TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T27137	Metabotropic glutamate receptor 1	B0YI4S	(1S,3R)-1-Amino-3-(carboxymethyl)cyclopentane-1-carboxylic Acid	Investigative	10012681	C8H13NO4	187.19	C1C[C@](C[C@@H]1CC(=O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B1U2ST	(2R,4R)-4-Amino-1-methylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302818	C7H12N2O4	188.18	CN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B1X8RG	(2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302608	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B29QMH	(2R)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine	Investigative	44569827	C9H13NO4	199.2	C1C2(CC1(C2)C(=O)O)C[C@H](C(=O)O)N	Ki = 210000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B2RYP6	2-Aminooctanedioic acid	Investigative	77937	C8H15NO4	189.21	C(CCC(C(=O)O)N)CCC(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B2Y1QJ	2-[(1R,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	10752213	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	Ki = 260000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B3HQT6	(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid	Investigative	44322745	C6H9N3O5	203.15	C[C@](CN1C(=O)NOC1=O)(C(=O)O)N	Ki = 500000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B3O1FQ	(RS)-Apica	Investigative	4694355	C10H12NO5P	257.18	C1CC(C2=C1C=C(C=C2)P(=O)(O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B48TJE	(2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302605	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC(=CC=C2)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B4XAP2	2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyric acid	Investigative	9837114	C6H9N3O3S	203.22	C(C[C@H](C(=O)O)N)C1=NSNC1=O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B53OZS	(2R)-(3'-Phosphonomethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569862	C9H16NO5P	249.2	C1C2(CC1(C2)CP(=O)(O)O)C[C@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B5J7WM	2-[(1R,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10489914	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@H]([C@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B5T6CU	(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid	Investigative	10359073	C19H21NO4	327.4	C1=CC=C(C=C1)C(C[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B5XW4D	(2R)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569860	C10H15NO4	213.23	C1C2(CC1(C2)CC(=O)O)C[C@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B7GRY1	(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid	Investigative	2733519	C6H9NO4	159.14	C1[C@@H]([C@H](N1)C(=O)O)CC(=O)O	EC50 = 210000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B7TMV2	3-[(R)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Investigative	10241509	C8H11NO4	185.18	C1C2(CC1(C2)C(=O)O)[C@H](C(=O)O)N	EC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B8CUY3	2-[(1S,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	7157252	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@@H]([C@@H]2C(=O)O)[C@@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B8GS1W	2-[(1R,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10704895	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@H]([C@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B8PEG2	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2R)-	Investigative	17758444	C5H9NO5S	195.2	C1[C@H]([C@@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki = 254000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B96LOR	D-2-Aminoadipic acid	Investigative	165627	C6H11NO4	161.16	C(C[C@H](C(=O)O)N)CC(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B9DR6Z	(S)-2-Amino-5-phosphonopentanoic acid	Investigative	1617110	C5H12NO5P	197.13	C(C[C@@H](C(=O)O)N)CP(=O)(O)O	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B9FH3U	Amino-(2-chloro-3,5-dihydroxy-phenyl)-acetic acid(S-CHPG)	Investigative	44322518	C8H8ClNO4	217.6	C1=C(C=C(C(=C1C(C(=O)O)N)Cl)O)O	Ki = 750000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	B9UZL3	(2R,4R)-4-Amino-1-(3,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302687	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC(=C(C=C2)Cl)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BA2HY3	(2S,3S,4S)-2-Amino-3,4-dihydroxy-pentanedioic Acid	Investigative	10442268	C5H9NO6	179.13	[C@H]([C@@H](C(=O)O)N)([C@@H](C(=O)O)O)O	EC50 = 257000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BA5F1H	(1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic acid	Investigative	11543205	C9H13NO4	199.2	C1C[C@@H]([C@H]2[C@@H]1CN[C@@H]2C(=O)O)C(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BA89FL	(2R,4R)-4-Amino-1-(naphthalen-1-ylmethyl)pyrrolidine-2,4-dicarboxylic Acid	Investigative	10358265	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC3=CC=CC=C32)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BA8XK5	2-[(1R,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10681240	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BB6KT7	(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302930	C14H18N2O4	278.3	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BBF7L9	(S)-Hibo	Investigative	10012356	C6H8N2O4	172.14	C1=C(ONC1=O)C[C@@H](C(=O)O)N	Ki = 250000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BC96JQ	(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid	Investigative	10330132	C6H11N3O4	189.17	C1[C@@H](N(C[C@]1(C(=O)O)N)N)C(=O)O	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BCD6I9	(2S)-2-Amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic acid	Investigative	10465478	C6H9N3O3S	203.22	C(C[C@@H](C(=O)O)N)C1=NSNC1=O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BCYB02	(2R,4R)-4-Amino-1-(2,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302896	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=C(C=C(C=C2)Cl)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BD08XI	(2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302929	C15H20N2O4	292.33	C1[C@@H](N(C[C@]1(C(=O)O)N)CCCC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BDX8L5	(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine	Investigative	10059959	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@@H]([C@@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BEW0U5	(RS)-3-Hydroxyphenylglycine	Investigative	1217	C8H9NO3	167.16	C1=CC(=CC(=C1)O)C(C(=O)O)N	Ki = 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BF1ZB7	(2R,4R)-4-Amino-1-(4-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302932	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=C(C=C2)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BFEN08	(R)-1-Amino-indan-1,5-dicarboxylic acid	Investigative	6603702	C11H11NO4	221.21	C1C[C@@](C2=C1C=C(C=C2)C(=O)O)(C(=O)O)N	IC50 = 214000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BFLU56	(R)-Ampa	Investigative	6604707	C7H10N2O4	186.17	CC1=C(C(=O)NO1)C[C@H](C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BGB5T3	(2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302931	C13H22N2O4	270.32	C1CCC(CC1)CN2C[C@](C[C@@H]2C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BGQN61	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2S)-	Investigative	17758445	C5H9NO5S	195.2	C1[C@@H]([C@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BH3I6O	2-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid	Investigative	22708855	C9H13NO4	199.2	C1CC2C(C1CC2(C(=O)O)N)C(=O)O	IC50 = 630000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BH41XD	2-Aminoheptanedioic acid	Investigative	101122	C7H13NO4	175.18	C(CCC(=O)O)CC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BH7NR6	2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid	Investigative	2733518	C6H7BrN2O4	251.03	C(C1=C(C(=O)NO1)Br)C(C(=O)O)N	Ki = 329000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BHS53B	(2R,4R)-4-Amino-1-benzhydrylpyrrolidine-2,4-dicarboxylic acid	Investigative	49799828	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BI2F3N	2-[(1S,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	10513896	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BI56LB	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1R,2R)-	Investigative	17758556	C5H9NO5S	195.2	C1[C@@H]([C@@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BJNB38	(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10560963	C8H11NO4	185.18	C1[C@H]2C[C@]([C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 232000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BK1E2B	alpha-Amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid	Investigative	173564	C6H8N2O4	172.14	CC1=C(C(=O)NO1)C(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BK8NL7	(1S,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid	Investigative	6604704	C7H11NO4	173.17	C1C[C@](C[C@H]1C(=O)O)(C(=O)O)N	EC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BKM51O	(2S)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569861	C9H16NO5P	249.2	C1C2(CC1(C2)CP(=O)(O)O)C[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BLVS56	(1r,3r)-1-Aminocyclopentane-1,3-dicarboxylic acid	Investigative	231345	C7H11NO4	173.17	C1C[C@@](C[C@@H]1C(=O)O)(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BNM4E5	2-[(1S,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10513895	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@@H]([C@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BO1SZ9	(2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302913	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BO9D5E	2-[(1R,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	10752214	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@H]([C@@H]2C(=O)O)[C@@H](C(=O)O)N	Ki = 205000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BOCA73	(2R,4R)-4-Amino-1-ethylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302837	C8H14N2O4	202.21	CCN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BP9BL1	(2S)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine	Investigative	44569826	C9H13NO4	199.2	C1C2(CC1(C2)C(=O)O)C[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BP9I2D	(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10465017	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@H]2C(=O)O)(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BR89DT	(1S,2S)-4-Aminocyclopentane-1,2,4-tricarboxylic acid	Investigative	10656383	C8H11NO6	217.18	C1[C@@H]([C@H](CC1(C(=O)O)N)C(=O)O)C(=O)O	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BSKL06	2-[(1S,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine	Investigative	10704896	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BSWF59	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2S)-	Investigative	17758555	C5H9NO5S	195.2	C1[C@H]([C@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BUBT35	(1S,2S)-1-Amino-2-(carboxymethyl)cyclopropane-1-carboxylic acid	Investigative	11768848	C6H9NO4	159.14	C1[C@H]([C@@]1(C(=O)O)N)CC(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BVM18G	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2R)-	Investigative	17758449	C5H9NO5S	195.2	C1[C@@H]([C@@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BW2BG1	(S)-3-Carboxy-4-hydroxyphenylglycine	Investigative	5311460	C9H9NO5	211.17	C1=CC(=C(C=C1[C@@H](C(=O)O)N)C(=O)O)O	IC50 = 290000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BWC90O	2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid	Investigative	44322843	C9H13NO4	199.2	C1C[C@](C2C1C[C@@H]2C(=O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BXIR36	2-Amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid	Investigative	10609381	C10H16N2O4	228.24	CC1=C(C(=O)NO1)CCCCC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BY4U5X	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2S)-	Investigative	17758450	C5H9NO5S	195.2	C1[C@H]([C@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BY5D3O	Cl-HIBO	Investigative	4694356	C6H7ClN2O4	206.58	C(C1=C(C(=O)NO1)Cl)C(C(=O)O)N	Ki = 860000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BYE7U4	(2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302855	C21H24N2O4	368.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BYK29C	(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302856	C20H22N2O4	354.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BYWE14	(2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302686	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=C(C=CC=C2Cl)Cl)C(=O)O	IC50 = 238500 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BZ07DY	2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid	Investigative	6604795	C8H12N2O4	200.19	CC1=C(C(=O)NO1)CC[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BZ20RS	L-2-Aminoadipic acid	Investigative	92136	C6H11NO4	161.16	C(C[C@@H](C(=O)O)N)CC(=O)O	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BZ5HB6	(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302819	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2Cl)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BZ67QI	2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-pentanoic acid	Investigative	44338561	C9H14N2O4	214.22	CC1=C(C(=O)NO1)CCCC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	BZP84A	2-[(1R,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine	Investigative	10198574	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D08CAB	D-aspartic acid	Investigative	83887	C4H7NO4	133.1	C([C@H](C(=O)O)N)C(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D09AQK	(R,S)-4-phosphonophenylglycine	Investigative	4545574	C8H10NO5P	231.14	C1=CC(=CC=C1C(C(=O)O)N)P(=O)(O)O	Ki > 500000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0D2GL	MPPG	Investigative	3972752	C9H12NO5P	245.17	CC(C1=CC=C(C=C1)P(=O)(O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0J2WN	PCCG-4	Investigative	5311344	C12H13NO4	235.24	C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	Ki > 270000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0L0YF	homo-AMPA	Investigative	4236420	C8H12N2O4	200.19	CC1=C(C(=O)NO1)CCC(C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0N0NJ	1-benzyl-APDC	Investigative	15508178	C13H16N2O4	264.28	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0O1AK	D-glutamic acid	Investigative	23327	C5H9NO4	147.13	C(CC(=O)O)[C@H](C(=O)O)N	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0OT9B	L-aspartic acid	Investigative	5960	C4H7NO4	133.1	C([C@@H](C(=O)O)N)C(=O)O	EC50 > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0OV2V	LY307452	Investigative	6324634	C21H25NO4	355.4	C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0PN6Z	L-AP4	Investigative	179394	C4H10NO5P	183.1	C(CP(=O)(O)O)[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T27137	Metabotropic glutamate receptor 1	D0T5SU	(S)-AMPA	Investigative	158397	C7H10N2O4	186.17	CC1=C(C(=O)NO1)C[C@@H](C(=O)O)N	EC50 > 1000000 nM	Non binder