TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T74607	Rap guanine nucleotide exchange factor 4	B0NR4E	2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide	Investigative	136244264	C22H26N4O2S	410.5	CC1=CC(=C(C(=C1)C)NC(=O)CSC2=NC(=C(C(=O)N2)C#N)C3CCCCC3)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B1CJA2	2-(4-Cyclohexyloxyphenyl)sulfonyl-1,3,5-trimethylbenzene	Investigative	71561954	C21H26O3S	358.5	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)OC3CCCCC3)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B1DEU5	(4,5-Dimethyl-Thiazol-2-Yl)-(2,4,6-Trimethyl-Phenyl)-Amine	Investigative	71561950	C14H18N2S	246.37	CC1=CC(=C(C(=C1)C)NC2=NC(=C(S2)C)C)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B1QSX0	4-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]piperidine	Investigative	71561956	C20H25NO3S	359.5	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)OC3CCNCC3)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B2QVH7	2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide	Investigative	136254219	C19H20N4O2S	368.5	C1CCC(CC1)C2=C(C(=O)NC(=N2)SCC(=O)NC3=CC=CC=C3)C#N	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B3YDQ5	2-[4-(2,4,6-Trimethylphenyl)sulfonylphenoxy]ethanamine	Investigative	71562076	C17H21NO3S	319.4	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)OCCN)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B5U4HK	Tert-butyl 4-[4-(2,4,6-trimethylphenyl)sulfonylphenoxy]piperidine-1-carboxylate	Investigative	71561955	C25H33NO5S	459.6	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)OC3CCN(CC3)C(=O)OC(C)(C)C)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B64YNT	2-Fluoro-5-[4-(2,4,6-trimethylphenyl)sulfonylphenyl]pyridine	Investigative	71561829	C20H18FNO2S	355.4	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C=C3)F)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B6IUP3	2-(4-Cyclohexylphenyl)sulfonyl-1,3,5-trimethylbenzene	Investigative	71561953	C21H26O2S	342.5	CC1=CC(=C(C(=C1)C)S(=O)(=O)C2=CC=C(C=C2)C3CCCCC3)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	B96CZO	2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetic acid	Investigative	136226119	C13H15N3O3S	293.34	C1CCC(CC1)C2=C(C(=O)NC(=N2)SCC(=O)O)C#N	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BA4CW5	Methyl 1-(2,4,6-trimethylphenyl)sulfonylindole-5-carboxylate	Investigative	71562202	C19H19NO4S	357.4	CC1=CC(=C(C(=C1)C)S(=O)(=O)N2C=CC3=C2C=CC(=C3)C(=O)OC)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BB0QV9	2-Ethyl-1-[4-(trifluoromethyl)phenyl]sulfonylpyrrole	Investigative	71562083	C13H12F3NO2S	303.3	CCC1=CC=CN1S(=O)(=O)C2=CC=C(C=C2)C(F)(F)F	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BE09GA	2-Anilino-6-cyclohexyl-4-oxo-1H-pyrimidine-5-carbonitrile	Investigative	136226122	C17H18N4O	294.35	C1CCC(CC1)C2=C(C(=O)NC(=N2)NC3=CC=CC=C3)C#N	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BGJ7O3	2-(4-Chloroanilino)-6-cyclohexyl-4-oxo-1H-pyrimidine-5-carbonitrile	Investigative	136244263	C17H17ClN4O	328.8	C1CCC(CC1)C2=C(C(=O)NC(=N2)NC3=CC=C(C=C3)Cl)C#N	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BH4J9W	2,4,6-Trimethyl-N-[3-[2-(2,4,6-trimethylphenyl)ethynyl]phenyl]aniline	Investigative	127045046	C26H27N	353.5	CC1=CC(=C(C(=C1)C)C#CC2=CC(=CC=C2)NC3=C(C=C(C=C3C)C)C)C	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BLYZ67	2-[(5-Cyano-6-cyclohexyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide	Investigative	136226115	C20H22N4O2S	382.5	CC1=CC=C(C=C1)NC(=O)CSC2=NC(=C(C(=O)N2)C#N)C3CCCCC3	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BMD74V	5-Cyano-6-cyclohexyl-2-thiouracil	Investigative	2735844	C11H13N3OS	235.31	C1CCC(CC1)C2=C(C(=O)NC(=S)N2)C#N	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BQ28HU	2-(2,5-Dimethylbenzylsulfanyl)-6-Oxo-4-Piperidin-4-Yl-1,6-Dihydro-Pyrimidine-5-Carbonitrile	Investigative	136254218	C19H22N4OS	354.5	CC1=CC(=C(C=C1)C)CSC2=NC(=C(C(=O)N2)C#N)C3CCNCC3	IC50 > 300000 nM	Non binder
T74607	Rap guanine nucleotide exchange factor 4	BUR85T	1,3,5-Trimethyl-2-(4-pentylphenyl)sulfonylbenzene	Investigative	71561952	C20H26O2S	330.5	CCCCCC1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2C)C)C	IC50 > 300000 nM	Non binder