TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T13057	Protein-tyrosine phosphatase SHP-2	D03SRY	Estramustine	Approved	259331	C23H31Cl2NO3	440.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl	IC50 > 300000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	D08QMX	Estradiol	Approved	5757	C18H24O2	272.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O	IC50 > 300000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B0XR5N	2-[(S)-Diethoxyphosphoryl-(4-nitroanilino)methyl]phenol	Investigative	57397769	C17H21N2O6P	380.3	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=C(C=C2)[N+](=O)[O-])OCC	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B15FWU	[(S)-(4-Hydroxyanilino)-(2-hydroxyphenyl)methyl]phosphonic acid	Investigative	57395972	C13H14NO5P	295.23	C1=CC=C(C(=C1)[C@@H](NC2=CC=C(C=C2)O)P(=O)(O)O)O	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B17QMN	(2E,5E)-5-[(4-Hydroxyphenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one	Investigative	135783301	C13H9N3O2S2	303.4	C1=CC(=CC=C1/C=C/2\\C(=O)N/C(=N\\C3=NC=CS3)/S2)O	Ki = 388000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B3LFU7	{3(S)-Methylcarbamoyl-2-[3-(3-sulfoamino-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinolin-7-YL}-sulfamic acid	Investigative	5327156	C20H24N4O8S2	512.6	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC(=CC=C3)NS(=O)(=O)O)C=C(C=C2)NS(=O)(=O)O	IC50 > 500000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B3LZI6	Sodium;(2R)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-sulfanylpropanoate	Investigative	57380662	C12H17NNaO6PS	357.3	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CS)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B4A8TL	2-[(S)-(4-Chloroanilino)-diethoxyphosphorylmethyl]phenol	Investigative	57399431	C17H21ClNO4P	369.8	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=C(C=C2)Cl)OCC	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B5DAY4	2-[(S)-(4-Bromoanilino)-diethoxyphosphorylmethyl]phenol	Investigative	57397768	C17H21BrNO4P	414.2	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=C(C=C2)Br)OCC	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B7D9LR	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(4-hydroxyphenyl)propanoate	Investigative	57380668	C18H21NNaO7P	417.3	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B7TX4O	(6R,8'R,9'S,13'S,14'S)-N,N-Bis(2-chloroethyl)-3'-methoxy-13'-methyl-2-oxospiro[1,3,2lambda5-oxazaphosphinane-6,17'-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene]-2-amine	Investigative	53319872	C25H37Cl2N2O3P	515.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@]24CCNP(=O)(O4)N(CCCl)CCCl)CCC5=C3C=CC(=C5)OC	IC50 > 300000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B82MAO	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(1H-imidazol-5-yl)propanoate	Investigative	57380664	C15H19N3NaO6P	391.29	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CC2=CN=CN2)C(=O)[O-])O.[Na+]	IC50 = 210000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	B8SA2E	Sodium;(2S,3R)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-hydroxybutanoate	Investigative	57380431	C13H19NNaO7P	355.26	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H]([C@@H](C)O)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BA07SJ	Sodium 2-((Ethoxy(Hydroxy)Phosphoryl)(2-Hydroxyphenyl)Methylamino)Acetate	Investigative	57380427	C11H15NNaO6P	311.2	CCOP(=O)(C(C1=CC=CC=C1O)NCC(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BA29IK	2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-methylphenol	Investigative	13779016	C10H8F6O2	274.16	CC1=CC(=C(C=C1)O)C(C(F)(F)F)(C(F)(F)F)O	IC50 = 201800 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BDBS69	2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-5-phenylphenol	Investigative	134134309	C15H10F6O2	336.23	C1=CC=C(C=C1)C2=CC(=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)O	IC50 > 500000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BK1WJ3	(2E,5E)-5-[(3-Nitrophenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one	Investigative	135783303	C13H8N4O3S2	332.4	C1=CC(=CC(=C1)[N+](=O)[O-])/C=C/2\\C(=O)N/C(=N\\C3=NC=CS3)/S2	Ki = 547500 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BL63SQ	2-(2-Hydroxy-1,1,1,3,3,3-hexafluoropropyl)-1-naphthol	Investigative	2775086	C13H8F6O2	310.19	C1=CC=C2C(=C1)C=CC(=C2O)C(C(F)(F)F)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BLZS75	(2E)-3-[3-Chloro-4-(4-fluorophenyl)phenyl]prop-2-enoic acid	Investigative	25023780	C15H10ClFO2	276.69	C1=CC(=CC=C1C2=C(C=C(C=C2)/C=C/C(=O)O)Cl)F	IC50 = 500000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BM2VB4	Trimethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester	Investigative	46830252	C21H32N2O8P2	502.4	CCOP(=O)(C(C1=CC=CC=C1O)NCCCNC(C2=CC=CC=C2O)P(=O)(O)OCC)O	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BMH2R4	2-[(S)-(2-Chloroanilino)-diethoxyphosphorylmethyl]phenol	Investigative	57390693	C17H21ClNO4P	369.8	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=CC=C2Cl)OCC	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BPF1T0	2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-phenylphenol	Investigative	134138834	C15H10F6O2	336.23	C1=CC=C(C=C1)C2=CC(=C(C=C2)O)C(C(F)(F)F)(C(F)(F)F)O	IC50 = 392200 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BPM59E	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(1H-indol-3-yl)propanoate	Investigative	57397770	C20H22N2NaO6P	440.4	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BQ56PL	Hexamethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester	Investigative	56589513	C24H38N2O8P2	544.5	CCOP(=O)(C(C1=CC=CC=C1O)NCCCCCCNC(C2=CC=CC=C2O)P(=O)(O)OCC)O	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BT57EG	Ethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester	Investigative	56589511	C20H30N2O8P2	488.4	CCOP(=O)(C(C1=CC=CC=C1O)NCCNC(C2=CC=CC=C2O)P(=O)(O)OCC)O	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BV3A5M	(2E,5E)-5-[(4-Nitrophenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one	Investigative	135783299	C13H8N4O3S2	332.4	C1=CC(=CC=C1/C=C/2\\C(=O)N/C(=N\\C3=NC=CS3)/S2)[N+](=O)[O-]	Ki = 473600 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BW2LX7	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]propanoate	Investigative	57380429	C12H17NNaO6P	325.23	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](C)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BWL5I1	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-phenylpropanoate	Investigative	57380666	C18H21NNaO6P	401.3	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CC2=CC=CC=C2)C(=O)[O-])O.[Na+]	IC50 > 10000000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BXV1B0	3-Ethynyl-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic Acid	Investigative	45378656	C18H13NO3	291.3	CN1C2=CC(=C(C=C2C(=C1C3=CC=CC=C3)C#C)C(=O)O)O	IC50 = 212000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BY7N2Q	1,1,1,3,3,3-Hexafluoro-2-phenylpropan-2-ol	Investigative	69748	C9H6F6O	244.13	C1=CC=C(C=C1)C(C(F)(F)F)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T13057	Protein-tyrosine phosphatase SHP-2	BZ0J2R	(2E,5E)-5-[(3-Chlorophenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one	Investigative	135783304	C13H8ClN3OS2	321.8	C1=CC(=CC(=C1)Cl)/C=C/2\\C(=O)N/C(=N\\C3=NC=CS3)/S2	Ki = 1088200 nM	Non binder