TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T64765 Histamine H3 receptor B1M4IN Ethyl 1-[4-[4-(phenylcarbamoylsulfamoyl)phenoxy]butyl]piperidine-4-carboxylate Investigative 60143923 C25H33N3O6S 503.6 CCOC(=O)C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3 IC50 > 100000000 nM Non binder T64765 Histamine H3 receptor B3ZI1L (4-Cyclobutylpiperazin-1-yl)-(6-cyclohexylspiro[2.5]octan-2-yl)methanone Investigative 76332844 C23H38N2O 358.6 C1CCC(CC1)C2CCC3(CC2)CC3C(=O)N4CCN(CC4)C5CCC5 Ki > 10000000 nM Non binder T64765 Histamine H3 receptor B6WB1P Ethyl 1-[3-(4-sulfamoylphenoxy)propyl]piperidine-4-carboxylate Investigative 60145490 C17H26N2O5S 370.5 CCOC(=O)C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)N IC50 > 10000000 nM Non binder T64765 Histamine H3 receptor B8HGE9 1-(2,5-Dichlorophenyl)-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea Investigative 60145632 C19H21Cl2N3O4S 458.4 C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl IC50 > 10000000 nM Non binder T64765 Histamine H3 receptor B8HMX5 1-Propan-2-yl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea Investigative 60145629 C16H25N3O4S 355.5 CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCN2CCCC2 IC50 > 100000000 nM Non binder T64765 Histamine H3 receptor B9YK0S Ethyl 1-[2-(4-sulfamoylphenoxy)ethyl]piperidine-4-carboxylate Investigative 34681379 C16H24N2O5S 356.4 CCOC(=O)C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)N IC50 > 10000000 nM Non binder T64765 Histamine H3 receptor BDEG38 1-Cyclohexyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea Investigative 60143762 C22H35N3O4S 437.6 C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCCN3CCCCC3 IC50 > 10000000 nM Non binder T64765 Histamine H3 receptor BKQ74I 1-Cyclohexyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea Investigative 60145631 C19H29N3O4S 395.5 C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCN3CCCC3 IC50 > 10000000 nM Non binder T64765 Histamine H3 receptor BQY2H7 Ethyl 1-[4-(4-sulfamoylphenoxy)butyl]piperidine-4-carboxylate Investigative 60145494 C18H28N2O5S 384.5 CCOC(=O)C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)N IC50 > 10000000 nM Non binder