TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T91959	NAD-dependent deacetylase sirtuin-3	D0U3EP	Resveratrol	Phase 3	445154	C14H12O3	228.24	C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O	EC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	D04JZE	CAMBINOL	Patented	3246390	C21H16N2O2S	360.4	C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	D0PL1I	US9359293, TA	Patented	122580129	C21H25N3O3S	399.5	CC(=S)NCCCCC(C(=O)NC1=CC=CC=C1)NC(=O)OC2=CC=CC=C2	IC50 > 205000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B01WYF	5-[[3-(Adamantane-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156756	C24H27N3O3	405.5	C1C2CC3CC1CC(C2)(C3)C(=O)NC4=CC=CC(=C4)COC5=CN=CC(=C5)C(=O)N	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B3JM9T	Nicotinamide	Investigative	936	C6H6N2O	122.12	C1=CC(=CN=C1)C(=O)N	IC50 = 377000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B4BEN9	4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-3-(4-methylphenyl)-2H-1,2-oxazol-5-one	Investigative	90654864	C21H16BrNO3	410.3	CC1=CC=C(C=C1)C2=C(C(=O)ON2)CC3=C(C=CC4=C3C=CC(=C4)Br)O	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B4BKP0	3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide	Investigative	24180124	C26H29N5O4S	507.6	COC1=CC(=CC(=C1OC)OC)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5	EC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B4HY1G	Thiomyristoyl	Investigative	126843233	C34H51N3O3S	581.9	CCCCCCCCCCCCCC(=S)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B58CMK	Chembl4129734	Investigative	145963700	C56H104N18O17S	1333.6	CCCCCCCCNC(=O)CCCSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)N	IC50 > 500000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B6GX7P	Tert-butyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	60141294	C24H28N4O4	436.5	CC1(CC(C2=C(O1)C=CC(=C2)NC(=O)OC(C)(C)C)NC(=O)NC3=CC=CC(=C3)C#N)C	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B6WC8A	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-thiophen-2-ylpyridine-3-carboxamide	Investigative	124156389	C23H18N4O3S	430.5	C1=CC(=CC(=C1)NC(=O)C2=CN=C(C=C2)C3=CC=CS3)COC4=CN=CC(=C4)C(=O)N	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B7U0PK	(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide	Investigative	56664966	C26H47N7O7	569.7	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCCC(=O)N)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 213500 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B8I7DM	5-[[3-[(4-Phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124155887	C26H21N3O3	423.5	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	B98MLD	(2S)-6-Acetamido-2-[[(2S)-6-[6-(1,3-benzothiazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130520	C37H58N8O7S2	791	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CCCCCSC1=NC2=CC=CC=C2S1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 > 1000000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BA6N5G	Ethyl 3-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-3-oxopropanoate	Investigative	44138532	C25H31N3O6	469.5	CCOC(=O)CC(=O)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BA93DJ	N-[1-(5-Carbamoyl-3-pyridyloxy)-5-naphthyl]-3-nitro-4-methylbenzamide	Investigative	101884812	C24H18N4O5	442.4	CC1=C(C=C(C=C1)C(=O)NC2=CC=CC3=C2C=CC=C3OC4=CN=CC(=C4)C(=O)N)[N+](=O)[O-]	IC50 = 232000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BBX06E	2-[3-(3-Fluorophenethyloxy)phenylamino]benzamide	Investigative	60148504	C21H19FN2O2	350.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC(=CC=C3)F	IC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BFQ0N8	(s)-8-Bromo-6-chloro-2-pentylchroman-4-one	Investigative	66560391	C14H16BrClO2	331.63	CCCCC[C@H]1CC(=O)C2=C(O1)C(=CC(=C2)Cl)Br	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BG6CA0	(R)-N-(2-(3-((3-Hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide	Investigative	24180126	C27H24N4O2S	468.6	C1CN(C[C@@H]1O)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=CC6=CC=CC=C6C=C5	EC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BH6S1K	5-[[3-[(4-Phenylmethoxybenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156311	C27H23N3O4	453.5	C1=CC=C(C=C1)COC2=CC=C(C=C2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BI8D0L	2-Anilinobenzamide	Investigative	96455	C13H12N2O	212.25	C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 235000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BJ5U4O	2-((3-Phenethoxyphenyl)Amino)Benzamide	Investigative	56935695	C21H20N2O2	332.4	C1=CC=C(C=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BJQ3X7	4-[(2-Hydroxy-3-methoxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654862	C22H20N2O3	360.4	CC1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C(=CC4=CC=CC=C43)OC)O	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BNX8Y3	8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid	Investigative	73355036	C51H40N6O23S6	1297.3	CC1=CCC(=CC1=NC(=O)C2=CC=C/C(=N\\C(=O)/N=C\\3/CC(=CC=C3)C(=O)N=C4CC(=CC=C4C)C(=O)N=C5CC=C(C6=C5C(=CC(=C6)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)/C2)C(=O)N=C7CC=C(C8=C7C(=CC(=C8)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BQ3J5I	Chembl4128353	Investigative	145960911	C58H108N18O17S	1361.7	CCCCCCCCCCNC(=O)CCCSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)N	IC50 > 500000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BUYH78	4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654861	C21H17BrN2O2	409.3	CC1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C=CC4=C3C=CC(=C4)Br)O	IC50 > 200000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	BV4JU2	N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide	Investigative	134433618	C26H24N4O3S2	504.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CC=CS4)C	IC50 > 300000 nM	Non binder
T91959	NAD-dependent deacetylase sirtuin-3	D03EGA	SRT1720	Investigative	24180125	C25H23N7OS	469.6	C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5	EC50 > 300000 nM	Non binder