TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T11615 Cystine/glutamate transporter D0D4CY Sulfapyridine Approved 5336 C11H11N3O2S 249.29 C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N IC50 > 1000000 nM Non binder T11615 Cystine/glutamate transporter B29JPR (R)-4-Carboxyphenylglycine Investigative 6604711 C9H9NO4 195.17 C1=CC(=CC=C1[C@H](C(=O)O)N)C(=O)O IC50 > 1000000 nM Non binder T11615 Cystine/glutamate transporter B2BM3Y Mesalamine Investigative 4075 C7H7NO3 153.14 C1=CC(=C(C=C1N)C(=O)O)O IC50 > 1000000 nM Non binder T11615 Cystine/glutamate transporter B4FVH6 Methyl 2-hydroxy-5-[(E)-2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethenyl]benzoate Investigative 19423407 C21H18N2O5S 410.4 COC(=O)C1=C(C=CC(=C1)/C=C/C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)O IC50 = 900000 nM Non binder T11615 Cystine/glutamate transporter B5C2KZ Methyl 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate Investigative 19423375 C21H16N2O5S 408.4 COC(=O)C1=C(C=CC(=C1)C#CC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)O IC50 > 1000000 nM Non binder T11615 Cystine/glutamate transporter B7O5GV Methyl 2-hydroxy-5-[2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoate Investigative 56683051 C21H20N2O5S 412.5 COC(=O)C1=C(C=CC(=C1)CCC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3)O IC50 > 1000000 nM Non binder T11615 Cystine/glutamate transporter BH3B8P 2-Hydroxy-5-[2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoic acid Investigative 19423412 C20H18N2O5S 398.4 C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)CCC3=CC(=C(C=C3)O)C(=O)O IC50 = 700000 nM Non binder T11615 Cystine/glutamate transporter BYE3I6 3-Phenylethynyl-benzoic acid Investigative 299283 C15H10O2 222.24 C1=CC=C(C=C1)C#CC2=CC(=CC=C2)C(=O)O IC50 = 270000 nM Non binder T11615 Cystine/glutamate transporter BZ84RG 3-[2-[4-(Pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoic acid Investigative 56673081 C20H18N2O4S 382.4 C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)CCC3=CC(=CC=C3)C(=O)O IC50 = 920000 nM Non binder