TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T30420	SET domain containing 8	B0Q8EH	6,7-Dimethoxy-2-N-methyl-2-N,4-N-bis(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191705	C29H48N6O2	512.7	CN(CCCCCN1CCCC1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B10YHG	6,7-Dimethoxy-N-methyl-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	118708799	C24H37N5O2	427.6	CN(CCCCCN1CCCC1)C2=NC(=NC3=CC(=C(C=C32)OC)OC)N4CCCC4	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B1GX6C	6,7-Dimethoxy-2-N-(4-nitrophenyl)-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191712	C25H32N6O4	480.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B2CKR6	2-N-Cyclohexyl-6,7-dimethoxy-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	118708808	C25H39N5O2	441.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3CCCCC3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B3Q8YP	N-(5-Pyrrolizinopentyl)-2-pyrrolizino-7-methoxyquinazoline-4-amine	Investigative	101882828	C22H33N5O	383.5	COC1=CC2=C(C=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B4E9XS	6,7-Dimethoxy-2-piperazin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	118708803	C23H36N6O2	428.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCNCC3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B4K3IC	6,7-Dimethoxy-2-N-(4-methoxyphenyl)-2-N-methyl-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191707	C27H37N5O3	479.6	CN(C1=CC=C(C=C1)OC)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B4VF8U	6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	118708804	C24H38N6O2	442.6	CN1CCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B6CGH2	2-N-(4-Fluorophenyl)-6,7-dimethoxy-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191716	C25H32FN5O2	453.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3=CC=C(C=C3)F)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B7QR8H	6,7-Dimethoxy-2-N-phenyl-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191709	C25H33N5O2	435.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3=CC=CC=C3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B81NSO	2-(Azepan-1-yl)-6,7-dimethoxy-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	118708801	C25H39N5O2	441.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCCCC3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B89ANS	N-(5-Pyrrolizinopentyl)-2-pyrrolizinoquinazoline-4-amine	Investigative	101882836	C21H31N5	353.5	C1CCN(C1)CCCCCNC2=NC(=NC3=CC=CC=C32)N4CCCC4	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B9DCN3	2-[(6,7-Dimethoxy-2-pyrrolidin-1-ylquinazolin-4-yl)amino]-N-[2-(4-methylpiperazin-1-yl)ethyl]acetamide	Investigative	122191351	C23H35N7O3	457.6	CN1CCN(CC1)CCNC(=O)CNC2=NC(=NC3=CC(=C(C=C32)OC)OC)N4CCCC4	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	B9GZL2	2-[(6,7-Dimethoxy-2-pyrrolidin-1-ylquinazolin-4-yl)amino]-N-(2-pyrrolidin-1-ylethyl)acetamide	Investigative	122191698	C22H32N6O3	428.5	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCC(=O)NCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BAER10	6,7-Dimethoxy-2-N-(4-methoxyphenyl)-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191710	C26H35N5O3	465.6	COC1=CC=C(C=C1)NC2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BAY8J5	6,7-Dimethoxy-N-(5-pyrrolidin-1-ylpentyl)-2-[4-(trifluoromethyl)phenyl]quinazolin-4-amine	Investigative	122191715	C26H31F3N4O2	488.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=C(C=C3)C(F)(F)F)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BCF56R	4-N-(6,7-Dimethoxy-2-pyrrolidin-1-ylquinazolin-4-yl)cyclohexane-1,4-diamine	Investigative	122191695	C20H29N5O2	371.5	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NC4CCC(CC4)N)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BHA34K	2-Chloro-6,7-dimethoxy-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	118708809	C19H27ClN4O2	378.9	COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)NCCCCCN3CCCC3)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BIS24G	6,7-Dimethoxy-2-N-methyl-2-N-(2-pyrrolidin-1-ylethyl)-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191702	C26H42N6O2	470.7	CN(CCN1CCCC1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BJ1L9W	N-[4-(Aminomethyl)cyclohexyl]-6,7-dimethoxy-2-pyrrolidin-1-ylquinazolin-4-amine	Investigative	122191696	C21H31N5O2	385.5	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NC4CCC(CC4)CN)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BJE8N4	6,7-Dimethoxy-2-(4-methoxyphenyl)-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	122191714	C26H34N4O3	450.6	COC1=CC=C(C=C1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BL1M5F	2-N-Cyclopentyl-6,7-dimethoxy-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	118708807	C24H37N5O2	427.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3CCCC3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BN42IW	N-(5-Pyrrolizinopentyl)-2-pyrrolizino-6-methoxy-7-hydroxyquinazoline-4-amine	Investigative	136845639	C22H33N5O2	399.5	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)O	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BP5TH6	6,7-Dimethoxy-4-N-(5-pyrrolidin-1-ylpentyl)-2-N-[4-(trifluoromethyl)phenyl]quinazoline-2,4-diamine	Investigative	122191711	C26H32F3N5O2	503.6	COC1=C(C=C2C(=C1)C(=NC(=N2)NC3=CC=C(C=C3)C(F)(F)F)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BP6F4W	6,7-Dimethoxy-2-N-methyl-2-N-phenyl-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191706	C26H35N5O2	449.6	CN(C1=CC=CC=C1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BQB96T	2-[(6,7-Dimethoxy-2-pyrrolidin-1-ylquinazolin-4-yl)amino]-N-(2-piperazin-1-ylethyl)acetamide	Investigative	122191699	C22H33N7O3	443.5	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCC(=O)NCCN4CCNCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BQJS95	6,7-Dimethoxy-2-phenyl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine	Investigative	122191713	C25H32N4O2	420.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)NCCCCCN4CCCC4)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BTIK35	6,7-Dimethoxy-2-N-methyl-2-N-(4-pyrrolidin-1-ylbutyl)-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191704	C28H46N6O2	498.7	CN(CCCCN1CCCC1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BUM06I	6,7-Dimethoxy-2-N-methyl-2-N-(4-nitrophenyl)-4-N-(5-pyrrolidin-1-ylpentyl)quinazoline-2,4-diamine	Investigative	122191708	C26H34N6O4	494.6	CN(C1=CC=C(C=C1)[N+](=O)[O-])C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder
T30420	SET domain containing 8	BWL71J	6,7-Dimethoxy-2-N-methyl-4-N-(5-pyrrolidin-1-ylpentyl)-2-N-(3-pyrrolidin-1-ylpropyl)quinazoline-2,4-diamine	Investigative	122191703	C27H44N6O2	484.7	CN(CCCN1CCCC1)C2=NC3=CC(=C(C=C3C(=N2)NCCCCCN4CCCC4)OC)OC	IC50 > 250000 nM	Non binder