TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T52450	Matrix metalloproteinase-1	B01CEJ	(1R,2S)-1-({3-Fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide	Investigative	25138228	C28H24FN3O4	485.5	C1[C@@H]([C@@]1(CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F)C(=O)N)C(=O)NO	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B09XSF	Hydroxamate deriv., 78	Investigative	24799779	C23H23N3O4	405.4	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)C[C@@]4(C[C@@H]4C(=O)NO)C(=O)N	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B0BMJ6	Benzyl N-[(4R)-4-[[4-(4-cyano-2-methylphenyl)piperazin-1-yl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate	Investigative	127026888	C25H32N6O6S	544.6	CC1=C(C=CC(=C1)C#N)N2CCN(CC2)S(=O)(=O)N[C@H](CCCNC(=O)OCC3=CC=CC=C3)C(=O)NO	IC50 > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B0U3TW	N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonyl(methyl)amino]acetamide	Investigative	72714083	C16H16Br2N2O5S	508.2	CN(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OCC2=CC(=CC(=C2)Br)Br	IC50 > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B16HKB	3-Hydroxy-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10492779	C7H11N5O3S2	277.3	CNC(=O)[C@H](CO)NC(=O)NC1=NNC(=S)S1	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B1FHG0	N-[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-isonicotinamide	Investigative	44324656	C21H19N3O6S	441.5	C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)C[C@H](C(=O)NO)NC(=O)C3=CC=NC=C3	IC50 = 900000 nM	Non binder
T52450	Matrix metalloproteinase-1	B1M9YH	(S)-2-(Benzyl-methyl-amino)-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-propionamide	Investigative	9889449	C23H24N2O5S	440.5	CN(CC1=CC=CC=C1)[C@H](CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)NO	IC50 = 475000 nM	Non binder
T52450	Matrix metalloproteinase-1	B1W8UQ	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581111	C30H28N2O5	496.6	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B2AW8L	(1R,2S)-Ethyl 2-(hydroxycarbamoyl)-1-(4-((2-methylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxylate	Investigative	44581071	C25H26N2O5	434.5	CCOC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B2IFY8	2-(Tosylamino)-3-[4-(phenylthio)phenylsulfonyl]propanehydroximic acid	Investigative	21130574	C22H22N2O6S3	506.6	CC1=CC=C(C=C1)S(=O)(=O)NC(CS(=O)(=O)C2=CC=C(C=C2)SC3=CC=CC=C3)C(=O)NO	IC50 = 600000 nM	Non binder
T52450	Matrix metalloproteinase-1	B2QG1F	N-[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-2,6-dimethoxy-benzamide	Investigative	44324546	C24H24N2O8S	500.5	COC1=C(C(=CC=C1)OC)C(=O)N[C@H](CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)NO	IC50 = 350000 nM	Non binder
T52450	Matrix metalloproteinase-1	B35BLH	4-[4-[2-(Diethylamino)ethoxy]phenyl]-N-hydroxy-2-[(7-methyl-2-oxochromen-3-yl)methyl]butanamide	Investigative	15986261	C27H34N2O5	466.6	CCN(CC)CCOC1=CC=C(C=C1)CCC(CC2=CC3=C(C=C(C=C3)C)OC2=O)C(=O)NO	IC50 = 557000 nM	Non binder
T52450	Matrix metalloproteinase-1	B3K4BP	Chembl4171886	Investigative	145950074	C12H15N3O7S	345.33	CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	B3YB7F	N-Hydroxy-2-[4-(8-quinolylmethoxy)phenylsulfonylamino]acetamide	Investigative	72713868	C18H17N3O5S	387.4	C1=CC2=C(C(=C1)COC3=CC=C(C=C3)S(=O)(=O)NCC(=O)NO)N=CC=C2	IC50 = 620000 nM	Non binder
T52450	Matrix metalloproteinase-1	B4OJT9	2-(Acetylamino)-3-(4-methoxyphenylsulfonyl)propanehydroximic acid	Investigative	18512733	C12H16N2O6S	316.33	CC(=O)NC(CS(=O)(=O)C1=CC=C(C=C1)OC)C(=O)NO	IC50 = 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	B4QEH7	(2R)-2-[(3R)-3-Amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-3-methylbutanamide	Investigative	53320639	C26H30N4O4	462.5	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)[C@@]4(CCN(C4=O)[C@H](C(C)C)C(=O)NO)N	IC50 = 4926000 nM	Non binder
T52450	Matrix metalloproteinase-1	B4XD6J	(R)-N-Methyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10854448	C13H15N5O2S2	337.4	CNC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)NC2=NNC(=S)S2	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B52VLK	N-[1-(Phenoxymethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid	Investigative	21700204	C23H20N2O4	388.4	C1=CC=C(C=C1)OCC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B61GXD	((4S,5S)-2-Benzyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol	Investigative	10262798	C13H15NO2	217.26	C=C[C@H]1[C@@H](N=C(O1)CC2=CC=CC=C2)CO	Ki > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	B62HUJ	(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid	Investigative	2140735	C17H13NO5S2	375.4	COC1=CC=C(C=C1)C2=CC=C(O2)/C=C/3\\C(=O)N(C(=S)S3)CC(=O)O	IC50 = 860000 nM	Non binder
T52450	Matrix metalloproteinase-1	B6C9GT	2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane	Investigative	9883002	C15H14O3S2	306.4	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki = 206000 nM	Non binder
T52450	Matrix metalloproteinase-1	B6WC8Y	N-[1-[4-(4-Cyanophenyl)phenoxy]-3-(4-fluorophenyl)propan-2-yl]-N-hydroxyformamide	Investigative	21699983	C23H19FN2O3	390.4	C1=CC(=CC=C1CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)F	IC50 = 14000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B70BNL	(2R)-5-[(Aminocarbonyl)amino]-2-[[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonyl]amino]-N-hydroxy-pentanamide	Investigative	72714324	C19H22Br2N4O6S	594.3	C1=CC(=CC=C1OCC2=CC(=CC(=C2)Br)Br)S(=O)(=O)N[C@H](CCCNC(=O)N)C(=O)NO	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	B71YOW	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-3-methylbutyl]formhydroxamic acid	Investigative	21700004	C20H22N2O3	338.4	CC(C)CC(COC1=CC=C(C=C1)C2=CC=C(C=C2)C#N)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B7L6VX	Chembl4160618	Investigative	145956426	C11H13N3O7S	331.3	C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)N[C@@H](CCC(=O)N)C(=O)O	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	B7ZPB6	[(4S,5S)-2-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol	Investigative	44394821	C12H12ClNO2	237.68	C=C[C@H]1[C@@H](N=C(O1)C2=CC=C(C=C2)Cl)CO	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	B83XTH	(2R)-N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]-4-(benzyloxycarbonylamino)butyramide	Investigative	72714322	C25H25Br2N3O7S	671.4	C1=CC=C(C=C1)COC(=O)NCC[C@H](C(=O)NO)NS(=O)(=O)C2=CC=C(C=C2)OCC3=CC(=CC(=C3)Br)Br	IC50 = 400000 nM	Non binder
T52450	Matrix metalloproteinase-1	B86BFX	N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide	Investigative	24881245	C17H26N4O4	350.4	CC(C)C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)NC(=O)NO	IC50 > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8JE1T	3-(4-(2-Oxo-2H-chromen-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzoic acid	Investigative	4085085	C19H12N2O4S	364.4	C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN(C(=S)N3)C4=CC=CC(=C4)C(=O)O	IC50 = 400000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8PZL2	N-Hydroxy-2-[[4-[[3-(trifluoromethoxy)phenyl]methoxy]phenyl]sulfonylamino]acetamide	Investigative	72713866	C16H15F3N2O6S	420.4	C1=CC(=CC(=C1)OC(F)(F)F)COC2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8R9AG	D-Leucyl-L-phenylalanine methylamide	Investigative	15296844	C16H25N3O2	291.39	CC(C)C[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)N	IC50 > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8RO3G	(1S,2R)-2-Cyano-N-hydroxy-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	11575995	C28H23N3O3	449.5	C1[C@@H]([C@@]1(CC2=CC=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)C#N)C(=O)NO	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8S0EX	{(4S,5S)-2-[2-(4-Bromo-phenyl)-vinyl]-5-vinyl-4,5-dihydro-oxazol-4-yl}-methanol	Investigative	44394601	C14H14BrNO2	308.17	C=C[C@H]1[C@@H](N=C(O1)/C=C/C2=CC=C(C=C2)Br)CO	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	B8SPR3	Thioacetic acid S-[(4S,5S)-2-(4-bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester	Investigative	44394668	C13H12BrNO2S	326.21	CC(=O)S[C@H]1[C@@H](OC(=N1)C2=CC=C(C=C2)Br)C=C	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B92ROM	(S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10758266	C12H13N5O2S2	323.4	C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)NC2=NNC(=S)S2	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	B96CHJ	(4S)-5-[[(2S)-5-[[Amino(nitramido)methylidene]amino]-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-4-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoic acid	Investigative	91867803	C26H47N10O14P	754.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N[N+](=O)[O-])C(=O)NCC(=O)O)NP(=O)(O)OCC	Ki = 270000 nM	Non binder
T52450	Matrix metalloproteinase-1	B9RK1H	2-(Acetylamino)-3-[4-(phenylthio)phenylsulfonyl]propanehydroximic acid	Investigative	18512737	C17H18N2O5S2	394.5	CC(=O)NC(CS(=O)(=O)C1=CC=C(C=C1)SC2=CC=CC=C2)C(=O)NO	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BA3M4C	N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide	Investigative	24881246	C17H26N4O4	350.4	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC)NC(=O)NO	IC50 = 270000 nM	Non binder
T52450	Matrix metalloproteinase-1	BAXL35	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-2-(2,5-dioxo-3,4,4-trimethylimidazolidine-1-yl)ethyl]formhydroxamic acid	Investigative	9932731	C23H24N4O5	436.5	CC1(C(=O)N(C(=O)N1C)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)C	IC50 = 2300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BAZ84D	[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-methyl-carbamic acid tert-butyl ester	Investigative	44325248	C21H26N2O7S	450.5	CC(C)(C)OC(=O)N(C)[C@H](CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 1600000 nM	Non binder
T52450	Matrix metalloproteinase-1	BB5AX6	2-(Benzyloxycarbonylamino)-3-(4-phenoxyphenylsulfonyl)propanehydroximic acid	Investigative	12074756	C23H22N2O7S	470.5	C1=CC=C(C=C1)COC(=O)NC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)NO	IC50 = 1400000 nM	Non binder
T52450	Matrix metalloproteinase-1	BB98UI	3,2-Diguanidinoneamine	Investigative	23645953	C14H30N8O6	406.44	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BBH0Z4	N-[1-(Phthalimidylmethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid	Investigative	21699985	C25H19N3O5	441.4	C1=CC=C2C(=C1)C(=O)N(C2=O)CC(COC3=CC=C(C=C3)C4=CC=C(C=C4)C#N)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BCE62Z	(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine	Investigative	6882342	C24H21N3O2S	415.5	COC1=C(C=C(C=C1)C2=CSC(=NC3=CC=CC=C3)N2/N=C/C4=CC=CC=C4)OC	IC50 = 360000 nM	Non binder
T52450	Matrix metalloproteinase-1	BCS3M4	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-2-(2,5-dioxo-4,4-dimethylimidazolidine-1-yl)ethyl]formhydroxamic acid	Investigative	10342176	C22H22N4O5	422.4	CC1(C(=O)N(C(=O)N1)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)C	IC50 = 2100000 nM	Non binder
T52450	Matrix metalloproteinase-1	BD4I8W	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-3-(2,5-dioxo-3,4,4-trimethylimidazolidine-1-yl)propyl]formhydroxamic acid	Investigative	21700080	C24H26N4O5	450.5	CC1(C(=O)N(C(=O)N1C)CCC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)C	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BE6XK4	N-[1-[4-(4-Cyanophenyl)phenoxy]-3-(3-methyl-6-oxopyridazin-1-yl)propan-2-yl]-N-hydroxyformamide	Investigative	21700151	C22H20N4O4	404.4	CC1=NN(C(=O)C=C1)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O	IC50 = 4200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BE9WV7	N-Hydroxy-2-[[4-[(4-phenylphenyl)methoxy]phenyl]sulfonylamino]acetamide	Investigative	72713863	C21H20N2O5S	412.5	C1=CC=C(C=C1)C2=CC=C(C=C2)COC3=CC=C(C=C3)S(=O)(=O)NCC(=O)NO	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BEU14G	Chembl4175156	Investigative	145949783	C16H23N3O7S	401.4	CCCCCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BF6ZI1	N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide	Investigative	44479458	C20H17NO6S2	431.5	CS(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)C3=CC=CC=C3C(=O)NO	IC50 > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BFZ5I0	Chembl4167291	Investigative	145955226	C15H21N3O7S	387.4	CC(C)CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BGV24B	Neamine guanidinylated deriv. 29	Investigative	23645959	C20H42N12O6	546.6	CO[C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1OC)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)OC)OC)N=C(N)N)N=C(N)N)N=C(N)N	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BH0Q9X	N-Hydroxy-2-[4-[3-bromo-5-(p-anisyl)benzyloxy]phenylsulfonylamino]acetamide	Investigative	72714085	C22H21BrN2O6S	521.4	COC1=CC=C(C=C1)C2=CC(=CC(=C2)COC3=CC=C(C=C3)S(=O)(=O)NCC(=O)NO)Br	IC50 > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BH8EG1	(2S,3S)-2-[[Ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoic acid	Investigative	44325257	C8H18NO5P	239.21	CC[C@H](C)[C@@H](C(=O)O)NP(=O)(O)OCC	Ki = 990000 nM	Non binder
T52450	Matrix metalloproteinase-1	BHJQ09	Dipotassium;(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(oxido)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoate	Investigative	73348408	C19H35K2N4O8P	556.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)[O-])NP(=O)([O-])OCC.[K+].[K+]	Ki = 240000 nM	Non binder
T52450	Matrix metalloproteinase-1	BI1T0K	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-3-(2,5-dioxo-4,4-dimethylimidazolidine-1-yl)propyl]formhydroxamic acid	Investigative	21700160	C23H24N4O5	436.5	CC1(C(=O)N(C(=O)N1)CCC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)C	IC50 = 14000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BI4MG1	(S)-N-Hydroxy-2-methylamino-3-(4-phenoxy-benzenesulfonyl)-propionamide	Investigative	44324646	C16H18N2O5S	350.4	CN[C@H](CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 440000 nM	Non binder
T52450	Matrix metalloproteinase-1	BI71JR	Chembl4210206	Investigative	23729138	C21H19NO3S	365.4	COC1=CC=C(C=C1)C2=CC=C(C=C2)SC3=CC=CC=C3CC(=O)NO	IC50 = 250000 nM	Non binder
T52450	Matrix metalloproteinase-1	BJ7L5D	N-[1-(4'-Cyano-4-biphenylyloxymethyl)-2-(2,5-dioxo-3-ethyl-4,4-dimethylimidazolidine-1-yl)ethyl]formhydroxamic acid	Investigative	10253223	C24H26N4O5	450.5	CCN1C(=O)N(C(=O)C1(C)C)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O	IC50 = 2400000 nM	Non binder
T52450	Matrix metalloproteinase-1	BJ9E3I	N-[1-(2,6-Dioxo-4,4-dimethylpiperidinomethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid	Investigative	21700163	C24H25N3O5	435.5	CC1(CC(=O)N(C(=O)C1)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O)C	IC50 = 360000 nM	Non binder
T52450	Matrix metalloproteinase-1	BJKR07	3-(4''-Cyanobiphenyl-4-yloxy)-N-hydroxy-2-methylpropanamide	Investigative	44286466	C17H16N2O3	296.32	CC(COC1=CC=C(C=C1)C2=CC=C(C=C2)C#N)C(=O)NO	IC50 = 2500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BJW37Y	N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]acetamide	Investigative	72714082	C15H14Br2N2O5S	494.2	C1=CC(=CC=C1OCC2=CC(=CC(=C2)Br)Br)S(=O)(=O)NCC(=O)NO	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BK2ZL3	Neamine guanidinylated deriv. 4	Investigative	9957228	C16H34N12O6	490.5	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN=C(N)N)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BK50SN	(2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-5-[[amino(nitramido)methylidene]amino]pentanoic acid	Investigative	44324826	C24H45N10O12P	696.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N[N+](=O)[O-])C(=O)O)NP(=O)(O)OCC	Ki = 1900000 nM	Non binder
T52450	Matrix metalloproteinase-1	BK8OU2	2-(Tert-Butoxycarbonylamino)-3-(4-methoxyphenylsulfonyl)propanehydroximic acid	Investigative	18368975	C15H22N2O7S	374.4	CC(C)(C)OC(=O)NC(CS(=O)(=O)C1=CC=C(C=C1)OC)C(=O)NO	IC50 = 1500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BKCH95	N-Hydroxy-2-[4-[3-bromo-5-(3-pyridyl)benzyloxy]phenylsulfonylamino]acetamide	Investigative	72711513	C20H18BrN3O5S	492.3	C1=CC(=CN=C1)C2=CC(=CC(=C2)COC3=CC=C(C=C3)S(=O)(=O)NCC(=O)NO)Br	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BKJS91	(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol	Investigative	44394595	C11H10BrNOS	284.17	C=C[C@H]1[C@@H](N=C(O1)C2=CC=C(C=C2)Br)S	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BKO9T8	(S)-N,N-Dimethyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10807861	C14H17N5O2S2	351.5	CN(C)C(=O)[C@H](CC1=CC=CC=C1)NC(=O)NC2=NNC(=S)S2	Ki = 226000 nM	Non binder
T52450	Matrix metalloproteinase-1	BL58TM	Chembl4162521	Investigative	145957734	C15H21N3O7S	387.4	CCCCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BM1RH2	2-(Acetylamino)-3-(4-phenoxyphenylsulfonyl)propanehydroximic acid	Investigative	12074753	C17H18N2O6S	378.4	CC(=O)NC(CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 770000 nM	Non binder
T52450	Matrix metalloproteinase-1	BM7Y9R	2-(Tosylamino)-3-(4-phenoxyphenylsulfonyl)propanehydroximic acid	Investigative	21130572	C22H22N2O7S2	490.6	CC1=CC=C(C=C1)S(=O)(=O)NC(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3)C(=O)NO	IC50 = 400000 nM	Non binder
T52450	Matrix metalloproteinase-1	BMD31S	N-[2-[4-(4-Cyanophenyl)phenoxy]-1-(4-fluorophenyl)ethyl]-N-hydroxyformamide	Investigative	21700191	C22H17FN2O3	376.4	C1=CC(=CC=C1C#N)C2=CC=C(C=C2)OCC(C3=CC=C(C=C3)F)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BN4Z6M	{[1-Hydroxycarbamoyl-2-(4-phenylsulfanyl-benzenesulfonyl)-ethylcarbamoyl]-methyl}-carbamic acid benzyl ester	Investigative	12074758	C25H25N3O7S2	543.6	C1=CC=C(C=C1)COC(=O)NCC(=O)NC(CS(=O)(=O)C2=CC=C(C=C2)SC3=CC=CC=C3)C(=O)NO	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BO08GV	(S)-N-Hydroxy-2-[methyl-(2-pyridin-4-yl-acetyl)-amino]-3-(4-phenoxy-benzenesulfonyl)-propionamide	Investigative	44325233	C23H23N3O6S	469.5	CN([C@H](CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO)C(=O)CC3=CC=NC=C3	IC50 = 258000 nM	Non binder
T52450	Matrix metalloproteinase-1	BO54DN	N-[1-(Phenylthiomethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid	Investigative	21700038	C23H20N2O3S	404.5	C1=CC=C(C=C1)SCC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O	IC50 = 4100000 nM	Non binder
T52450	Matrix metalloproteinase-1	BO6HQ2	(1R,2S)-1-(3-Fluoro-4-((2-phenylquinolin-4-yl)methoxy)benzyl)-N2-hydroxy-N1,N1-dimethylcyclopropane-1,2-dicarboxamide	Investigative	44580801	C30H28FN3O4	513.6	CN(C)C(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC(=C(C=C2)OCC3=CC(=NC4=CC=CC=C43)C5=CC=CC=C5)F	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BO9WL8	(4s)-3-{[4-(4-Cyano-2-Methylphenyl)piperazin-1-Yl]sulfonyl}-N-Hydroxy-1,3-Thiazolidine-4-Carboxamide	Investigative	117094707	C16H21N5O4S2	411.5	CC1=C(C=CC(=C1)C#N)N2CCN(CC2)S(=O)(=O)N3CSC[C@@H]3C(=O)NO	IC50 = 346000 nM	Non binder
T52450	Matrix metalloproteinase-1	BOPA16	(S)-1-(4-Methyl-1-(methylamino)-1-oxopentan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea	Investigative	10494668	C10H17N5O2S2	303.4	CC(C)C[C@@H](C(=O)NC)NC(=O)NC1=NNC(=S)S1	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BOQ73U	[(S)-1-Hydroxycarbamoyl-2-(4-phenylsulfanyl-benzenesulfonyl)-ethyl]-carbamic acid benzyl ester	Investigative	44324878	C23H22N2O6S2	486.6	C1=CC=C(C=C1)COC(=O)N[C@H](CS(=O)(=O)C2=CC=C(C=C2)SC3=CC=CC=C3)C(=O)NO	IC50 = 8000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BOXP53	(2R)-2-[[4-[4-[(5-Bromo-4-methoxy-3-methyl-1-benzofuran-2-yl)methoxy]phenyl]phenyl]sulfonylamino]-3-methylbutanoic acid	Investigative	11342435	C28H28BrNO7S	602.5	CC1=C(OC2=C1C(=C(C=C2)Br)OC)COC3=CC=C(C=C3)C4=CC=C(C=C4)S(=O)(=O)N[C@H](C(C)C)C(=O)O	IC50 > 400000 nM	Non binder
T52450	Matrix metalloproteinase-1	BQN7T5	N-[1-[4-(4-Cyanophenyl)phenoxy]propan-2-yl]-N-hydroxyformamide	Investigative	10402302	C17H16N2O3	296.32	CC(COC1=CC=C(C=C1)C2=CC=C(C=C2)C#N)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BR28PO	Chembl4163839	Investigative	145959777	C18H19N3O7S	421.4	C1=CC=C(C=C1)CNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BR63CU	N-Hydroxy-2-[4-(3-bromobenzyloxy)phenylsulfonylamino]acetamide	Investigative	72713864	C15H15BrN2O5S	415.3	C1=CC(=CC(=C1)Br)COC2=CC=C(C=C2)S(=O)(=O)NCC(=O)NO	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BRC53V	N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide	Investigative	71682917	C17H19NO4S	333.4	C1C[C@@H]([C@H](C1)O)NS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BS31HJ	N-[[(4,5-Dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine	Investigative	10543975	C12H12N4O3S2	324.4	C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)NC2=NNC(=S)S2	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BSC72X	(1S,2R)-N-Hydroxy-2-((S)-2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-(4-((2-phenylquinolin-4-yl)methoxy)benzyl)cyclopropanecarboxamide	Investigative	44580802	C33H33N3O5	551.6	C1C[C@H](N(C1)C(=O)[C@]2(C[C@@H]2C(=O)NO)CC3=CC=C(C=C3)OCC4=CC(=NC5=CC=CC=C54)C6=CC=CC=C6)CO	Ki > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BSJB18	4-Phenoxy-N-[(1S,2S)-2-sulfanylcyclopentyl]benzamide	Investigative	71683062	C18H19NO2S	313.4	C1C[C@@H]([C@H](C1)S)NC(=O)C2=CC=C(C=C2)OC3=CC=CC=C3	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BSK63Q	Z-L-Leu-L-Phe-OMe	Investigative	13968141	C24H30N2O5	426.5	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)OCC2=CC=CC=C2	IC50 > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BSU85Q	N-[1-(Succinimidylmethyl)-2-(4'-cyano-4-biphenylyloxy)ethyl]formhydroxamic acid	Investigative	21699971	C21H19N3O5	393.4	C1CC(=O)N(C1=O)CC(COC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N(C=O)O	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BTM06O	Chembl4203044	Investigative	145976497	C24H21NO4S	419.5	COC1=CC=C(C=C1)C2=CC=C(C=C2)SC3=CC=CC=C3C4CCC(=O)N(C4=O)O	IC50 = 260000 nM	Non binder
T52450	Matrix metalloproteinase-1	BTY29M	2-Amino-3-[4-(phenylthio)phenylsulfonyl]propanehydroximic acid	Investigative	21130555	C15H16N2O4S2	352.4	C1=CC=C(C=C1)SC2=CC=C(C=C2)S(=O)(=O)CC(C(=O)NO)N	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BU0RG8	[(S)-1-Hydroxycarbamoyl-2-(4-phenylsulfanyl-benzenesulfonyl)-ethyl]-carbamic acid tert-butyl ester	Investigative	44324934	C20H24N2O6S2	452.5	CC(C)(C)OC(=O)N[C@H](CS(=O)(=O)C1=CC=C(C=C1)SC2=CC=CC=C2)C(=O)NO	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BU2K9N	(S)-N-Cyclohexylmethyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide	Investigative	10502187	C19H25N5O2S2	419.6	C1CCC(CC1)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)NC3=NNC(=S)S3	Ki > 200000 nM	Non binder
T52450	Matrix metalloproteinase-1	BU47OQ	2-(Benzyloxycarbonylamino)-3-[4-(phenylthio)phenylsulfonyl]propanehydroximic acid	Investigative	12074757	C23H22N2O6S2	486.6	C1=CC=C(C=C1)COC(=O)NC(CS(=O)(=O)C2=CC=C(C=C2)SC3=CC=CC=C3)C(=O)NO	IC50 > 10000000 nM	Non binder
T52450	Matrix metalloproteinase-1	BU6SW3	(2S)-2-[[Ethoxy(hydroxy)phosphoryl]amino]-4-methylpentanoic acid	Investigative	44324953	C8H18NO5P	239.21	CCOP(=O)(N[C@@H](CC(C)C)C(=O)O)O	Ki = 950000 nM	Non binder
T52450	Matrix metalloproteinase-1	BV71PC	(4S)-5-[[(2S)-1-(Carboxymethylamino)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoic acid	Investigative	44325141	C26H48N9O12P	709.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O)NP(=O)(O)OCC	Ki = 403000 nM	Non binder
T52450	Matrix metalloproteinase-1	BW56EN	2-[[(2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[ethoxy(hydroxy)phosphoryl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetic acid	Investigative	44324822	C26H49N10O11P	708.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O)NP(=O)(O)OCC	Ki = 460000 nM	Non binder
T52450	Matrix metalloproteinase-1	BW5FE4	1,3,2-Triguanidinoneamine	Investigative	11328354	C15H32N10O6	448.48	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N=C(N)N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N=C(N)N)O)O)N=C(N)N	Ki > 300000 nM	Non binder
T52450	Matrix metalloproteinase-1	BW6ND4	2-Amino-3-(4-methoxyphenylsulfonyl)propanehydroximic acid	Investigative	18368941	C10H14N2O5S	274.3	COC1=CC=C(C=C1)S(=O)(=O)CC(C(=O)NO)N	IC50 = 250000 nM	Non binder
T52450	Matrix metalloproteinase-1	BWJ9T2	[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl]methanol	Investigative	15941413	C16H16O4S2	336.4	C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)CO	Ki = 205000 nM	Non binder
T52450	Matrix metalloproteinase-1	BX28NQ	Chembl4164016	Investigative	145960035	C13H17N3O7S	359.36	CCNC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BXH05U	Chembl4170455	Investigative	145956298	C14H19N3O7S	373.38	CC(C)NC(=O)CC[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)[N+](=O)[O-]	IC50 > 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BXUI62	Benzyl N-[(4R)-4-[[4-[(3,5-dibromophenyl)methoxy]phenyl]sulfonylamino]-5-(hydroxyamino)-5-oxopentyl]carbamate	Investigative	72714323	C26H27Br2N3O7S	685.4	C1=CC=C(C=C1)COC(=O)NCCC[C@H](C(=O)NO)NS(=O)(=O)C2=CC=C(C=C2)OCC3=CC(=CC(=C3)Br)Br	IC50 = 370000 nM	Non binder
T52450	Matrix metalloproteinase-1	BZ62KE	[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-carbamic acid tert-butyl ester	Investigative	44324889	C20H24N2O7S	436.5	CC(C)(C)OC(=O)N[C@H](CS(=O)(=O)C1=CC=C(C=C1)OC2=CC=CC=C2)C(=O)NO	IC50 = 500000 nM	Non binder
T52450	Matrix metalloproteinase-1	BZBI17	Thioacetic acid S-((4S,5S)-2-biphenyl-4-yl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester	Investigative	44394758	C19H17NO2S	323.4	CC(=O)S[C@H]1[C@@H](OC(=N1)C2=CC=C(C=C2)C3=CC=CC=C3)C=C	Ki > 400000 nM	Non binder
T52450	Matrix metalloproteinase-1	BZHS15	(S)-2-Acetylamino-N-hydroxy-3-(4-phenylsulfanyl-benzenesulfonyl)-propionamide	Investigative	44324879	C17H18N2O5S2	394.5	CC(=O)N[C@H](CS(=O)(=O)C1=CC=C(C=C1)SC2=CC=CC=C2)C(=O)NO	IC50 = 10000000 nM	Non binder