TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T78932	TYK2 tyrosine kinase	D04LKS	Ruxolitinib	Approved	25126798	C17H18N6	306.4	C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	D0EG1I	Tofacitinib	Approved	9926791	C16H20N6O	312.37	C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	D0Y7IC	Baricitinib	Approved	44205240	C16H17N7O2S	371.4	CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B14TYK	2-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide	Investigative	137632226	C14H21N5O3S	339.42	CN(C1CC(C1)NS(=O)(=O)CCOC)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B1B3NP	4-[[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]sulfamoylamino]butanenitrile	Investigative	137646690	C15H21N7O2S	363.4	CN(C1CC(C1)NS(=O)(=O)NCCCC#N)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B1BO2U	1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	78324136	C15H21N5O2S	335.4	CN(C1CC(C1)NS(=O)(=O)CC2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B1MIJ9	4-[[3-[[Ethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine	Investigative	137646834	C14H22N6O2S	338.43	CCN(C)S(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B1SX8B	3-N-(Cyclopropylmethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine	Investigative	78324435	C15H22N6O2S	350.4	CN(C1CC(C1)NS(=O)(=O)NCC2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B20PWQ	3-Methoxy-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide	Investigative	137642024	C15H23N5O3S	353.4	CN(C1CC(C1)NS(=O)(=O)CCCOC)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B21CKT	Schembl21615478	Investigative	137659382	C17H19N5O2S	357.4	CN(C1CC(C1)NS(=O)(=O)C2=CC=CC=C2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B38FYN	1-Cyclobutyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	137633647	C16H23N5O2S	349.5	CN(C1CC(C1)NS(=O)(=O)CC2CCC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B3D4BJ	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]piperidine-1-sulfonamide	Investigative	137650515	C16H24N6O2S	364.5	CN(C1CC(C1)NS(=O)(=O)N2CCCCC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B3HSA7	3,3,3-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide	Investigative	137658504	C14H18F3N5O2S	377.39	CN(C1CC(C1)NS(=O)(=O)CCC(F)(F)F)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B3O6GA	N-Methyl-N-[3-(propylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	78320046	C15H22N4O2S	322.4	CCCS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B4DY1E	3-N-(Cyclopropylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine	Investigative	137648948	C14H20N6O2S	336.42	CN(C1CC(C1)NS(=O)(=O)NC2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B4YAX1	3-N-(Ethylsulfamoyl)-1-N-methyl-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine	Investigative	137638414	C13H20N6O2S	324.4	CCNS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B5VB7J	N-(Cyclopropylmethyl)-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	137654955	C17H25N5O2S	363.5	CN(CC1CC1)S(=O)(=O)CC2CC(C2)N(C)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B6MH2F	1-N-Methyl-3-N-(propylsulfamoyl)-1-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)cyclobutane-1,3-diamine	Investigative	137660642	C14H22N6O2S	338.43	CCCNS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B75GRU	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide	Investigative	137654686	C13H19N5O2S	309.39	CCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B7UG4C	4,4,4-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide	Investigative	137648975	C15H20F3N5O2S	391.4	CN(C1CC(C1)NS(=O)(=O)CCCC(F)(F)F)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B8U5NT	N-(Cyclopropylmethyl)-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	137632648	C16H23N5O2S	349.5	CN(C1CC(C1)CS(=O)(=O)NCC2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	B9UJN0	2-Methyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide	Investigative	78323837	C15H23N5O2S	337.4	CC(C)CS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BBP05T	N-Methyl-N-[3-(pyrrolidin-1-ylsulfonylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	137658008	C16H23N5O2S	349.5	CN(C1CC(C1)CS(=O)(=O)N2CCCC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BC9B7K	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]cyclopropanesulfonamide	Investigative	137635161	C14H19N5O2S	321.4	CN(C1CC(C1)NS(=O)(=O)C2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BG73NS	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-phenylmethanesulfonamide	Investigative	137648009	C18H21N5O2S	371.5	CN(C1CC(C1)NS(=O)(=O)CC2=CC=CC=C2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BGJ87C	N-Butyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	137653042	C16H25N5O2S	351.5	CCCCNS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BH2GI7	1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide	Investigative	122192069	C15H21N5O	287.36	C1CNCCC1C2=NC3=C(N2CCN)C=CC(=C3)C(=O)N	IC50 = 759500 nM	Non binder
T78932	TYK2 tyrosine kinase	BH52GV	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]butane-1-sulfonamide	Investigative	137643915	C15H23N5O2S	337.4	CCCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BHN0S6	N-[3-(Benzenesulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	118868914	C18H20N4O2S	356.4	CN(C1CC(C1)CS(=O)(=O)C2=CC=CC=C2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BI1J3U	4-Fluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]benzenesulfonamide	Investigative	137656619	C17H18FN5O2S	375.4	CN(C1CC(C1)NS(=O)(=O)C2=CC=C(C=C2)F)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BI9A8H	4-[[3-[[2-Cyanoethyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine	Investigative	78324744	C15H21N7O2S	363.4	CN(CCC#N)S(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BLAW35	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-1-(oxetan-3-yl)methanesulfonamide	Investigative	78324132	C15H21N5O3S	351.4	CN(C1CC(C1)NS(=O)(=O)CC2COC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BLJH09	N-[3-(Butylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	78320048	C16H24N4O2S	336.5	CCCCS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BOZT32	4-[[3-[[Cyclopropyl(methyl)sulfamoyl]amino]cyclobutyl]-methylamino]-7H-pyrrolo[2,3-d]pyrimidine	Investigative	137635759	C15H22N6O2S	350.4	CN(C1CC1)S(=O)(=O)NC2CC(C2)N(C)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BP7I8K	3-Cyano-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide	Investigative	137661391	C15H20N6O2S	348.4	CN(C1CC(C1)NS(=O)(=O)CCCC#N)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BQ24ON	Abrocitinib	Investigative	78323835	C14H21N5O2S	323.42	CCCS(=O)(=O)NC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BQ5CZ7	N-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	122199230	C12H17N5O2S	295.36	CN(C1CC(C1)NS(=O)(=O)C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BQ75YV	2,2,2-Trifluoro-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]ethanesulfonamide	Investigative	78323836	C13H16F3N5O2S	363.36	CN(C1CC(C1)NS(=O)(=O)CC(F)(F)F)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BR9T4N	N-Ethyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	137641404	C14H21N5O2S	323.42	CCNS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BT8DK0	N-Butyl-N-methyl-1-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide	Investigative	118868847	C17H27N5O2S	365.5	CCCCN(C)S(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BUA02C	1-[3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]-N-propylmethanesulfonamide	Investigative	137636771	C15H23N5O2S	337.4	CCCNS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BV32NU	N-[3-(Cyclopropylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	137650880	C15H20N4O2S	320.4	CN(C1CC(C1)CS(=O)(=O)C2CC2)C3=NC=NC4=C3C=CN4	IC50 > 200000 nM	Non binder
T78932	TYK2 tyrosine kinase	BZOG85	N-[3-(Ethylsulfonylmethyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Investigative	137661888	C14H20N4O2S	308.4	CCS(=O)(=O)CC1CC(C1)N(C)C2=NC=NC3=C2C=CN3	IC50 > 200000 nM	Non binder