TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T30372	Trypanosoma Cruzipain	D0AZ3C	Imatinib	Approved	5291	C29H31N7O	493.6	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5	IC50 = 207000 nM	Non binder
T30372	Trypanosoma Cruzipain	D0BP9C	Etravirine	Approved	193962	C20H15BrN6O	435.3	CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N	IC50 > 200000 nM	Non binder
T30372	Trypanosoma Cruzipain	B13CKZ	5-[(E)-[(3-Nitrobenzoyl)hydrazinylidene]methyl]furan-2-carboxylic acid	Investigative	44285453	C13H9N3O6	303.23	C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)N/N=C/C2=CC=C(O2)C(=O)O	IC50 = 3020000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B1KY2S	N-[(E)-Furan-3-ylmethylideneamino]-2,4-dimethoxybenzamide	Investigative	44285357	C14H14N2O4	274.27	COC1=CC(=C(C=C1)C(=O)N/N=C/C2=COC=C2)OC	IC50 = 6030000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B1O5GS	3-Hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]naphthalene-2-carboxamide	Investigative	6898835	C16H11N3O5	325.27	C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC=C(O3)[N+](=O)[O-])O	IC50 = 166000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B1QPS5	{[(Benzylsulfonyl)amino]methyl}boronic Acid	Investigative	49837085	C8H12BNO4S	229.07	B(CNS(=O)(=O)CC1=CC=CC=C1)(O)O	IC50 > 500000 nM	Non binder
T30372	Trypanosoma Cruzipain	B1Z8DJ	Potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate	Investigative	4234241	C11H15KOS2	266.5	C1CC2C(C1)C3CC2CC3OC(=S)[S-].[K+]	IC50 > 600000 nM	Non binder
T30372	Trypanosoma Cruzipain	B23WMV	3-Nitro-N'-({5-nitro-2-furyl}methylene)benzohydrazide	Investigative	6893983	C12H8N4O6	304.21	C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-]	IC50 = 200000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B2MS7J	2-[1-Carboxy-2-(4-hydroxyphenyl)ethyl]-1,3-dioxoisoindoline-5-carboxylic acid	Investigative	3239413	C18H13NO7	355.3	C1=CC(=CC=C1CC(C(=O)O)N2C(=O)C3=C(C2=O)C=C(C=C3)C(=O)O)O	IC50 > 10000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B5ECQ9	N-[(E)-(4-Bromothiophen-2-yl)methylideneamino]quinoline-3-carboxamide	Investigative	44285294	C15H10BrN3OS	360.2	C1=CC=C2C(=C1)C=C(C=N2)C(=O)N/N=C/C3=CC(=CS3)Br	IC50 = 33100000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B82SIA	Sporanox	Investigative	3793	C35H38Cl2N8O4	705.6	CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl	IC50 > 200000 nM	Non binder
T30372	Trypanosoma Cruzipain	B8ZC1O	N-[(E)-[4-(Dimethylamino)naphthalen-1-yl]methylideneamino]-3,4-dihydroxybenzamide	Investigative	44285306	C20H19N3O3	349.4	CN(C)C1=CC=C(C2=CC=CC=C21)/C=N/NC(=O)C3=CC(=C(C=C3)O)O	IC50 = 61700000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B9F1HU	2-Hydroxy-benzoic acid [5-(4-chloro-phenyl)-furan-2-ylmethylene]-hydrazide	Investigative	6868805	C18H13ClN2O3	340.8	C1=CC=C(C(=C1)C(=O)N/N=C/C2=CC=C(O2)C3=CC=C(C=C3)Cl)O	IC50 = 10000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	B9NR0Y	Chembl4208600	Investigative	145963780	C24H27N3O4	421.5	CNC(=O)/C=C/C1(CC1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	Ki = 398107.17 nM	Non binder
T30372	Trypanosoma Cruzipain	BD25VN	3-Hydroxy-7-methoxy-N-[(E)-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophen-2-yl]methylideneamino]naphthalene-2-carboxamide	Investigative	10480017	C22H17F3N4O3S	474.5	CN1C(=CC(=N1)C(F)(F)F)C2=CC=C(S2)/C=N/NC(=O)C3=C(C=C4C=CC(=CC4=C3)OC)O	IC50 = 5010000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BD9KB8	Amiodarone hydrochloride	Investigative	441325	C25H30ClI2NO3	681.8	CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl	IC50 = 206000 nM	Non binder
T30372	Trypanosoma Cruzipain	BE0TY7	Menatetrenone	Investigative	5282367	C31H40O2	444.6	CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\\C)/CC/C=C(\\C)/CC/C=C(\\C)/CCC=C(C)C	IC50 > 200000 nM	Non binder
T30372	Trypanosoma Cruzipain	BFN59Z	3,7-Bis(4-methoxybenzoyl)-1-methyl-5-propyl-3,7-diazabicyclo[3.3.1]nonan-9-one	Investigative	1305492	C27H32N2O5	464.6	CCCC12CN(CC(C1=O)(CN(C2)C(=O)C3=CC=C(C=C3)OC)C)C(=O)C4=CC=C(C=C4)OC	IC50 > 600000 nM	Non binder
T30372	Trypanosoma Cruzipain	BH2U9C	[(2,5-Dichlorophenyl)carbamoyl]methyl 3-methylbenzoate	Investigative	1670121	C16H13Cl2NO3	338.2	CC1=CC(=CC=C1)C(=O)OCC(=O)NC2=C(C=CC(=C2)Cl)Cl	IC50 > 200000 nM	Non binder
T30372	Trypanosoma Cruzipain	BH4T7Z	5-[(E)-[(3,5-Dimethoxybenzoyl)hydrazinylidene]methyl]furan-2-carboxylic acid	Investigative	44285805	C15H14N2O6	318.28	COC1=CC(=CC(=C1)C(=O)N/N=C/C2=CC=C(O2)C(=O)O)OC	IC50 = 100000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BH8EC7	2-Hydroxy-N'-{(E)-[5-(2-nitrophenyl)furan-2-yl]methylidene}benzohydrazide	Investigative	6868806	C18H13N3O5	351.3	C1=CC=C(C(=C1)C2=CC=C(O2)/C=N/NC(=O)C3=CC=CC=C3O)[N+](=O)[O-]	IC50 = 50100000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BKN21G	2-Hydroxy-3-methyl-N-[(E)-(5-methylsulfanylthiophen-2-yl)methylideneamino]benzamide	Investigative	44285853	C14H14N2O2S2	306.4	CC1=C(C(=CC=C1)C(=O)N/N=C/C2=CC=C(S2)SC)O	IC50 = 100000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BL03JX	N-[(E)-[5-(2-Chlorophenyl)furan-2-yl]methylideneamino]-3-hydroxynaphthalene-2-carboxamide	Investigative	44285654	C22H15ClN2O3	390.8	C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC=C(O3)C4=CC=CC=C4Cl)O	IC50 = 1660000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BLF45G	2-(2,5-Dichlorophenylamino)-2-oxoethyl picolinate	Investigative	1088642	C14H10Cl2N2O3	325.1	C1=CC=NC(=C1)C(=O)OCC(=O)NC2=C(C=CC(=C2)Cl)Cl	IC50 > 200000 nM	Non binder
T30372	Trypanosoma Cruzipain	BOC0A6	2-(2,5-Dimethyl-pyrrol-1-yl)-3-phenyl-propionic acid	Investigative	654761	C15H17NO2	243.3	CC1=CC=C(N1C(CC2=CC=CC=C2)C(=O)O)C	IC50 > 600000 nM	Non binder
T30372	Trypanosoma Cruzipain	BPM0W5	2-Hydroxy-N'-[(E)-quinolin-4-ylmethylidene]benzohydrazide	Investigative	6891142	C17H13N3O2	291.3	C1=CC=C2C(=C1)C(=CC=N2)/C=N/NC(=O)C3=CC=CC=C3O	IC50 = 33100000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BQ8VY5	N-[(E)-[5-(3-Nitrophenyl)furan-2-yl]methylideneamino]naphthalene-2-carboxamide	Investigative	44285672	C22H15N3O4	385.4	C1=CC=C2C=C(C=CC2=C1)C(=O)N/N=C/C3=CC=C(O3)C4=CC(=CC=C4)[N+](=O)[O-]	IC50 = 166000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BRAT36	N-[(E)-[4-(Dimethylamino)naphthalen-1-yl]methylideneamino]quinoline-4-carboxamide	Investigative	44285321	C23H20N4O	368.4	CN(C)C1=CC=C(C2=CC=CC=C21)/C=N/NC(=O)C3=CC=NC4=CC=CC=C34	IC50 = 166000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BTJZ82	N-[(E)-[4-(Dimethylamino)naphthalen-1-yl]methylideneamino]benzamide	Investigative	44285305	C20H19N3O	317.4	CN(C)C1=CC=C(C2=CC=CC=C21)/C=N/NC(=O)C3=CC=CC=C3	IC50 = 2000000000000000 nM	Non binder
T30372	Trypanosoma Cruzipain	BTMB89	4-({[(Dihydroxyboranyl)methyl]sulfamoyl}methyl)benzoic Acid	Investigative	49837191	C9H12BNO6S	273.08	B(CNS(=O)(=O)CC1=CC=C(C=C1)C(=O)O)(O)O	IC50 > 500000 nM	Non binder