TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T26463	DNA polymerase alpha catalytic p180	B04PHA	[[(2R,3S,5R)-5-(6-Amino-8-bromopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate	Investigative	11764703	C22H33BrN5O10P	638.4	CC(C)(C)C(=O)OCOP(=O)(OC[C@@H]1[C@H](C[C@@H](O1)N2C3=NC=NC(=C3N=C2Br)N)O)OCOC(=O)C(C)(C)C	Ki = 548000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B2E0KV	Dihydrocholesterol	Investigative	6665	C27H48O	388.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B2GAP0	1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diol	Investigative	76325888	C29H52O3	448.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B46VLT	N-[(2S)-1-Acetylpyrrolidine-2-carbonyl]-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid	Investigative	90654420	C16H22F2N5O8P	481.35	CC(=O)N1CCC[C@H]1C(=O)NP(=O)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 = 410000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B4Y2QT	(2S)-1-Acetyl-N-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]pyrrolidine-2-carboxamide	Investigative	90654415	C16H22F2N5O7PS	497.4	CC(=O)N1CCC[C@H]1C(=O)NP(=S)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B5XT6E	6H-Purin-6-one, 1,9-dihydro-2-((3-ethyl-4-methylphenyl)amino)-	Investigative	135435086	C14H15N5O	269.3	CCC1=C(C=CC(=C1)NC2=NC3=C(C(=O)N2)NC=N3)C	Ki = 1760000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B7M5JS	N-[(2S)-2-Acetamido-3-phenylpropanoyl]-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid	Investigative	90654421	C20H24F2N5O8P	531.4	CC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NP(=O)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B7O9IL	N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]acetamide	Investigative	90654414	C11H15F2N4O6PS	400.3	CC(=O)NP(=S)(O)OC[C@@H]1[C@H](C([C@@H](O1)N2C=CC(=NC2=O)N)(F)F)O	EC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B8KGW7	[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-(pyridine-4-carbonyl)phosphonamidic acid	Investigative	90654418	C15H16F2N5O7P	447.29	C1=CN=CC=C1C(=O)NP(=O)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	B8RJV2	[[(2S,3R,5S)-5-(4-Amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate	Investigative	497311	C10H17FN3O12P3	483.17	CC1=CN(C(=O)N=C1N)[C@@H]2C[C@H]([C@@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)F	IC50 > 200000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BAG2X5	2-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol	Investigative	9802791	C29H50O2	430.7	C[C@H](CCCC(C)C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCCO)C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BB5R3O	N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]benzamide	Investigative	24771829	C16H17F2N4O6PS	462.4	C1=CC=C(C=C1)C(=O)NP(=S)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 = 350000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BBCU85	2,4-Pyrimidinediamine, 6-chloro-N4-(3,4-dichlorophenyl)-	Investigative	238747	C10H7Cl3N4	289.5	C1=CC(=C(C=C1NC2=CC(=NC(=N2)N)Cl)Cl)Cl	IC50 > 1000000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BC5EA8	(beta-D-2'',3''-Dideoxy-5''-F-cytidine-5''-triphosphate)	Investigative	53317946	C9H15FN3O12P3	469.15	C1C[C@@H](O[C@@H]1[C@H](OP(=O)(O)OP(=O)(O)OP(=O)(O)O)F)N2C=CC(=NC2=O)N	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BF24GL	2-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol	Investigative	44396529	C31H52O2	456.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OCCO)C)C)C(C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BHPM16	[[(2R,3R,4R,5R)-4-Chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	Investigative	73669532	C10H16ClN2O14P3	516.61	C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)Cl	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BKFP98	[[(2S,3R,5S)-3-Fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	Investigative	497307	C10H16FN2O13P3	484.16	CC1=CN(C(=O)NC1=O)[C@@H]2C[C@H]([C@@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)F	IC50 > 200000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BM6W5Y	1-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol	Investigative	44396581	C29H50O3	446.7	C[C@H](CCCC(C)C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BME6W0	[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-benzoylphosphonamidic acid	Investigative	90654416	C16H17F2N4O7P	446.3	C1=CC=C(C=C1)C(=O)NP(=O)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BMI4J5	1-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol	Investigative	44396563	C31H52O3	472.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)OC(CO)O)C)C)C(C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BN9GP1	[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-N-(pyridine-3-carbonyl)phosphonamidic acid	Investigative	90654417	C15H16F2N5O7P	447.29	C1=CC(=CN=C1)C(=O)NP(=O)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 = 250000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BQ2BL9	(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol	Investigative	44396595	C29H48O	412.7	CC[C@H](/C=C/[C@@H](C)[C@H]1CCC2[C@@]1(CCC3C2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BTJY56	Remdesivir triphosphate	Investigative	56832906	C12H16N5O13P3	531.2	C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N)N	IC50 > 200000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BY82RV	2-[(3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-3-yloxy]ethanol	Investigative	66825540	C29H52O2	432.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@@H](C4)OCCO)C)C	IC50 > 500000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	BZ8ME3	Bicyclic pyrimidinone, (R)-22b	Investigative	54709839	C19H24FN5O5S	453.5	CN(C)S(=O)(=O)N(C)[C@@H]1CCCN2C1=NC(=C(C2=O)O)C(=O)NCC3=CC=C(C=C3)F	IC50 > 200000 nM	Non binder
T26463	DNA polymerase alpha catalytic p180	D02DLW	Cholesterol	Investigative	5997	C27H46O	386.7	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C	IC50 > 500000 nM	Non binder