TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T12499 LCK tyrosine protein kinase D0M9QZ ABT-869 Phase 3 11485656 C21H18FN5O 375.4 CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N IC50 = 500000 nM Non binder T12499 LCK tyrosine protein kinase D00OWF HARMINE Patented 5280953 C13H12N2O 212.25 CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC IC50 > 250000 nM Non binder T12499 LCK tyrosine protein kinase B0B8ZM 2-Hydroxy-5-naphthalen-2-yl-benzoic Acid Investigative 10244533 C17H12O3 264.27 C1=CC=C2C=C(C=CC2=C1)C3=CC(=C(C=C3)O)C(=O)O IC50 > 200000 nM Non binder T12499 LCK tyrosine protein kinase B0LWH9 3-Carbamoyl-7,8-dihydroxy-2-iminochromene Investigative 135469311 C10H8N2O4 220.18 C1=CC(=C(C2=C1C=C(C(=N)O2)C(=O)N)O)O IC50 = 750000 nM Non binder T12499 LCK tyrosine protein kinase B0SWX7 2-(4-Hydroxy-phenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791380 C16H10O5 282.25 C1=CC=C2C(=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)O)C(=O)O IC50 = 1595000 nM Non binder T12499 LCK tyrosine protein kinase B14DWE Methyl 2-(4-nitrophenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791369 C17H11NO6 325.27 COC(=O)C1=C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B18ULK 4',6,8-Trinitro-7-hydroxyflavone Investigative 10248746 C15H7N3O9 373.23 C1=CC(=CC=C1C2=CC(=O)C3=CC(=C(C(=C3O2)[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] IC50 = 1565000 nM Non binder T12499 LCK tyrosine protein kinase B1Y5SU 3,4,5-Trimethoxy-N-(4-pyridinyl)benzamide Investigative 2306385 C15H16N2O4 288.3 COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=NC=C2 IC50 > 2775000 nM Non binder T12499 LCK tyrosine protein kinase B23ZFV 4',8-Dinitro-5-hydroxyflavone Investigative 11723994 C15H8N2O7 328.23 C1=CC(=CC=C1C2=CC(=O)C3=C(C=CC(=C3O2)[N+](=O)[O-])O)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B24AVP [4-Amino-2-[[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]amino]-5-thiazolyl](3-methoxyphenyl)methanone Investigative 9933545 C24H29N5O2S 451.6 CC(C)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC(=C(S3)C(=O)C4=CC(=CC=C4)OC)N IC50 > 100000000 nM Non binder T12499 LCK tyrosine protein kinase B24FKX 4',8-Dinitro-5-methoxyflavone Investigative 10020232 C16H10N2O7 342.26 COC1=C2C(=O)C=C(OC2=C(C=C1)[N+](=O)[O-])C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B29CIU 2-(4-Nitrophenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791377 C16H9NO6 311.24 C1=CC=C2C(=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B2AJI1 4',6-Diamino-5-hydroxyflavone Investigative 10445729 C15H12N2O3 268.27 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=CC(=C3O)N)N IC50 = 223000 nM Non binder T12499 LCK tyrosine protein kinase B2B5VJ 7-Hydroxy-2-(4-nitrophenyl)chromen-4-one Investigative 14791391 C15H9NO5 283.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C=C3)O)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B2C3UT 2-(4-Bromophenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791376 C16H9BrO4 345.14 C1=CC=C2C(=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)Br)C(=O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B2LB0G 4-[(2,4-Dinitro-phenyl)-hydrazonomethyl]-benzene-1,2-diol Investigative 135752285 C13H10N4O6 318.24 C1=CC(=C(C=C1/C=N/NC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-])O)O IC50 = 352000 nM Non binder T12499 LCK tyrosine protein kinase B2MA4F 4,4'-Vinylenedipyridine Investigative 776222 C12H10N2 182.22 C1=CN=CC=C1/C=C/C2=CC=NC=C2 IC50 = 307000 nM Non binder T12499 LCK tyrosine protein kinase B2N9UK 3,4,5-Trimethoxy-N-3-pyridylbenzamide Investigative 678080 C15H16N2O4 288.3 COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CN=CC=C2 IC50 = 999000 nM Non binder T12499 LCK tyrosine protein kinase B3GW9N 4',6,8-Trinitroflavone Investigative 10316258 C15H7N3O8 357.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=CC(=C3)[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B3IP4L Nicotinamide, N-(4-pyridyl)- Investigative 3049109 C11H9N3O 199.21 C1=CC(=CN=C1)C(=O)NC2=CC=NC=C2 IC50 = 2117000 nM Non binder T12499 LCK tyrosine protein kinase B3R7KX 3-Nitrobenzaldehyde phenylhydrazone Investigative 9581370 C13H11N3O2 241.24 C1=CC=C(C=C1)N/N=C/C2=CC(=CC=C2)[N+](=O)[O-] IC50 > 3316000 nM Non binder T12499 LCK tyrosine protein kinase B3VX4I 5,7-Dihydroxy-2-(4-nitrophenyl)chromen-4-one Investigative 11197310 C15H9NO6 299.23 C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B3XE6A 4',8-Dinitro-6-methoxyflavone Investigative 11724908 C16H10N2O7 342.26 COC1=CC2=C(C(=C1)[N+](=O)[O-])OC(=CC2=O)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B3ZR5N 1,2-Bis(4-pyridyl)ethane Investigative 78630 C12H12N2 184.24 C1=CN=CC=C1CCC2=CC=NC=C2 IC50 = 2909000 nM Non binder T12499 LCK tyrosine protein kinase B43LDS 3-(2,4-Bis-benzyloxy-6-hydroxy-phenyl)-3-oxo-propionic acid ethyl ester Investigative 14791363 C25H24O6 420.5 CCOC(=O)CC(=O)C1=C(C=C(C=C1OCC2=CC=CC=C2)OCC3=CC=CC=C3)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B4CDG1 4',8-Dinitroflavone Investigative 10041189 C15H8N2O6 312.23 C1=CC2=C(C(=C1)[N+](=O)[O-])OC(=CC2=O)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B4GHL2 (S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-methylcarbamoyl-butyric acid Investigative 44277500 C17H24N3O9P 445.4 CC(=O)N[C@@H](CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NC IC50 = 350000 nM Non binder T12499 LCK tyrosine protein kinase B4J2RG 3,5-Dimethoxy-N-pyridin-4-yl-benzamide Investigative 814765 C14H14N2O3 258.269 COC1=CC(=CC(=C1)C(=O)NC2=CC=NC=C2)OC IC50 = 3097000 nM Non binder T12499 LCK tyrosine protein kinase B4LHT5 Stilbene-3,3'-diol Investigative 15664638 C14H12O2 212.24 C1=CC(=CC(=C1)O)/C=C/C2=CC(=CC=C2)O IC50 = 234000 nM Non binder T12499 LCK tyrosine protein kinase B5FML8 2-(4-Methoxyphenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14304982 C17H12O5 296.27 COC1=CC=C(C=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B5G4ZO trans-1-(2-Pyridyl)-2-(4-pyridyl)ethylene Investigative 6303920 C12H10N2 182.22 C1=CC=NC(=C1)/C=C/C2=CC=NC=C2 IC50 = 615000 nM Non binder T12499 LCK tyrosine protein kinase B5JPZ8 5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine Investigative 9907612 C18H20ClFN6 374.8 C1CC(CCC1N)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl IC50 = 300000 nM Non binder T12499 LCK tyrosine protein kinase B5T0NF (E)-2-Cyano-3-(3,4,5-trihydroxyphenyl)prop-2-enamide Investigative 5388680 C10H8N2O4 220.18 C1=C(C=C(C(=C1O)O)O)/C=C(\\C#N)/C(=O)N IC50 = 2000000 nM Non binder T12499 LCK tyrosine protein kinase B6IQ0W 3-[(2,4-Dinitro-phenyl)-hydrazonomethyl]-benzene-1,2-diol Investigative 135403151 C13H10N4O6 318.24 C1=CC(=C(C(=C1)O)O)/C=N/NC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2514000 nM Non binder T12499 LCK tyrosine protein kinase B6KJO7 1,2-Bis-benzyloxy-4-[2-(3-benzyloxy-phenyl)-vinyl]-benzene Investigative 10436007 C35H30O3 498.6 C1=CC=C(C=C1)COC2=C(C=C(C=C2)/C=C/C3=CC(=CC=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase B6PE5D 3,3',4,5'-Tetrahydroxybibenzyl Investigative 152444 C14H14O4 246.26 C1=CC(=C(C=C1CCC2=CC(=CC(=C2)O)O)O)O IC50 = 1560000 nM Non binder T12499 LCK tyrosine protein kinase B78HYX 3-(3,5-Dibromo-4-methoxyphenyl)-2-(2-pyridinyl)acrylonitrile Investigative 5467800 C15H10Br2N2O 394.06 COC1=C(C=C(C=C1Br)/C=C(\\C#N)/C2=CC=CC=N2)Br IC50 > 2530000 nM Non binder T12499 LCK tyrosine protein kinase B7H6LB 3,5-Dimethoxy-N-pyridin-2-yl-benzamide Investigative 788949 C14H14N2O3 258.269 COC1=CC(=CC(=C1)C(=O)NC2=CC=CC=N2)OC IC50 = 205000 nM Non binder T12499 LCK tyrosine protein kinase B7K5WL Methyl 2-(4-hydroxyphenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791382 C17H12O5 296.27 COC(=O)C1=C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)O IC50 = 439000 nM Non binder T12499 LCK tyrosine protein kinase B7M1FV 4',6,8-Triamino-7-hydroxyflavone Investigative 10356450 C15H13N3O3 283.28 C1=CC(=CC=C1C2=CC(=O)C3=CC(=C(C(=C3O2)N)O)N)N IC50 = 754000 nM Non binder T12499 LCK tyrosine protein kinase B7Y9VE 7-Methoxy-2-(4-nitrophenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791378 C17H11NO7 341.27 COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B7YH1Q 1-(5-Methyl-1H-imidazol-4-yl)-9H-beta-carboline Investigative 44269518 C15H12N4 248.28 CC1=C(N=CN1)C2=NC=CC3=C2NC4=CC=CC=C34 IC50 > 250000 nM Non binder T12499 LCK tyrosine protein kinase B87XUZ Methyl 2-(4-(benzyloxy)phenyl)-6-methoxy-4-oxo-4H-chromene-3-carboxylate Investigative 14791373 C25H20O6 416.4 COC1=CC2=C(C=C1)OC(=C(C2=O)C(=O)OC)C3=CC=C(C=C3)OCC4=CC=CC=C4 IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B8GLI3 3-Isoquinolinecarboxamide, 6,7-dihydroxy-N-(phenylmethyl)- Investigative 135408977 C17H14N2O3 294.3 C1=CC=C(C=C1)CNC(=O)C2=CC3=CC(=C(C=C3C=N2)O)O IC50 > 1000000 nM Non binder T12499 LCK tyrosine protein kinase B8ROY7 6-Methoxy-2-(4-nitrophenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791379 C17H11NO7 341.27 COC1=CC2=C(C=C1)OC(=C(C2=O)C(=O)O)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B97KEM Methyl 2-(3,5-dimethoxyphenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791365 C19H16O6 340.3 COC1=CC(=CC(=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)OC)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B97NXL 3,4-Dihydroxy-trans-stilbene Investigative 10176710 C14H12O2 212.24 C1=CC=C(C=C1)/C=C/C2=CC(=C(C=C2)O)O IC50 = 203000 nM Non binder T12499 LCK tyrosine protein kinase B9U7FJ 1,2-Bis-benzyloxy-4-styryl-benzene Investigative 10475630 C28H24O2 392.5 C1=CC=C(C=C1)COC2=C(C=C(C=C2)/C=C/C3=CC=CC=C3)OCC4=CC=CC=C4 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase B9VJW0 4H-1-Benzopyran-3-carboxylic acid, 4-oxo-2-(3,4,5-trimethoxyphenyl)- Investigative 14304977 C19H16O7 356.3 COC1=CC(=CC(=C1OC)OC)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase B9WYC0 (E)-3,5,4'-Tribenzyloxystilbene Investigative 10217778 C35H30O3 498.6 C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C/C3=CC(=CC(=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase B9X1GO Methyl 3-(2-hydroxy-4-methoxyphenyl)-3-oxopropanoate Investigative 14791361 C11H12O5 224.21 COC1=CC(=C(C=C1)C(=O)CC(=O)OC)O IC50 = 1160000 nM Non binder T12499 LCK tyrosine protein kinase BAB08K 6,7-Dihydroxyquinoline-3-carboxamide Investigative 135399258 C10H8N2O3 204.18 C1=C2C=C(C(=CC2=NC=C1C(=O)N)O)O IC50 = 610000 nM Non binder T12499 LCK tyrosine protein kinase BAF24D 6-Methoxy-3-(methoxycarbonyl)-2-(4-nitrophenyl)-4H-benzopyran-4-one Investigative 5007981 C18H13NO7 355.3 COC1=CC2=C(C=C1)OC(=C(C2=O)C(=O)OC)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BAJ45E Methyl 7-methoxy-2-(4-nitrophenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791370 C18H13NO7 355.3 COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BBH9Z3 Methyl 2-(4-(benzyloxy)phenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791371 C24H18O5 386.4 COC(=O)C1=C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCC4=CC=CC=C4 IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BBX6I1 5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester Investigative 14791389 C31H23NO8 537.5 COC(=O)C1=C(OC2=C(C1=O)C(=CC(=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BC24JF Nitrogenistein Investigative 5058788 C15H9NO5 283.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=CC(=C3)O)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BC8HX5 Benzenepropanoic acid, 2,3,4-trihydroxy-beta-oxo-, methyl ester Investigative 14791364 C10H10O6 226.18 COC(=O)CC(=O)C1=C(C(=C(C=C1)O)O)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BDG2H1 3',6-Diamino-7-hydroxyflavone Investigative 10265006 C15H12N2O3 268.27 C1=CC(=CC(=C1)N)C2=CC(=O)C3=CC(=C(C=C3O2)O)N IC50 = 502000 nM Non binder T12499 LCK tyrosine protein kinase BE5CD3 4',8-Diamino-6-methoxyflavone Investigative 10085171 C16H14N2O3 282.29 COC1=CC2=C(C(=C1)N)OC(=CC2=O)C3=CC=C(C=C3)N IC50 = 382000 nM Non binder T12499 LCK tyrosine protein kinase BE83KO 3-(3,5-Dibromo-4-methoxyphenyl)-2-(3-pyridinyl)acrylonitrile Investigative 5467796 C15H10Br2N2O 394.06 COC1=C(C=C(C=C1Br)/C=C(\\C#N)/C2=CN=CC=C2)Br IC50 > 2530000 nM Non binder T12499 LCK tyrosine protein kinase BED7H3 N-[(3,4,5-Trimethoxyphenyl)methyl]pyridin-2-amine Investigative 12373545 C15H18N2O3 274.31 COC1=CC(=CC(=C1OC)OC)CNC2=CC=CC=N2 IC50 > 2916000 nM Non binder T12499 LCK tyrosine protein kinase BEO67N 2,4-Dihydroxybenzaldehyde (2,4-dinitrophenyl)hydrazone Investigative 135533486 C13H10N4O6 318.24 C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])N/N=C/C2=C(C=C(C=C2)O)O IC50 = 1005000 nM Non binder T12499 LCK tyrosine protein kinase BF2WL6 Methyl 3-(2-hydroxyphenyl)-3-oxopropanoate Investigative 12381316 C10H10O4 194.18 COC(=O)CC(=O)C1=CC=CC=C1O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BF3RU9 1,2-Bis-benzyloxy-4-[2-(4-benzyloxy-phenyl)-vinyl]-benzene Investigative 10323644 C35H30O3 498.6 C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C/C3=CC(=C(C=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase BF7JS4 1-Methyl-3-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyridin-1-ium;iodide Investigative 45266326 C17H20INO3 413.25 C[N+]1=CC=CC(=C1)/C=C/C2=CC(=C(C(=C2)OC)OC)OC.[I-] IC50 > 1936000 nM Non binder T12499 LCK tyrosine protein kinase BFP76X N-Pyridin-4-ylpyridine-4-carboxamide Investigative 3758644 C11H9N3O 199.21 C1=CN=CC=C1C(=O)NC2=CC=NC=C2 IC50 = 2323000 nM Non binder T12499 LCK tyrosine protein kinase BH3QL1 3-(3,5-Dibromo-4-hydroxy-phenyl)-2-pyridin-2-yl-propionitrile Investigative 44293432 C14H10Br2N2O 382.05 C1=CC=NC(=C1)C(CC2=CC(=C(C(=C2)Br)O)Br)C#N IC50 > 2094000 nM Non binder T12499 LCK tyrosine protein kinase BH7FR6 1,2-Di(2-pyridyl)ethylene Investigative 5374802 C12H10N2 182.22 C1=CC=NC(=C1)/C=C/C2=CC=CC=N2 IC50 = 1229000 nM Non binder T12499 LCK tyrosine protein kinase BHQ0I2 (R)-3-(3,4-Dihydroxy-phenyl)-2-[(E)-3-(3,4-dihydroxy-phenyl)-allylamino]-propionic acid methyl ester Investigative 44343708 C19H21NO6 359.4 COC(=O)[C@@H](CC1=CC(=C(C=C1)O)O)NC/C=C/C2=CC(=C(C=C2)O)O IC50 > 500000 nM Non binder T12499 LCK tyrosine protein kinase BHVX69 Methyl 2-(4-aminophenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791387 C17H13NO4 295.29 COC(=O)C1=C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)N IC50 = 810000 nM Non binder T12499 LCK tyrosine protein kinase BI12GD Methyl 2-(4-methoxyphenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791367 C18H14O5 310.3 COC1=CC=C(C=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BI5U8D 2-[2-(3,4,5-Trimethoxy-phenyl)-vinyl]-pyridine Investigative 5905112 C16H17NO3 271.31 COC1=CC(=CC(=C1OC)OC)/C=C/C2=CC=CC=N2 IC50 = 2175000 nM Non binder T12499 LCK tyrosine protein kinase BI8VR7 Methyl 2-(4-(benzyloxy)phenyl)-7-methoxy-4-oxo-4H-chromene-3-carboxylate Investigative 14791372 C25H20O6 416.4 COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)OCC4=CC=CC=C4)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BIL2W6 4',8-Diamino-5-methoxyflavone Investigative 10468973 C16H14N2O3 282.29 COC1=C2C(=O)C=C(OC2=C(C=C1)N)C3=CC=C(C=C3)N IC50 = 1621000 nM Non binder T12499 LCK tyrosine protein kinase BIN53S 1,3-Bis-benzyloxy-5-[2-(3-benzyloxy-phenyl)-vinyl]-benzene Investigative 10413576 C35H30O3 498.6 C1=CC=C(C=C1)COC2=CC=CC(=C2)/C=C/C3=CC(=CC(=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase BIWD05 4-[2-(4-Methoxy-phenyl)-vinyl]-pyridine Investigative 735606 C14H13NO 211.26 COC1=CC=C(C=C1)/C=C/C2=CC=NC=C2 IC50 > 3787000 nM Non binder T12499 LCK tyrosine protein kinase BJ92RT 2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-pyridine Investigative 23075146 C15H15NO2 241.28 COC1=C(C=C(C=C1)/C=C/C2=CC=CC=N2)OC IC50 = 829000 nM Non binder T12499 LCK tyrosine protein kinase BJH35V 3-Hydroxy-4-methoxybenzaldehyde phenylhydrazone Investigative 5339689 C14H14N2O2 242.27 COC1=C(C=C(C=C1)/C=N/NC2=CC=CC=C2)O IC50 = 2106000 nM Non binder T12499 LCK tyrosine protein kinase BJP7L0 Methyl 2-(4-bromophenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791368 C17H11BrO4 359.2 COC(=O)C1=C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)Br IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BJT06G 3-[2-(3,4,5-Trimethoxyphenyl)ethyl]pyridine Investigative 368070 C16H19NO3 273.33 COC1=CC(=CC(=C1OC)OC)CCC2=CN=CC=C2 IC50 > 2927000 nM Non binder T12499 LCK tyrosine protein kinase BK0T8N (Z)-3-(3-Bromo-4-hydroxy-5-methoxy-phenyl)-2-pyridin-3-yl-acrylonitrile Investigative 44293106 C15H11BrN2O2 331.16 COC1=C(C(=CC(=C1)/C=C(\\C#N)/C2=CN=CC=C2)Br)O IC50 = 242000 nM Non binder T12499 LCK tyrosine protein kinase BK2FR4 4-[(E)-2-(3,4,5-Trimethoxyphenyl)ethenyl]pyridine Investigative 5388744 C16H17NO3 271.31 COC1=CC(=CC(=C1OC)OC)/C=C/C2=CC=NC=C2 IC50 = 2285000 nM Non binder T12499 LCK tyrosine protein kinase BK5V1Q 4',8-Diamino-7-hydroxyflavone Investigative 10423146 C15H12N2O3 268.27 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3)O)N)N IC50 = 328000 nM Non binder T12499 LCK tyrosine protein kinase BKXT98 3-(2,4-Bis-benzyloxy-6-hydroxy-phenyl)-3-oxo-propionic acid methyl ester Investigative 14791362 C24H22O6 406.4 COC(=O)CC(=O)C1=C(C=C(C=C1OCC2=CC=CC=C2)OCC3=CC=CC=C3)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BL2S3O 4-Oxo-2-[4-(3,4,5-trimethoxy-benzoylamino)-phenyl]-4H-chromene-3-carboxylic acid methyl ester Investigative 14791388 C27H23NO8 489.5 COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=C(C=C2)C3=C(C(=O)C4=CC=CC=C4O3)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BL53BV 2-(3,5-Dimethoxyphenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791374 C18H14O6 326.3 COC1=CC(=CC(=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BL9O3T 2-Cyano-3-(3,5-dihydroxy-phenyl)-acrylamide Investigative 5388679 C10H8N2O3 204.18 C1=C(C=C(C=C1O)O)/C=C(\\C#N)/C(=O)N IC50 = 500000 nM Non binder T12499 LCK tyrosine protein kinase BLQ16G 5-(3,5-Dihydroxyphenethyl)-1,3-benzenediol Investigative 10377245 C14H14O4 246.26 C1=C(C=C(C=C1O)O)CCC2=CC(=CC(=C2)O)O IC50 = 487000 nM Non binder T12499 LCK tyrosine protein kinase BM5VN3 3-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1-methylpyridin-1-ium;iodide Investigative 45266328 C16H18INO2 383.22 C[N+]1=CC=CC(=C1)/C=C/C2=CC(=C(C=C2)OC)OC.[I-] IC50 > 2088000 nM Non binder T12499 LCK tyrosine protein kinase BM5Z0G Methyl 3-bromopropanoate;3-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]pyridine Investigative 44307875 C20H24BrNO5 438.3 COC1=CC(=CC(=C1OC)OC)/C=C/C2=CN=CC=C2.COC(=O)CCBr IC50 > 1825000 nM Non binder T12499 LCK tyrosine protein kinase BMF71C 5,7-Dihydroxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791390 C16H9NO8 343.24 C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)C(=O)O)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BN08XE (2E)-2-Cyano-3-(4-hydroxyphenyl)prop-2-enamide Investigative 5328796 C10H8N2O2 188.18 C1=CC(=CC=C1/C=C(\\C#N)/C(=O)N)O IC50 = 1000000 nM Non binder T12499 LCK tyrosine protein kinase BNLS21 4',8-Diamino-5-hydroxyflavone Investigative 10355659 C15H12N2O3 268.27 C1=CC(=CC=C1C2=CC(=O)C3=C(C=CC(=C3O2)N)O)N IC50 = 326000 nM Non binder T12499 LCK tyrosine protein kinase BNOX21 2-(4-Acetylamino-phenyl)-6-methoxy-4-oxo-4H-chromene-3-carboxylic acid methyl ester Investigative 44379379 C20H17NO6 367.4 CC(=O)NC1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C=CC(=C3)OC)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BOPR02 1,3-Bis-benzyloxy-5-styryl-benzene Investigative 10318364 C28H24O2 392.5 C1=CC=C(C=C1)COC2=CC(=CC(=C2)/C=C/C3=CC=CC=C3)OCC4=CC=CC=C4 IC50 > 2030000 nM Non binder T12499 LCK tyrosine protein kinase BPFZ24 4-[2-(3,4-Dimethoxy-phenyl)-vinyl]-pyridine Investigative 703616 C15H15NO2 241.28 COC1=C(C=C(C=C1)/C=C/C2=CC=NC=C2)OC IC50 = 622000 nM Non binder T12499 LCK tyrosine protein kinase BQ16DZ Methyl 2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromene-3-carboxylate Investigative 14791366 C19H16O6 340.3 COC1=C(C=C(C=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)OC)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BQY38X 4',5,7-Trinitro-6-hydroxyflavone Investigative 9976589 C15H7N3O9 373.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BR4M0T Methyl 2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromene-3-carboxylate Investigative 14791383 C18H14O6 326.3 COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)O)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BR76TQ 3-(4-Methoxystyryl)pyridine Investigative 11593704 C14H13NO 211.26 COC1=CC=C(C=C1)/C=C/C2=CN=CC=C2 IC50 > 3787000 nM Non binder T12499 LCK tyrosine protein kinase BR7LP3 3-[(E)-2-(3,4,5-Trimethoxyphenyl)ethenyl]pyridine Investigative 5388745 C16H17NO3 271.31 COC1=CC(=CC(=C1OC)OC)/C=C/C2=CN=CC=C2 IC50 = 516000 nM Non binder T12499 LCK tyrosine protein kinase BS3F6T 2-(3,4,5-Trimethoxyphenyl)-4H-chromen-4-one Investigative 332208 C18H16O5 312.3 COC1=CC(=CC(=C1OC)OC)C2=CC(=O)C3=CC=CC=C3O2 IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BSEL69 4',8-Dinitro-6-hydroxyflavone Investigative 10404203 C15H8N2O7 328.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=CC(=C3)O)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BSF6B7 Methyl 4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromene-3-carboxylate Investigative 372421 C20H18O7 370.4 COC1=CC(=CC(=C1OC)OC)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BT3Y5D 2-Imino-2H-chromene-3-carboxamide Investigative 598873 C10H8N2O2 188.18 C1=CC=C2C(=C1)C=C(C(=N)O2)C(=O)N IC50 = 1500000 nM Non binder T12499 LCK tyrosine protein kinase BT6OR3 4-((E)-2-Pyridin-3-yl-vinyl)-benzene-1,2-diol Investigative 44308029 C13H11NO2 213.23 C1=CC(=CN=C1)/C=C/C2=CC(=C(C=C2)O)O IC50 = 638000 nM Non binder T12499 LCK tyrosine protein kinase BTCA19 2-Cyano-3-(3-hydroxy-phenyl)-acrylamide Investigative 5388676 C10H8N2O2 188.18 C1=CC(=CC(=C1)O)/C=C(\\C#N)/C(=O)N IC50 = 1500000 nM Non binder T12499 LCK tyrosine protein kinase BTHB18 Methyl 3-(2-hydroxy-5-methoxyphenyl)-3-oxopropanoate Investigative 3684055 C11H12O5 224.21 COC1=CC(=C(C=C1)O)C(=O)CC(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BTMW67 6,7-Dihydroxyisoquinoline-3-carboxamide Investigative 135484881 C10H8N2O3 204.18 C1=C2C=C(N=CC2=CC(=C1O)O)C(=O)N IC50 = 1900000 nM Non binder T12499 LCK tyrosine protein kinase BTN6G5 Methyl 2-(4-acetamidophenyl)-7-methoxy-4-oxo-4H-chromene-3-carboxylate Investigative 14791386 C20H17NO6 367.4 CC(=O)NC1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C=C(C=C3)OC)C(=O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BTR91Y 2-(4-Hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-3-carboxylic acid Investigative 14791381 C17H12O6 312.27 COC1=CC2=C(C=C1)C(=O)C(=C(O2)C3=CC=C(C=C3)O)C(=O)O IC50 = 1032000 nM Non binder T12499 LCK tyrosine protein kinase BU4S7W Methyl 2-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromene-3-carboxylate Investigative 14791384 C18H14O6 326.3 COC1=CC2=C(C=C1)OC(=C(C2=O)C(=O)OC)C3=CC=C(C=C3)O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BU5TH9 6,7-Dihydroxy-N-phenyl-3-isoquinolinecarboxamide hydrochloride Investigative 135438239 C16H12N2O3 280.28 C1=CC=C(C=C1)NC(=O)C2=CC3=CC(=C(C=C3C=N2)O)O IC50 = 600000 nM Non binder T12499 LCK tyrosine protein kinase BU8HD3 7-Hydroxy-2-imino-2H-chromene-3-carboxamide Investigative 135400585 C10H8N2O3 204.18 C1=CC2=C(C=C1O)OC(=N)C(=C2)C(=O)N IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BUEV75 4H-1-Benzopyran-3-carboxylic acid, 2-(3,4-dimethoxyphenyl)-4-oxo- Investigative 14791375 C18H14O6 326.3 COC1=C(C=C(C=C1)C2=C(C(=O)C3=CC=CC=C3O2)C(=O)O)OC IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BUI5Q7 (3,5-Dimethoxy-benzyl)-pyridin-2-yl-amine Investigative 15931493 C14H16N2O2 244.29 COC1=CC(=CC(=C1)CNC2=CC=CC=N2)OC IC50 > 3275000 nM Non binder T12499 LCK tyrosine protein kinase BUP8Y5 4',6-Dinitro-7-hydroxyflavone Investigative 10336593 C15H8N2O7 328.23 C1=CC(=CC=C1C2=CC(=O)C3=CC(=C(C=C3O2)O)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BV0X2E 4',6-Dinitro-5-hydroxyflavone Investigative 10426617 C15H8N2O7 328.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=CC(=C3O)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BV4LN5 4-Nitrobenzaldehydephenylhydrazone Investigative 9584504 C13H11N3O2 241.24 C1=CC=C(C=C1)N/N=C/C2=CC=C(C=C2)[N+](=O)[O-] IC50 > 3316000 nM Non binder T12499 LCK tyrosine protein kinase BW2X1K Ac-YEEIE Investigative 446044 C32H45N5O14 723.7 CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)C IC50 > 200000 nM Non binder T12499 LCK tyrosine protein kinase BW90KV 3,5-Dimethoxy-N-pyridin-3-ylbenzamide Investigative 3295701 C14H14N2O3 258.269 COC1=CC(=CC(=C1)C(=O)NC2=CN=CC=C2)OC IC50 = 619000 nM Non binder T12499 LCK tyrosine protein kinase BWQ23K 4',8-Dinitro-7-hydroxyflavone Investigative 10381816 C15H8N2O7 328.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3)O)[N+](=O)[O-])[N+](=O)[O-] IC50 = 1876000 nM Non binder T12499 LCK tyrosine protein kinase BXHS25 3,4,5-Trimethoxy-N-pyridin-2-ylbenzamide Investigative 659323 C15H16N2O4 288.3 COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=N2 IC50 = 260000 nM Non binder T12499 LCK tyrosine protein kinase BXZ0W5 3-[2-(3,4-Dimethoxyphenyl)ethyl]pyridine Investigative 15931492 C15H17NO2 243.3 COC1=C(C=C(C=C1)CCC2=CN=CC=C2)OC IC50 = 1315000 nM Non binder T12499 LCK tyrosine protein kinase BY1U7R Ethyl 3-(2-hydroxyphenyl)-3-oxopropanoate Investigative 10867503 C11H12O4 208.21 CCOC(=O)CC(=O)C1=CC=CC=C1O IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BY6BL7 1-(2-Chloro-5-nitro-phenyl)-9H-beta-carboline Investigative 44269404 C17H10ClN3O2 323.7 C1=CC=C2C(=C1)C3=C(N2)C(=NC=C3)C4=C(C=CC(=C4)[N+](=O)[O-])Cl IC50 > 250000 nM Non binder T12499 LCK tyrosine protein kinase BYFH93 2-(4-Nitrophenyl)-4H-chromen-4-one Investigative 622510 C15H9NO4 267.24 C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC=C(C=C3)[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase BZ0MU1 7-Fluoro-1-methyl-9H-pyrido[3,4-b]indole Investigative 44269392 C12H9FN2 200.21 CC1=NC=CC2=C1NC3=C2C=CC(=C3)F IC50 > 250000 nM Non binder T12499 LCK tyrosine protein kinase BZR6I4 4'-Hydroxyflavone Investigative 229016 C15H10O3 238.24 C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC=C(C=C3)O IC50 = 504000 nM Non binder T12499 LCK tyrosine protein kinase BZU32O 3-Carbamoyl-6,7-dihydroxy-2-iminochromene Investigative 135452204 C10H8N2O4 220.18 C1=C2C=C(C(=N)OC2=CC(=C1O)O)C(=O)N IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase D02SRA Y-c[D-Pen-D-(2')Nal-GSFC]KR-NH2 Investigative 44312288 C49H69N13O10S2 1064.3 CC(=O)N[C@H]1C(=O)N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](CSSC1(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)CC2=CC=CC=C2)CO)CC3=CC4=CC=CC=C4C=C3 IC50 > 800000 nM Non binder T12499 LCK tyrosine protein kinase D09DVB Y-c[D-Pen-(2R,3R)-2-Me-(2')Nal-GSFC]KR-NH2 Investigative 44312287 C57H78N14O11S2 1199.5 C[C@H]([C@@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](CSSC([C@H](C(=O)N1)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)CC3=CC=CC=C3)CO)C4=CC5=CC=CC=C5C=C4 IC50 = 260000 nM Non binder T12499 LCK tyrosine protein kinase D09RYV Ro-0505124 Investigative 9911652 C23H25N5O3S 451.5 CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC(=C(S3)C(=O)C4=CC5=C(C=C4)OCCO5)N IC50 > 100000000 nM Non binder T12499 LCK tyrosine protein kinase D0B4PI Y-c[D-Pen-(2R,3S)-2-Me-(2')Nal-GSFC]KR-NH2 Investigative 44312309 C57H78N14O11S2 1199.5 C[C@@H]([C@@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](CSSC([C@H](C(=O)N1)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)CC3=CC=CC=C3)CO)C4=CC5=CC=CC=C5C=C4 IC50 = 470000 nM Non binder T12499 LCK tyrosine protein kinase D0Q2UZ Y-c[D-Pen-(2S,3R)-2-Me-(2')Nal-GSFC]KR-NH2 Investigative 44312307 C57H78N14O11S2 1199.5 C[C@H]([C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](CSSC([C@H](C(=O)N1)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)CC3=CC=CC=C3)CO)C4=CC5=CC=CC=C5C=C4 IC50 = 260000 nM Non binder T12499 LCK tyrosine protein kinase D0V2LK 6-Nitro-2-(4-nitro-phenyl)-chromen-4-one Investigative 10244983 C15H8N2O6 312.23 C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=CC(=C3)[N+](=O)[O-])[N+](=O)[O-] IC50 > 2000000 nM Non binder T12499 LCK tyrosine protein kinase D0W7LW Y-c[D-Pen-(2S,3S)-2-Me-(2')Nal-GSFC]KR-NH2 Investigative 44312308 C57H78N14O11S2 1199.5 C[C@@H]([C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](CSSC([C@H](C(=O)N1)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)CC3=CC=CC=C3)CO)C4=CC5=CC=CC=C5C=C4 IC50 = 220000 nM Non binder