TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T11808	Kallikrein-5	B1DKQ4	2-O-[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] 1-O-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate	Investigative	76317472	C23H31NO7	433.5	CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3OCC4=CC=CC=C4	IC50 = 520700 nM	Non binder
T11808	Kallikrein-5	BDN6S5	[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoate	Investigative	76328379	C23H33NO7S	467.6	CC(C)(C)OC(=O)N[C@@H](CCSC)C(=O)O[C@@H]1CO[C@H]2[C@@H]1OC[C@H]2OCC3=CC=CC=C3	IC50 = 356600 nM	Non binder
T11808	Kallikrein-5	BE47TJ	Benzyl (2R)-2-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	76335659	C26H30N2O6	466.5	C1C[C@@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)N[C@H]3CO[C@H]4[C@@H]3OC[C@H]4OCC5=CC=CC=C5	IC50 = 320600 nM	Non binder
T11808	Kallikrein-5	BH14DR	Tert-butyl N-[(2R)-1-[[(3S,3aR,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	76324824	C23H34N2O6	434.5	CC(C)[C@H](C(=O)N[C@H]1CO[C@H]2[C@@H]1OC[C@H]2OCC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 = 479800 nM	Non binder
T11808	Kallikrein-5	BP7O1U	[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate	Investigative	76310252	C29H34N2O7	522.6	CC(C)(C)OC(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OCC5=CC=CC=C5	IC50 = 376600 nM	Non binder
T11808	Kallikrein-5	BVDG31	N-[(Z)-3-[[(3R,3Ar,6R,6aS)-6-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]amino]-1-(1,3-benzodioxol-5-yl)-3-oxoprop-1-en-2-yl]benzamide	Investigative	70686944	C30H28N2O7	528.6	C1[C@H]([C@@H]2[C@H](O1)[C@@H](CO2)OCC3=CC=CC=C3)NC(=O)/C(=C/C4=CC5=C(C=C4)OCO5)/NC(=O)C6=CC=CC=C6	Ki = 357100 nM	Non binder
T11808	Kallikrein-5	BXDR94	[(3R,3Ar,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate	Investigative	76328377	C23H33NO7	435.5	CC(C)[C@H](C(=O)O[C@@H]1CO[C@H]2[C@@H]1OC[C@H]2OCC3=CC=CC=C3)NC(=O)OC(C)(C)C	IC50 = 222900 nM	Non binder