocaril Zeftera Basilea Pharmaceutica and Johnson & Johnson Pharmaceutical Research and Development Antibacterial (complicated skin and skin structure infections (cSSSI), including non-limb-threatening diabetic foot infections without concomitant osteomyelitis, against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 2008 Doripenem; S-4661 Finibax; Doribax; Finbax Shionogi & Co and Johnson & Johnson Antibacterial ND Streptomyces cattleya (15759042) 2007 Ertapenem sodium Invanz Merck (AstraZeneca) Antibacterial ND Streptomyces cattleya (15759042) 2002 Biapenem Omegacin Meiji Seika (Wyeth) Antibacterial ND Streptomyces cattleya (15759042) 2002 Cefoselis Wincef Fujisawa Antibacterial (Infection of Staphylococcus aureus and Pseudomonas aeruginosa) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1998 Mezlocillin Mezlin Bayer Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1997 Cefaclor; cefachlor; cefaclorum Ceclor; Ceclor CD; Distaclor; Keflor; Raniclor Not Available Antibacterial (infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1997 Cefcapene pivoxil Flomox Shionogi Antibacterial (Respiratory and urinary tract infections, heptatic infections, ophthalmological and otorhinolarynological infections, skin/soft tissue infections, and for use in gynacology, dentistry and oral surgery, and highly active against a wide variety of Gram-positive and Gram-negative bacteria, except for several strains such as Pseudomonas aeruginosa and enterococci) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1997 Faropenem sodium; fropenam Farom Louisville-based Replidyne Antibacterial ND Streptomyces cattleya (15759042) 1997 Faropenem Farom . Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1997 Cefozopran HCl Firstcin Takeda Antibacterial (Severe infections caused by staphylococci and enterococci. Cefozopran displays a broad antibacterial spectrum against Gram-positive and Gram-negative organisms. It is potentially active against Staphylococcus aureas, Enterococcus faecalis, Pseudomonas aeroginosa and Citrobacter freundii) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1995 Cefditoren pivoxil Meiact Meiji Seika Antibacterial (A broad range of bacterial infections including dermatological and other community acquired infections. Against both Gram-positive and Gram-negative bacteria such as S. pneumoniae and S. marcescens) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1994 Meropenem Merrem Zeneca Antibacterial ND Streptomyces cattleya (15759042) 1994 Panipenem; betamipron Carbenin Sankyo Antibacterial ND Streptomyces cattleya (15759042) 1994 Piperacillin; Tazobactam Zozyn; Tazocin; Zobactin; Zosyn; Pipracil Wyeth, Toyama, GSK Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1993 Cefepime Maxipime; Neopime; Maxcef; Cepimax; Cepimex and Axepim Bristol-Myers Squibb, Elan Pharma, Neomed Antibacterial (Lower respiratory tract infections especially pneumonia, intra-abdominal and urinary tract infections, skin and soft tissue infections, chronic osteomyelitis and in prophylaxis of biliary tract and prostate infections. Cefepime has broad spectrum antimicrobial activity against Staphylococcus, Streptococcus, Pseudomonas, and the Enterobacteriaceae) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1993 Tazobactam sodium Tazocillin Lederle Antibacterial (A broad range of both Gram-positive and -negative organisms, lower respiratory tract, urinary tract, intra-abdominal, biliary and skin and soft tissue infections) ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1992 Cefprozil; cefproxil Cefzil; Procef Bristol-Myers Squibb Antibacterial (Otitis media, uncomplicated skin and skin structure infections plus upper/lower respiratory tract infections, and exhibits great activity against S. aureus, S. epidermidis, Listeria monocytogenes, Streptococci, H. influenzae, Propionibacterium acnes, Clostridium perfringens and difficile) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1992 Loracarbef Lorabid Lilly Antibacterial (Upper and lower respiratory tract infections, urinary tract and skin infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1992 Cefetamet pivoxil HCl Globocef Roche Antibacterial (Community-acquired respiratory and urinary tract infections and effective in penicillin-resistant pneumococci, gonococci and H. influenzae infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1992 Ceftibuten Cedax; Seftem Shionogi Antibacterial (Gram-negative bacterial-related urinary/respiratory tract and gynecological infections, acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1992 Cefpirome sulfate Cefrom Hoechst AG and Roussel Uclaf Antibacterial (Severe urinary and respiratory tract infections, including septicemia and nosocomial infections, and effective in infections of Klebsiella, methicillin-sensitive staphylococci, penicillin-resistant pneumococci, E. coli) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1992 Oxacillin sodium Bactocill; Prostaphilin Abbott Laboratories Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1991 Cefotiam hexetil hydrochloride Pansporin T Takeda Antibacterial (Respiratory infections especially against Streptococci strains) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1991 Cefdinir Omnicef; Cefzon Fujisawa and Abbott Laboratories Antibacterial (Infections of Gram-positive bacteria, especially Staphylococci, common bacterial infections of the ear, sinus, throat, and skin) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1991 Cefodizime sodium Neucef Hoechst; Taiho Antibacterial (Bacterial infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1990 Cefpodoxime proxetil Vantin; Banan; Simplicef; PECEF Sankyo, Pharmacia & Upjohn Antibacterial (Bacterial infections in children) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1989 Cefmetazole sodium Zefazone Pharmacia and Upjohn Antibacterial (Bacterial infection) ND Streptomyces clavuligerus (17940818); Streptomyces cattleya (1367371); Amycolatopsis lactamdurans (7275839) 1989 Flomoxef sodium Flumarin Shionogi Antibacterial (Post-operative, urinary tract and abdominal cavity infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1988 Lenampicillin HCI Varacillin Kanebo Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1987 Sultamicillin tosilate Unasyn; Ampictam; Unacid Pifzer Antibacterial (soft tissue, respiratory and urinary tract infections, even against many ampicillin-resistant strains) ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1987 Aspoxicillin Doyle Not Available Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1987 Cefminox sodium Meicelin; lijiannuo Meiji Seika/Bristol Antibacterial (respiratory system infection urinary tract infection, Intra-abdominal Infection, pelvic infection, sepsis) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Cefuroxime axetil Ceftin; Zinnat; Altacef; Axet; Biofuroksym; Cefteja; Ceftum; Cetil; Ecocef; Forcef; Kefstar; Shincef; Xylid; Zamur; Zinacef; Zinadol; Zinoximor GlaxoSmithKline, Glenmark, Xeno Pharmaceuticals, Bioton S.A., Quadra, Lupin, Xeno Pharmaceuticals, Aristo, Wockhardt, Pharmaniaga, Mepha, Glaxo Wellcome Antibacterial (Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease, Serious bacterial infections with a broad spectrum of action and resistant to most beta-lactamases) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Cefuzonam sodium Cosmosin Lederle/Takeda Antibacterial (A large percentage of Gram-negative bacteria and some Gram-positive bacteria, including those resistant to other third-generation cephalosporins) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Cefixime Suprax; Cefspan Fujisawa, Wyeth, Lupin Antibacterial (Gram-negative bacteria infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Cefpimizole Ajicef Ajinomoto and Mochida Antibacterial (Infections of a spectrum narrower than cefotaxime and cefoperazone) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Cefteram pivoxil Tomiron Toyama Antibacterial (Urinary tract infections with a broad spectrum of Citrobacter, indole-positive Proteus and Enterobacter species resistant to cefaclor, cephalexin and amoxicillin) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1987 Ticarcillin; Clavulanate Timentin; Ticar Beecham, GlaxoSmithKline Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1986 Sulbactam sodium Sulperazone . Beta-lactamase inhibitor ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1986 Cefpiramide sodium Sepatren Sumitomo and Upjohn Antibacterial (Antibiotics) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1985 Cefbuperazone sodium Tomiporan Toyama Antibacterial (Antibiotics) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1985 Cefoxitin sodium Mefoxin Merck & Co., Inc. Antibacterial (Septicemia and lower respiratory tract, urinary tract, intra-abdominal, gynecological, bone and joint, skin and skin structure infections, gram-negative and gram-positive bacteria including anaerobes) ND Streptomyces clavuligerus (17940818); Streptomyces cattleya (1367371); Amycolatopsis lactamdurans (7275839) 1985 Imipenem Primaxin Not Available Antibacterial (for the treatment of bacterial infections caused by susceptible bacteria.) ND Streptomyces cattleya (15759042) 1985 Imipenem; cilastatin Zienam Merck Antibacterial (Bacterial infections of Pseudomonas aeruginosa and the Enterococcus species) ND Streptomyces cattleya (15759042) 1985 Nafcillin Unipen; Nafcil; Nallpen; Naphcillin Not Available Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1984 Temocillin disodium Temopen Beecham, Eumedica Pharmaceuticals Antibacterial (Multiresistant Gram negative bacteria) ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1984 Amoxicillin; Clavulanic acid Augmentin UK-based Beecham Antibacterial ND Emericella nidulans (16598003); Streptomyces clavuligerus (15620274); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1984 Cefonicid sodium; cefonicide; cefonicid Monocid Smith Klein & French Antibacterial (Urinary tract and lower respiratory tract infections, skin and skin structure infections, and bone and joint infections, as well as in surgical prophylaxis) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1984 Ceforanide Precef Bristol Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1984 Cefotetan sodium Cefotan; Apatef Yamanouchi and AstraZeneca Antibacterial (Bacterial infection) ND Streptomyces clavuligerus (17940818); Streptomyces cattleya (1367371); Amycolatopsis lactamdurans (7275839) 1984 Cefotetan disodium Yamatetan Yamanouchi Antibacterial ND Streptomyces clavuligerus (17940818); Streptomyces cattleya (1367371); Amycolatopsis lactamdurans (7275839) 1984 Cefmenoxime HCl Tacef Takeda Antibacterial (Antibiotics against E. coli, C. diversus, Klebsiella, P. Mirabilis, Salmonella, Shigella, Neiseria spp., S. pyogenes, S.Pneumoniae and H. influenzae) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1983 Ceftazidime pentahydrate Ceptaz; Fortaz; Tanicef; Fortum; Fortam Glaxo Antibacterial (broad spectrum activity against Gram-positive and Gram-negative bacteria) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1983 Apalcillin sodium Lumota . Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1982 Ceftizoxime sodium Epocelin Fujisawa Pharmaceutical Antibacterial (Bacterial infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1982 Ceftriaxone sodium Rocephin NeoMed and Hoffman-La Roche Antibacterial (broad spectrum activity against Gram positive and Gram negative bacteria) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1982 Moxalactam disodium; Latamoxef Shiomarin Hailing Chemipharma Antibacterial (anaerobic infection) ND Streptomyces clavuligerus (17940818); Streptomyces cattleya (1367371); Amycolatopsis lactamdurans (7275839) 1982 Cefotiam HCl Pansporin Takeda Antibacterial (Respiratory infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Cefamandole nafate; cephamandole Mandol Eli Lil ley Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Cefditoren Spectracef Cornerstone BioPharma Antibacterial (uncomplicated skin and skin structure infections. community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis (ABECB), pharyngitis, tonsillitis) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Cefoperazone sodium Cefobid; Cefobis Pfizer Antibacterial (Especially against Pseudomonas infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Cefotaxime sodium Claforan Sanofi-Aventis Antibacterial (broad spectrum activity against Gram positive and Gram negative bacteria) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Ceftiofur Excede Pfizer Antibacterial (swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis and Streptococcus suis) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1981 Cefadroxil; cefadroxil hemihydrate Duricef; Cefadroxil Aurobindo Pharma Limited and Sandoz Antibacterial (mild to moderate susceptible infections such as the bacteria "Streptococcus pyogenes", otherwise known as strep throat) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1980 Cefsulodin Not Available . Antibiotic ND Acremonium chrysogenum 1980 Cyclacillin Not Available . Antibiotic ND Penicillium chrysogenum; Emericella nidulans; Aspergillus flavus 1979 Azlocillin Azlin; Azlocillin; Securopen Bayer Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1977 Cefalexin; cephalexin Keflex; Keftal; Cefanox; Sporidex Lilly, Ranbaxy and Ivax Pharms Antibacterial (urinary tract infections, respiratory tract infections (including sinusitis, otitis media, pharyngitis, tonsillitis and pneumonia, bronchitis), skin and soft tissue infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1976 Bacampicillin Spectrobid; Penglobe Pfizer and AstraZeneca Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1975 Amoxicillin; amoxycillin Amoxil; Allmox; Amotid; Amoxenga; Amoxipen; Amoxivan; Amoxybid; Amoxyn SmithKline Beecham Laboratories Ltda. Antibacterial (pneumonia; bronchitis; infection of the ear, urinary tract, skin and venereal disease) ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1974 Cloxacillin; Cloxacillin Sodium Cloxapen; Orbenin; Tegopen; Coxapen Farabi and. Kosar pharmaceutical companies, Beecham Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1974 Cefapirin; cephapirin Cefadyl Not Available Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1974 Cefradine; cephradine Velocef; Velosef; Anspor Xinya Co. Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1974 Carbenicillin Geopen; Pyopen Not Available Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1972 Carindacillin; carbenicillin indanyl Geocillin; Pyopen; Geogen Pfizer Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1972 Dicloxacillin; dicoxacillin Diclocil; Dycill; Dynapen; Pathocil BMS Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1971 Cefazolin; cefazoline; cephazolin Ancef; Kefzol; Zolicef; Cefacidal; Cefamezin; Cefrina; Elzogram; Faxilen; Gramaxin; Kefazol; Kefol; Kefzolan; Kezolin; Novaporin Lilly and Fujisawa Antibacterial (bacterial infections of the skin) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1971 Flucloxacillin; floxacillin Flopen and Floxapen CSL and GSK Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1970 Mecillinam; amdinocillin; pivmecillinam; amdinocillin pivoxil Coactin; Selexid; Coactabs Leo Pharmaceuticals, etc. Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1970 Cefaloglycin; cephaloglycin Kafocin Lilly Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1970 Penicillamine Not Available . Antibiotic ND Penicillium chrysogenum; Emericella nidulans; Aspergillus flavus 1970 Epicillin Dexacillin Sandoz, Niirnberg Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1967 Cefalotin sodium; cephalothin Keflin; Seffin Lilly Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1964 Cefroxadine Tiroxin Samjin Pharma Co. Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1964 Ceftezole; ceftezol Celoslin; Fosran; Cetrazole Not Available Antibacterial (Bacterial infection) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1964 Cefacetrile; cephacetrile Celospor; Celtol; Cristacef Not Available Antibacterial (Gram-positive and Gram-negative bacterial infections) ND Emericellopsis minima (16290171); Amycolatopsis lactamdurans (16290171); Streptomyces clavuligerus (16290171); Acremonium chrysogenum (16290171) 1964 Ampicillin; pivampicillin Omnipen; Pentrex; Pentrexl; Pentrexyl; Vampen; Wypicil Stadapharm GmbH Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1961 Meticillin; methicillin Staphcillin; Dimocillin; Metacillin Beecham Antibacterial ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1960 Phenoxymethylpenicillin; penicillin V Ledercillin VK; Pen-Veek; Beepen-VK Freedom Pharmacy Antibacterial (bronchitis, pneumonia, angina, scarlet fever, gonorrhea, syphilis, purulent skin and soft-tissue wounds, and other infectious diseases) ND Emericella nidulans (16598003); Penicillium chrysogenum (18707625); Aspergillus flavus (16290171) 1947 Alitretinoin Panretin . Anticancer ND Daucus carota 1999 Acitretin Neotigason . Antipsoriatic ND Daucus carota 1989 Nabilone Cesamet Valeant Pharmaceuticals International Neurological disease (used for the control of nausea and vomiting, caused by chemotherapeutic agents used in the treatment of cancer, in patients who have failed to respond adequately to conventional antiemetic treatments) ND Cannabis sativa (18751909) 1982 Beta-acetyldigoxin Novodigal Not Available Cardiovascular disease ND Digitalis lanata (3879679); Digitalis purpurea (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%) 1985 Alpha-acetyldigoxin Dioxanin; Lanatilin; Sandolanid Not Available Cardiovascular disease ND Digitalis lanata (3879679); Digitalis purpurea (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%) 1980 Zinostatin stimalamer Smancs Not Available Oncological disease ND Streptomyces carzinostaticus (17918933) 1994 Salmeterol Serevent GlaxoSmithKline Immunological, inflammatory and related disease - Inflammatory disease (asthma) ND Ephedra sinica (9014353) 1994 Docarpamine Tanadopa Not Available Cardiotonic ND Homo sapiens (17309302) 1994 Ibopamine HCI Inopamil; Scandine . Cardiotonic ND Homo sapiens (17309302) 1984 Salbutamol; albuterol Ventolin; Ventorlin; Asthalin; Proventil and ProAir GlaxoSmithKline, Cipla, Schering-Plough and Teva Immunological, inflammatory and related disease - Inflammatory disease (asthma) ND Ephedra sinica (9014353) 1981 Terbutyline Not Available . Antihypertensive ND Homo sapiens (Advances in Amino Acid Mimetics and Peptidomimetics, Volume 1) 1980 Propranolol Inderal; Inderal LA; Avlocardyl; Deralin; Dociton; Inderalici; InnoPran XL; Sumial AstraZeneca and Wyeth Cardiovascular disease (hypertension, prophylaxis of migraine) ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1967 Omacetaxine mepesuccinate Synribo Ivax Chronic or accelerated-phase chronic myeloid leukaemia ND Cephalotaxus harringtonia 2012 Sofalcone Solon Taisho Antiulcer ND Sophora prostrata (750329); Sophora alopecuroides (18338601); Sophora flavescens (15103704) 1984 Cetrorelix Cetrotide Asta Medica Fertility enhancer (female infertility) ND Homo sapiens (17309302) 1999 Carfilzomib Kyprolis Onyx Multiple myeloma ND Actinomyces sp 2012 Cabergoline Dostinex . Antihyperprolactinemia ND Claviceps 1993 Pergolide mesylate Permax . AntiParkinsonian ND Ipomoea violacea; Turbina corymbosa 1988 Metergolin Liserdol . Antihyperprolactinemia ND Ipomoea violacea; Turbina corymbosa 1987 Elliptinium acetate Celiptium Sanofi Oncological disease ND Tabernaemontana (3547187); Ochrosia elliptica (%Intramolecular cyclization of ortho-(cyclohex-2-enyl) anilines synthesis of ellipticine, 1992, by A. G. Mustafin, I. N. Khalilov, E. V. Tal'vinskii, I. B. Abdrakhmanov, L. V. Spirikhin and G. A. Tolstikov%); Aspidosperma (%The biogenetic, synthetic and biochemical aspects of ellipticine, an antitumor alkaloid, 1985, by Vinod K. Kansal and Pierre Potier%); Strychnos (3547187); Apocynaceae (16009521) 1983 Lisuride maleate Dopergin . Antihyperprolactinemia ND Claviceps 1982 Brovincamine fumarate Sabromin Sankyo Vasodilator, cerebral ND Vinca minor (16130744) 1986 Ethyl icosapentate Epadel Mochida Antithrombotic (Decrease platelet aggregation, reduce blood viscosity and increase erythrocyte deformability) ND Listonella pelagia (16348815); Shewanella pneumatophori (16280496) 1990 Dosmalfate Diotul Not Available Gastroprotectant ND Homo sapiens (17309302) 2000 Dronedarone HCl Multaq Sanofi¨CAventis Atrial fibrillation and atrial flutter ND Ammi visnaga 2009 Ciclesonide Alvesco Not Available Antiasthmatic ND Homo sapiens (17309302) 2005 Halobetasol propionate Ultravate Not Available Antiinflammatory ND Homo sapiens (17309302) 1991 Halopredone acetate Haloart Not Available Antiarthritic ND Homo sapiens (17309302) 1988 Deflazacort Deflan Lepetit/Merrell Antiinflammatory ND Homo sapiens (17309302) 1986 Budesonide Pulmicort Not Available Antiasthmatic ND Homo sapiens (17309302) 1981 Betamethasone butyrate propion Antebate Not Available Antiinflammatory ND Homo sapiens (17309302) 1994 Mifepristone Mifegyne Not Available Abortifacient ND Homo sapiens (17309302) 1988 Difluprednate Durezol Sirion Inflammation and pain associated with ocular surgery ND Homo sapian 2008 Dutaseride Duagen . BPH ND Homo sapiens (17309302) 2001 Loteprednol etabonate Lotemax Bausch & Lomb Inflammatory disease (steroid-responsive inflammatory conditons of the palpebral and bulbar conjunctiva, cornea and anterior segment of the ocular globe and seasonal allergic conjunctivitis) ND Homo sapiens (17309302) 1998 Flutamide Eulexin Not Available Oncological disease (for the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate) ND Homo sapiens (17309302) 1996 Rimexolone Vexol Alcon Inflammatory disease (postoperative inflammation following ocular surgery and anterior uveitis) ND Homo sapiens (17309302) 1995 Finasteride Proscar Not Available 5 alpha-reductase inhibitor ND Homo sapiens (17309302) 1992 Fluticasone propionate Flixonase Glaxo Inflammatory disease (seasonal rhinitis and asthma) ND Homo sapiens (17309302) 1990 Hydrocortisone aceponate Retef Not Available Antiinflammatory ND Homo sapiens (17309302) 1988 Mometasone furoate Elocon Not Available Antiinflammatory ND Homo sapiens (17309302) 1987 Prednicarbate Dermatop Cassella-Riedel Inflammatory disease (cutaneous inflammatory disorders such as eczema and psoriasis) ND Homo sapiens (17309302) 1986 Alclometasone dipropionate Vaderm Schering Inflammatory disease (atopic dermatitis and psoriasis) ND Homo sapiens (17309302) 1985 Halometasone Sicorten Ciba-Geigy Inflammatory disease (acute and chronic eczematous dermatoses and psoriasis) ND Homo sapiens (17309302) 1983 Hydrocortisone butyrate Pandel Taisho Inflammatory disease (various acute and chronic contact, eczematous, and atopic dermatoses and psoriasis) ND Homo sapiens (17309302) 1983 Testosterone undecanoate Restandol Organon Greece Hypogonadism ND Homo sapiens (17309302) 1981 Methyltestosterone Android Valeant Pharmaceuticals, Inc. Oncological disease (primary hypogonadism (male) and advancing inoperable metastatic mammary cancer (female)) ND Homo sapiens (17309302) 1974 Prednisolone Prednisolone Teva pharmaceuticals USA Oncological disease (acute leukemia of childhood and leukemias and lymphomas in adults) ND Homo sapiens (17309302) 1970 Fluoxymesterone Androxy Upsher-smith laboratories, Inc. Oncological disease (metastatic mammary cancer in female) ND Homo sapiens (17309302) 1965 Nandrolone phenpropionate Durabolin-50 Organon Oncological disease (osteoporosis in postmenopausal women) ND Homo sapiens (17309302) 1959 Nadrolone phenylpropionate Not Available . Anticancer ND Homo sapiens 1959 Dexamethasone Decadron Merck & Co., Inc. Oncological disease (multiple myeloma and primary or metastatic brain tumours) ND Homo sapiens (17309302) 1958 Triamcinolone Kenalog; Aristocort; Nasacort; Tri-Nasal; Triderm; Azmacort; Trilone; Volon A; Tristoject; Fougera; Tricortone,Triesence Not Available Oncological disease (various disorders in which corticosteroids are indicated) ND Homo sapiens (17309302) 1958 Methylprednisolone Medrol Pharmacia and Upjohn Company Oncological disease (leukemias and lymphomas in adults and acute leukemia of childhood) ND Homo sapiens (17309302) 1955 Telavancin Not Available Theravance (developed with Astellas Pharma) Antibiotic ND Amycolatopsis orientalis 2009 Fondaparinux sodium Arixtra . DVT; anticoagulant ND Homo sapiens (17309302) 2002 Bemiparin sodium Hibor . DVT; anticoagulant ND Homo sapiens (17309302) 1998 Certoparin sodium Alphaparin . DVT; anticoagulant ND Homo sapiens (17309302) 1996 Zinc hyaluronate Curioscii Not Available Vulnerary ND Homo sapiens (17309302) 1996 Parnaparin sodium Fluxum . DVT; anticoagulant ND Homo sapiens (17309302) 1993 Reviparin sodium Clivarin Not Available Anticoagulant ND Homo sapiens (17309302) 1993 Danaparoid sodium Orgaran . DVT; anticoagulant ND Homo sapiens (17309302) 1992 Lmw heparin Sandoparin Not Available Anticoagulant ND Homo sapiens (17309302) 1989 Enoxaparin Lovenox . DVT; anticoagulant ND Homo sapiens (17309302) 1987 Dalteparin sodium Fragmin . DVT; anticoagulant ND Homo sapiens (17309302) 1985 Nadroparin calcium Fraxiparine Not Available Anticoagulant ND Homo sapiens (17309302) 1985 Vapreotide acetate Docrised Not Available Anticancer ND Homo sapiens (17309302) 2004 Teriparatide Forteo Eli lilly and company Osteoporosis (Osteoporosis in postmenopausal women) ND Homo sapiens (17309302) 2002 Lanreotide acetate Somatuline LP Beaufour-Ipsen Growth hormone deficiency (acromegaly when surgery or radiotherapy have failed to restore normal growth hormone secretion) ND Homo sapiens (17309302) 1995 Histrelin Supprelin Roberts For the treatment of central precocious puberty, also be used to treat endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and acute intermittent porphyria ND Homo sapiens (17309302) 1993 Nafarelin acetate Synarel Syntex Precocious puberty and endometriosis ND Homo sapiens (17309302) 1990 Octreotide Sandostatin Sandoz Antisecretory (Hormone-secreting tumors; diabetes mellitus; hypotension, orthostatic; hyperinsulinism; hypergastrinemia; and small bowel fistula) ND Homo sapiens (17309302) 1988 Teriparatide acetate Parathar Eli lilly and company Calcium metabolism (Osteoporosis) ND Homo sapiens (17309302) 1987 Pasireotide diaspartate Signifor Novartis Cushing's disease ND Homo sapian 2012 Liraglutide Victoza Novo Nordisk Anti-diabetes ND Homo sapiens 2010 Nesiritide Natrecor Scios Inc. Congestive heart failure ND Homo sapiens (17309302) 2001 Ganirelix acetate Orgalutran Not Available Ovulationi ND Homo sapiens (17309302) 2000 Captopril; SQ14225; capropril Capoten Bristol-Myers Squibb Cardiovascular disease (hypertension and some types of congestive heart failure) ND Bothrops jararaca (2985149) 1996 Deslorelin Somagard; Ovuplant Roberts Pharmaceuticals Oncological disease (prostate cancer, central precocious puberty, and endometriosis) ND Homo sapiens (17309302) 1989 Goserelin Zoladex ICI Oncological disease (breast cancer, prostate carcinoma, endometriosis) ND Homo sapiens (17309302) 1987 Triptorelin Gonapeptyl Depot; Decapeptyl Tulane University Oncological disease (advanced prostate cancer) ND Homo sapiens (17309302) 1986 Gonadoreline-6-D-trp acetate Decapeptyl Ferring Oncological disease (advanced prostate cancer) ND Homo sapiens (17309302) 1986 Leuprolide acetate Carcinil; Enantone; Eligard Abbott Oncological disease (for treatment of advanced prostate and breast cancer, endometriosis, uterine fibroids and premature puberty) ND Homo sapiens (17309302) 1984 Buserelin acetate Suprefact Hoechst AG Oncological disease (advanced prostate cancer, endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility) ND Homo sapiens (17309302) 1984 Desirudin Iprivask Not Available Deep vein thrombosis (DVT) ND Haementeria officinalis (16796374); Hirudo medicinalis (17098288) 2003 Bivalirudin; bivalrudin Angiomax MDCO Cardiovascular and metabolic disease (reduce the risk of blood clotting in adults with severe chest pain (unstable angina) who are undergoing a procedure to open blocked arteries in the heart) ND Haementeria officinalis (16796374); Hirudo medicinalis (17098288) 2000 Hirulog Hirulog Not Available Anticoagulation ND Haementeria officinalis (16796374); Hirudo medicinalis (17098288) 2000 Lepirudin Refludan Not Available Antithrombotic ND Haementeria officinalis (16796374); Hirudo medicinalis (17098288) 1997 Exenatide; exenatide-4; extenatide Byetta Eli Lilly and Amylin Pharmaceuticals Cardiovascular and metabolic disease (type 2 diabetes) ND Heloderma suspectum (15806196) 2005 Nedocromil sodium Tildade . Antiallergic ND Marsdenieae 1986 Anidulafungin; VER-002; V-echinocandin; LY-303366 Eraxis; Ecalta Astellas-Pfizer, Vicuron Pharmaceuticals Antifungal (invasive and oesophageal candidiasis and candidemia) ND Aspergillus(15620274); Emericella rugulosa (15806196) 2007 Micafungin sodium; FK463 Mycamine; Funguard Fujisawa, Astellas Antifungal (candidemia, acute disseminated candidiasis, candida peritonitis, abscesses and esophageal candidiasis) ND Coleophoma empetri (17192162) 2002 Atosiban Tractocile . Premature birth ND Homo sapiens (17309302) 2000 Eribulin; E7389; NSC-707389; eribulin mesylate Halaven Eisai Oncological disease (metastatic breast cancer) ND Halichondria okadai (10843209) 2010 Everolimus; RAD-001; SDZ RAD Afinitor; Certican Novartis Anticancer (RCC) ND Streptomyces hygroscopicus (18497896) 2009 Temsirolimus; CCI-779 Torisel Pfizer, Wyeth Anticancer (advanced kidney cancer and advanced renal cell carcinoma (RCC)) ND Streptomyces hygroscopicus (18497896) 2007 Pimecrolimus; SDZ-ASM-981; ascomycin Elidel Novartis and Galderma Immunological, inflammatory and related disease (atopic dermatitis) ND Streptomyces hygroscopicus (16796374) 2001 Zotarolimus; ABT-578 Zotarolimus Medtronic Oncological disease ND Streptomyces hygroscopicus (18497896) 1996 Desvenlafaxine Pristiq Wyeth Major depressive disorder ND Remove (Acacia Rigidula) 2008 Buprenorphine Suboxone; Subutex Biotek Inc. in collaboration with the National Institute on Drug Abuse (NIDA) Neurological disease (for the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 2002 Oxycodone HCl OxyContin; Eukodal; Eucodal; Dinarkon Purdue Pharma LP Neurological disease (for the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 1996 Nalmefene HCI Revex Somaxon Neurological disease (for the management of alcohol dependence, and for the treatment of other addictions such as pathological gambling and addiction to shopping) ND Papaver bracteatum (15806196); Papaver somniferum (15806196) 1995 Naltrexone HCI ReVia DuPont, Biotek Inc Neurological disease (for use in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids, heroin addiction, narcotic addiction and alcohol dependence) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 1984 Dextromethorphan; DXM; DM Pediatric Not Available Neurological disease - Antitussive (for treatment and relief of dry cough) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 1982 Nalbuphine Nubain; Nalbuphinum Not Available Neurological disease (for the relief of moderate to severe pain) ND Papaver bracteatum (12548835); Papaver somniferum (15806196) 1979 Naloxone; naltrexate Narcan; Nalone; Narcanti Mundipharma Research Neurological disease (for the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 1971 Oxymorphone Numorphan; Numorphone; Opana; Opana ER Endo Pharmaceuticals Neurological disease (for the treatment of moderate-to-severe pain) ND Papaver bracteatum (3879679); Papaver somniferum (15806196) 1959 Lisdexamfetamine; NRP104 Vyvanse New River Pharmaceuticals Neurological disease (Attention-Deficit Hyperactivity Disorder (ADHD)) ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 2007 Dextroamphetamine sulfate Not Available . ADHD; narcolepsy ND Acacia rigidula; Ephedra sinica; Senegalia berlandieri 1976 Tranylcypromine sulfate Not Available . Major depressive episode without melancholia ND Acacia rigidula; Ephedra sinica; Senegalia berlandieri 1961 Methamphetamine Desoxyn Not Available Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1943 Colistimethate sodium Not Available . Pulmonary infections ND Paenibacillus polymyxa 1970 Abiraterone Zytiga Centocor Ortho Biotech Metastatic castration-resistant prostate cancer ND Homo sapian 2011 Ulipristal Ella HRA Pharma Contraception ND Homo sapian 2010 Anecortave acetate Retaane Not Available Macular degeneration ND Homo sapiens (17309302) 2006 Estradiol; nomegestrol acetate Naemis Th¨¦ramex Hormone replacement therapy ND Homo sapiens (17309302) 2003 Drospirenone Yasmin Not Available Contraception ND Homo sapiens (17309302) 2000 Medroxyprogesterone; estradiol Lunelle Johnson controls Contraception ND Homo sapiens (17309302) 2000 Trimegestone Totelle Sekvens Wyeth-Ayerst Hormone replacement therapy ND Homo sapiens (17309302) 2000 Exemestane; 6-methylenandrosta-1,4-diene-3,17-dione Aromasin . Anticancer ND Homo sapiens (17309302) 1999 Exemestane Not Available . Anticancer ND Homo sapiens 1999 Tibolone Livial . Anabolic metabolism ND Homo sapiens (17309302) 1988 Nomegestrol acetate Lutenyl Theramex Progestogen (gynecological conditions associated with luteal deficiency) ND Homo sapiens (17309302) 1986 Norgestimate Cilest Cilag Progestogen (gynecological conditions) ND Homo sapiens (17309302) 1986 Promegestone Surgestone Labs. Cassenne Progestogen (various gynecological conditions due to luteal insufficiency, such as premenopausal disorders, dysmenorrhea, and premenstrual syndrome) ND Homo sapiens (17309302) 1983 Calusterone Methosarb Pharmacia & Upjohn Company Oncological disease (breast cancer) ND Homo sapiens (17309302) 1973 Megestrol acetate Megace Bristol-Myers Squibb Oncological disease (endometrial carcinoma, breast cancer, anorexia and cachexia) ND Homo sapiens (17309302) 1971 Megesterol acetate Not Available . Anticancer (advanced carcinoma of the breast and endometrium) ND Homo sapiens 1971 Norethindrone acetate Norlutin Dugamed pharmaceuticals, Inc. Oncological disease (secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer) ND Homo sapiens (17309302) 1970 Testolactone Teslac Bristol-Myers Squibb Oncological disease (advanced breast cancer) ND Homo sapiens (17309302) 1970 Hydroxyprogesterone Delalutin; Proluton depot Not Available Oncological disease (advanced mammary carcinoma in the postmenopausal woman) ND Homo sapiens (17309302) 1965 Prednisone Deltasone; Liquid Pred Pharmacia and Upjohn and Company Oncological disease (acute leukemia of childhood and leukemias and lymphomas in adults) ND Homo sapiens (17309302) 1965 Medroxyprogesterone acetate Depo-provera Pharmacia and Upjohn Company Oncological disease (breast and endometrial neoplasms) ND Homo sapiens (17309302) 1958 Tafluprost Zioptan Merck Sharp Dohme Elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension ND Homo sapian 2012 Ticagrelor Brilinta AstraZeneca Thrombotic cardiovascular events in patients with acute coronary syndrome ND Homo sapian 2011 Dalfampridine Ampyra Acorda Therapeutics Improving walking in patients with multiple sclerosis ND Bone oil 2010 Carbenoxolone; CBX; glycyrrhetinic acid hydrogen sucinate Biogastrone; Gastrausil; Bisgastron Winthrop (UK) Immunological, inflammatory and related disease (oesophageal ulceration, gastric and inflammation) ND Glycyrrhiza glabra (6522506) 2003 Artesunate; amodiaquine; ASAQ Coarsucam; Winthrop Sanofi-aventis Antiparasitic (malaria) ND Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Artemisia annua (18497896); Cinchona (18454580) 2008 Artemether¨C lumefantrine Coartem Novartis Malaria ND Artemisia annua 2009 Co-artemether; artemether-lumofantrine; artemether-lumefantrine Riamet; Co-Artem WHO Antiparasitic (malaria) ND Artemisia annua (18497896) 2003 Artesunate; AS Artesunate Chinese scientists Antiparasitic (malaria) ND Artemisia annua (18497896) 2002 Arteether; beta arteether Artemotil; Artecef Artecef BV (Central Drug Institute, Brocacef) Antiparasitic (malaria) ND Artemisia annua (18497896) 2000 Dihydroartemisinin Artekin Holleykin Pharmaceuticals Antiparasitic (malaria) ND Artemisia annua (18497896) 1998 Artemether Artemetheri Not Available Antiparasitic (malaria) ND Artemisia annua (18497896) 1987 Sermorelin acetate Geref Serono Laboratories Growth hormone deficiency (for the treatment of dwarfism and pediatric growth disorders, prevention of HIV-induced weight loss) ND Homo sapiens (17309302) 1998 Lubiprostone Amitiza Sucampo Pharmaceuticals Chronic idiopathic constipation ND Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 2006 Treprostinil sodium Remodulin . Antihypertensive; pulmonary ND Homo sapiens (17309302) 2002 Latanoprost Xalatan Pharmacia & pjohn Antiglaucoma ND Manduca sexta (11886778); Artemisia dracunculus (DukePED-123); Allium sativum (DukePED-54) 1996 Unoprostone isopropyl ester Rescula . Antiglaucoma ND Manduca sexta (11886778); Prunus tomentosa (18449498); Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1994 Beraprost sodium Dorner . Platelet aggreg. inhib. ND Homo sapiens (17309302) 1992 Iloprost Ilomedin . Platelet aggreg. inhib. ND Homo sapiens (17309302) 1992 Limaprost Opalmon Ono Antithrombotic (pulmonary emphysema, tuberculosis and chronic lung disease) ND Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1988 Ornoprostil Alloca Ono Antiulcer (gastric ulcer) ND Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1987 Rosaprostol Rosal Instituto Biochemico Italiano Antiulcer (gastric and duodenal ulcers) ND Manduca sexta (11886778); Prunus tomentosa (18449498); Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-53); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1985 Misoprostol Cytotec Searle Antiulcer (gastric and duodenal ulcers) ND Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1985 Enprostil Gardrin Syntex Antiulcer (gastric and duodenal ulcers) ND Manduca sexta (11886778); Prunus tomentosa (18449498); Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1985 Gemeprost Cervagem May & Baker Abortifacient (used for preoperative dilation of cervix before surgical abortion) ND Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Allium sativum (DukePED-54); Allium cepa (DukePED-53); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1983 Sulprostone Nalador Schering Abortifacient (abortusinductie (maternale of foetale indicatie). Inleiding van de geboorte bij intra-uteriene vruchtdood. Postpartale atonische bloeding.) ND Manduca sexta (11886778); Prunus tomentosa (18449498); Populus balsamifera (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%); Larix sibirica (%¨¦. D. Levin, Sh. T. Alaudinov and V. ¨¦. Identification of prostaglandins E (series 1 and 2) isolated from the living tissues of Larix sibirica and Populus balzamifera. Chemistry of Natural Compounds. Volume 20, Number 5, (1984)%) 1981 Doxercalciferol Hectorol . Calcium metabolism ND Agaricus bisporus 1999 Levonorgestrel; ethinyl estradiol Preven Wyeth-Ayerst Contraception ND Homo sapiens (17309302) 1998 Tacalcitol Bonalfa . Antipsoriatic ND Agaricus bisporus 1993 Lucinactant Surfaxin Discovery Laboratories Prevention of respiratory distress syndrome ND 2012 Tigecycline; GAR-936 Tygacil Wyeth Antibacterial (complicated skin and skin structure infections (cSSSIs) and complicated intra-abdominal infections) ND Streptomyces viridifaciens (18588016); Streptomyces aureofaciens (11677904) 2005 Methacycline; metacycline; methacyclin Rondomycin Hovione Antibacterial ND Streptomyces rimosus (16959966) 2001 Minocycline hydrochloride; minocycline Minocin; Minomycin; Minocin; Minoderm; Arestin; Akamin; Aknemin; Solodyn; Dynacin; Sebomin; Mino-Tabs Lederle Laboratories Antibacterial ND Streptomyces viridifaciens (18588016); Streptomyces aureofaciens (11677904) 2001 Doxycycline Vibramycin; Monodox; Microdox; Periostat; Vibra-Tabs; Doryx; Vibrox; Adoxa; Doxyhexal; Atridox Pfizer Antibacterial ND Streptomyces rimosus (16959966) 1967 Clomocycline Not Available Not Available Antibacterial ND Streptomyces viridifaciens (18588016); Streptomyces aureofaciens (11677904) 1965 Lymecycline Tetralysal 300 Galderma Antibacterial ND Streptomyces viridifaciens (18588016); Streptomyces aureofaciens (11677904) 1963 Flutropium bromide Flubron Not Available Antitussive ND Atropa belladonna (16198377); Mandragora officinarum (11710734); Datura stramonium (11710734) 1988 Cimetropium bromide Alginor deAngelini Antispasmodic (Increased tone and motility of the gastrointestinal, biliary and urogenital tracts) ND Datura metel (3879679) 1985 Oxitropium bromide Oxivent Dieckmann Bronchodilator (Bronchial asthma) ND Datura metel (3879679) 1983 Vinorelbine; VRLB; navelvine Navelbine Burroughs Wellcome, Pierre Fabre Oncological disease (non-small cell lung cancer, advanced breast cancer, ovarian cancer and Hodgkins disease) ND Catharanthus roseus (18053006) 1994 Vindesine; VDS Eldisine; Eldesine Not Available Oncological disease (for treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis) ND Catharanthus roseus (18053006) 1979 Taltirelin Ceredist Not Available CNS Stimulant ND Homo sapiens (17309302) 2000 Polaprezinc Promac Not Available Antiulcer ND Homo sapiens (17309302) 1994 Propentofylline propionate Hextol . Vasodilator; cerebral ND Homo sapiens (17309302) 1988 Doxofylline Ansimar ABC S.p.A. Bronchodilator (Asthma and similar bronchospastic disorders) ND Theobroma angustifolium (DukeDB-1205); Coffea arabica (DukeDB-289); Camellia sinensis (3879679); Theobroma bicolor (DukeDB-1206); Paullinia cupana (DukeDB-703); Theobroma cacao (DukeDB-1010) 1985 Linagliptin Tradjenta Boehringer Ingelheim Type 2 diabetes ND Homo sapian 2011 Gramicidin S Not Available . Antibiotic ND Bacillus brevis (62820) 1942 Cabazitaxel; XRP-6258 Jevtana Sanofi¨CAventis Anticacer ND Taxus baccata (12008000); Corylus avellana (12008000); Taxus brevifolia (18690825); Taxus wallichiana (16129603); Seimatoantlerium tepuiense (12008000) 2010 Pralatrexate Folotyn cancers ND 2009 Raltitrexed Tomudex cancers ND 1996 Enfuvirtide; T-20 Fuzeon . Antiviral (human immunovirus (HIV) infections) ND Human immunodeficiency virus 1 2003 CARGLUMIC ACID CARBAGLU ND 2010 Fingolimod; FTY720 Gilenya Novartis and Mitsubishi Tanabe Immunological, inflammatory and related disease (multiple sclerosis, immunosuppression) ND Isaria (18497896) 2010 mifamurtide Junovan anticancer ND Gram positive and Gram negative bacteria 2010 vinflunine Javlor anticancer ND Catharanthus roseus 2010 zucapsacin Civanex osteoarthritis ND chili peppers 2010 nalfurafine HCl Remitch uremic pruritis ND opium 2009 dienogest Dinagest endometriosis ND Homo sapiens 2008 sugammadex sodium Bridion antidote (neuromuscular block) ND green plants 2008 biolimus a9 BioMatrix restenosis ND Streptomyces hygroscopicus 2008 Ixabepilone; BMS-247550 Ixempra Bristol-Myers Squibb Oncological disease (advanced breast cancer) ND Sorangium cellulosum (16796374) 2007 Sphingosomal topotecan; INX-0076 Not Available Inex pharmaceuticals Oncological disease ND Ophiorrhiza pumila (16129603); Mappia foetida (16129603); Camptotheca acuminata (18690825) 2007 Retapamulin; SB-275833 Altabax/Altargo GlaxoSmithKline (GSK) Antibacterial (impetigo caused by Staphylococcus aureus or Streptococcus pyogenes) ND Clitopilus scyphoides (18071246); Pleurotus 2007 Nilotinib; AMN-107 Tasigna Novartis Anticancer (CML with imatinib resistance and/or intolerance) ND Lentzea albida (19132059) 2007 fluticasone furoate Allermist antiallergic ND Homo sapiens 2007 Suberoylanilide hydroxamic acid (SAHA) Zolinza Merck Oncological disease ND Streptomyces hygroscopicus (7786288) 2006 Conjugated estrogens b Enjuvia Not Available Hormone replacement therapy ND Homo sapiens (17309302) 2005 Pralmorelin GHRP Kaken 100 Not Available Treatment of GH deficiency ND Homo sapiens (17309302) 2005 triproamylin acetate Normylin antidiabetic ND Homo sapiens 2005 Belotecan hydrochloride; Camptobell; CDK-602 Camtobell Chong Kun Dang Oncological disease (treat ovarian, colorectal, and small-cell lung cancers) ND Ophiorrhiza pumila (16129603); Mappia foetida (16129603); Camptotheca acuminata (18690825) 2004 Telithromycin Ketek Aventis Pharmaceuticals, Sanofi-Aventis Antibacterial (Mild to moderate respiratory infections) ND Saccharopolyspora erythraea (15806196) 2004 Estradiol; levonorgestrel Climara Pro Not Available Hormone replacement therapy ND Homo sapiens (17309302) 2004 talaporfin sodium Laserphyrin anticancer ND 2004 Belotecan hydrocholoride Not Available . Anticancer (small-cell lung cancer) ND Camptotheca acuminata 2004 Epipodophyllotoxin Not Available Brystol-Myers Squibb Oncological disease ND Dysosma pleiantha (16129603); Sinopodophyllum hexandrum (16673335); Podophyllum peltatum (18690825) 2003 Miglustat; N-butyl-1-deoxynojirimycin Zavesca Actelion, Teva (CellTech), Oxford Glycosides Cardiovascular and metabolic disease (Type 1 Gaucher disease) ND Lendenfeldia chondrodes (17080688); Morus alba (8050098); Streptomyces lavendulae (16796374); Streptomyces (18497896) 2003 Isoprenaline Isoprel; Medihaler-Iso Not Available Cardiovascular disease (mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis) ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 2003 Drospirenone; estradiol Angeliq Not Available Hormone replacement therapy ND Homo sapiens (17309302) 2003 EPLERENONE INSPRA ND Homo sapiens 2002 Fulvestrant; ICI-182, 780 Faslodex Not Available Anticancer ND Homo sapiens (17309302) 2002 Acetyldigitoxin Acigoxin; Acylanid; Crystodigin Not Available Cardiovascular disease (used for fast digitalization in congestive heart failure) ND Digitalis purpurea (13127018) 2002 Etonogestrel; ethinylestradiol NuvaRing Not Available Contraception ND Homo sapiens (17309302) 2002 Sodium oxybate Xyrem Jazz Pharmaceuticals, Inc. Narcolepsy (Cataplexy) ND Homo sapiens (17309302) 2002 CASPOFUNGIN ACETATE CANCIDAS ND Aspergillus nidulans var. echinulatus 2001 Gusperimus trihydrochloride; 15-deoxyspergualin Spanidin Bristol-Myers Squibb Immunological, inflammatory and related disease (immunosuppressant) ND Brevibacillus laterosporus (6508320) 2001 Imatinib mesilate; CGP5714B; glivec; STI571 Gleevec; Glivec Novartis Pharmaceuticals Anticancer (chronic myelogenous leukaemia (CML) and metastatic malignant gastrointestinal stromal tumors (GIST)) ND Lentzea albida (19132059) 2001 Falecalcitrol Horner; Fulstan . Sec. hyperthryoidism ND Agaricus bisporus; Salmonidae 2001 Norelgestromin; ethinylestradiol Ortho Evra Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Contraception ND Homo sapiens (17309302) 2001 fudosteine Cleanal / Spelear expectorant ND 2001 egualen sodium Azuloxa antiulcer ND Matricaria chamomilla 2000 maxacalcitol Prezios calcium metabolism ND 2000 Colforsin daropate HCI Adele; Adehl Nippon Kayaku Cardiovascular and metabolic disease (cardiotonic) ND Plectranthus barbatus (15806196) 1999 Dalfopristin; Quinupristin Synercid Sanofi-Aventis and Rhone-Poulenc Rorer Pharmaceuticals Inc. Antibacterial ND Streptomyces pristinaespiralis (16290171) 1999 Melevodopa; CHF-1301; L-dopa-methyester Levomet Chiesi Neurological disease - AntiParkinsonian (parkinson's disease & syndrome) ND Mucuna pruriens (18310948) 1999 Conjugated estrogens a Conestin Not Available Hormone replacement therapy ND Homo sapiens (17309302) 1999 rapacuronium bromide Raplon muscle relaxant ND Homo sapiens 1999 Miglitol Diastabol; Glyset Bayer Cardiovascular and metabolic disease (type 2 diabetes mellitus) ND Lendenfeldia chondrodes (17080688); Morus alba (8050098); Streptomyces lavendulae (16796374); Streptomyces (18497896) 1998 Orlistat; tetrahydrolipstatin Xenical; Alli Roche and GlaxoSmithKline Cardiovascular and metabolic disease (antiobesity) ND Streptomyces toxytricini (17175037) 1998 Paricalcitol Zemplar . Calcium metabolism ND Agaricus bisporus; Salmonidae 1998 Flurithromycin ethylsuccinate Ritro Pierrel Antibacterial (Serious nosocomial respiratory infections) ND Saccharopolyspora erythraea (15806196) 1997 Etoposide phosphate Etopophos; Etopopos Bristol-Myers Squibb (BMS) Oncological disease (for the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer, also for the treatment of other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme) ND Dysosma pleiantha (16129603); Sinopodophyllum hexandrum (16673335); Podophyllum peltatum (18690825) 1996 Topotecan HCl Hycamtin; Hycamptin; Hycamtim GlaxoSmithKline Oncological disease (for the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy, also ovarian cancer and lung cancer) ND Ophiorrhiza pumila (16129603); Mappia foetida (16129603); Camptotheca acuminata (18690825) 1996 ALENDRONATE SODIUM FOSAMAX ND plants,animals 1995 Docetaxel Taxotere Sanofi-Aventis Oncological disease (for anthracycline-refractory advanced breast, ovarian cancer, head and neck cancer, stomach cancer and now also used in non-small cell lung cancer regimens) ND Taxus baccata (14716141); Taxus brevifolia (18690825); Taxus wallichiana (16129603) 1995 Mycophenolate mofetil CellCept Roche Immunological, inflammatory and related disease ND Penicillium fagi (16311630); Penicillium bialowiezense (16311630); Penicillium roqueforti (16311630); Penicillium carneum (16311630); Aspergillus unilateralis (16311630); Penicillium brevicompactum (16311630); Byssochlamys nivea (16311630) 1995 Estrogen; medroxyproesterone Prempro; Premphase Not Available Hormone replacement therapy ND Homo sapiens (17309302) 1995 tirilazad mesylate Freedox subarachnoid hemorrhage ND Homo sapiens 1995 Irinotecan hydrochloride; CPT-11 Campto; Camptosar; Topotecin; Hycamp Pharmacia (now Pfizer), Yakult Honsha and Daiichi Seiyaku Oncological disease (treat ovarian, colorectal, small-cell lung, colon and cervical cancers) ND Ophiorrhiza pumila (16129603); Mappia foetida (16129603); Camptotheca acuminata (18690825) 1994 Camptothecin; Irinotecan Campto; Camptosar Pharmacia (now Pfizer), Yakult Honsha and Daiichi Seiyaku Oncological disease (treat ovarian, colorectal, small-cell lung, colon and cervical cancers) ND Ophiorrhiza pumila (16129603); Mappia foetida (16129603); Camptotheca acuminata (18690825) 1994 trimetrexate glucuronate Neutrexin PCP/Toxoplasmosis ND Leafy vegetables 1994 Formestane Lentaron Not Available Anticancer ND Homo sapiens (17309302) 1993 Dirithromycin Nortron . Antibacterial ND Saccharopolyspora erythraea (15806196) 1993 Tretinoin tocoferil Olcenon . Antiulcer ND Daucus carota 1993 miltefosine Miltex anticancer ND Homo sapiens 1993 ecabet sodium Gastrom antiulcer ND Pines, Conifers 1993 Teniposide; VM-26 Vumon Bristol-Myers Squibb (BMS) Oncological disease (for the treatment of refractory acute lymphoblastic leukaemia and childhood acute lymphocytic leukemia) ND Dysosma pleiantha (16129603); Sinopodophyllum hexandrum (16673335); Podophyllum peltatum (18690825) 1992 Sapropterin hydrochloride Biopten . Hyperphenylalaninemia ND Homo sapiens (17309302) 1992 Arteflene; RO 42¨C1611 Not Available Not Available Antiparasitic (malaria) ND Artabotrys (12521264) 1991 Calcipotriol Daivonex . Antipsoriatic ND Agaricus bisporus; Salmonidae 1991 Nitisinone; NTBC Orfadin Rare Diseases Therapeutics (AstraZeneca), Swedish Orphan, Orphan Pharmaceuticals Antityrosinaemia (hereditary tyrosinemia type 1) ND Callistemon citrinus (16198377); Leptospermum (8588876) 1991 Clarithromycin Klaricid; Biaxin; Klabax; Claripen; Claridar; Fromilid; Clacid; infex Abbott and Taisho Pharmaceutical Antibacterial (Skin, urinary and respiratory tract infections. pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), skin and skin structure infections, and, in HIV and AIDS patients to prevent, and to treat, disseminated Mycobacterium avium complex (MAC)) ND Saccharopolyspora erythraea (15806196) 1990 eflornithine HCl Ornidyl antiparasitic ND Homo sapiens 1990 pumactant Alec ND 1990 Ipriflavone Osten . Calcium metabolism ND Fabaceae 1989 Carumonam Amasulin Not Available Antibacterial ND Chromobacterium violaceum (6805424) 1988 Erythromycin acistrate; CAS 96128-89-1 Erasis Orion, Eli Lilly Antibacterial (Respiratory tract infections, skin infections and chlamydial urethritis) ND Saccharopolyspora erythraea (15806196) 1988 Azithromycin Zithromax; Sunamed; APO-Azithromycin; ATM; Zithromac; Vinzam/Zitromax; Zmax; Sumamed; Aztrin; Zitrocin; Azibiot; Azifine; AziCip; Azi Sandoz Pliva, Pfizer Antibacterial (Respiratory and urinary infections, middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia and sinusitis) ND Saccharopolyspora erythraea (15806196) 1988 Choline alfoscerate Delecit . Nootropic ND Homo sapiens (17309302) 1988 secalciferol Osteo D calcium metabolism ND Homo sapiens 1988 Roxithromycin Rulid; Surlid; Rulide; Biaxsig; Roxar; Roximycin; Coroxin Roussel, Hoechst Uclaf Antibacterial (respiratory tract, urinary and soft tissue infections) ND Saccharopolyspora erythraea (15806196) 1987 Hidrosmin Venosmil . Cardiovascular disease ND Penicillium jensenii (12649179); Melilotus officinalis (12649179); Penicillium janczewskii (12649179); Melilotus albus (12649179) 1987 Gestodene; ethinylestradiol Femodene Not Available Contraception ND Homo sapiens (17309302) 1987 Rokitamycin Ricamycin Toyo Jozo Co., Ltd. Antibacterial (respiratory and genital infections) ND Streptomyces mycarofaciens (6333529) 1986 Gestrinone Dimetrose Sarsa Antiprogestogenic ND Homo sapiens (17309302) 1986 idebenone Avan nootropic ND Homo sapiens 1986 Mefloquine HCI Lariam; Fansimef Hoffmann-La Roche Antiparasitic (malaria) ND Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Cinchona (18454580) 1985 Thymopentin Sintomodulina Italfarmaco Immunomodulator (Primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other disease with manifestations of disturbed immune balance) ND Homo sapiens (17309302) 1985 Elcatonin Diatin Not Available Calcium metabolism ND Anguilla japonica (CID 16129700) 1985 nabumetone Relifex antiinflammatory ND Many plants 1985 haem arginate Normosang porphyria ND Homo sapiens 1985 Teprenone Selbex Eisai Antiulcer ND Homo sapiens (17309302) 1984 Nicorandil Sigmart Chugai Vasodilator; coronary (Angina pectoris) ND Oryza sativa (18564421) 1984 melinamide Artes Oil hypocholesterolemic ND 1984 Epoprostenol sodium Flolan . Platelet aggreg. inhib. ND Homo sapiens (17309302) 1983 sodium cellulose PO4 Calcibind ND 1983 Vecuronium bromide Norcuron . Muscle relaxant ND Homo sapiens (17309302) 1982 Atenolol Tenormin AstraZeneca Pharmaceuticals Cardiovascular disease (for the treatment of hypertension, coronary heart disease, arrhythmias, angina (chest pain) and the treatment and reduce of the risk of heart complications following myocardial infarction (heart attack)) ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1981 Desogestrel; ethinylestradiol Marvelon Not Available Contraception ND Homo sapiens (17309302) 1981 cefsoludin sodium Takesulin antibacterial ND 1981 Estramustine Emcyt Pharmacia and Upjohn Company Antineoplastic (Prostatic neoplasms) ND Homo sapiens (17309302) 1980 Toposar; VP-16 VePesid Bristol-Myers Squibb (BMS) Oncological disease (for the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer, also for the treatment of other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme, wilms¡¯ tumours, different types of genital tumours (carcinoma verrucosus, for example), and in non-Hodgkin and other lymphomas and lung cancer) ND Dysosma pleiantha (16129603); Sinopodophyllum hexandrum (16673335); Podophyllum peltatum (18690825) 1980 Ribavirin Rebetol ICN Antiviral (DNA and RNA viruses infection) ND Streptomyces candidus (6119109); Streptomyces showdoensis (16591497) 1980 Metoprolol tartrate Lopressor; Lopresor Novartis Cardiovascular disease (for the treatment of hypertension and angina pectoris) ND Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1978 Ipratropium; ipratropium bromide Atrovent; Apovent Not Available Anticholinergic (chronic obstructive pulmonary disease (COPD)) ND Atropa belladonna (16796374); Mandragora officinarum (11710734); Datura stramonium (11710734) 1977 Fosfestrol Not Available . Anticancer ND Homo sapiens 1972 Clindamycin Cleocin; Dalacin; Evoclin; Duac Pfizer, Stiefel, Sanofi Aventis Antibacterial ND Streptomyces lincolnensis (14633101) 1970 Troleandomycin; oleandocetine Tao; Cyclamycin; Evramicina; Matromicina; Treolmicina; Tribiocillina Not Available Antibacterial ND Saccharopolyspora erythraea (15806196) 1969 Ethinyl estradiol (none given) Wyeth-Ayerst Antineoplastic (Oral contraceptives) ND Homo sapiens (17309302) 1965 Virginiamycin Not Available . Antibiotic ND Streptomyces pristinaespiralis 1959 Thiamphenicol Not Available . Antibiotic ND Streptomyces venezuelae 1955 Tubocurarine; d-tubocurarine Curare; Delacurarine; Jexin; Tubarine Not Available Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure, Skeletal muscle relaxant ND Chondrodendron tomentosum (3879679); Curarea (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Strychnos (17017999) 1942 Chloroquine Avlochlor; Quingamine US during World War II Antiparasitic (malaria) ND Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Cinchona (18454580) 1940 Aspirin; acetylsalicylic acid; ASA Aspirin Bayer Immunological, inflammatory and related disease - Inflammatory disease (analgesic, anti-inflammatory, antipyretic) ND Salix alba (16216276) 1898 Icatibant Firazyr Shire Hereditary angioedema NM Homo sapian 2011 Peginesatide acetate Omontys Affymax Anaemia due to chronic kidney disease NM Homo sapian 2012 Rilpivirine Edurant Tibotec HIV-1 infection NM 2011 Telaprevir Incivek Vertex HCV genotype 1 NM HCV 2011 Degarelix Firmagon Ferring Advanced prostate cancer NM Homo sapian 2008 Pemetrexed Alimta cancers NM 2004 laninamivir octanoate Inavir antiviral NM 2010 ZANAMIVIR RELENZA NM 1999 OSELTAMIVIR PHOSPHATE TAMIFLU NM 1999 quinagolide hydrochloride Norprolac antihyperprolactinemia NM Homo sapiens 1994 Tenofovir disoproxil fumarate Viread Gilead Sciences Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 2001 Kinetin Kinerase . Skin photodamage S* Nicotiana tabacum 1999 Didanosine; 2',3'-dideoxyinosine; DDI Videx; Videx EC Bristol-Myers Squibb Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 1991 Thioguanine Lanvis; Tabloid; Wellcome U3B Hitchings, Elion, and associates at the Wellcome Research Laboratories Oncological disease (for remission induction and remission consolidation treatment of acute nonlymphocytic leukemias) S* Homo sapiens (17309302) 1966 Mercaptopurine Mercaptopurine; Ismipur; Leukerin; Leupurin; Mercaleukim; Mercaleukin; Mern; Puri-Nethol; Purimethol; Purinethol Hitchings, Elion, and associates at the Wellcome Research Laboratories Oncological disease (treatment of lymphobastomas, myeloblastoma leucosis, and to treat neuroleukemia) S* Homo sapiens (17309302) 1953 Gabapentin Neurontin . Antiepileptic S* Homo sapiens (17309302) 1993 Acamprosate Aotal . Alcohol deterrent S* Homo sapiens (17309302) 1989 Progabide Gabrene Synthelabo Anticonvulsant (A wide variety of seizure disorders) S* Homo sapiens (17309302) 1985 Mitoxantrone HCI Novantrone Lederle Oncological disease (for treating severe nonlymphatic leukemia, breast cancer, advanced localized and metastatic mammary carcinomas) S* Streptomyces peucetius (16545946) 1984 Befunolol HCI Bentox . Antiglaucoma S* Homo sapiens (17309302) 1983 Celiprolol HCl Selectol . Antihypertensive S* Homo sapiens (17309302) 1983 Ethanolamine oleate Ethamolin . Sclerosant S* Homo sapiens (17309302) 1989 Eptazocine HBr Sedapain . Analgesic S* Papaver somniferum 1987 Nateglinide Starsis . Antidiabetic S* Homo sapiens (17309302) 1999 Entecavir Baraclude . Antiviral (Hepatitis B infection) S* Hepatitis B virus; Homo sapiens (17309302) 2005 Clofarabine Clolar . Anticancer S* Homo sapiens (17309302) 2005 Nelarabine Arranon . Anticancer S* Homo sapiens (17309302) 2005 Adefovir dipivoxil Hepsera . Antiviral (hepatitis B and herpes simplex virus infection) S* Hepatitis B virus; Simplexvirus; Homo sapiens (17309302) 2002 Valganciclovir Valcyte . Antiviral (Cytomegalovirus) S* Homo sapiens (17309302); Cytomegalovirus 2001 Abacavir sulfate Ziagen Glaxo Wellcome Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 1999 Valaciclovir HCl Valtrex . Antiviral (Herpes simplex and herpes zoster (shingles)) S* Human herpesvirus 3; Homo sapiens (17309302); Human herpesvirus 1; Human herpesvirus 2 1995 Fludarabine phosphate Fludara . Anticancer S* Homo sapiens (17309302) 1991 Ganciclovir Cymevene . Antiviral (Cytomegalovirus (CMV)) S* Homo sapiens (17309302); Cytomegalovirus 1988 Vidarabine; adenine arabinoside; Ara-A; arabinosyladenine; aciclovir Zovirax; Vira-a GlaxoSmithKline and Monarch Pharmaceuticals, Inc. Antiviral (epithelial keratitis caused by Herpes simplex virus) S* Streptomyces griseus (10888010); Streptomyces antibioticus (2648996); Tethya (15279577) 1981 Acyclovir Zovirax GlaxoSmithKline and Monarch Pharmaceuticals, Inc. Antiviral (epithelial keratitis caused by Herpes simplex virus) S* Streptomyces griseus (10888010); Streptomyces antibioticus (2648996); Tethya (15279577) 1981 Inosine pranobex Imunovir . Antiviral (Measles) S* Morbillivirus; Homo sapiens (17309302) 1981 Capecitabine Xeloda . Anticancer S* Homo sapiens (17309302) 1998 Carmofur Mifurol . Anticancer S* Homo sapiens (17309302) 1981 Floxuridine Sterile FUDR Heidelberger Oncological disease (for palliative management of gastrointestinal adenocarcinoma metastatic to the liver) S* Streptomyces griseus (10888010); Streptomyces antibioticus (2648996); Tethya (15279577) 1971 Decitabine Dacogen . Anticancer S* Homo sapiens (17309302) 2006 Azacytidine Vidaza . Anticancer (Myelodysplastic syndrome) S* Homo sapiens (17309302) 2004 Emtricitabine Emtriva Gilead (formerly Triangle) Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 2003 Cidofovir Vistide . Antiviral (Cytomegalovirus (CMV)) S* Homo sapiens (17309302); Cytomegalovirus 1996 Lamivudine Epivir Glaxo Wellcome Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 1995 Gemcitabine HCl Gemzar . Anticancer S* Homo sapiens (17309302) 1995 Stavudine Zerit Bristol-Myers Squibb Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 1994 Cytarabine ocfosfate Starsaid Yamasa and Nippon Kayaku Oncological disease (for the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia) S* Streptomyces griseus (10888010); Streptomyces antibioticus (2648996); Tethya (15279577) 1993 Sorivudine Usevir . Antiviral (Herpes simplex virus type I (HSV-1), Varicella zoster virus (VZV), Epstein-Barr virus (EBV)) S* Human herpesvirus 3; Homo sapiens (17309302); Human herpesvirus 4; Human herpesvirus 1 1993 Epervudine Hevizos . Antiviral (Acute and retidivirute infections of the skin and mucous membranes, caused by Herpes simplex, herpes zoster) S* Simplexvirus; Homo sapiens (17309302); Varicellovirus 1988 Zidovudine; ZDV; AZT; azidothymidine; 3'-azido-3'-deoxythymidine Retrovir Burroughs Wellcome Co. Antiviral (human immunovirus (HIV) infections) S* Human immunodeficiency virus 1; Tethya (15279577) 1987 Doxifluridine Furtulon . Anticancer S* Homo sapiens (17309302) 1987 Enocitabine Sunrabin . Anticancer S* Homo sapiens (17309302) 1983 Cytosine arabinoside; Ara-C DepoCyt; Cytosar-U ENZON Pharmaceuticals, Inc. and Upjohn (then Pharmacia and now Pfizer) Oncological disease (hematological malignancies such as leukemia and non-Hodgkin lymphoma) S* Tethya (15279577) 1969 Vismodegib Erivedge Genentech Metastatic or locally advanced basal cell carcinoma S* Veratrum californicum 2012 Penciclovir Vectavir . Antiviral (Various herpesvirus invections) S* Homo sapiens (17309302); Human herpesvirus 1; Human herpesvirus 2 1996 Famciclovir Famvir . Antiviral (Various herpesvirus infections, most commonly for herpes zoster (shingles)) S* Homo sapiens (17309302); Varicellovirus 1994 Glatiramer acetate Copaxone . Multiple sclerosis S* Homo sapiens (17309302) 1997 Bulaquine; chloroquine Aablaquin CDRI Antiparasitic S* Cinchona officinalis (%Drugs from nature past achievements future prospects 2002 by Gordon M Cragg, David J Newman%); Cinchona (18454580) 2000 Verteporfin Visudyne . Photosensitizer S* Homo sapiens (17309302) 2000 Cisatracurium besilate Nimbex . Muscle relaxant S* Leontice leontopetalum 1995 Zalcitabine; DDC; DDCYD; Dideoxycytidine Hivid Roche Antiviral (human immunovirus (HIV) infections) S* Homo sapiens; Human immunodeficiency virus 1 1992 Atovaquone Mepron . Antiparasitic (Pneumocystis pneumonia, Toxoplasmosis, Malaria, Babesia) S* Homo sapiens (17309302) 1992 Mivacurium chloride Mivacron . Muscle relaxant S* Leontice leontopetalum 1992 Doxacurium chloride Nuromax . Muscle relaxant S* Leontice leontopetalum 1991 Fosfosal Disdolen . Analgesic S* Salix 1984 Indoramin HCl Wydora . Antihypertensive S* Glycine max 1981 Fluorouracil Adrucil; Carzonal; Efudex; Fluoroplex; Kecimeton; Phtoruracil; Queroplex; Timazin Hoshi Oncological disease (treat carcinomas of the head, neck, colon, rectum, breast, stomach, bladder, pancreas, and for actinic and solar creatitis) S* Streptomyces griseus (10888010); Streptomyces antibioticus (2648996); Tethya (15279577) 1962 Methotrexate Methotrexate; Abitrexate; Antifolan; Arbitrexate; Emtexate; Folex; Ledertrexate; Metatrexan; Methotrate; Mexate; Rheumatrex; Trexall Northern Ireland Medicines Governance Oncological disease (treat severe lymphatic leukemia, choriocarcinoma, non-Hodgkin¡¯s lymphoma, bone carcinoma, as well as head, neck, breast, and lung tumors) S* Homo sapiens (17309302) 1954 Argatroban Slonnon Glaxo Antithrombotic S*/NM Homo sapiens (15692265) 1990 Droxidopa DOPS . AntiParkinsonian S*/NM Homo sapiens (17309302) 1989 Remoxipride hydrochloride Roxiam . Antipsychotic S*/NM Homo sapiens (17309302) 1990 Dopexamine Dopacard . Cardiotonic S*/NM Homo sapiens (17309302) 1989 Denopamine Kalgut . Cardiotonic S*/NM Homo sapiens (17309302) 1988 Abarelix Plenaxis Praecis Pharmaceuticals Oncological disease (for palliative treatment of advanced prostate cancer) S*/NM Homo sapiens (17309302) 2004 Moexipril HCI Univasc Schwarz, Warner-Lambert Cardiovascular disease (for treatment of patients with hypertension) S*/NM Bothrops jararaca (10888010) 1995 Spirapril HCI Renormax; Setrilan Sandoz, Schering-Plough Cardiovascular disease (used to treat hypertension) S*/NM Bothrops jararaca (2985149) 1995 Temocapril hydrochloride Acecol Sankyo, Nippon Boehringer Ingelheim Cardiovascular disease (used to treat hypertension) S*/NM Bothrops jararaca (10888010) 1994 Trandolapril Odrik; Udrik; Gopten; Mavik Roussel Uclaf, Knoll Cardiovascular disease (used to treat hypertension) S*/NM Bothrops jararaca (10888010) 1993 Imidapril HCI Tanatil Tanabe Cardiovascular disease (used to treat hypertension) S*/NM Bothrops jararaca (10888010) 1993 Fosinopril sodium Staril Bristol-Myers Squibb Cardiovascular disease (for the treatment of hypertension and the management of heart failure) S*/NM Bothrops jararaca (10888010) 1991 Benazepril hydrochloride Cibacen; Lotensin Ciba-Geigy Cardiovascular disease (essential hypertension) S*/NM Bothrops jararaca (16796374) 1990 Cilazapril Inhibace Hoffmann-La Roche Cardiovascular disease (mild to moderate hypertension) S*/NM Bothrops jararaca (16796374) 1990 Ramipril Triatec; Tritace; Ramace; Altace King Pharmaceuticals and Labs Hoechst Cardiovascular disease (mild to moderate hypertension and congestive heart failure) S*/NM Bothrops jararaca (2985149) 1989 Quinapril Accupro; Accupril Pfizer and Warner-Lambert Cardiovascular disease (hypertension and congestive heart failure) S*/NM Bothrops jararaca (2985149) 1989 Delapril Adecut Takeda Cardiovascular disease (essential hypertension) S*/NM Bothrops jararaca (16796374) 1989 Alacepril Cetapril Dainippon Cardiovascular disease (used to treat hypertension) S*/NM Bothrops jararaca (10888010) 1988 Perindopril Aceon; Coversyl Servier Cardiovascular disease (used in patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction) S*/NM Bothrops jararaca (2985149) 1988 Enalaprilat Renitec Merck & Co Cardiovascular disease (for the treatment of hypertension and heart failure) S*/NM Bothrops jararaca (15806196) 1987 Lisinopril Prinivil Merck, ICI Cardiovascular disease (for the treatment of hypertension, heart failure and acute myocardial infarction) S*/NM Bothrops jararaca (10888010) 1987 Enalapril maleate Reniten Merck & Co Cardiovascular disease (for the treatment of hypertension and heart failure) S*/NM Bothrops jararaca (15806196) 1984 Darunavir; TMC114 Prezista . Antiviral S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 2006 Atazanavir; BMS-232632 Reyataz Bristol-Myers, Novartis Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 2003 Fosamprenavir Lexiva Glaxo Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 2003 Lopinavir; ABT-378 Kaletra; Aluviran; Koletra Abbott, Triangle Pharm. Inc. Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 2000 Amprenavir Agenerase . Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 1999 Neflinavir mesylate; nelfinavir mesylate Viracept Pfizer Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 1997 Ritonavir Norvir Abbott Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 1996 Indinavir sulfate; IDV Crixivan Merck Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 1996 Saquinavir mesylate Invirase Roche Antiviral (human immunovirus (HIV) infections) S*/NM Actinomyces (510563); Streptomyces testaceus (2988085); Streptomyces argenteolus subsp. toyonakensis (4912600) 1995 Tadalafil Cialis Eli Lily and Company Male sexual dysfunction (impotence) S*/NM Homo sapiens (15602548) 2003 Vardenafil Levitra Bayer Healthcare and GlaxoSmithKline (GSK) Male sexual dysfunction (impotence) S*/NM Homo sapiens (15602548) 2003 Sildenafil citrate Viagra; Revatio Pfizer Male sexual dysfunction (male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH)) S*/NM Homo sapiens (15602548) 1998 Bucladesine sodium Actosin . Cardiotonic S*/NM Homo sapiens (17309302) 1984 Pitavastatin Livalo Sankyo/Kowa (Kowa/Nissan Chemical) Cardiovascular disease (hypocholesterolemic and dyslipidemia) S*/NM Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374) 2009 Rosuvastatin calcium Crestor AstraZeneca (Shionogi & Co) Cardiovascular disease (hypercholesterolemia and dyslipidemia) S*/NM Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374) 2003 Atorvastatin calcium; atorvastin calcium Lipitor Pfizer Cardiovascular disease (for management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia, hypocholesterolemic and lowering blood cholesterol) S*/NM Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374) 1997 Fluvastatin sodium Lescol; Canef Sandoz Cardiovascular disease (for management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia) S*/NM Pseudonocardia autotrophica (DB00175); Penicillium brevicompactum (10888010); Penicillium citrinum (16796374) 1994 Tiotropium bromide Spiriva; Spiriva Handihaler Boehringer Ingelheim and Pfizer Anticholinergic - Bronchospasm associated with chronic obstructive pulmonary disease (COPD) S*/NM Atropa belladonna (16198377); Mandragora officinarum (11710734); Datura stramonium (11710734) 2002 Dabigatran; BIBR 953 Pradaxa; Pradax Boehringer Ingelheim Antithrombotic S*/NM Homo sapiens (15692265) 2010 Tegaserod maleate Zelmac . IBS S*/NM Homo sapiens (17309302) 2001 Levalbuterol HCI Xopenex Sepracor Immunological, inflammatory and related disease - Inflammatory disease (asthma, bronchospasm in patients with reversible obstructive airway disease) S*/NM Ephedra sinica (15925954) 1999 Fomivirsen sodium Vitravene . Antiviral (cytomegalovirus retinitis (CMV)) S*/NM Cytomegalovirus 1998 Rizatriptan benzoate Maxalt . Antimigraine S*/NM Homo sapiens (17309302) 1998 Ramosetron Nasea . Antiemetic S*/NM Homo sapiens (17309302) 1996 Ropinirole HCl ReQuip . AntiParkinsonian S*/NM Homo sapiens (17309302) 1996 Sertindole Serdolect . Neuroleptic S*/NM Homo sapiens (17309302) 1996 Sumatriptan succinate Imigran . Antimigraine S*/NM Homo sapiens (17309302) 1991 Salmeterol xinafoate Serevent Glaxo Immunological, inflammatory and related disease - Inflammatory disease (reversible airway obstruction in asthma and chronic bronchitis) S*/NM Ephedra sinica (15925954) 1990 Betaxolol HCI Betaxon; Betoptic; Betoptic S; Kerlone Robert & Carriere Cardiovascular disease (for the management of hypertension) S*/NM Ephedra sinica (15925954); Senegalia berlandieri (Clement, Beverly A., Goff, Erik Allen Burt, Christina M. and Forbes, T. David A. (1997). Toxic amines and alkaloids from Acacia berlandieri. Phytochemistry 46(2), pp 249-254); Acacia rigidula (Clement, Beverly A., Goff, Christina M. and Forbes, T. David A. (1998). Toxic amines and alkaloids from Acacia rigidula. Phytochemistry 49(5), pp 1377-1380) 1983 Aliskiren hemifumarate Tekturna S*/NM 2007 Tipranavir Aptivus S*/NM 2005 Eptifibatide Integrilin S*/NM 1998 Pazopanib; GW-786034 Votrient GlaxoSmithKline Anticancer (RCC) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2009 Lapatinib; lapatanib; GW2016; GSK572016 Tykerb GlaxoSmithKline Anticancer (HER2 positive breast cancer) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2007 Sunitinib malate; SU11248 Sutent Pfizer Anticancer (RCC, GIST) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2006 Sorafenib Nexavar Bayer Anticancer (RCC, liver carcinoma) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2005 Erlotinib hydrochloride Tarceva Roche/Genentech Anticancer (NSCL and pancreatic carcinoma) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2004 Gefitinib Iressa AstraZeneca Anticancer (NSCLC) S/NM Spinacia oleracea (15153188); Zea mays (15153188); Pisum sativum (15153188); Cocos nucifera (15153188) 2002 Rotigotine Neupro . AntiParkinsonian S/NM Homo sapiens (17309302) 2006 Bortezomib; PS-341; LDP-341; MLN-341 Velcade Millennium Pharmaceuticals Anticancer (Multiple myeloma) S/NM Homo sapiens (17921103) 2003 Temoporfin Foscan . Anticancer S/NM Homo sapiens (17309302) 2002 Olmesartan medoxil Benicar . Antihypertensive S/NM Rattus norvegicus (3171969) 2002 Telmisartan Micardis . Antihypertensive S/NM Rattus norvegicus (3171969) 1999 Candesartan cilexetil Atacand . Antihypertensive S/NM Rattus norvegicus (3171969) 1997 Eprosartan Teveten . Antihypertensive S/NM Rattus norvegicus (3171969) 1997 Irbesartan Avapro . Antihypertensive S/NM Rattus norvegicus (3171969) 1997 Valsartan Diovan . Antihypertensive S/NM Rattus norvegicus (3171969) 1996 Losartan potassium Cozaar . Antihypertensive S/NM Rattus norvegicus (3171969) 1994 Maraviroc; UK-427,857 Not Available Not Applicable Antiviral (human immunovirus (HIV) infections) S/NM Homo sapiens (17921103) 2007 Dasatinib Sprycel Bristol-Myers Squibb Anticancer (CML with imatinib resistance and/or intolerance) S/NM Lentzea albida (19132059) 2006 Ximelagatran Exanta . DVT; anticoagulant S/NM Homo sapiens (15692265) 2004 Tandospirone Sediel . Anxiolytic S/NM Homo sapiens (17309302) 1996 Tirofiban hcl Aggrastat S/NM 1998