TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T28893	Muscarinic acetylcholine receptor M1	B02WDC	Xanomeline	Investigative	60809	C14H23N3OS	281.42	CCCCCCOC1=NSN=C1C2=CCCN(C2)C	Ki = 251000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B0LCK4	4-[4-(4-Hydroxy-4,4-diphenylbutyl)-4-methylpiperazin-4-ium-1-yl]-1,1-diphenylbutan-1-ol;iodide	Investigative	44448499	C37H45IN2O2	676.7	C[N+]1(CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)CCCC(C4=CC=CC=C4)(C5=CC=CC=C5)O.[I-]	Ki = 141000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B12LNH	Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44422698	C9H20INO2	301.17	C[C@@H]1COC[C@@H](O1)C[N+](C)(C)C.[I-]	EC50 = 1260000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B19XTZ	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)-1-methylpiperidin-1-ium-4-yl]-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	Investigative	44448383	C44H58I2N2O2	900.8	C[N+]1(CCC(CC1)C2CC[N+](CC2)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCC(C5=CC=CC=C5)(C6=CC=CC=C6)O.[I-].[I-]	Ki = 1660000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B1ISW7	1-[3-[4-(9-Hydroxynonyl)piperidin-1-yl]propyl]-3,4-dihydroquinolin-2-one	Investigative	118719928	C26H42N2O2	414.6	C1CN(CCC1CCCCCCCCCO)CCCN2C(=O)CCC3=CC=CC=C32	EC50 = 245470.89 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B1KPY8	4-[4-(1,1-Dimethylpiperidin-1-ium-4-yl)-1-methylpiperidin-1-ium-1-yl]-1,1-diphenylbutan-1-ol;diiodide	Investigative	44448379	C29H44I2N2O	690.5	C[N+]1(CCC(CC1)C2CC[N+](CC2)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)C.[I-].[I-]	Ki = 120000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B2TBK1	Trimethyl-[[(2R,6S)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	24865894	C9H20INO2	301.17	C[C@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	EC50 = 120000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B2TJ5E	4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797390	C36H46Cl2N2O2	609.7	CN(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCN(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 4070000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B47IWT	Ethyl 17-methoxy-6-methyl-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate	Investigative	4995951	C23H24N2O4	392.4	CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C	Ki = 437000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B4QG5Z	4-[4-[1-(4-Hydroxy-4,4-diphenylbutyl)piperidin-4-yl]piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797389	C42H54Cl2N2O2	689.8	C1CN(CCC1C2CCN(CC2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCCC(C5=CC=CC=C5)(C6=CC=CC=C6)O.Cl.Cl	Ki = 1260000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B5DKA3	(4-Hydroxy-4,4-diphenylbutyl)-[3-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]propyl]-dimethylazanium;diiodide	Investigative	44448418	C39H52I2N2O2	834.6	C[N+](C)(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCC[N+](C)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-].[I-]	Ki = 138000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B5HRN9	Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide	Investigative	44422691	C9H20INO2	301.17	CC1COCC(O1)C[N+](C)(C)C.[I-]	EC50 = 2040000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B6N0GH	Methyl 4-(2-benzamidoethylamino)bicyclo[2.2.2]octane-1-carboxylate	Investigative	70685669	C19H26N2O3	330.4	COC(=O)C12CCC(CC1)(CC2)NCCNC(=O)C3=CC=CC=C3	EC50 = 6200000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B7GB0M	Ethyl (1S,5R)-3-[2-[(3-fluoro-4-methylbenzoyl)amino]ethylamino]-8-azabicyclo[3.2.1]octane-8-carboxylate	Investigative	70689860	C20H28FN3O3	377.5	CCOC(=O)N1[C@@H]2CC[C@H]1CC(C2)NCCNC(=O)C3=CC(=C(C=C3)C)F	EC50 = 470000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B8I6ZL	(-)-(R)-2-(3-(1-(1H-Pyrazol-1-yl)ethyl)benzo[b]thiophen-2-yl)-N,N-dimethylethanamine	Investigative	46830289	C17H21N3S	299.4	C[C@H](C1=C(SC2=CC=CC=C21)CCN(C)C)N3C=CC=N3	Ki > 10000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B8JN9T	1,1-Diphenyl-4-piperazin-1-ylbutan-1-ol;dihydrochloride	Investigative	49797395	C20H28Cl2N2O	383.4	C1CN(CCN1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl.Cl	Ki = 1660000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B9C0OK	4-[3-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]propyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797388	C37H48Cl2N2O2	623.7	CN(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCCN(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 741000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	B9O7SZ	(-)-(R)-N,N-Dimethyl-2-(3-(1-(thiazol-5-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine	Investigative	46884202	C17H20N2S2	316.5	C[C@@H](C1=CN=CS1)C2=C(SC3=CC=CC=C32)CCN(C)C	Ki > 10000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BB5IA1	Ethyl (4aS,8aS)-1-(2-benzamidoethyl)-2,3,4,4a,5,7,8,8a-octahydro-1,6-naphthyridine-6-carboxylate	Investigative	70683564	C20H29N3O3	359.5	CCOC(=O)N1CC[C@H]2[C@H](C1)CCCN2CCNC(=O)C3=CC=CC=C3	EC50 = 3200000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BBRO92	Ethyl (1S,5R)-6-[2-[(2-methylbenzoyl)amino]ethylamino]-3-azabicyclo[3.1.0]hexane-3-carboxylate	Investigative	70687825	C18H25N3O3	331.4	CCOC(=O)N1C[C@@H]2[C@H](C1)C2NCCNC(=O)C3=CC=CC=C3C	EC50 = 4100000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BCA76V	(4-Hydroxy-4,4-diphenylbutyl)-[2-[(4-hydroxy-4,4-diphenylbutyl)-dimethylazaniumyl]ethyl]-dimethylazanium;diiodide	Investigative	44448456	C38H50I2N2O2	820.6	C[N+](C)(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CC[N+](C)(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-].[I-]	Ki = 38000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BCAJ53	1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride	Investigative	49797392	C26H31ClN2O	423	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C4=CC=CC=C4.Cl	Ki = 2750000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BE7M1V	4-(4,4-Dimethylpiperazin-4-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448537	C22H31IN2O	466.4	C[N+]1(CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C.[I-]	Ki = 339000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BEZJ94	4-(1-Methyl-4-phenylpiperazin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448495	C27H33IN2O	528.5	C[N+]1(CCN(CC1)C2=CC=CC=C2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.[I-]	Ki = 57500000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BF31XV	(-)-(R)-N,N-Dimethyl-2-(3-(1-(thiazol-4-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine	Investigative	46884201	C17H20N2S2	316.5	C[C@@H](C1=CSC=N1)C2=C(SC3=CC=CC=C32)CCN(C)C	Ki = 4759000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BITE13	6-Acetoxy-8-methyl-8-azonia-bicyclo[3.2.1]octane	Investigative	10035281	C10H17NO2	183.25	CC(=O)OC1CC2CCCC1N2C	Ki = 281838.29 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BJ98XO	Ethyl (4aR,8aS)-1-(2-benzamidoethyl)-2,3,4,4a,5,7,8,8a-octahydro-1,6-naphthyridine-6-carboxylate	Investigative	70685670	C20H29N3O3	359.5	CCOC(=O)N1CC[C@H]2[C@@H](C1)CCCN2CCNC(=O)C3=CC=CC=C3	EC50 = 1200000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BM6Q1Z	Diphenidol hydrochloride	Investigative	66266	C21H28ClNO	345.9	C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl	Ki = 2340000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BO5EF9	Acid red 52	Investigative	9916275	C27H29N2NaO7S2	580.7	CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](CC)CC)C=C3O2)C4=C(C=C(C=C4)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+]	Ki > 1000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BP2VC7	4-[4-(4-Hydroxy-4,4-diphenylbutyl)piperazin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797391	C36H44Cl2N2O2	607.6	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)CCCC(C4=CC=CC=C4)(C5=CC=CC=C5)O.Cl.Cl	Ki = 1170000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BR7AM0	Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate	Investigative	25010776	C18H27N3O3	333.4	CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C	EC50 = 1600000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BRC7N9	4-(4-Methylpiperazin-1-yl)-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797394	C21H30Cl2N2O	397.4	CN1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.Cl.Cl	Ki = 129000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BVL56C	1-Methyl-5-(4-(2-(2-(2-(2-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)-1,2,3,6-tetrahydropyridine	Investigative	9809330	C24H36N6O5S2	552.7	CN1CCC=C(C1)C2=NSN=C2OCCOCCOCCOCCOC3=NSN=C3C4=CCCN(C4)C	Ki = 10000000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BX84RC	4-(1-Methylpiperidin-1-ium-1-yl)-1,1-diphenylbutan-1-ol;iodide	Investigative	44448645	C22H30INO	451.4	C[N+]1(CCCCC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O.[I-]	Ki = 5010000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BZD1R6	4-[4-(1-Methylpiperidin-4-yl)piperidin-1-yl]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797387	C27H40Cl2N2O	479.5	CN1CCC(CC1)C2CCN(CC2)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 174000000000000 nM	Non binder
T28893	Muscarinic acetylcholine receptor M1	BZGE23	Rac-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine	Investigative	11623845	C17H20N2S2	316.5	CC(C1=C(SC2=CC=CC=C21)CCN(C)C)C3=NC=CS3	Ki = 2072000 nM	Non binder