TTD - Therapeutic Targets Databse Version 4.3.02 (2011.08.25) File Name: List of 368 nature-derived current and past clinical trial drugs and their species origins. Following the seminal works of Newman and Cragg (J Nat Prod. 2007 Mar;70(3):461-77), the drug types are defined as follows: "B" Biological, a peptide or protein either isolated from an organism/cell line or produced by biotechnological means in a surrogate host; "N" Natural product; "ND" Derived from a natural product and is usually a semisynthetic modification; "NM" Natural product mimic; "S*" Made by total synthesis based on the pharmacophore from a natural product; "V" Vaccine. Reference: Zhu F, Qin C, Tao L, Liu X, Shi Z, Ma X, Jia J, Tan Y, Cui C, Lin J, Tan C, Jiang Y, Chen Y. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (PNAS). 2011 Aug 2;108(31):12943-8. Drug name Clinical trial status Drug type Species origin (family) Therapeutic class or targeted disease 1,5-DCQA Phase I N Cynara cardunculus (Asteraceae) Antiviral 1,5-DCQA Phase I N Inula britannica (Asteraceae) Antiviral 10- Hydroxycamptothecin Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease 10- Hydroxycamptothecin Phase II ND Mappia foetida (Icacinaceae) Oncological disease 10- Hydroxycamptothecin Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease 9-aminocamptothecin Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease 9-aminocamptothecin Phase II ND Mappia foetida (Icacinaceae) Oncological disease 9-aminocamptothecin Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease A366833 Phase I ND Epipedobates tricolor (Dendrobatidae) Analgesic ABJ-879 Phase I ND Sorangium cellulosum (Polyangiaceae) Oncological disease ABT-518 Phase I S/NM Homo sapiens (Hominidae) Solid tumours ABT-594 Phase II ND Epipedobates tricolor (Dendrobatidae) Neurological disease ABT-869 Phase I ND Zea mays (Poaceae) Anticancer ABT-869 Phase I ND Cocos nucifera (Arecaceae) Anticancer ABT-869 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer ABT-869 Phase I ND Pisum sativum (Fabaceae) Anticancer ACV1 Phase II N Conus catus (Conidae) Pain AE-941 Phase III ND Squalus acanthias (Squalidae) Oncological disease AEE-788 Phase II ND Zea mays (Poaceae) Oncological disease AEE-788 Phase II ND Cocos nucifera (Arecaceae) Oncological disease AEE-788 Phase II ND Spinacia oleracea (Amaranthaceae) Oncological disease AEE-788 Phase II ND Pisum sativum (Fabaceae) Oncological disease AG3340 Phase III S*/NM Homo sapiens (Hominidae) Cancer AG7088 Phase II S*/NM Human rhinovirus sp. (Picornaviridae) Common cold Alpha-Conotoxin Vc1.1 Phase II N Conus victoriae (Conidae) Neurological disease Alvespimycin Phase II ND Streptomyces hygroscopicus subsp. geldanus (Streptomycetaceae) Oncological disease ALX 111 Phase III N Homo sapiens (Hominidae) Osteoporosis AMG706 Phase II ND Zea mays (Poaceae) Anticancer AMG706 Phase II ND Cocos nucifera (Arecaceae) Anticancer AMG706 Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer AMG706 Phase II ND Pisum sativum (Fabaceae) Anticancer Aminocandin Phase I ND Aspergillus sydowii (Trichocomaceae) Antifungal Anabaseine Phase I N Paranemertes peregrina (Paranemertes) Neurological disease Anabaseine Phase I N Amphiporus angulatus (Amphiporidae) Neurological disease Ancrod Phase III N Calloselasma rhodostoma (Viperidae) Immunological, inflammatory and related disease Anhydrovinblastine Phase I ND Catharanthus roseus (Apocynaceae) Oncological disease Aplaviroc Phase II S/NM Homo sapiens (Hominidae) Antiviral AraC/Bryostatin 1 Phase I N Bugula neritina (Bugulidae) Oncological disease AraC/Bryostatin 1 Phase I N Tethya (Tethyidae) Oncological disease Arenastatin A Phase I N Dysidea (Dysideidae) Oncological disease Artemisone Phase II ND Artemisia annua (Asteraceae) Antiparasitic Arterolane Phase II ND Artemisia annua (Asteraceae) Antiparasitic AVE-8062 Phase III ND Combretum (Combretaceae) Oncological disease AVE-8063 Phase I ND Combretum (Combretaceae) Oncological disease AVE-8064 Phase I ND Combretum (Combretaceae) Oncological disease AVE9633 Phase I ND Anomodon attenuatus (Anomodontaceae) Oncological disease AVE9633 Phase I ND Claopodium crispifolium (Leskeaceae) Oncological disease Axitinib Phase II ND Zea mays (Poaceae) Anticancer Axitinib Phase II ND Cocos nucifera (Arecaceae) Anticancer Axitinib Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer Axitinib Phase II ND Pisum sativum (Fabaceae) Anticancer Azamulin Phase I ND Pleurotus (Pleurotaceae) Antibiotic AZD-0530 Phase I ND Zea mays (Poaceae) Anticancer AZD-0530 Phase I ND Cocos nucifera (Arecaceae) Anticancer AZD-0530 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer AZD-0530 Phase I ND Pisum sativum (Fabaceae) Anticancer AZD-3409 Phase I S/NM Homo sapiens (Hominidae) Anticancer BAL-19403 Phase I ND Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial Batimastat Phase III S/NM Homo sapiens (Hominidae) Anticancer BAY-57-9352 Phase I ND Zea mays (Poaceae) Anticancer BAY-57-9352 Phase I ND Cocos nucifera (Arecaceae) Anticancer BAY-57-9352 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer BAY-57-9352 Phase I ND Pisum sativum (Fabaceae) Anticancer BBI concentrate Phase II N Glycine max (Fabaceae) Cancer BC-3205 Phase I ND Clitopilus scyphoides (Entolomataceae) Antibacterial BC-3205 Phase I ND Pleurotus (Pleurotaceae) Antibacterial BC-3781 Phase II ND Pleurotus (Pleurotaceae) Antibiotic BC-7013 Phase I ND Clitopilus scyphoides (Entolomataceae) Antibacterial Becatecarin Phase II ND Lentzea albida (Actinosynnemataceae) Oncological disease Bengamide A Phase I ND Ancorinidae (Ancorinidae) Oncological disease Bengamide A Phase I ND Myxococcus virescens (Myxococcaceae) Oncological disease Benzoxazinorifamycin Phase II ND Amycolatopsis mediterranei (Pseudonocardiaceae) Antibacterial Benzoxazinorifamycin Phase II ND Amycolatopsis rifamycinica (Pseudonocardiaceae) Antibacterial Berubicin Phase II ND Streptomyces peucetius (Streptomycetaceae) Oncological disease Beta-lapachone Phase II ND Tabebuia (Bignoniaceae) Oncological disease Betulinic acid Phase I N Syzygium claviflorum (Myrtaceae) Oncological disease Bevirimat Phase II ND Syzygium claviflorum (Myrtaceae) Antiviral Bizelesin Phase I ND Streptomyces (Streptomycetaceae) Oncological disease BMS-182248 Phase II ND Streptomyces peucetius (Streptomycetaceae) Oncological disease BMS-184476 Phase II ND Taxus wallichiana (Taxaceae) Oncological disease BMS-184476 Phase II ND Taxus brevifolia (Taxaceae) Oncological disease BMS-188797 Phase II ND Taxus wallichiana (Taxaceae) Oncological disease BMS-188797 Phase II ND Taxus brevifolia (Taxaceae) Oncological disease BMS-214662 Phase I S/NM Homo sapiens (Hominidae) Anticancer BMS-247550 Phase III ND Sorangium cellulosum (Polyangiaceae) Anticancer BMS-250749 Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease BMS-250749 Phase I ND Mappia foetida (Icacinaceae) Oncological disease BMS-250749 Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease BMS-275183 Phase I ND Taxus wallichiana (Taxaceae) Oncological disease BMS-275183 Phase I ND Taxus brevifolia (Taxaceae) Oncological disease BMS-275291 Phase III S*/NM Homo sapiens (Hominidae) Cancer BMS-310705 Phase I ND Sorangium cellulosum (Polyangiaceae) Oncological disease BMS-582664 Phase I ND Zea mays (Poaceae) Anticancer BMS-582664 Phase I ND Cocos nucifera (Arecaceae) Anticancer BMS-582664 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer BMS-582664 Phase I ND Pisum sativum (Fabaceae) Anticancer BMS-599626 Phase I ND Zea mays (Poaceae) Anticancer BMS-599626 Phase I ND Cocos nucifera (Arecaceae) Anticancer BMS-599626 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer BMS-599626 Phase I ND Pisum sativum (Fabaceae) Anticancer BNP-1350 Phase III ND Camptotheca acuminata (Cornaceae) Oncological disease BNP-1350 Phase III ND Mappia foetida (Icacinaceae) Oncological disease BNP-1350 Phase III ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Bosutinib Phase I ND Zea mays (Poaceae) Anticancer Bosutinib Phase I ND Cocos nucifera (Arecaceae) Anticancer Bosutinib Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer Bosutinib Phase I ND Pisum sativum (Fabaceae) Anticancer Brostallicin Phase II ND Streptomyces netropsis (Streptomycetaceae) Oncological disease Bruceantin Phase II N Brucea antidysenterica (Simaroubaceae) Oncological disease Bryostatin 1 Phase II ND Bugula neritina (Bugulidae) Oncological disease Cabazitaxel Phase III ND Taxus wallichiana (Taxaceae) Oncological disease Cabazitaxel Phase III ND Taxus brevifolia (Taxaceae) Oncological disease Calanolide A In Clinical Trial N Calophyllum (Calophyllaceae) Antiviral Camptothecin In Clinical Trial N Camptotheca acuminata (Cornaceae) Oncological disease Camptothecin In Clinical Trial N Mappia foetida (Icacinaceae) Oncological disease Camptothecin In Clinical Trial N Ophiorrhiza pumila (Rubiaceae) Oncological disease Canertinib Phase II ND Zea mays (Poaceae) Anticancer Canertinib Phase II ND Cocos nucifera (Arecaceae) Anticancer Canertinib Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer Canertinib Phase II ND Pisum sativum (Fabaceae) Anticancer Cannabidiol Phase II N Cannabis sativa (Cannabaceae) Anxiety and psychosis Capsaicin Phase II N Capsicum annuum (Solanaceae) Neurological disease Capsaicin Phase II N Capsicum frutescens (Solanaceae) Neurological disease Capsaicin Phase II N Zingiber officinale (Zingiberaceae) Neurological disease Capsaicin Phase II N Capsicum annuum (Solanaceae) Neurological disease Capsaicin Phase II N Capsicum frutescens (Solanaceae) Neurological disease Capsaicin Phase II N Zingiber officinale (Zingiberaceae) Neurological disease Carfilzomib Phase III S/NM Actinomyces (Actinomycetaceae) Multiple myeloma Castor oil In Clinical Trial N Ricinus communis (Euphorbiaceae) Constipation CBR-2092 Phase I ND Amycolatopsis mediterranei (Pseudonocardiaceae) Antibacterial CBR-2092 Phase I ND Amycolatopsis rifamycinica (Pseudonocardiaceae) Antibacterial Cediranib Phase II ND Zea mays (Poaceae) Anticancer Cediranib Phase II ND Cocos nucifera (Arecaceae) Anticancer Cediranib Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer Cediranib Phase II ND Pisum sativum (Fabaceae) Anticancer Ceftaroline acetate Phase II ND Acremonium chrysogenum (Acremonium) Antibacterial Ceftaroline acetate Phase II ND Amycolatopsis lactamdurans (Pseudonocardiaceae) Antibacterial Ceftaroline acetate Phase II ND Emericellopsis minima (Emericellopsis) Antibacterial Ceftaroline acetate Phase II ND Streptomyces clavuligerus (Streptomycetaceae) Antibacterial Ceftizoxime alapivoxil In Clinical Trial ND Acremonium chrysogenum (Acremonium) Antibacterial Ceftizoxime alapivoxil In Clinical Trial ND Amycolatopsis lactamdurans (Pseudonocardiaceae) Antibacterial Ceftizoxime alapivoxil In Clinical Trial ND Emericellopsis minima (Emericellopsis) Antibacterial Ceftizoxime alapivoxil In Clinical Trial ND Streptomyces clavuligerus (Streptomycetaceae) Antibacterial Ceftobiprole Phase III ND Acremonium chrysogenum (Acremonium) Antibacterial Ceftobiprole Phase III ND Amycolatopsis lactamdurans (Pseudonocardiaceae) Antibacterial Ceftobiprole Phase III ND Emericellopsis minima (Emericellopsis) Antibacterial Ceftobiprole Phase III ND Streptomyces clavuligerus (Streptomycetaceae) Antibacterial Cematodin Phase II ND Dolabella auricularia (Aplysiidae) Oncological disease Cematodin Phase II ND Symploca sp. VP642a (Symploca) Oncological disease Cematodin Phase II ND Symploca sp. VP642b (Symploca) Oncological disease Cematodin Phase II ND Symploca sp. VP642c (Symploca) Oncological disease CEP-1347 Phase III ND Lentzea albida (Actinosynnemataceae) Neurological disease CEP-7055 Phase I ND Lentzea albida (Actinosynnemataceae) Oncological disease Cerivastatin In Clinical Trial S*/NM Pseudonocardia autotrophica (Pseudonocardiaceae) Cardiovascular disease Cerivastatin In Clinical Trial S*/NM Penicillium brevicompactum (Trichocomaceae) Cardiovascular disease Cerivastatin In Clinical Trial S*/NM Penicillium citrinum (Trichocomaceae) Cardiovascular disease Cethromycin Phase III ND Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial CGS-27023A Phase II S*/NM Homo sapiens (Hominidae) Cancer CGX-1160 Phase II N Conus geographus (Conidae) Neurological disease Civamide Phase III ND Capsicum annuum (Solanaceae) Neurological disease Civamide Phase III ND Capsicum frutescens (Solanaceae) Neurological disease Civamide Phase III ND Zingiber officinale (Zingiberaceae) Neurological disease CKD-732 In Clinical Trial ND Aspergillus fumigatus (Trichocomaceae) Oncological disease CM101/ZDO101 Phase II N Streptococcus (Streptococcaceae) Anticancer CMB 401 Phase II ND Micromonospora echinospora (Micromonosporaceae) Oncological disease CNF-1010 In Clinical Trial ND Streptomyces hygroscopicus subsp. geldanus (Streptomycetaceae) Oncological disease COL-3 Phase II S*/NM Homo sapiens (Hominidae) Cancer Combretastatin A-4 phosphate Phase III ND Combretum (Combretaceae) Oncological disease Conantokin-G Phase II N Conus geographus (Conidae) Neurological disease Conantokin-T Phase II N Conus tulipa (Conidae) Neurological disease CP 7075 Phase II ND Cannabis sativa (Cannabaceae) Neurological disease CP-724714 Phase I ND Zea mays (Poaceae) Anticancer CP-724714 Phase I ND Cocos nucifera (Arecaceae) Anticancer CP-724714 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer CP-724714 Phase I ND Pisum sativum (Fabaceae) Anticancer CP-751,871 Phase III ND Lentzea albida (Actinosynnemataceae) Oncological disease Crofelemer Phase III N Croton lechleri (Euphorbiaceae) Antiviral Cryptophycin-52 Phase II ND Taxus wallichiana (Taxaceae) Anticancer Cryptophycin-52 Phase II ND Taxus brevifolia (Taxaceae) Anticancer Cryptophycin-52 Phase II ND Taxus baccata (Taxaceae) Anticancer Cryptophycin-52 Phase II ND Corylus avellana (Betulaceae) Anticancer Cryptophycin-52 Phase II ND Seimatoantlerium tepuiense (Amphisphaeriaceae) Anticancer Curcumin Phase II ND Curcuma longa (Zingiberaceae) Oncological disease DA-5018 Phase II ND Capsicum annuum (Solanaceae) Neurological disease DA-5018 Phase II ND Capsicum frutescens (Solanaceae) Neurological disease DA-5018 Phase II ND Zingiber officinale (Zingiberaceae) Neurological disease DA-6034 Phase II ND Artemisia argyi (Asteraceae) Immunological, inflammatory and related disease Daidzein Phase I N Glycine max (Fabaceae) Oncological disease Daidzein Phase I N Cicer arietinum (Fabaceae) Oncological disease Daidzein Phase I N Cullen corylifolium (Fabaceae) Oncological disease Daidzein Phase I N Genista tinctoria (Fabaceae) Oncological disease Daidzein Phase I N Lens culinaris (Fabaceae) Oncological disease Daidzein Phase I N Medicago sativa (Fabaceae) Oncological disease Daidzein Phase I N Phaseolus coccineus (Fabaceae) Oncological disease Daidzein Phase I N Phaseolus lunatus (Fabaceae) Oncological disease Daidzein Phase I N Pisum sativum (Fabaceae) Oncological disease Daidzein Phase I N Pueraria (Fabaceae) Oncological disease Daidzein Phase I N Sophora prostrata (Fabaceae) Oncological disease Daidzein Phase I N Trifolium pratense (Fabaceae) Oncological disease Daidzein Phase I N Vicia faba (Fabaceae) Oncological disease Daidzein Phase I N Vigna angularis (Fabaceae) Oncological disease Daidzein Phase I N Vigna radiata (Fabaceae) Oncological disease Daidzein Phase I N Vigna unguiculata ssp. unguiculata (Fabaceae) Oncological disease Dalbavancin Phase III ND Nonomuraea sp. ATCC 39727 (Streptosporangiaceae) Antibacterial Dapagliflozin Phase III ND Malus x domestica (Rosaceae) Neurological disease Datelliptium acetate Phase II ND Aspidosperma (Apocynaceae) Oncological disease Datelliptium acetate Phase II ND Apocynaceae (Apocynaceae) Oncological disease Datelliptium acetate Phase II ND Ochrosia elliptica (Apocynaceae) Oncological disease Datelliptium acetate Phase II ND Strychnos (Loganiaceae) Oncological disease Datelliptium acetate Phase II ND Tabernaemontana (Apocynaceae) Oncological disease Debio 9902 Phase II ND Huperzia serrata (Lycopodiaceae) Neurological disease Debio-025 Phase II ND Claviceps purpurea (Clavicipitaceae) Antiviral Debio-025 Phase II ND Cylindrocarpon lucidum (Nectriaceae) Antiviral Debio-025 Phase II ND Tolypocladium inflatum (Clavicipitaceae) Antiviral Deforolimus Phase III ND Streptomyces hygroscopicus (Streptomycetaceae) Oncological disease Dehydelone Phase I ND Sorangium cellulosum (Polyangiaceae) Oncological disease Dehydrodidemnin B Phase II N Aplidium (Polyclinidae) Oncological disease Dehydrodidemnin B Phase II N Trididemnum (Didemnidae) Oncological disease Devacade In Clinical Trial ND Aspergillus alliaceus (Trichocomaceae) Neurological disease DHA-paclitaxel Phase III ND Taxus wallichiana (Taxaceae) Oncological disease DHA-paclitaxel Phase III ND Taxus brevifolia (Taxaceae) Oncological disease Diascorbate salt Phase II ND Streptomyces aureofaciens (Streptomycetaceae) Antifungal Didemnin B In Clinical Trial N Trididemnum (Didemnidae) Oncological disease Diflomotecan Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease Diflomotecan Phase II ND Mappia foetida (Icacinaceae) Oncological disease Diflomotecan Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Dimethyl succinyl betulinic acid Phase II N Syzygium cumini (Myrtaceae) Antiviral Dirithromycin In Clinical Trial ND Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial Discodermolide In Clinical Trial ND Discodermia dissoluta (Theonellidae) Oncological disease Ditalin In Clinical Trial N Digitalis purpurea (Plantaginaceae) Cancer DMBX-anabaseine Phase II ND Amphiporus angulatus (Amphiporidae) Neurological disease DMBX-anabaseine Phase II ND Amphiporus lactifloreus (Amphiporidae) Neurological disease DMBX-anabaseine Phase II ND Paranemertes peregrina (Paranemertes) Neurological disease Dolastatin 10 In Clinical Trial ND Symploca sp. VP642a (Symploca) Oncological disease Dolastatin 10 In Clinical Trial ND Symploca sp. VP642b (Symploca) Oncological disease Dolastatin 10 In Clinical Trial ND Symploca sp. VP642c (Symploca) Oncological disease Dolastatin 10 In Clinical Trial ND Symploca hydnoides (Symploca) Oncological disease Dolastatin 10 In Clinical Trial ND Dolabella auricularia (Aplysiidae) Oncological disease Dolastatin 15 In Clinical Trial N Symploca sp. VP642a (Symploca) Oncological disease Dolastatin 15 In Clinical Trial N Symploca sp. VP642b (Symploca) Oncological disease Dolastatin 15 In Clinical Trial N Symploca sp. VP642c (Symploca) Oncological disease Dolastatin 15 In Clinical Trial N Dolabella auricularia (Aplysiidae) Oncological disease DRF-1042 Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease DRF-1042 Phase II ND Mappia foetida (Icacinaceae) Oncological disease DRF-1042 Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease E7107 Phase I ND Streptomyces platensis (Streptomycetaceae) Oncological disease E7974 Phase I ND Cymbastela (Axinellidae) Oncological disease E7974 Phase I ND Hemiasterella (Hemiasterellidae) Oncological disease E7974 Phase I ND Hemiasterella (Hemiasterellidae) Oncological disease EC145 Phase I ND Catharanthus roseus (Apocynaceae) Oncological disease ECO-4601 Phase II ND Micromonospora aurantiaca (Micromonosporaceae) Oncological disease Edotecarin Phase III ND Lentzea albida (Actinosynnemataceae) Oncological disease Elomotecan Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease Elomotecan Phase I ND Mappia foetida (Icacinaceae) Oncological disease Elomotecan Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Elsamitrucin Phase II ND Streptomyces chartreusis (Streptomycetaceae) Oncological disease EndoTAG-1 Phase II ND Taxus wallichiana (Taxaceae) Oncological disease EndoTAG-1 Phase II ND Taxus brevifolia (Taxaceae) Oncological disease Enzastaurin Phase III ND Lentzea albida (Actinosynnemataceae) Oncological disease EP-420 Phase II ND Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial Epigallocatechin gallate Phase II N Camellia sinensis (Theaceae) Oncological disease Epothilone D Phase II ND Sorangium cellulosum (Polyangiaceae) Oncological disease Eritoran Phase III ND Rhodobacter sphaeroides (Rhodobacteraceae) Antibacterial Everolimus Phase III ND Streptomyces hygroscopicus (Streptomycetaceae) Oncological disease Exatecan Phase III ND Camptotheca acuminata (Cornaceae) Oncological disease Exatecan Phase III ND Mappia foetida (Icacinaceae) Oncological disease Exatecan Phase III ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Exendin Phase II ND Homo sapiens (Hominidae) Diabetes Fara/Bryostatin 1 Phase I N Bugula neritina (Bugulidae) Oncological disease Faropenem daloxate Phase III ND Streptomyces cattleya (Streptomycetaceae) Antibacterial Flavopiridol Phase III ND Meliaceae (Meliaceae) Oncological disease Flavopiridol Phase III ND Dysoxylum (Meliaceae) Oncological disease Fostriecin Phase I N Streptomyces pulveraceus (Streptomycetaceae) Oncological disease Friulimicin B Phase I N Actinoplanes friuliensis (Micromonosporaceae) Antibacterial Galarubicin In Clinical Trial ND Streptomyces peucetius (Streptomycetaceae) Oncological disease Gantacurium chloride In Clinical Trial ND Strychnos (Loganiaceae) Neurological disease Gantacurium chloride In Clinical Trial ND Anomospermum grandifolium (Menispermaceae) Neurological disease Gantacurium chloride In Clinical Trial ND Chondrodendron tomentosum (Menispermaceae) Neurological disease Genistein Phase II ND Glycine max (Fabaceae) Oncological disease Gimatecan Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease Gimatecan Phase II ND Mappia foetida (Icacinaceae) Oncological disease Gimatecan Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Girolline In Clinical Trial N Cymbastela (Axinellidae) Oncological disease GL-331 Phase II ND Dysosma pleiantha (Berberidaceae) Oncological disease GL-331 Phase II ND Podophyllum peltatum (Berberidaceae) Oncological disease GL-331 Phase II ND Sinopodophyllum hexandrum (Berberidaceae) Oncological disease GPI-0100 In Clinical Trial ND Quillaja saponaria (Quillajaceae) Immunological, inflammatory and related disease GSK 565154 In Clinical Trial ND Clitopilus scyphoides (Entolomataceae) Antibacterial GSK 742510 In Clinical Trial ND Clitopilus scyphoides (Entolomataceae) Antibacterial GSK-189075/KGT-1681 Phase II ND Malus x domestica (Rosaceae) Neurological disease GW640385 Phase II S/NM Human immunodeficiency virus 1 (Retroviridae) Antiviral GW823093C Phase II S*/NM Homo sapiens (Hominidae) Diabetes mellitus Halichondrin B In Clinical Trial N Lissodendoryx (Coelosphaeridae) Oncological disease Halichondrin B In Clinical Trial N Halichondria okadai (Halichondriidae) Oncological disease Heparvit Phase II ND Apium graveolens var. dulce (Apiaceae) Antiviral Heparvit Phase II ND Fraxinus ornus (Oleaceae) Antiviral Heparvit Phase II ND Galium odoratum (Rubiaceae) Antiviral Heparvit Phase II ND Matricaria recutita (Asteraceae) Antiviral Heparvit Phase II ND Petroselinum crispum (Apiaceae) Antiviral HKI-272 Phase II ND Zea mays (Poaceae) Anticancer HKI-272 Phase II ND Cocos nucifera (Arecaceae) Anticancer HKI-272 Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer HKI-272 Phase II ND Pisum sativum (Fabaceae) Anticancer Homocamptothecin Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease Homocamptothecin Phase I ND Mappia foetida (Icacinaceae) Oncological disease Homocamptothecin Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Homoharringtonine Phase III ND Cephalotaxus fortunei (Cephalotaxaceae) Oncological disease Homoharringtonine Phase III ND Cephalotaxus harringtonia (Cephalotaxaceae) Oncological disease HTI-286 Phase II ND Cymbastela (Axinellidae) Oncological disease HTI-286 Phase II ND Hemiasterella (Hemiasterellidae) Oncological disease IdB 1016 Phase II ND Silybum marianum (Asteraceae) Oncological disease IDEC-132 Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease IDEC-132 Phase II ND Mappia foetida (Icacinaceae) Oncological disease IDEC-132 Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease IDN-6556 Phase II S*/NM Hepatitis C virus (Flaviviridae) Hepatitis C Ilepatril Phase III ND Bothrops jararaca (Viperidae) Cardiovascular and metabolic disease ILX651 Phase I ND Dolabella auricularia (Aplysiidae) Anticancer IM862 Phase III N Bos taurus (Bovidae) Anticancer IMGN-242 Phase II ND Anomodon attenuatus (Anomodontaceae) Oncological disease IMGN-242 Phase II ND Claopodium crispifolium (Leskeaceae) Oncological disease IMGN-901 Phase I ND Anomodon attenuatus (Anomodontaceae) Oncological disease IMGN-901 Phase I ND Claopodium crispifolium (Leskeaceae) Oncological disease IMGN-901 Phase I ND Anomodon attenuatus (Anomodontaceae) Oncological disease IMGN-901 Phase I ND Claopodium crispifolium (Leskeaceae) Oncological disease Incyclinide In Clinical Trial ND Streptomyces aureofaciens (Streptomycetaceae) Antibacterial Incyclinide In Clinical Trial ND Streptomyces viridifaciens (Streptomycetaceae) Antibacterial Indirubin Phase II N Indigofera tinctoria (Fabaceae) Oncological disease Indirubin Phase II N Isatis tinctoria (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica oleracea var. acephala (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica oleracea var. botrytis (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica oleracea var. capitata (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica oleracea var. gemmifera (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica oleracea var. italica (Brassicaceae) Oncological disease Indole-3-carbinol Phase I N Brassica rapa subsp. Rapa (Brassicaceae) Oncological disease Ingenol 3-angelate Phase II ND Euphorbia esula (Euphorbiaceae) Oncological disease Ingenol 3-angelate Phase II ND Euphorbia peplus (Euphorbiaceae) Oncological disease Ingenol 3-angelate Phase II ND Euphorbia serrata (Euphorbiaceae) Oncological disease Inotuzumab ozogamicin Phase III ND Micromonospora echinospora (Micromonosporaceae) Oncological disease IPL-512,602 Phase II ND Petrosia (Petrosiidae) Inflammatory disease IPL512602 Phase II ND Petrosia (Petrosiidae) Asthma IPL-550,260 Phase I ND Petrosia (Petrosiidae) Inflammatory disease IPL-576,092 Phase II ND Petrosia (Petrosiidae) Inflammatory disease Irofulven Phase III ND Omphalotus japonicus (Omphalotaceae) Oncological disease Irofulven Phase III ND Omphalotus illudens (Omphalotaceae) Oncological disease Irofulven Phase III ND Omphalotus nidiformis (Omphalotaceae) Oncological disease Irofulven Phase III ND Omphalotus olivascens var. indigo (Omphalotaceae) Oncological disease ISA247 Phase II ND Tolypocladium inflatum (Clavicipitaceae) Transplantation ISA-247 Phase II ND Claviceps purpurea (Clavicipitaceae) Immunological, inflammatory and related disease ISA-247 Phase II ND Cylindrocarpon lucidum (Nectriaceae) Immunological, inflammatory and related disease ISA-247 Phase II ND Tolypocladium inflatum (Clavicipitaceae) Immunological, inflammatory and related disease ISA-247 Phase II ND Claviceps purpurea (Clavicipitaceae) Immunological, inflammatory and related disease ISA-247 Phase II ND Cylindrocarpon lucidum (Nectriaceae) Immunological, inflammatory and related disease ISA-247 Phase II ND Tolypocladium inflatum (Clavicipitaceae) Immunological, inflammatory and related disease Isochlorogenic acid Phase I N Inula britannica (Asteraceae) Antiviral Isofagomine Phase II ND Lendenfeldia chondrodes (Thorectidae) Cardiovascular and metabolic disease Isofagomine Phase II ND Morus alba (Moraceae) Cardiovascular and metabolic disease Isofagomine Phase II ND Streptomyces lavendulae (Streptomycetaceae) Cardiovascular and metabolic disease Isothiocynate allyl In Clinical Trial N Brassica nigra (Brassicaceae) Flavoring agents JC-9 Phase II ND Curcuma longa (Zingiberaceae) Anticancer Kahalalide F Phase II ND Bryopsis pennata (Bryopsidaceae) Oncological disease Kahalalide F Phase II ND Elysia rufescens (Placobranchidae) Oncological disease KRN-5500 Phase II ND Streptomyces alanosinicus (Streptomycetaceae) Neurological disease KRN633 Phase I ND Zea mays (Poaceae) Anticancer KRN633 Phase I ND Cocos nucifera (Arecaceae) Anticancer KRN633 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer KRN633 Phase I ND Pisum sativum (Fabaceae) Anticancer KRN-7000 In Clinical Trial ND Agelas mauritiana (Agelasidae) Oncological disease KRX-0601 Phase II ND Lentzea albida (Actinosynnemataceae) Oncological disease KW-2189 Phase II ND Streptomyces sp. (Streptomycetaceae) Oncological disease L-744832 In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer L-778123 In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer LAF-389 Phase I ND Ancorinidae (Ancorinidae) Oncological disease LAF-389 Phase I ND Myxococcus virescens (Myxococcaceae) Oncological disease L-annamycin Phase II ND Streptomyces peucetius (Streptomycetaceae) Oncological disease Larotaxel dehydrate Phase III ND Taxus wallichiana (Taxaceae) Oncological disease Larotaxel dehydrate Phase III ND Taxus brevifolia (Taxaceae) Oncological disease LBM415 Phase III ND Streptomyces (Streptomycetaceae) Antibacterial Lestaurtinib Phase III ND Lentzea albida (Actinosynnemataceae) Oncological disease Lobeline Phase II N Lobelia inflata (Campanulaceae) Neurological disease Lonafarnib In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer LU-103793 In Clinical Trial ND Symploca sp. VP642a (Symploca) Oncological disease LU-103793 In Clinical Trial ND Symploca sp. VP642b (Symploca) Oncological disease LU-103793 In Clinical Trial ND Symploca sp. VP642c (Symploca) Oncological disease LU-103793 In Clinical Trial ND Dolabella auricularia (Aplysiidae) Oncological disease Lurtotecan Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease Lurtotecan Phase II ND Mappia foetida (Icacinaceae) Oncological disease Lurtotecan Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Lyostaphin Phase II N Staphylococcus simulans (Staphylococcaceae) Antibiotic MAG-CPT Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease MAG-CPT Phase I ND Mappia foetida (Icacinaceae) Oncological disease MAG-CPT Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Manoalide Phase II N Luffariella (Thorectidae) Inflammatory disease Marimastat In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer Maytansine Phase II N Maytenus (Celastraceae) Oncological disease MBI-3253 Phase II ND Castanospermum australe (Fabaceae) Antiviral MC-1 Phase III ND Zea mays (Poaceae) Cardiovascular and metabolic disease ME-1036 Phase I ND Streptomyces cattleya (Streptomycetaceae) Antibacterial Metastat Phase II S/NM Streptomyces (Streptomycetaceae) Anticancer Methopterosin Phase II N Pseudopterogorgia elisabethae (Gorgoniidae) Inflammatory disease Methylnaltrexone Phase III ND Papaver somniferum (Papaveraceae) Neurological disease Mevastatin In Clinical Trial N Pseudonocardia autotrophica (Pseudonocardiaceae) Cardiovascular disease Mevastatin In Clinical Trial N Penicillium brevicompactum (Trichocomaceae) Cardiovascular disease Mevastatin In Clinical Trial N Penicillium citrinum (Trichocomaceae) Cardiovascular disease Midostaurin Phase II ND Lentzea albida (Actinosynnemataceae) Oncological disease Migalastat Phase II ND Streptomyces lydicus (Streptomycetaceae) Cardiovascular and metabolic disease Milataxel Phase II ND Taxus wallichiana (Taxaceae) Oncological disease Milataxel Phase II ND Taxus brevifolia (Taxaceae) Oncological disease Mitemcinal Phase II ND Saccharopolyspora erythraea (Pseudonocardiaceae) Cardiovascular and metabolic disease Mithramycin In Clinical Trial N Streptomyces (Streptomycetaceae) Oncological disease MK-0431 Phase II S*/NM Homo sapiens (Hominidae) Diabetes mellitus MK-944a Phase I ND Actinomyces (Actinomycetaceae) Anti-HIV MLN2704 Phase II ND Anomodon attenuatus (Anomodontaceae) Oncological disease MLN2704 Phase II ND Claopodium crispifolium (Leskeaceae) Oncological disease MMI270 In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer Moli1901 Phase II N Streptomyces cinnamoneus (Streptomycetaceae) Antibacterial Moranoline Phase I ND Lendenfeldia chondrodes (Thorectidae) Cardiovascular and metabolic disease Moranoline Phase I ND Morus alba (Moraceae) Cardiovascular and metabolic disease Moranoline Phase I ND Streptomyces lavendulae (Streptomycetaceae) Cardiovascular and metabolic disease Morphine-6-glucuronide Phase III ND Papaver somniferum (Papaveraceae) Neurological disease NB-506 Phase II ND Streptomyces sp. (Streptomycetaceae) Oncological disease Nemorubicin Phase II ND Streptomyces peucetius (Streptomycetaceae) Oncological disease NIM 811 Phase I ND Claviceps purpurea (Clavicipitaceae) Antiviral NIM 811 Phase I ND Cylindrocarpon lucidum (Nectriaceae) Antiviral NIM 811 Phase I ND Tolypocladium inflatum (Clavicipitaceae) Antiviral NK-105 Phase II ND Taxus wallichiana (Taxaceae) Oncological disease NK-105 Phase II ND Taxus brevifolia (Taxaceae) Oncological disease NK-611 Phase II ND Dysosma pleiantha (Berberidaceae) Oncological disease NK-611 Phase II ND Podophyllum peltatum (Berberidaceae) Oncological disease NK-611 Phase II ND Sinopodophyllum hexandrum (Berberidaceae) Oncological disease Noscapine Phase I ND Papaver somniferum (Papaveraceae) Oncological disease NPI-0052 Phase I ND Salinispora tropica (Micromonosporaceae) Oncological disease NPI-2358 Phase I ND Aspergillus ustus (Trichocomaceae) Oncological disease NSC 630176 Phase II N Chromobacterium violaceum (Neisseriaceae) Oncological disease NSC 650426 In Clinical Trial ND Streptomyces alanosinicus (Streptomycetaceae) Oncological disease NV-52 Phase II N Glycine max (Fabaceae) Immunological, inflammatory and related disease NVP-AUY922 Phase I ND Streptomyces hygroscopicus subsp. geldanus (Streptomycetaceae) Anticancer NVP-DPP728 Phase II S*/NM Homo sapiens (Hominidae) Diabetes mellitus NVP-LAF237 Phase II S*/NM Homo sapiens (Hominidae) Diabetes mellitus NVP-LAQ824 Phase I ND Helicoma ambiens (Tubeufiaceae) Oncological disease NVP-LAQ824 Phase I ND Pseudoceratinidae (Pseudoceratinidae) Oncological disease NVP-LAQ824 Phase I ND Streptomyces hygroscopicus (Streptomycetaceae) Oncological disease NXL-103 Phase II ND Streptomyces pristinaespiralis (Streptomycetaceae) Antibacterial NXL-103 Phase II ND Streptomyces virginiae (Streptomycetaceae) Antibacterial Obatoclax Phase II ND Serratia marcescens (Enterobacteriaceae) Oncological disease Omacetaxine mepesuccinate Phase III ND Cephalotaxus fortunei (Cephalotaxaceae) Anticancer Omapatrilat Phase II S*/NM Bothrops jararaca (Viperidae) Hypertension Omega-conotoxin CVID Phase II N Conus catus (Conidae) Neurological disease Omtriptolide In Clinical Trial ND Tripterygium wilfordii (Celastraceae) Oncological disease Oritavancin Phase II ND Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial Oritavancin Phase II ND Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial Ortataxel Phase II ND Taxus wallichiana (Taxaceae) Oncological disease Ortataxel Phase II ND Taxus brevifolia (Taxaceae) Oncological disease OSI-930 Phase I ND Zea mays (Poaceae) Anticancer OSI-930 Phase I ND Cocos nucifera (Arecaceae) Anticancer OSI-930 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer OSI-930 Phase I ND Pisum sativum (Fabaceae) Anticancer OXi4503 Phase I ND Combretum (Combretaceae) Oncological disease Oxocalanolide Phase I ND Calophyllum (Calophyllaceae) Antiviral P57A3 Phase II N Hoodia gordonii (Apocynaceae) Cardiovascular disease PA-1050040 Phase I ND Syzygium claviflorum (Myrtaceae) Anti-HIV Paclitaxel poliglumex Phase III ND Taxus wallichiana (Taxaceae) Oncological disease Paclitaxel poliglumex Phase III ND Taxus brevifolia (Taxaceae) Oncological disease Paclitaxel/Bryostatin 1 Phase II N Bugula neritina (Bugulidae) Oncological disease Paclitaxel/Bryostatin 1 Phase II N Taxus wallichiana (Taxaceae) Oncological disease Paclitaxel/Bryostatin 1 Phase II N Taxus brevifolia (Taxaceae) Oncological disease Panobinostat Phase III ND Aplysinella rhax (Aplysinellidae) Oncological disease Patupilone Phase III ND Sorangium cellulosum (Polyangiaceae) Oncological disease PD-332991 Phase I ND Zea mays (Poaceae) Anticancer PD-332991 Phase I ND Cocos nucifera (Arecaceae) Anticancer PD-332991 Phase I ND Spinacia oleracea (Amaranthaceae) Anticancer PD-332991 Phase I ND Pisum sativum (Fabaceae) Anticancer PDX101 Phase I ND Streptomyces hygroscopicus (Streptomycetaceae) Oncological disease PEG-CPT Phase II ND Camptotheca acuminata (Cornaceae) Oncological disease PEG-CPT Phase II ND Mappia foetida (Icacinaceae) Oncological disease PEG-CPT Phase II ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Perillyl alcohol Phase II N Carum carvi (Apiaceae) Oncological disease Perillyl alcohol Phase II N Matricaria chamomilla var. recutita (Asteraceae) Oncological disease Perillyl alcohol Phase II N Cymbopogon martinii (Poaceae) Oncological disease Perillyl alcohol Phase II N Juniperus sabina (Cupressaceae) Oncological disease Perillyl alcohol Phase II N Laurus nobilis (Lauraceae) Oncological disease Perillyl alcohol Phase II N Lavandula (Lamiaceae) Oncological disease Perillyl alcohol Phase II N Mentha spicata (Lamiaceae) Oncological disease Perillyl alcohol Phase II N Monarda didyma (Lamiaceae) Oncological disease Perillyl alcohol Phase II N Perilla frutescens (Lamiaceae) Oncological disease Perillyl alcohol Phase II N Salvia (Lamiaceae) Oncological disease PF-3709270 Phase I N Streptomyces cattleya (Streptomycetaceae) Antibacterial PF4548043 Phase I ND Saccharopolyspora erythraea (Pseudonocardiaceae) Cardiovascular and metabolic disease Phenethyl isothiocyanate Phase I N Sinapis alba (Brassicaceae) Oncological disease Phenoxodiol Phase III ND Glycine max (Fabaceae) Oncological disease Phenoxodiol Phase III ND Cicer arietinum (Fabaceae) Oncological disease Phenoxodiol Phase III ND Cullen corylifolium (Fabaceae) Oncological disease Phenoxodiol Phase III ND Genista tinctoria (Fabaceae) Oncological disease Phenoxodiol Phase III ND Lens culinaris (Fabaceae) Oncological disease Phenoxodiol Phase III ND Medicago sativa (Fabaceae) Oncological disease Phenoxodiol Phase III ND Phaseolus coccineus (Fabaceae) Oncological disease Phenoxodiol Phase III ND Phaseolus lunatus (Fabaceae) Oncological disease Phenoxodiol Phase III ND Pisum sativum (Fabaceae) Oncological disease Phenoxodiol Phase III ND Pueraria (Fabaceae) Oncological disease Phenoxodiol Phase III ND Sophora prostrata (Fabaceae) Oncological disease Phenoxodiol Phase III ND Trifolium pratense (Fabaceae) Oncological disease Phenoxodiol Phase III ND Vicia faba (Fabaceae) Oncological disease Phenoxodiol Phase III ND Vigna angularis (Fabaceae) Oncological disease Phenoxodiol Phase III ND Vigna radiata (Fabaceae) Oncological disease Phenoxodiol Phase III ND Vigna unguiculata ssp. unguiculata (Fabaceae) Oncological disease Phenserine tartrate In Clinical Trial ND Hippomane mancinella (Euphorbiaceae) Neurological disease Phenserine tartrate In Clinical Trial ND Physostigma venenosum (Fabaceae) Neurological disease PLD-118 Phase II ND Bacillus cereus (Bacillaceae) Antifungal Plitidepsin Phase II ND Aplidium (Polyclinidae) Oncological disease PM00104/50 Phase I ND Jorunna (Kentrodorididae) Oncological disease PM02734 Phase I ND Bryopsis pennata (Bryopsidaceae) Oncological disease PM02734 Phase I ND Elysia rufescens (Placobranchidae) Oncological disease Podophyllotoxin Phase I N Podophyllum peltatum (Berberidaceae) Anticancer PPI-2458 In Clinical Trial ND Aspergillus fumigatus (Trichocomaceae) Oncological disease PPL-100 Phase I S/NM Human immunodeficiency virus 1 (Retroviridae) Antiviral Prinomastat Phase II S/NM Homo sapiens (Hominidae) Early-stage cancer Prostratin Phase I N Thymelaeaceae (Thymelaeaceae) Antiviral Prostratin Phase I N Homalanthus nutans (Euphorbiaceae) Antiviral Prostratin Phase I N Pimelea (Thymelaeaceae) Antiviral Protopanaxadiol In Clinical Trial ND Panax ginseng (Araliaceae) Oncological disease Protoveratine A In Clinical Trial N Veratrum album (Melanthiaceae) Hypertension Protoveratine B In Clinical Trial N Veratrum album (Melanthiaceae) Hypertension PS-519 Phase I ND Streptomyces (Streptomycetaceae) acute stroke PSN9301 Phase II S*/NM Homo sapiens (Hominidae) Diabetes mellitus PTK-0796 Phase II ND Streptomyces aureofaciens (Streptomycetaceae) Antibacterial Pyridoxamine Phase II ND Zea mays (Poaceae) Cardiovascular and metabolic disease PZ-601 Phase II N Streptomyces cattleya (Streptomycetaceae) Antibacterial QS-21A Phase II N Quillaja saponaria (Quillajaceae) Immunological disease QS-21B Phase III N Quillaja saponaria (Quillajaceae) Immunological disease Ramoplanin Phase III ND Actinoplanes (Micromonosporaceae) Antibacterial Rebimastat Phase III S/NM Homo sapiens (Hominidae) Anticancer Retaspimycin Phase II ND Streptomyces hygroscopicus subsp. geldanus (Streptomycetaceae) Oncological disease RO033-4649 Phase I S/NM Human immunodeficiency virus 1 (Retroviridae) Antiviral Romidepsin Phase III ND Chromobacterium violaceum (Neisseriaceae) Oncological disease Rostafuroxin Phase II ND Acokanthera oblongifolia (Apocynaceae) Cardiovascular and metabolic disease Rostafuroxin Phase II ND Acokanthera oppositifolia (Apocynaceae) Cardiovascular and metabolic disease Rostafuroxin Phase II ND Acokanthera (Apocynaceae) Cardiovascular and metabolic disease Rostafuroxin Phase II ND Strophanthus gratus (Apocynaceae) Cardiovascular and metabolic disease Rubitecan Phase III ND Mappia foetida (Icacinaceae) Anticancer Rubitecan Phase III ND Camptotheca acuminata (Cornaceae) Anticancer Rubitecan Phase III ND Ophiorrhiza pumila (Rubiaceae) Anticancer Ruboxistaurin Phase III ND Lentzea albida (Actinosynnemataceae) Cardiovascular and metabolic disease RWJ-442831 Phase I ND Acremonium chrysogenum (Acremonium) Antibacterial RWJ-442831 Phase I ND Amycolatopsis lactamdurans (Pseudonocardiaceae) Antibacterial RWJ-442831 Phase I ND Emericellopsis minima (Emericellopsis) Antibacterial RWJ-442831 Phase I ND Streptomyces clavuligerus (Streptomycetaceae) Antibacterial S23906-1 Phase I ND Sarcomelicope (Rutaceae) Oncological disease S-3304 Phase II S/NM Homo sapiens (Hominidae) Solid tumours Sabarubicin Phase II ND Streptomyces peucetius (Streptomycetaceae) Oncological disease Sagopilone Phase II ND Sorangium cellulosum (Polyangiaceae) Oncological disease SCH 503034 Phase II S*/NM Hepatitis C virus (Flaviviridae) Hepatitis C SCH 530348 Phase III ND Galbulimima (Himantandraceae) Cardiovascular and metabolic disease SCH 6 Phase I S*/NM Hepatitis C virus (Flaviviridae) Hepatitis C Scillaren A In Clinical Trial N Charybdis maritima (Asparagaceae) Cancer Seliciclib Phase II ND Zea mays (Poaceae) Oncological disease Seliciclib Phase II ND Cocos nucifera (Arecaceae) Oncological disease Seliciclib Phase II ND Spinacia oleracea (Amaranthaceae) Oncological disease Seliciclib Phase II ND Pisum sativum (Fabaceae) Oncological disease Sergliflozin etabonate In Clinical Trial ND Malus x domestica (Rosaceae) Neurological disease SGN-35 Phase I ND Dolabella auricularia (Aplysiidae) Oncological disease SGN-35 Phase I ND Symploca sp. VP642a (Symploca) Oncological disease SGN-35 Phase I ND Symploca sp. VP642b (Symploca) Oncological disease SGN-35 Phase I ND Symploca sp. VP642c (Symploca) Oncological disease Silatecan Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease Silatecan Phase I ND Mappia foetida (Icacinaceae) Oncological disease Silatecan Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Simotaxel In Clinical Trial ND Taxus wallichiana (Taxaceae) Oncological disease Simotaxel In Clinical Trial ND Taxus brevifolia (Taxaceae) Oncological disease SN2310 Phase I ND Camptotheca acuminata (Cornaceae) Oncological disease SN2310 Phase I ND Mappia foetida (Icacinaceae) Oncological disease SN2310 Phase I ND Ophiorrhiza pumila (Rubiaceae) Oncological disease Soblidotin Phase II ND Dolabella auricularia (Aplysiidae) Oncological disease Soblidotin Phase II ND Symploca sp. VP642a (Symploca) Oncological disease Soblidotin Phase II ND Symploca sp. VP642b (Symploca) Oncological disease Soblidotin Phase II ND Symploca sp. VP642c (Symploca) Oncological disease Soblidotin Phase II ND Symploca hydnoides (Symploca) Oncological disease Spectinomycin hydrochloride In Clinical Trial N Streptomyces spectabilis (Streptomycetaceae) Antibacterial Spisulosine In Clinical Trial ND Mactromeris polynyma (Mactridae) Oncological disease SPP100 Phase III S*/NM Homo sapiens (Hominidae) Hypertension Squalamine Phase III ND Squalus acanthias (Squalidae) Oncological disease SU-14813 Phase II ND Zea mays (Poaceae) Anticancer SU-14813 Phase II ND Cocos nucifera (Arecaceae) Anticancer SU-14813 Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer SU-14813 Phase II ND Pisum sativum (Fabaceae) Anticancer SU-6668 Phase II ND Zea mays (Poaceae) Anticancer SU-6668 Phase II ND Cocos nucifera (Arecaceae) Anticancer SU-6668 Phase II ND Spinacia oleracea (Amaranthaceae) Anticancer SU-6668 Phase II ND Pisum sativum (Fabaceae) Anticancer Sulopenem Phase I N Streptomyces cattleya (Streptomycetaceae) Antibacterial TAFA-93 Phase I ND Streptomyces hygroscopicus (Streptomycetaceae) Immunological, inflammatory and related disease Tafluposide Phase I ND Dysosma pleiantha (Berberidaceae) Oncological disease Tafluposide Phase I ND Podophyllum peltatum (Berberidaceae) Oncological disease Tafluposide Phase I ND Sinopodophyllum hexandrum (Berberidaceae) Oncological disease Tanespimycin Phase III ND Streptomyces hygroscopicus subsp. geldanus (Streptomycetaceae) Oncological disease Tanomastat In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer Taribavirin Phase II ND Streptomyces candidus (Streptomycetaceae) Antiviral Taribavirin Phase II ND Streptomyces showdoensis (Streptomycetaceae) Antiviral Tasidotin Phase II ND Dolabella auricularia (Aplysiidae) Oncological disease Tasidotin Phase II ND Symploca sp. VP642a (Symploca) Oncological disease Tasidotin Phase II ND Symploca sp. VP642b (Symploca) Oncological disease Tasidotin Phase II ND Symploca sp. VP642c (Symploca) Oncological disease TD-1792 Phase II ND Acremonium chrysogenum (Acremonium) Antibacterial TD-1792 Phase II ND Amycolatopsis lactamdurans (Pseudonocardiaceae) Antibacterial TD-1792 Phase II ND Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial TD-1792 Phase II ND Emericellopsis minima (Emericellopsis) Antibacterial TD-1792 Phase II ND Streptomyces clavuligerus (Streptomycetaceae) Antibacterial Tebipenem pivoxil Phase III ND Streptomyces cattleya (Streptomycetaceae) Antibacterial Tecogalan Phase II N Arthrobacter sp. (Micrococcaceae) Oncological disease Teduglutide Phase III ND Homo sapiens (Hominidae) Short Bowel Syndrome Telavancin Phase III ND Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial Terameprocol Phase II ND Larrea tridentata (Zygophyllaceae) Oncological disease Tesetaxel Phase II ND Taxus wallichiana (Taxaceae) Oncological disease Tesetaxel Phase II ND Taxus brevifolia (Taxaceae) Oncological disease Tetrodin Phase I N Atelopus (Bufonidae) Neurological disease Tetrodin Phase I N Atelopus peruensis (Bufonidae) Neurological disease Tetrodin Phase I N Colostethus inguinalis (Dendrobatidae) Neurological disease Tetrodin Phase I N Hapalochlaena maculosa (Octopodidae) Neurological disease Tetrodin Phase I N Takifugu chrysops (Tetraodontidae) Neurological disease Tetrodin Phase I N Takifugu niphobles (Tetraodontidae) Neurological disease Tetrodin Phase I N Takifugu oblongus (Tetraodontidae) Neurological disease Tetrodin Phase I N Takifugu pardalis (Tetraodontidae) Neurological disease Tetrodin Phase I N Taricha torosa (Salamandridae) Neurological disease Tetrodin Phase I N Vibrio alginolyticus (Vibrionaceae) Neurological disease Tetrodotoxin Phase III N Atelopus (Bufonidae) Neurological disease Tetrodotoxin Phase III N Atelopus peruensis (Bufonidae) Neurological disease Tetrodotoxin Phase III N Colostethus inguinalis (Dendrobatidae) Neurological disease Tetrodotoxin Phase III N Hapalochlaena maculosa (Octopodidae) Neurological disease Tetrodotoxin Phase III N Takifugu chrysops (Tetraodontidae) Neurological disease Tetrodotoxin Phase III N Takifugu niphobles (Tetraodontidae) Neurological disease Tetrodotoxin Phase III N Takifugu oblongus (Tetraodontidae) Neurological disease Tetrodotoxin Phase III N Takifugu pardalis (Tetraodontidae) Neurological disease Tetrodotoxin Phase III N Taricha torosa (Salamandridae) Neurological disease Tetrodotoxin Phase III N Vibrio alginolyticus (Vibrionaceae) Neurological disease Tiacumicin B Phase III ND Dactylosporangium aurantiacum (Micromonosporaceae) Antibacterial Tipifarnib In Clinical Trial S/NM Homo sapiens (Hominidae) Anticancer TL-310 In Clinical Trial ND Taxus wallichiana (Taxaceae) Oncological disease TL-310 In Clinical Trial ND Taxus brevifolia (Taxaceae) Oncological disease TMC-114 Phase III S/NM Human immunodeficiency virus 1 (Retroviridae) Antiviral TNP-470 Phase III ND Aspergillus fumigatus (Trichocomaceae) Oncological disease Tomopenem Phase II ND Streptomyces cattleya (Streptomycetaceae) Antibacterial TPI-287 Phase II ND Taxus wallichiana (Taxaceae) Oncological disease TPI-287 Phase II ND Taxus brevifolia (Taxaceae) Oncological disease Trastuzumab-DM1 Phase II ND Anomodon attenuatus (Anomodontaceae) Oncological disease Trastuzumab-DM1 Phase II ND Claopodium crispifolium (Leskeaceae) Oncological disease Triphendiol Phase I ND Glycine max (Fabaceae) Oncological disease Trodusquemine Phase I N Squalus acanthias (Squalidae) Cardiovascular and metabolic disease TS-033 Phase II ND Malus x domestica (Rosaceae) Neurological disease Vandetanib Phase III ND Zea mays (Poaceae) Anticancer Vandetanib Phase III ND Cocos nucifera (Arecaceae) Anticancer Vandetanib Phase III ND Spinacia oleracea (Amaranthaceae) Anticancer Vandetanib Phase III ND Pisum sativum (Fabaceae) Anticancer Vatalanib Phase III ND Zea mays (Poaceae) Anticancer Vatalanib Phase III ND Cocos nucifera (Arecaceae) Anticancer Vatalanib Phase III ND Spinacia oleracea (Amaranthaceae) Anticancer Vatalanib Phase III ND Pisum sativum (Fabaceae) Anticancer Vicriviroc In Clinical Trial S/NM Homo sapiens (Hominidae) Antiviral Vincristine/Bryostatin 1 Phase I N Bugula neritina (Bugulidae) Oncological disease Vincristine/Bryostatin 1 Phase I N Catharanthus roseus (Apocynaceae) Oncological disease Vinflunine Phase III ND Catharanthus roseus (Apocynaceae) Oncological disease Voclosporin Phase III ND Claviceps purpurea (Clavicipitaceae) Immunological, inflammatory and related disease Voclosporin Phase III ND Cylindrocarpon lucidum (Nectriaceae) Immunological, inflammatory and related disease Voclosporin Phase III ND Tolypocladium inflatum (Clavicipitaceae) Immunological, inflammatory and related disease Vorinostat Phase II ND Streptomyces hygroscopicus (Streptomycetaceae) Anticancer VX-740 Phase II S*/NM Homo sapiens (Hominidae) Rheumatoid arthritis VX-950 Phase II S*/NM Hepatitis C virus (Flaviviridae) Hepatitis C WAP-8294A2 In Clinical Trial N Lysobacter sp. (Xanthomonadaceae) Antibacterial WX-UK1 Phase I S*/NM Homo sapiens (Hominidae) Cancer Xen-2174 Phase II N Conus marmoreus (Conidae) Neurological disease XR-9051 Phase I ND Streptomyces sp. (Streptomycetaceae) Oncological disease YM-543 Phase II ND Malus x domestica (Rosaceae) Neurological disease ZD6126 In Clinical Trial ND Colchicum autumnale (Colchicaceae) Oncological disease Ziconotide Phase III N Conus (Conidae) Chronic pain ZP10 Phase III ND Homo sapiens (Hominidae) Anti-diabetes