TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T21307	MAPK-activated protein kinase 2	B01PIK	(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methanamine	Investigative	44441132	C13H17N3O	231.29	COC1=CC2=C(C=C1)NC3=C2CCNC3CN	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B16WBM	6-Methoxy-1-methyl-2,3,4,9-tetrahydropyrido[3,4-b]indole-1-carboxylic acid	Investigative	612268	C14H16N2O3	260.29	CC1(C2=C(CCN1)C3=C(N2)C=CC(=C3)OC)C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B1X9EM	4-(4-(4-(4-Methylpiperazin-1-yl)phenylamino)quinolin-6-yl)benzoic acid	Investigative	49862123	C27H26N4O2	438.5	CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=C(C=CC4=NC=C3)C5=CC=C(C=C5)C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B1Z0XG	3-((Dimethylamino)methyl)-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441146	C16H21N3O3	303.36	CN(C)CC1CC2=C(C(N1)C(=O)O)NC3=C2C=C(C=C3)OC	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B2JG3P	5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)-7-N-methylpyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60200406	C19H22ClFN6	388.9	CN(C1=CC(=C(C=C1)F)Cl)C2=CC(=NC3=CC=NN32)NC4CCC(CC4)N	IC50 > 300000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B43EJH	6-(2-Morpholinoethylamino)-4-(4-phenoxyphenylamino)-1,7-naphthyridine-3-carbonitrile	Investigative	44405504	C27H26N6O2	466.5	C1COCCN1CCNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC=C(C=C4)OC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B4ZAH7	6-Methoxy-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-carboxylic acid	Investigative	44441123	C13H13NO4	247.25	COC1=CC2=C(C=C1)NC3=C2CCOC3C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B50NCP	1,3-Diamino-6-hydroxy-9-phenyl-9H-xanthene-2-carbonitrile	Investigative	122197385	C20H15N3O2	329.4	C1=CC=C(C=C1)C2C3=C(C=C(C=C3)O)OC4=C2C(=C(C(=C4)N)C#N)N	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B5JCH6	[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[tert-butyl(2-hydroxyethyl)amino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetate	Investigative	24807809	C29H41NO9	547.6	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CCO)C(C)(C)C)/C4=C(C3=O)O)COC)C)C	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	B8X0EU	N-[4-(4-Methylpiperazin-1-yl)phenyl]-6-thiophen-2-ylquinolin-4-amine	Investigative	49862088	C24H24N4S	400.5	CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=C(C=CC4=NC=C3)C5=CC=CS5	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BA2W5K	6-Methoxy-9H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44269421	C13H10N2O3	242.23	COC1=CC2=C(C=C1)NC3=C2C=CN=C3C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BC3NE0	1,3-Bis(ethylamino)-6,7-dihydroxy-9H-xanthene-2-carbonitrile	Investigative	122197371	C18H19N3O3	325.4	CCNC1=CC2=C(CC3=CC(=C(C=C3O2)O)O)C(=C1C#N)NCC	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BC98PU	6-Methoxy-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid	Investigative	21399939	C14H15NO3	245.27	COC1=CC2=C(C=C1)NC3=C2CCCC3C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BDL6G4	6-(2-Morpholinoethylamino)-4-(4-(phenylthio)phenylamino)-1,7-naphthyridine-3-carbonitrile	Investigative	16085320	C27H26N6OS	482.6	C1COCCN1CCNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC=C(C=C4)SC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BDZ08U	2,4-Diamino-10,10-dioxo-5H-thiochromeno[2,3-b]pyridine-3-carbonitrile	Investigative	9971229	C13H10N4O2S	286.31	C1C2=CC=CC=C2S(=O)(=O)C3=NC(=C(C(=C31)N)C#N)N	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BE5P8J	2,4-Diamino-5H-thiochromeno[2,3-b]pyridine-3-carbonitrile	Investigative	10467496	C13H10N4S	254.31	C1C2=CC=CC=C2SC3=NC(=C(C(=C31)N)C#N)N	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BEPZ14	5-N-(4-Aminocyclohexyl)-2-tert-butyl-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60199605	C22H28ClFN6	430.9	CC(C)(C)C1=NN2C(=C1)N=C(C=C2NC3=CC(=C(C=C3)F)Cl)NC4CCC(CC4)N	IC50 > 300000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BF5P3R	6-Methoxy-5-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441115	C14H16N2O3	260.29	CC1=C(C=CC2=C1C3=C(N2)C(NCC3)C(=O)O)OC	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BHY15P	N,6-Diphenylquinolin-4-amine	Investigative	49862702	C21H16N2	296.4	C1=CC=C(C=C1)C2=CC3=C(C=CN=C3C=C2)NC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BI93VF	6-Methoxy-9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441135	C14H16N2O3	260.29	CN1C2=C(C=C(C=C2)OC)C3=C1C(NCC3)C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BJH64U	6-Methoxy-3-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441142	C14H13F3N2O3	314.26	COC1=CC2=C(C=C1)NC3=C2CC(NC3C(=O)O)C(F)(F)F	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BJU6E4	6-Bromo-N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine	Investigative	49862087	C20H21BrN4	397.3	CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=C(C=CC4=NC=C3)Br	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BMR7I4	6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxamide	Investigative	44441130	C13H15N3O2	245.28	COC1=CC2=C(C=C1)NC3=C2CCNC3C(=O)N	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BOBT79	Substituted 6-aminoquinoline-3-carbonitrile, 36	Investigative	44143372	C27H27Cl2FN8	553.5	CC(C)N1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BOH1W0	8-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441113	C13H14N2O3	246.26	COC1=CC=CC2=C1NC3=C2CCNC3C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BRE4P2	(1E,4S,4Ar,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione	Investigative	11526786	C29H42N2O8	546.7	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(C)CCCN(C)C)/C4=C(C3=O)O)COC)C)C	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BRF7S0	(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methanol	Investigative	44441131	C13H16N2O2	232.28	COC1=CC2=C(C=C1)NC3=C2CCNC3CO	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BRH50L	7-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441112	C13H14N2O3	246.26	COC1=CC2=C(C=C1)C3=C(N2)C(NCC3)C(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BUT1L9	5-N-(4-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60199603	C19H22ClFN6	388.9	CC1=NN2C(=C1)N=C(C=C2NC3=CC(=C(C=C3)F)Cl)NC4CCC(CC4)N	IC50 > 300000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BW9C2Z	8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-(1-propylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl}amino)quinoline-3-carbonitrile	Investigative	44143371	C27H27Cl2FN8	553.5	CCCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BXG12Z	Tpl2-IN-I	Investigative	44450544	C21H14ClFN6	404.8	CN(C1=CN=CC=C1)C2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 = 110000000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BY03SX	Methyl 6-methoxy-9H-pyrido[3,4-b]indole-1-carboxylate	Investigative	44441122	C14H12N2O3	256.26	COC1=CC2=C(C=C1)NC3=C2C=CN=C3C(=O)OC	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BY75LV	4-(4-Benzylphenylamino)-6-(2-morpholinoethylamino)-1,7-naphthyridine-3-carbonitrile	Investigative	11496376	C28H28N6O	464.6	C1COCCN1CCNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC=C(C=C4)CC5=CC=CC=C5	IC50 > 400000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BYV0O9	1,3-Diamino-6-methoxy-9-phenyl-9H-xanthene-2-carbonitrile	Investigative	122197379	C21H17N3O2	343.4	COC1=CC2=C(C=C1)C(C3=C(O2)C=C(C(=C3N)C#N)N)C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BYV87C	2-(6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid	Investigative	4274924	C14H16N2O3	260.29	COC1=CC2=C(C=C1)NC3=C2CCNC3CC(=O)O	IC50 > 200000 nM	Non binder
T21307	MAPK-activated protein kinase 2	BZ73XN	4-(3-Chloro-4-fluoro-phenylamino)-6-(2-morpholin-4-yl-ethylamino)-1,7-naphthyridine-3-carbonitrile	Investigative	44143344	C21H20ClFN6O	426.9	C1COCCN1CCNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 > 400000 nM	Non binder
T21307	MAPK-activated protein kinase 2	D0E3OL	GNF-PF-2857	Investigative	4567175	C20H22N4	318.4	CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC=NC4=CC=CC=C43	IC50 > 200000 nM	Non binder