TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T83904	NAD-dependent deacetylase sirtuin-2	D0U3EP	Resveratrol	Phase 3	445154	C14H12O3	228.24	C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O	EC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B05BTZ	4-(2-(4-(4-Chlorophenyl)-5-mercapto-4H-1,2,4-triazol-3-yl)ethyl)phenol	Investigative	2796669	C16H14ClN3OS	331.8	C1=CC(=CC=C1CCC2=NNC(=S)N2C3=CC=C(C=C3)Cl)O	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B12GER	Chembl4166056	Investigative	145953107	C30H37N5O4S	563.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCN[C@@H]4CCCC[C@H]4O)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B1SOC2	1-(6-Chloro-2,2-dimethyl-3,4-dihydrochromen-4-yl)-3-(4-nitrophenyl)thiourea	Investigative	11639738	C18H18ClN3O3S	391.9	CC1(CC(C2=C(O1)C=CC(=C2)Cl)NC(=S)NC3=CC=C(C=C3)[N+](=O)[O-])C	IC50 > 200000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B2LY4F	Chembl4168392	Investigative	145954819	C31H31N5O5S	585.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CNC(=O)OCC4=CC=CC=C4)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B3R5BJ	Chembl4167724	Investigative	145952756	C26H21N5O3S2	515.6	C1=CC2=NN=C(N2C=C1)SCC(=O)NC3=CC=CC(=C3)COC4=CC=C(C=C4)NC(=O)C5=CC=CS5	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B41TEX	2-((4-(3-(4-(2-Hydroxybenzylideneamino)phenoxy)propoxy)phenylimino)methyl)phenol	Investigative	2725546	C29H26N2O4	466.5	C1=CC=C(C(=C1)C=NC2=CC=C(C=C2)OCCCOC3=CC=C(C=C3)N=CC4=CC=CC=C4O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B46ULT	Chembl4162080	Investigative	145961009	C25H27N5O4S	493.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CNC(=O)C)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B4BKP0	3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide	Investigative	24180124	C26H29N5O4S	507.6	COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5	EC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B58CMK	Chembl4129734	Investigative	145963700	C56H104N18O17S	1333.6	CCCCCCCCNC(=O)CCCSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)N	IC50 = 237000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B5JW9F	Chembl4176250	Investigative	145971711	C29H35N5O5S	565.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCNC(=O)OC(C)(C)C)C	IC50 = 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B5WF3A	Sirt6-IN-5	Investigative	9324490	C19H14N2O6	366.3	C1=COC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O	IC50 = 453000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B5Y7QD	N-[(3-Pyridin-3-yl-1H-1,2,4-triazol-5-yl)methyl]pyrazine-2-carboxamide	Investigative	46958766	C13H11N7O	281.27	C1=CC(=CN=C1)C2=NNC(=N2)CNC(=O)C3=NC=CN=C3	IC50 = 2291000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B7CKG1	3-(3-(4-(Phenoxymethyl)phenyl)ureido)benzoic acid	Investigative	2812103	C21H18N2O4	362.4	C1=CC=C(C=C1)OCC2=CC=C(C=C2)NC(=O)NC3=CC=CC(=C3)C(=O)O	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B7U5NL	4-(3-{[Amino(phenylimino)methyl]sulfanyl}-2,5-dioxo-1-pyrrolidinyl)benzoic acid	Investigative	3106525	C18H15N3O4S	369.4	C1C(C(=O)N(C1=O)C2=CC=C(C=C2)C(=O)O)SC(=NC3=CC=CC=C3)N	IC50 = 1744000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B8U0JR	5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid	Investigative	6496840	C19H14N2O6	366.3	C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O	IC50 = 751000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B8U5WQ	(S)-Methyl 2-((S)-2-((S)-2-acetamidopropanamido)-6-pivalamidohexanamido)propanoate	Investigative	46919223	C20H36N4O6	428.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C(C)(C)C)C(=O)N[C@@H](C)C(=O)OC)NC(=O)C	IC50 = 338000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B8Z1XH	4,4'-Bis[(2-hydroxyethyl)methylamino]benzophenone	Investigative	2818089	C19H24N2O3	328.4	CN(CCO)C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)N(C)CCO	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B98MLD	(2S)-6-Acetamido-2-[[(2S)-6-[6-(1,3-benzothiazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130520	C37H58N8O7S2	791	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CCCCCSC1=NC2=CC=CC=C2S1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 > 200000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	B9JNW6	4-((4-(2,3-Dihydro-1H-inden-2-yl)-5-hydroxy-4H-1,2,4-triazol-3-ylthio)methyl)-7-hydroxy-2H-chromen-2-one	Investigative	5714655	C21H17N3O4S	407.4	C1C(CC2=CC=CC=C21)N3C(=O)NN=C3SCC4=CC(=O)OC5=C4C=CC(=C5)O	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BBH53V	Ser-Asp-Lys(epsilon-thioAc)Leu-Ile	Investigative	44572705	C27H48N6O9S	632.8	CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)N	IC50 = 238000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BBL18O	4-((4-(4-(3,4-Dihydroxybenzylideneamino)benzyl)phenylimino)methyl)benzene-1,2-diol	Investigative	2803145	C27H22N2O4	438.5	C1=CC(=CC=C1CC2=CC=C(C=C2)N=CC3=CC(=C(C=C3)O)O)N=CC4=CC(=C(C=C4)O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BCEX93	(S)-2-((S)-6-Acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoic acid	Investigative	52944947	C16H28N4O6	372.42	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)C	IC50 = 223000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BD27RS	2-(2-Oxo-2-(4-(2-(trifluoromethyl)quinolin-4-yl)piperazin-1-yl)ethylthio)acetic acid	Investigative	2809977	C18H18F3N3O3S	413.4	C1CN(CCN1C2=CC(=NC3=CC=CC=C32)C(F)(F)F)C(=O)CSCC(=O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BD67GB	5-(4-Benzamido-2-methoxy-5-methylphenylamino)-5-oxo-3-phenylpentanoic acid	Investigative	2812815	C26H26N2O5	446.5	CC1=CC(=C(C=C1NC(=O)C2=CC=CC=C2)OC)NC(=O)CC(CC(=O)O)C3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BE2ZL1	1,3-Dimethyl-2,4-dioxo-N-[4-(pyridin-4-ylmethyl)phenyl]quinazoline-6-sulfonamide	Investigative	1258010	C22H20N4O4S	436.5	CN1C2=C(C=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)CC4=CC=NC=C4)C(=O)N(C1=O)C	IC50 = 242000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BE4J3V	1-[2-[[5-(Naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]amino]-2-oxoethyl]pyridin-1-ium-3-carboxamide;chloride	Investigative	127028111	C22H19ClN4O2S	438.9	C1=CC=C2C(=C1)C=CC=C2CC3=CN=C(S3)NC(=O)C[N+]4=CC=CC(=C4)C(=O)N.[Cl-]	IC50 = 289000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BFD53O	Chembl4164971	Investigative	145960080	C30H37N5O5S	579.7	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCCNC(=O)OC(C)(C)C)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BFKD70	Chembl4163136	Investigative	145958990	C26H23N7O3S	513.6	CN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)OCC3=CC(=CC=C3)NC(=O)CSC4=NN=C5N4C=CC=C5	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BFMW41	4-[[4-(Furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid	Investigative	6496838	C19H14N2O6	366.3	C1=COC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)C(=O)O)O	IC50 = 482000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BFQ8L4	Chembl4165789	Investigative	145953758	C30H24N2O4S	508.6	C1=CC=C2C(=C1)C=CC=C2OCC(=O)NC3=CC=CC(=C3)COC4=CC=C(C=C4)NC(=O)C5=CC=CS5	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BG6CA0	(R)-N-(2-(3-((3-Hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide	Investigative	24180126	C27H24N4O2S	468.6	C1CN(C[C@@H]1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5	EC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BGHR78	5-(9-Oxoxanthen-2-yl)oxypentanoic Acid	Investigative	2818241	C18H16O5	312.3	C1=CC=C2C(=C1)C(=O)C3=C(O2)C=CC(=C3)OCCCCC(=O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BH28OT	4-(3-(2-Hydroxybenzamido)phenylamino)-4-oxobut-2-enoic acid	Investigative	5929343	C17H14N2O5	326.3	C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)NC(=O)/C=C/C(=O)O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BH3V8M	2-((4-(4-(4-(2-Hydroxybenzylideneamino)phenoxy)butoxy)phenylimino)methyl)phenol	Investigative	4344009	C30H28N2O4	480.6	C1=CC=C(C(=C1)C=NC2=CC=C(C=C2)OCCCCOC3=CC=C(C=C3)N=CC4=CC=CC=C4O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BIJ50B	Chembl4171097	Investigative	145952006	C27H24N2O3S2	488.6	CC1=CC(=CC=C1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BJNR21	2-(3,5-Dimethylphenyl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	127028107	C24H22N2OS2	418.6	CC1=CC(=CC(=C1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C	IC50 = 207000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BJQ3X7	4-[(2-Hydroxy-3-methoxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654862	C22H20N2O3	360.4	CC1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C(=CC4=CC=CC=C43)OC)O	IC50 > 200000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BMI8S5	Chembl4162839	Investigative	145958500	C27H25N5O3S	499.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=CC(=C3)NC(=O)C4=CC=CC=N4)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BO60IC	3-[[3-(Naphthalen-1-yl)1,2,4-oxadiazole-5-carbonyl]amino]-1-[3-trifluoromethylphenyl]urea	Investigative	24949216	C21H14F3N5O3	441.4	C1=CC=C2C(=C1)C=CC=C2C3=NOC(=N3)C(=O)NNC(=O)NC4=CC=CC(=C4)C(F)(F)F	IC50 = 257000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BOC86J	2-[4-[(E)-2-Phenylethenyl]anilino]benzamide	Investigative	60167126	C21H18N2O	314.4	C1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BOP74I	Chembl4160877	Investigative	145957670	C22H19N5O3S2	465.6	C1=CC(=CC(=C1)NC(=O)CSC2=NC=NN2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BP7R4X	6-(2-Hydroxy-ethylsulfanyl)-2-(2-pyridin-2-yl-ethyl)-benzo[de]isoquinoline-1,3-dione	Investigative	2826537	C21H18N2O3S	378.4	C1=CC=NC(=C1)CCN2C(=O)C3=C4C(=C(C=C3)SCCO)C=CC=C4C2=O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BPX0E4	Chembl4164275	Investigative	145961629	C25H25N5O3S2	507.6	CC(C)N1C(=NC=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4	IC50 = 269153.48 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ0S5P	5-(2-Methyl-1,3,4,5-tetrahydropyrido[4,3-b]indol-8-yl)pyrimidin-2-amine	Investigative	118731307	C16H17N5	279.34	CN1CCC2=C(C1)C3=C(N2)C=CC(=C3)C4=CN=C(N=C4)N	IC50 > 250000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ60JZ	Chembl4173850	Investigative	145949537	C30H26N4O4	506.6	CN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)OCC3=CC(=CC=C3)NC(=O)COC4=CC=CC5=CC=CC=C54	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BQ9HV5	2-(4-((2-(Tert-butoxycarbonyl)-3-phenylpropanoyloxy)methyl)phenyl)acetic acid	Investigative	3815520	C23H27NO6	413.5	CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C(=O)OCC2=CC=C(C=C2)CC(=O)O	IC50 > 1000000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BQT24R	Chembl4172874	Investigative	145952477	C24H27N5O3S	465.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)CCN)C	IC50 = 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BS9X3N	2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide	Investigative	3518449	C11H10F3N5OS2	349.4	CC1=CC(=NC(=N1)SCC(=O)NC2=NN=C(S2)C(F)(F)F)C	IC50 = 502800 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BT2BA3	2-[[4-(1,3-Dioxoisoindol-2-yl)benzoyl]amino]-5-hydroxybenzoic acid	Investigative	1230959	C22H14N2O6	402.4	C1=CC=C2C(=C1)C(=O)N(C2=O)C3=CC=C(C=C3)C(=O)NC4=C(C=C(C=C4)O)C(=O)O	IC50 = 333000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BUYH78	4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654861	C21H17BrN2O2	409.3	CC1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C=CC4=C3C=CC(=C4)Br)O	IC50 > 200000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BVT89E	2-Methyl-8-(4-methylsulfonylphenyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole	Investigative	118731176	C19H20N2O2S	340.4	CN1CCC2=C(C1)C3=C(N2)C=CC(=C3)C4=CC=C(C=C4)S(=O)(=O)C	IC50 > 250000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BW6Y7Z	Chembl4173707	Investigative	145951020	C28H26N2O4S	486.6	CC1=CC(=CC(=C1)OCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4)C	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BX69ZY	Chembl4160492	Investigative	145961648	C27H24N2O4S2	504.6	COC1=CC(=CC=C1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BX8YB7	Methyl (2S)-2-[[(2S)-2-acetamido-6-(ethanethioylamino)hexanoyl]amino]propanoate	Investigative	54757799	C14H25N3O4S	331.43	C[C@@H](C(=O)OC)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)C	IC50 = 862000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	BXB50E	2-[4-[Benzoyl(methyl)amino]anilino]benzamide	Investigative	60167270	C21H19N3O2	345.4	CN(C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N)C(=O)C3=CC=CC=C3	IC50 > 300000 nM	Non binder
T83904	NAD-dependent deacetylase sirtuin-2	D02AYX	2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione	Investigative	1403654	C11H6N2O3	214.18	C1=CC=C2C(=C1)C=C3C(=O)NC(=O)N=C3O2	IC50 = 243600 nM	Non binder