TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T62449	Checkpoint kinase-1	B21HTI	6-(5-Methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	49797938	C13H11N7	265.27	CC1=C(C=NN1)C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 66069344.8 nM	Non binder
T62449	Checkpoint kinase-1	B2BIU1	(4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanol	Investigative	49797814	C16H13N5O	291.31	C1=CC(=CC=C1CO)C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 25703957.83 nM	Non binder
T62449	Checkpoint kinase-1	B2WX0H	3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)aniline	Investigative	49797811	C15H12N6	276.3	C1=CC(=CC(=C1)N)C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 35481338.92 nM	Non binder
T62449	Checkpoint kinase-1	B30OYL	4-[[4-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methyl]morpholine	Investigative	76311610	C20H20N6O	360.4	C1COCCN1CC2=CC=C(C=C2)C3=CN=C4N3C=C(N=C4)C5=CNN=C5	IC50 = 45708818.96 nM	Non binder
T62449	Checkpoint kinase-1	B47ALW	(4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanamine	Investigative	46911674	C16H14N6	290.32	C1=CC(=CC=C1CN)C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 501187233.6 nM	Non binder
T62449	Checkpoint kinase-1	B4NJD3	1-[(E)-[2-Chloro-6-(4-chlorophenyl)imidazo[2,1-b]thiazol-5-yl]methyleneamino]guanidine	Investigative	9572070	C13H11Cl3N6S	389.7	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)Cl.Cl	IC50 > 7900000 nM	Non binder
T62449	Checkpoint kinase-1	B5IB8O	4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline	Investigative	49797917	C15H12N6	276.3	C1=CC(=CC=C1C2=CN=C3N2C=C(N=C3)C4=CNN=C4)N	IC50 = 38904514.5 nM	Non binder
T62449	Checkpoint kinase-1	B6FCN1	4-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)aniline	Investigative	49797939	C15H12N6	276.3	C1=CC(=CC=C1C2=CN3C(=CN=C3C=N2)C4=CNN=C4)N	IC50 = 66069344.8 nM	Non binder
T62449	Checkpoint kinase-1	B6T9WU	3-(1H-Indol-3-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	136016456	C17H12N6	300.32	C1=CC=C2C(=C1)C(=CN2)C3=CN=C4N3C=C(N=C4)C5=CNN=C5	IC50 = 154881661.9 nM	Non binder
T62449	Checkpoint kinase-1	B7RO3J	3-Phenyl-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	49797838	C15H11N5	261.279	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 33113112.15 nM	Non binder
T62449	Checkpoint kinase-1	B86ZYI	6-(1H-Pyrazol-4-yl)-3-pyridin-3-ylimidazo[1,2-a]pyrazine	Investigative	76322493	C14H10N6	262.27	C1=CC(=CN=C1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 10000000 nM	Non binder
T62449	Checkpoint kinase-1	B8A1MH	6-(1h-Pyrazol-3-Yl)-3-(1h-Pyrazol-4-Yl)imidazo[1,2-A]pyrazine	Investigative	46911673	C12H9N7	251.25	C1=C(NN=C1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 660693448 nM	Non binder
T62449	Checkpoint kinase-1	B8GD5S	[3-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methanol	Investigative	76326092	C16H13N5O	291.31	C1=CC(=CC(=C1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4)CO	IC50 = 21877616.24 nM	Non binder
T62449	Checkpoint kinase-1	B8M6OK	4-[[3-[6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl]phenyl]methyl]morpholine	Investigative	76333357	C20H20N6O	360.4	C1COCCN1CC2=CC(=CC=C2)C3=CN=C4N3C=C(N=C4)C5=CNN=C5	IC50 = 43651583.22 nM	Non binder
T62449	Checkpoint kinase-1	B9OL1W	3-(1H-Pyrazol-4-yl)-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine	Investigative	49797936	C14H10N6	262.27	C1=CN=CC=C1C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 39810717.06 nM	Non binder
T62449	Checkpoint kinase-1	BD61SY	3-(4-Phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	76315190	C21H15N5O	353.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=CN=C4N3C=C(N=C4)C5=CNN=C5	IC50 = 10000000 nM	Non binder
T62449	Checkpoint kinase-1	BGY45V	6-Phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	49797937	C15H11N5	261.279	C1=CC=C(C=C1)C2=CN3C(=CN=C3C=N2)C4=CNN=C4	IC50 = 58884365.54 nM	Non binder
T62449	Checkpoint kinase-1	BQE5S8	6-(1H-Pyrazol-4-yl)-3-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine	Investigative	136016455	C13H10N6	250.26	C1=CNC(=C1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 23442288.15 nM	Non binder
T62449	Checkpoint kinase-1	BV1X8C	3,6-Bis(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	46911672	C12H9N7	251.25	C1=C(C=NN1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 199526231.5 nM	Non binder
T62449	Checkpoint kinase-1	BWI1L9	(3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanol	Investigative	49797813	C16H13N5O	291.31	C1=CC(=CC(=C1)C2=CN3C(=CN=C3C=N2)C4=CNN=C4)CO	IC50 = 34673685.05 nM	Non binder
T62449	Checkpoint kinase-1	BY7SP2	6-(1-Benzyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a]pyrazine	Investigative	49797840	C22H17N5	351.4	C1=CC=C(C=C1)CN2C=C(C=N2)C3=CN4C(=CN=C4C=N3)C5=CC=CC=C5	IC50 = 208000 nM	Non binder
T62449	Checkpoint kinase-1	BYOQ76	3-(1-Methylpyrazol-4-yl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine	Investigative	76326091	C13H11N7	265.27	CN1C=C(C=N1)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 45708818.96 nM	Non binder
T62449	Checkpoint kinase-1	BZ1GV8	(3-(3-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanamine	Investigative	49797812	C16H14N6	290.32	C1=CC(=CC(=C1)C2=CN3C(=CN=C3C=N2)C4=CNN=C4)CN	IC50 = 288403150.3 nM	Non binder