TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T92609	Adrenergic receptor alpha-1A	B03PWY	3-[2-[4-(2-Ethoxyphenyl)piperazin-1-yl]ethyl]-5H-pyrimido[5,4-b]indol-4-one	Investigative	11112527	C24H27N5O2	417.5	CCOC1=CC=CC=C1N2CCN(CC2)CCN3C=NC4=C(C3=O)NC5=CC=CC=C54	Ki = 102000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B0UJC2	3-{3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl}-3,5-dihydro-4h-pyrimido[5,4-b]indol-4-one	Investigative	11825888	C24H27N5O2	417.5	COC1=CC=CC=C1N2CCN(CC2)CCCN3C=NC4=C(C3=O)NC5=CC=CC=C54	Ki = 60300000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B2F7SX	3-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	4013695	C23H25N5O3	419.5	COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 3720000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B38RKS	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-5H-pyrimido[5,4-b]indol-4-one	Investigative	11761245	C23H25N5O2	403.5	COC1=CC=CC=C1N2CCN(CC2)CCN3C=NC4=C(C3=O)NC5=CC=CC=C54	Ki = 708000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B39CIL	Phenylpropanolamine	Investigative	4786; 10297	C9H13NO	151.21	CC(C(C1=CC=CC=C1)O)N	EC50 = 230000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B4SJN7	3-[2-[4-(2-Ethoxyphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	10950119	C24H27N5O3	433.5	CCOC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 138000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B57VTU	3-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Investigative	10917023	C25H29N5O2	431.5	CC1=NC2=C(C(=O)N1CCCN3CCN(CC3)C4=CC=CC=C4OC)NC5=CC=CC=C52	Ki = 204000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B5LDU7	3-[2-[4-(4-Propan-2-ylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	10928161	C25H29N5O2	431.5	CC(C)C1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 77600000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B7F6QL	2-Ethyl-3-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-5H-pyrimido[5,4-b]indol-4-one	Investigative	11812340	C26H31N5O2	445.6	CCC1=NC2=C(C(=O)N1CCCN3CCN(CC3)C4=CC=CC=C4OC)NC5=CC=CC=C52	Ki = 93300000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	B9U5LH	3-[2-[4-(4-Butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	10950355	C26H31N5O2	445.6	CCCCC1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 1E+28 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BE3U4F	2-Ethyl-3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-5H-pyrimido[5,4-b]indol-4-one	Investigative	11729700	C25H29N5O2	431.5	CCC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=CC=CC=C4OC)NC5=CC=CC=C52	Ki = 20400000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BE97ZA	3-[2-[4-(2-Methoxyphenyl)piperidin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	10093481	C24H26N4O3	418.5	COC1=CC=CC=C1C2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 646000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BJMI90	3-[2-(2,4,4a,5-Tetrahydro-1H-pyrazino[2,1-c][1,4]benzoxazin-3-yl)ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	44329993	C23H23N5O3	417.5	C1CN2C(CN1CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O)COC6=CC=CC=C62	Ki = 126000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BJN8E6	3-[2-[4-(2-Chlorophenyl)-1-piperazinyl]ethyl]-1H-pyrimido[5,4-b]indole-2,4(3H,5H)-dione	Investigative	15054191	C22H22ClN5O2	423.9	C1CN(CCN1CCN2C(=O)C3=C(C4=CC=CC=C4N3)NC2=O)C5=CC=CC=C5Cl	Ki = 214000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BK7JE0	3-[2-[4-(4-Propan-2-ylphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione	Investigative	11144809	C25H28N4O2S	448.6	CC(C)C1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5S4)NC3=O	Ki = 1E+27 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BNRH37	3-[2-[4-(4-Tert-butylphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Investigative	11102302	C27H33N5O	443.6	CC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=CC=C(C=C4)C(C)(C)C)NC5=CC=CC=C52	Ki = 1660000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BP69UG	(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol	Investigative	46869265	C19H21NO2	295.4	C1CNC[C@@H]2[C@@H]1[C@@H](CC3=C2C=CC(=C3O)O)C4=CC=CC=C4	Ki = 340000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BR20IS	2-Methyl-3-[2-[4-(4-propan-2-ylphenyl)piperazin-1-yl]ethyl]-5H-pyrimido[5,4-b]indol-4-one	Investigative	10895266	C26H31N5O	429.6	CC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=CC=C(C=C4)C(C)C)NC5=CC=CC=C52	Ki = 282000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BR67BU	3-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-2-methyl-5H-pyrimido[5,4-b]indol-4-one	Investigative	10971791	C24H27N5O2	417.5	CC1=NC2=C(C(=O)N1CCN3CCN(CC3)C4=CC=CC=C4OC)NC5=CC=CC=C52	Ki = 331000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BSVH26	3-[2-[4-(2-Hydroxyphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	15480820	C22H23N5O3	405.4	C1CN(CCN1CCN2C(=O)C3=C(C4=CC=CC=C4N3)NC2=O)C5=CC=CC=C5O	Ki = 112000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BWSV21	3-[2-[4-(4-Cyclohexylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	10863664	C28H33N5O2	471.6	C1CCC(CC1)C2=CC=C(C=C2)N3CCN(CC3)CCN4C(=O)C5=C(C6=CC=CC=C6N5)NC4=O	Ki = 10000000000000000 nM	Non binder
T92609	Adrenergic receptor alpha-1A	BZ65QT	3-[2-[4-(4-Tert-butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione	Investigative	11762075	C26H31N5O2	445.6	CC(C)(C)C1=CC=C(C=C1)N2CCN(CC2)CCN3C(=O)C4=C(C5=CC=CC=C5N4)NC3=O	Ki = 100000000000000000 nM	Non binder