TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T01280	Beta-site APP-cleaving enzyme 2	B1YS7X	N-[[4-(1,3-Dihydroisoindol-2-ylmethyl)phenyl]methyl]-2-(4-phenylphenyl)acetamide	Investigative	71583022	C30H28N2O	432.6	C1C2=CC=CC=C2CN1CC3=CC=C(C=C3)CNC(=O)CC4=CC=C(C=C4)C5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T01280	Beta-site APP-cleaving enzyme 2	B21NZE	N-[[4-(Aminomethyl)phenyl]methyl]-2-(3-fluoro-4-phenylphenyl)propanamide	Investigative	71584646	C23H23FN2O	362.4	CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)NCC3=CC=C(C=C3)CN	IC50 = 207200 nM	Non binder
T01280	Beta-site APP-cleaving enzyme 2	B8AX0Q	N-[[4-(Aminomethyl)phenyl]methyl]-2-(4-phenylphenyl)acetamide;2,2,2-trifluoroacetic acid	Investigative	71719252	C24H23F3N2O3	444.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CC(=O)NCC3=CC=C(C=C3)CN.C(=O)(C(F)(F)F)O	IC50 > 1000000 nM	Non binder
T01280	Beta-site APP-cleaving enzyme 2	BLJD56	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-(2,3,4,5,6-pentafluorophenyl)phenyl]acetamide	Investigative	71582923	C22H17F5N2O	420.4	C1=CC(=CC=C1CC(=O)NCC2=CC=C(C=C2)CN)C3=C(C(=C(C(=C3F)F)F)F)F	IC50 = 245900 nM	Non binder
T01280	Beta-site APP-cleaving enzyme 2	BW4QK3	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-[3-(trifluoromethyl)phenyl]phenyl]acetamide	Investigative	71582924	C23H21F3N2O	398.4	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(C=C2)CC(=O)NCC3=CC=C(C=C3)CN	IC50 = 319000 nM	Non binder