TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T19244	S-mephenytoin 4-hydroxylase	D08QCJ	Thiabendazole	Approved	5430	C10H7N3S	201.25	C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3	Ki = 245000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	D06ZVC	WAY-181187	Discontinued in Phase 1	10150497	C15H13ClN4O2S2	380.9	C1=CC=C2C(=C1)C(=CN2S(=O)(=O)C3=C(N=C4N3C=CS4)Cl)CCN	IC50 > 500000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B09BPL	1-[5-(6-Methoxynaphthalen-2-yl)pyridin-3-yl]ethanone	Investigative	25034348	C18H15NO2	277.3	CC(=O)C1=CN=CC(=C1)C2=CC3=C(C=C2)C=C(C=C3)OC	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B0YA2H	Pyridine, 3-(4-methyl-1H-imidazol-1-yl)-	Investigative	44388612	C9H9N3	159.19	CC1=CN(C=N1)C2=CN=CC=C2	IC50 > 300000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B29YTW	2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide	Investigative	10861643	C17H25FN2O4S	372.5	CC(C)C[C@H](C=O)NC(=O)[C@H](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F	IC50 = 492000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B2QHP6	Pyridine, 2-fluoro-5-(4-methyl-3-thienyl)-	Investigative	11389927	C10H8FNS	193.24	CC1=CSC=C1C2=CN=C(C=C2)F	IC50 > 400000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B4QX3P	Dimethyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amine	Investigative	10654534	C10H12N2	160.22	CN(C)CC#CC1=CN=CC=C1	Ki > 400000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B4ZE8L	2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}piperazin-1-yl)-quinoline-6-carbonitrile	Investigative	44192200	C27H25N5O2	451.5	CC1=NC2=C(C=C1)C3=C(C=C2)OC[C@@H](O3)CN4CCN(CC4)C5=NC6=C(C=C5)C=C(C=C6)C#N	IC50 = 358000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B5X4MU	4-Allyl-N-benzyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10895263	C25H23N3O2S	429.5	C=CCC1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=CC=C2)C3=CC=NN3C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B68KGF	4-Allyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10948187	C19H19N3O2S	353.4	CN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)CC=C	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B7WX4U	3,3'-Bipyridine	Investigative	68487	C10H8N2	156.18	C1=CC(=CN=C1)C2=CN=CC=C2	IC50 > 300000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	B8YKP1	(5-Pyridin-3-ylthiophen-2-yl)methanamine;(5-pyridin-3-ylthiophen-2-yl)methanimine	Investigative	44388657	C30H26N6S3	566.8	C1=CC(=CN=C1)C2=CC=C(S2)CN.C1=CC(=CN=C1)C2=CC=C(S2)C=N.C1=CC(=CN=C1)C2=CC=C(S2)C=N	IC50 = 208000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BB3H5J	2-[[2-(3,4-Dichlorophenoxy)phenyl]methylsulfinyl]acetamide	Investigative	11588489	C15H13Cl2NO3S	358.2	C1=CC=C(C(=C1)CS(=O)CC(=O)N)OC2=CC(=C(C=C2)Cl)Cl	IC50 = 216000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BK36VF	(NZ)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine	Investigative	11355925	C10H8N2O2	188.18	C1=CC(=CN=C1)C2=CC=C(O2)/C=N\\O	IC50 = 398000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BPKY46	3-(2-Methyl-1H-imidazol-1-yl)pyridine	Investigative	16654686	C9H9N3	159.19	CC1=NC=CN1C2=CN=CC=C2	Ki > 300000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BV1B3U	5-Hydroxy saxagliptin	Investigative	23645678	C18H25N3O3	331.4	C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)(CC(C5)(C4)O)O)N	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BV8YP7	3-(Pyridin-3-yl)propan-1-amine	Investigative	13557523	C8H12N2	136.19	C1=CC(=CN=C1)CCCN	Ki > 400000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BXWL30	(5R)-3-[3-Fluoro-4-(1-oxidotetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamide	Investigative	23729988	C15H17FN2O4S	340.4	C1CS(=O)CCC1C2=C(C=C(C=C2)N3C[C@@H](OC3=O)C(=O)N)F	IC50 > 900000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BY4K6H	3-Methyl-4-phenylthiophene	Investigative	11993868	C11H10S	174.26	CC1=CSC=C1C2=CC=CC=C2	Ki > 400000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	BY96PQ	Pyridine, 2-fluoro-5-(3-thienyl)-	Investigative	11389737	C9H6FNS	179.22	C1=CC(=NC=C1C2=CSC=C2)F	IC50 > 400000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	D06HOI	BMS-269223	Investigative	44249821	C23H28N6O3	436.5	CC1=CC2=C(O1)C=CC(=C2)NC(=N[C@H]3CCCCN(C3=O)CC(=O)N4CCCC4)NC#N	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	D0J1QT	BMS-344577	Investigative	44473100	C31H37N7O5	587.7	CC1=CC2=C(O1)C=CC(=C2)NC(=N[C@H]3CCCCN(C3=O)CC(=O)N4CCCC4)NC(=O)C5=CN=C(C=C5)C(=O)N(C)C	IC50 > 200000 nM	Non binder
T19244	S-mephenytoin 4-hydroxylase	D0VD5O	2-fluoro-5-(3-methylthiophen-2-yl)pyridine	Investigative	11148236	C10H8FNS	193.24	CC1=C(SC=C1)C2=CN=C(C=C2)F	Ki > 400000 nM	Non binder