TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94033	Coagulation factor IIa	D0I0RJ	Amiloride	Approved	16231	C6H8ClN7O	229.63	C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N	IC50 >> 250000 nM	Non binder
T94033	Coagulation factor IIa	B03ZOI	3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44304098	C22H17IN4O2	496.3	C1=CC=C2C=C3C(=CC2=C1)C=C(C(=C3I)O)C(=O)NC4=CC=C(C=C4)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B0C6HD	Dihydrospumigin M	Investigative	139589789	C30H42N6O7	598.7	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=C(C=C2)O)NC(=O)C(CCC3=CC=C(C=C3)O)O)C(=O)N[C@H](CCCN=C(N)N)CO	IC50 = 250000 nM	Non binder
T94033	Coagulation factor IIa	B0E1OY	1beta,5beta-Bis[4-(4-guanidinophenylacetyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397357	C36H50N10O6	718.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)N=C(N)N	Ki = 255000 nM	Non binder
T94033	Coagulation factor IIa	B0HX8B	{(S)-1-[(S)-2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidine-1-carbonyl]-4-guanidino-butyl}-carbamic acid tert-butyl ester	Investigative	44287838	C22H41N9O5	511.6	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B0N2BO	4-[(4-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71462160	C14H16ClN3O3S	341.8	COC1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B0NE4Z	Chembl4209404	Investigative	9859977	C13H6F2N2O2	260.19	C1=CC(=C(C(=C1)F)C2=NC3=C(C=CN=C3)C(=O)O2)F	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B0XOL8	(S)-2-{(S)-2-[(S)-2-(4-Amino-butyrylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10392081	C29H40N4O5	524.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCN	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B0XT3P	1-(4-Benzyloxy-benzyl)-piperidin-4-ylamine	Investigative	36596148	C19H24N2O	296.4	C1CN(CCC1N)CC2=CC=C(C=C2)OCC3=CC=CC=C3	Ki = 581000 nM	Non binder
T94033	Coagulation factor IIa	B12YBD	N-(4-Guanidino-phenyl)-2-hydroxy-5-methoxy-benzamide	Investigative	44304047	C15H16N4O3	300.31	COC1=CC(=C(C=C1)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B13HLB	N-(4-Guanidino-phenyl)-2-hydroxy-4-methyl-benzamide	Investigative	44304006	C17H20N4O2	312.37	CC1=CC(=C(C=C1)C(=O)N(C)C2=CC=C(C=C2)N=C(N)N)OC	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B13NWD	Sodium;[3-ethoxycarbonyl-6-(4-methoxybenzoyl)oxy-2-methyl-1-benzofuran-5-yl] sulfate	Investigative	53391976	C20H17NaO10S	472.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OC(=O)C3=CC=C(C=C3)OC)C.[Na+]	IC50 = 501187.23 nM	Non binder
T94033	Coagulation factor IIa	B14CAG	(2S)-N-[(3-Chlorophenyl)methyl]-1-(2-cyclohexylethyl)pyrrolidine-2-carboxamide	Investigative	118736063	C20H29ClN2O	348.9	C1CCC(CC1)CCN2CCC[C@H]2C(=O)NCC3=CC(=CC=C3)Cl	Ki = 370000 nM	Non binder
T94033	Coagulation factor IIa	B16NHF	4-Acetyl-1-[1-(5-dimethylamino-naphthalene-1-sulfonyl)-pyrrolidine-2-carbonyl]-6-methyl-hexahydro-cyclopenta[b]pyrrol-5-one	Investigative	11113965	C26H32N4O5S	512.6	C[C@H]1[C@@H]2[C@H](CCN2C(=O)[C@@H]3CCCN3S(=O)(=O)C4=CC=CC5=C4C=CC=C5N(C)C)N(C1=O)C(=O)C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B1CR2E	1beta,5beta-Bis[4-[3-(4-guanidinophenyl)propionyl]piperazinocarbonyloxy]cyclooctane	Investigative	18397347	C38H54N10O6	746.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CC=C(C=C5)N=C(N)N	Ki = 537000 nM	Non binder
T94033	Coagulation factor IIa	B1CT9K	Chembl47466	Investigative	73347209	C29H47N5O8	593.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 507000 nM	Non binder
T94033	Coagulation factor IIa	B1CYT3	1-(4-Benzyloxy-benzyl)-pyridinium	Investigative	44292151	C19H18NO+	276.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)C[N+]3=CC=CC=C3	Ki > 500000 nM	Non binder
T94033	Coagulation factor IIa	B1KIC5	N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(Aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide	Investigative	57395841	C38H51N7O7	717.9	CC[C@H](C)[C@@H]1C(=O)N[C@H](/C=C/C(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)N1)CC3=CC(=CC=C3)CN)NC(=O)C)CC4=CC=C(C=C4)O	Ki = 680000 nM	Non binder
T94033	Coagulation factor IIa	B1KRA8	Schembl20625734	Investigative	9573034	C12H18N8	274.33	C/C(=N\\N=C(N)N)/C1=CC=C(C=C1)/C(=N/N=C(N)N)/C	Ki = 786000 nM	Non binder
T94033	Coagulation factor IIa	B1SK6R	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-methylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carboxylate	Investigative	44315788	C36H58N10O6	726.9	CN1CCC(CC1)CCNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N	Ki = 269000 nM	Non binder
T94033	Coagulation factor IIa	B1VA3Q	(3S,3Ar,6aS)-1-Cyclopropanecarbonyl-4-[(S)-1-(5-dimethylamino-naphthalene-1-sulfonyl)-pyrrolidine-2-carbonyl]-3-methyl-hexahydro-pyrrolo[3,2-b]pyrrol-2-one	Investigative	6476665	C28H34N4O5S	538.7	C[C@H]1[C@@H]2[C@H](CCN2C(=O)[C@@H]3CCCN3S(=O)(=O)C4=CC=CC5=C4C=CC=C5N(C)C)N(C1=O)C(=O)C6CC6	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B20PSG	N-[3-(2-Amino-ethoxy)-5-methyl-phenyl]-benzenesulfonamide	Investigative	15289347	C15H18N2O3S	306.4	CC1=CC(=CC(=C1)OCCN)NS(=O)(=O)C2=CC=CC=C2	Ki = 240000 nM	Non binder
T94033	Coagulation factor IIa	B26BID	3-Amino-N-{3-[(S)-2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(4-aminomethyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-propionamide	Investigative	44569333	C26H38N6O4S	530.7	C1CN(CCC1CCN)C(=O)[C@H](CC2=CC=C(C=C2)CN)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCN	Ki = 325000 nM	Non binder
T94033	Coagulation factor IIa	B2JRL9	Chembl44650	Investigative	73354789	C26H41N5O9	567.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 446000 nM	Non binder
T94033	Coagulation factor IIa	B2QI8F	{1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-1-methyl-ethylamino}-acetic acid	Investigative	11849374	C24H29N5O4	451.5	CC(C)(C(=O)NC1(CC2=CC=CC=C2C1)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B2VPT6	5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[2-[(3-carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]benzoic acid	Investigative	44421845	C29H31N5O6	545.6	CC(C)C[C@@H](C(=O)N)NC(=O)C1=CC(=C(C=C1)C2=C(C=C(C=C2)NC)C(=O)NC3=CC=CC(=C3)C(=O)N)C(=O)O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B32SIB	Chembl4207916	Investigative	145978637	C25H20Na2O12S2	622.5	CC1=C(C2=CC(=C(C=C2O1)OCC3=CC(=CC=C3)OS(=O)(=O)[O-])OCC4=CC(=CC=C4)S(=O)(=O)[O-])C(=O)OC.[Na+].[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B35SUM	Sodium;[2-[(2-methyl-1,3-benzothiazol-6-yl)oxymethyl]-1,3-benzothiazol-6-yl] sulfate	Investigative	118723898	C16H11N2NaO5S3	430.5	CC1=NC2=C(S1)C=C(C=C2)OCC3=NC4=C(S3)C=C(C=C4)OS(=O)(=O)[O-].[Na+]	IC50 = 327000 nM	Non binder
T94033	Coagulation factor IIa	B37CHY	{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-2-methyl-propylamino}-acetic acid	Investigative	10367232	C25H31N5O4	465.5	CC(C)[C@H](C(=O)NC1(CC2=CC=CC=C2C1)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B37FGK	(2S)-1-[(2R)-2-Aminopropyl]-N-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	118736065	C15H23Cl2N3O	332.3	C[C@H](CN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl)N.Cl	Ki = 512000 nM	Non binder
T94033	Coagulation factor IIa	B39FWI	3-(6-Carbamimidoyl-benzofuran-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid	Investigative	10094458	C24H26N4O4	434.5	CC(=N)N1CC[C@@H](C1)OC2=CC=C(C=C2)C(CC3=CC4=C(O3)C=C(C=C4)C(=N)N)C(=O)O	IC50 > 400000 nM	Non binder
T94033	Coagulation factor IIa	B3IC8Q	4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44304086	C21H16BrN5O2	450.3	C1=CC=C2C=C3C(=CC2=C1)C=C(C(=C3Br)O)C(=O)NC4=CN=C(C=C4)N=C(N)N	Ki = 330000 nM	Non binder
T94033	Coagulation factor IIa	B3KQ2O	(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-4-methylpentanamide	Investigative	56666511	C36H48N6O5S	676.9	CC(C)C[C@@H](C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NS(=O)(=O)CC3=CC=CC=C3	IC50 > 580000 nM	Non binder
T94033	Coagulation factor IIa	B3N0QG	(3R,6As)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid ethyl ester	Investigative	44351097	C12H17NO4	239.27	CCOC(=O)N1CC[C@H]2C1[C@H](C(=O)O2)CC=C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B3QJ0K	(2R,4S)-1-[(2S)-5-(Diaminomethylamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid	Investigative	70697537	C23H38N6O5S	510.7	C[C@H]1CCN([C@H](C1)C(=O)O)C(=O)[C@H](CCCNC(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C	Ki = 280000 nM	Non binder
T94033	Coagulation factor IIa	B3SI4P	5-Chloropyridin-3-yl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	10593976	C16H9Cl2NO4	350.1	C1=CC2=C(C=C1CCl)C=C(C(=O)O2)C(=O)OC3=CC(=CN=C3)Cl	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B3YDV7	(2S)-N-[(3-Chlorophenyl)methyl]-1-(3-methylbutyl)pyrrolidine-2-carboxamide	Investigative	118736061	C17H25ClN2O	308.8	CC(C)CCN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 580000 nM	Non binder
T94033	Coagulation factor IIa	B46HDI	Chembl4218970	Investigative	145969641	C22H23NaO9S	486.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=CC(=CC=C3)OC(C)C)C.[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B4A5KU	4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44304099	C22H17BrN4O2	449.3	C1=CC=C2C=C3C(=CC2=C1)C=C(C(=C3Br)O)C(=O)NC4=CC=C(C=C4)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B4AEO6	3-[(3,4-Dimethoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71458633	C16H20ClN3O4S	385.9	COC1=C(C=C(C=C1)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B4H8RW	{(S)-1-[1-(1-Formyl-4-guanidino-butylcarbamoyl)-1-methyl-ethylcarbamoyl]-4-guanidino-butyl}-carbamic acid tert-butyl ester	Investigative	73347180	C21H41N9O5	499.6	CC(C)(C)OC(=O)N[C@H](CCCN=C(N)N)C(=O)NC(C)(C)C(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B4IT1B	{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-2,3-dihydro-1H-phenalen-2-ylcarbamoyl]-2-methyl-propylamino}-acetic acid	Investigative	11849428	C29H33N5O4	515.6	CC(C)[C@H](C(=O)NC1(CC2=CC=CC3=C2C(=CC=C3)C1)C(=O)NCC4=CC=C(C=C4)C(=N)N)NCC(=O)O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B56DJG	1,3-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]adamantane	Investigative	44315449	C40H56N12O6	800.9	C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)OCC34CC5CC(C3)CC(C5)(C4)COC(=O)N6CCN(CC6)C(=O)NCC7=CC=C(C=C7)N=C(N)N	Ki = 363000 nM	Non binder
T94033	Coagulation factor IIa	B5AV6S	Chembl45045	Investigative	73345717	C29H47N5O8	593.7	CC[C@H](C)[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 507000 nM	Non binder
T94033	Coagulation factor IIa	B5JE7T	N-(4-Guanidino-phenyl)-2-hydroxy-3-methyl-benzamide	Investigative	44304353	C15H16N4O2	284.31	CC1=C(C(=CC=C1)C(=O)NC2=CC=C(C=C2)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B5K8EU	(2S)-N-[(3-Chlorophenyl)methyl]-1-(3-phenylpropyl)pyrrolidine-2-carboxamide	Investigative	118736064	C21H25ClN2O	356.9	C1C[C@H](N(C1)CCCC2=CC=CC=C2)C(=O)NCC3=CC(=CC=C3)Cl	Ki = 550000 nM	Non binder
T94033	Coagulation factor IIa	B5L2CK	3-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477531	C18H17F3N4O7S	490.4	C1=CC(=CC(=C1)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)C(=O)O.C(=O)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B5YZF0	(2S)-1-[(2R)-2-Aminobutyl]-N-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	118736067	C16H25Cl2N3O	346.3	CC[C@H](CN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl)N.Cl	Ki = 430000 nM	Non binder
T94033	Coagulation factor IIa	B61LFO	Ethyl 2-[(2E)-2-carbamimidoylimino-6-hydroxy-1,3-benzothiazol-3-yl]acetate	Investigative	70686249	C12H14N4O3S	294.33	CCOC(=O)CN\\1C2=C(C=C(C=C2)O)S/C1=N/C(=N)N	Ki = 481000 nM	Non binder
T94033	Coagulation factor IIa	B6BPZ4	(S)-2-{(S)-2-[(S)-2-(7-Amino-heptanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10347951	C32H46N4O5	566.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCN	IC50 = 330000 nM	Non binder
T94033	Coagulation factor IIa	B6HEL0	(2S)-N-[(3-Chlorophenyl)methyl]-1-(4-methylpentyl)pyrrolidine-2-carboxamide	Investigative	118736062	C18H27ClN2O	322.9	CC(C)CCCN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 400000 nM	Non binder
T94033	Coagulation factor IIa	B6JFW5	Chembl4216440	Investigative	9112697	C19H20N4O4S	400.5	CC1=CSC(=O)N1CC(=O)OCC(=O)NC2=C(N(N=C2C)C3=CC=CC=C3)C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B6MVO0	n-(4-Carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide	Investigative	4300	C15H13ClIN3O2	429.64	CC1=CC(=C(C(=C1)I)O)C(=O)NC2=CC(=C(C=C2)C(=N)N)Cl	Ki = 245000 nM	Non binder
T94033	Coagulation factor IIa	B6R0QV	4-[(3-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71458627	C14H16ClN3O3S	341.8	COC1=CC=CC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B6V7YC	N-[2-(3-Carbamimidoyl-phenoxy)-ethyl]-benzamide	Investigative	44297783	C16H17N3O2	283.32	C1=CC=C(C=C1)C(=O)NCCOC2=CC=CC(=C2)C(=N)N	Ki = 800000 nM	Non binder
T94033	Coagulation factor IIa	B6WCU7	((S)-4-Amino-1-{[(1-formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-butyl)-carbamic acid tert-butyl ester	Investigative	73351772	C18H35N7O5	429.5	CC(C)(C)OC(=O)N[C@H](CCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B72ZMX	3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44303912	C25H24N4O3	428.5	CC(C)OC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CC=C(C=C4)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B78ZBK	N-(4-Guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44303733	C14H14N4O2	270.29	C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B79EXU	Sodium;[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl]oxymethyl]-1H-indol-5-yl] sulfate	Investigative	118723908	C38H36NNaO16S	817.7	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OCC5=C(C6=C(N5)C=CC(=C6)OS(=O)(=O)[O-])C(=O)OCC)C(=O)OCC)OC)C.[Na+]	IC50 = 304000 nM	Non binder
T94033	Coagulation factor IIa	B7CEB5	Chembl4211470	Investigative	16289649	C23H21N5O4	431.4	CC1=C(C(=NN1C2=CC=CC=C2)C)NC(=O)COC(=O)CN3C=NC4=CC=CC=C4C3=O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B7GX2B	Piperidin-4-yl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409930	C16H16ClNO4	321.75	C1CNCCC1OC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B7GYO6	2-Aminoethyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409709	C13H12ClNO4	281.69	C1=CC2=C(C=C1CCl)C=C(C(=O)O2)C(=O)OCCN	IC50 = 284000 nM	Non binder
T94033	Coagulation factor IIa	B7LYX9	3alpha-(4-Amidinobutyl)-1,2,3,3aalpha,8,8abeta-hexahydroindeno[2,1-b]pyrrole-2-one	Investigative	44290501	C16H21N3O	271.36	C1[C@H]2[C@@H]([C@H](C(=O)N2)CCCCC(=N)N)C3=CC=CC=C31	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B7PFW8	Sodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-2-methyl-1H-indol-5-yl)oxymethyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-5-yl] sulfate	Investigative	118723906	C29H31N2NaO11S	638.6	CCOC(=O)C1=C(NC2=C1C=C(C=C2)OCC3=C(C4=C(N3C(=O)OC(C)(C)C)C=CC(=C4)OS(=O)(=O)[O-])C(=O)OCC)C.[Na+]	IC50 = 425000 nM	Non binder
T94033	Coagulation factor IIa	B7RIF4	Chembl47797	Investigative	73350301	C27H42N6O9	594.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 341000 nM	Non binder
T94033	Coagulation factor IIa	B7VT1Z	(S)-1-Butyryl-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide	Investigative	45141149	C16H21ClN2O2	308.8	CCCC(=O)N1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 322000 nM	Non binder
T94033	Coagulation factor IIa	B85DZR	(12E)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,12,18,20,22,27(30),28-nonaen-26-one	Investigative	134131077	C29H33N7O3	527.6	CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCC/C=C/CCCOC2=CC(=N1)N)N=C3	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B8AEO7	((S)-4-{[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-methyl}-3-oxo-1-phenylmethanesulfonyl-piperazin-2-yl)-acetic acid	Investigative	44377016	C24H31N7O7S2	593.7	C1CN([C@H](C(=O)N1CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2)CC(=O)O)S(=O)(=O)CC3=CC=CC=C3	IC50 = 325000 nM	Non binder
T94033	Coagulation factor IIa	B8AFI9	4-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44304046	C14H13ClN4O2	304.73	C1=CC(=CC=C1NC(=O)C2=C(C=C(C=C2)Cl)O)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B8EPU3	3-Guanidinophenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409708	C18H14ClN3O4	371.8	C1=CC(=CC(=C1)OC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O)N=C(N)N	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	B8EUF5	(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamide	Investigative	56680051	C39H46N6O5S	710.9	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)NS(=O)(=O)CC4=CC=CC=C4	IC50 > 640000 nM	Non binder
T94033	Coagulation factor IIa	B8M4EP	5-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44303719	C14H13BrN4O2	349.18	C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Br)O)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	B8O2DV	1,4-Bis[[2-oxo-2-(1-amidino-4-piperidinylmethylamino)ethyl]carbamoyloxymethyl]benzene	Investigative	44289153	C28H44N10O6	616.7	C1CN(CCC1CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3CCN(CC3)C(=N)N)C(=N)N	Ki = 386000 nM	Non binder
T94033	Coagulation factor IIa	B8U7HR	20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one	Investigative	134131303	C29H33N7O3	527.6	CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCCCC=CCCOC2=CC(=N1)N)N=C3	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B8WY6S	Chembl47874	Investigative	73345713	C32H45N5O9	643.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 672000 nM	Non binder
T94033	Coagulation factor IIa	B8Y7HO	(2S)-1-[(2R)-2-Amino-3-methylbutyl]-N-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	118736069	C17H27Cl2N3O	360.3	CC(C)[C@H](CN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl)N.Cl	Ki = 370000 nM	Non binder
T94033	Coagulation factor IIa	B92QCK	Disodium;[3-ethoxycarbonyl-6-[(3-ethoxycarbonyl-6-methoxy-5-sulfonatooxy-1-benzofuran-2-yl)methoxy]-2-methyl-1-benzofuran-5-yl] sulfate	Investigative	53391543	C25H22Na2O16S2	688.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)C.[Na+].[Na+]	IC50 = 758577.58 nM	Non binder
T94033	Coagulation factor IIa	B94SEB	Sodium;[6-methoxy-3-(2-methoxyethoxycarbonyl)-2-[[6-methoxy-3-(2-methoxyethoxycarbonyl)-2-methyl-1-benzofuran-5-yl]oxymethyl]-1-benzofuran-5-yl] sulfate	Investigative	53392255	C28H29NaO15S	660.6	CC1=C(C2=CC(=C(C=C2O1)OC)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCCOC)C(=O)OCCOC.[Na+]	IC50 = 375000 nM	Non binder
T94033	Coagulation factor IIa	B96BFN	(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-N-[(1R,2S)-3-cyclohexyl-1-hydroxy-1-(1,3-thiazol-2-yl)propan-2-yl]-4-methylpentanamide	Investigative	44307502	C27H40N4O3S	500.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1CCCCC1)[C@H](C2=NC=CS2)O)NC(=O)[C@H](CC3=CC=CC=C3)N	IC50 > 530000 nM	Non binder
T94033	Coagulation factor IIa	B9AN7K	N-(3,5-Bis(-1-(2-carbamimidoylhydrazono)ethyl)phenyl)-4-guanidinobutanamide	Investigative	53321291	C17H28N12O	416.5	C/C(=N\\N=C(N)N)/C1=CC(=CC(=C1)NC(=O)CCCN=C(N)N)/C(=N/N=C(N)N)/C	Ki = 800000 nM	Non binder
T94033	Coagulation factor IIa	B9C0QP	Chembl45112	Investigative	73356336	C26H41N5O8	551.6	CC[C@H](C)[C@@H](C(=O)NCCC(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 406000 nM	Non binder
T94033	Coagulation factor IIa	B9LU5N	4-(N-Phenylsulfamoyl)Benzamidinium Chloride	Investigative	71449631	C13H14ClN3O2S	311.79	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B9OBX0	2-Phenyl-1H-benzimidazole-5-carboxamidine	Investigative	11009950	C14H12N4	236.27	C1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 340000 nM	Non binder
T94033	Coagulation factor IIa	B9QWN5	(3R)-4-[5-Carbamimidoyl-2-(2-carboxy-2-oxoethyl)phenoxy]-3-[(1-pyridin-4-ylpiperidine-4-carbonyl)amino]butanoic acid	Investigative	10951324	C25H29N5O7	511.5	C1CN(CCC1C(=O)N[C@H](CC(=O)O)COC2=C(C=CC(=C2)C(=N)N)CC(=O)C(=O)O)C3=CC=NC=C3	Ki = 680000 nM	Non binder
T94033	Coagulation factor IIa	B9SG8F	[2-[(3,5-Dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-phenylacetate	Investigative	16285203	C21H21N3O3	363.4	CC1=C(C(=NN1C2=CC=CC=C2)C)NC(=O)COC(=O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	B9SU7Q	Chembl4212825	Investigative	145965556	C19H16Na2O12S2	546.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=CC(=CC=C3)OS(=O)(=O)[O-])C.[Na+].[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	B9U0ZL	Chembl295218	Investigative	73348717	C28H43N5O9	593.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@@H]1CC(CN1C(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O)O	IC50 = 298000 nM	Non binder
T94033	Coagulation factor IIa	B9VGY7	3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44304097	C23H20N4O3	400.4	COC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CC=C(C=C4)N=C(N)N)O	Ki = 205000 nM	Non binder
T94033	Coagulation factor IIa	B9YKW8	((S)-5-Amino-1-{[(1-formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-pentyl)-carbamic acid tert-butyl ester	Investigative	54555233	C20H39N9O5	485.6	CC(C)(C)OC(=O)N[C@H](CCCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 = 400000 nM	Non binder
T94033	Coagulation factor IIa	B9Z2JB	Chembl4202894	Investigative	145975277	C13H12Na2O12S2	470.3	CC1=C(C2=CC(=C(C=C2O1)OC)OS(=O)(=O)[O-])C(=O)OCCOS(=O)(=O)[O-].[Na+].[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BA4F9W	[5-[4-[[4-[(E)-N'-Methoxycarbonylcarbamimidoyl]phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate	Investigative	44289180	C37H57N9O8	755.9	COC(=O)/N=C(\\C1=CC=C(C=C1)CNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5)/N	Ki = 561000 nM	Non binder
T94033	Coagulation factor IIa	BA4XM6	(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester	Investigative	44372863	C21H25N5O5	427.5	C1=CC=C(C=C1)COC(=O)N[C@H](CO)C(=O)NCC(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 230000 nM	Non binder
T94033	Coagulation factor IIa	BA59YG	N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-(2-oxo-piperazin-1-yl)-acetamide	Investigative	44376468	C15H23N7O3S	381.5	C1CN(C(=O)CN1)CC(=O)N[C@H](CCCN=C(N)N)C(=O)C2=NC=CS2	IC50 = 220000 nM	Non binder
T94033	Coagulation factor IIa	BA68DE	N-[2-(3-Carbamimidoyl-phenoxy)-ethyl]-4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzamide	Investigative	17788740	C23H29N5O3	423.5	CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)C(=O)NCCOC3=CC=CC(=C3)C(=N)N	Ki = 440000 nM	Non binder
T94033	Coagulation factor IIa	BA7SG3	3-Methoxy-benzamidine	Investigative	5108695	C8H10N2O	150.18	COC1=CC=CC(=C1)C(=N)N	Ki = 794328.23 nM	Non binder
T94033	Coagulation factor IIa	BAFR74	Chembl4211424	Investigative	145966681	C31H26Na2O17S2	780.6	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)OC5=CC(=CC=C5)OS(=O)(=O)[O-])C.[Na+].[Na+]	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BAM4I8	4-[(4-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71453255	C15H18ClN3O3S	355.8	COC1=CC=C(C=C1)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BAZ79C	Chembl432400	Investigative	73353029	C26H42N4O3S	490.7	CC[C@H](C)[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(CCCCCCN)C2CSCCC2=O)N	Ki = 720000 nM	Non binder
T94033	Coagulation factor IIa	BB43IX	3-(5-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid	Investigative	10091962	C22H23N3O4	393.4	C1CNC[C@H]1OC2=CC=C(C=C2)C(CC3=CC4=C(O3)C=CC(=C4)C(=N)N)C(=O)O	IC50 = 230000 nM	Non binder
T94033	Coagulation factor IIa	BB6NR1	Chembl298334	Investigative	73353280	C27H42N6O9	594.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 711000 nM	Non binder
T94033	Coagulation factor IIa	BBF4U6	(S)-N-(3-Chlorobenzyl)-1-propionylpyrrolidine-2-carboxamide	Investigative	45141148	C15H19ClN2O2	294.77	CCC(=O)N1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 330000 nM	Non binder
T94033	Coagulation factor IIa	BBY1C6	4-Ethoxy-N-(4-guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44303824	C16H18N4O3	314.34	CCOC1=CC(=C(C=C1)C(=O)NC2=CC=C(C=C2)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BC15YK	Chembl44386	Investigative	73348728	C26H41N5O8	551.6	CC[C@H](C)[C@@H](C(=O)N[C@H](C)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 593000 nM	Non binder
T94033	Coagulation factor IIa	BC20LY	4-[(3,4-Dimethoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71456771	C15H18ClN3O4S	371.8	COC1=C(C=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BC7BO5	Dihydrospumigin N	Investigative	145974544	C30H42N6O7	598.7	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=C(C=C2)O)NC(=O)C(CCC3=CC=C(C=C3)O)O)C(=O)N[C@@H](CCCN=C(N)N)CO	IC50 = 250000 nM	Non binder
T94033	Coagulation factor IIa	BC7F8S	(2S)-2-Acetamido-N-[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide	Investigative	56676740	C34H42N6O4	598.7	CC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC3=CC=CC=C3	IC50 > 400000 nM	Non binder
T94033	Coagulation factor IIa	BC7L3X	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylate	Investigative	44315392	C35H56N10O6	712.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCC(CC5)N	Ki = 274000 nM	Non binder
T94033	Coagulation factor IIa	BCAL64	3-Hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44304104	C22H18N4O2	370.4	C1=CC=C2C=C3C=C(C(=CC3=CC2=C1)C(=O)NC4=CC=C(C=C4)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BCBT57	4-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477532	C19H19F3N4O7S	504.4	C1=CC(=CC=C1C(=O)O)NC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BD0CT1	Chembl295809	Investigative	73353283	C28H43N5O8	577.7	CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 582000 nM	Non binder
T94033	Coagulation factor IIa	BD96JC	Substituted biphenyl derivative, 21	Investigative	17809181	C26H26N4O4	458.5	CC(C)CNC(=O)C1=CC(=C(C=C1)C2=CC=CC=C2C(=O)NC3=CC=C(C=C3)C(=N)N)C(=O)O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BDS14M	Acetic acid;(2S)-N-[(4-carbamimidoylphenyl)methyl]-1-ethylpyrrolidine-2-carboxamide	Investigative	137635103	C19H30N4O5	394.5	CCN1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N.CC(=O)O.CC(=O)O	Ki = 250000 nM	Non binder
T94033	Coagulation factor IIa	BDZ05P	[3-[2-[(4-Methylphenyl)methyl]-3,9-dioxo-1H-chromeno[2,3-c]pyrrol-1-yl]phenyl] hydrogen sulfate	Investigative	71517739	C25H19NO7S	477.5	CC1=CC=C(C=C1)CN2C(C3=C(C2=O)OC4=CC=CC=C4C3=O)C5=CC(=CC=C5)OS(=O)(=O)O	IC50 = 743000 nM	Non binder
T94033	Coagulation factor IIa	BE01YA	4-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)butanamide;hydrochloride	Investigative	71460458	C19H25ClN4O5S	456.9	COC1=C(C=C(C=C1)NC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BE7W3K	Arg-pro-pro-gly-phe	Investigative	3081453	C27H40N8O6	572.7	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O	IC50 = 601000 nM	Non binder
T94033	Coagulation factor IIa	BEWX42	(S)-2-{(S)-2-[(S)-2-(6-Guanidino-hexanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10077222	C32H46N6O5	594.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCN=C(N)N	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BF1E5X	Chembl46428	Investigative	73350298	C27H43N5O9	581.7	CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 394000 nM	Non binder
T94033	Coagulation factor IIa	BF4K6S	N-(4-Guanidino-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide	Investigative	44304100	C15H15IN4O2	410.21	CC1=CC(=C(C(=C1)I)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BF5BK1	Chembl297802	Investigative	73348718	C28H45N5O8	579.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 318000 nM	Non binder
T94033	Coagulation factor IIa	BFGD03	1beta,5beta-Bis[4-[3-(1-amidino-4-piperidinyl)propionyl]piperazinocarbonyloxy]cyclooctane	Investigative	18397345	C36H62N10O6	730.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CCC5CCN(CC5)C(=N)N	Ki = 213000 nM	Non binder
T94033	Coagulation factor IIa	BFNP84	N-[1-(1-Amino-isoquinolin-6-ylmethyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(toluene-4-sulfonylamino)-acetamide	Investigative	22665887	C26H31N5O4S	509.6	CC1=CC=C(C=C1)S(=O)(=O)NCC(=O)NC(CC2=CC3=C(C=C2)C(=NC=C3)N)C(=O)N4CCCCC4	IC50 = 357000 nM	Non binder
T94033	Coagulation factor IIa	BFOB67	4-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477530	C18H17F3N4O7S	490.4	C1=CC(=CC=C1C(=O)O)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BGCB48	alpha-Ketothiazole analogue 27	Investigative	16098905	C22H37N7O4S	495.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C1=NC=CS1)NC(=O)C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BGI7H5	3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44304084	C21H16IN5O2	497.3	C1=CC=C2C=C3C(=CC2=C1)C=C(C(=C3I)O)C(=O)NC4=CN=C(C=C4)N=C(N)N	Ki = 310000 nM	Non binder
T94033	Coagulation factor IIa	BH0MW1	4-[[(3R)-5-[2-[(4-Carbamimidoylphenyl)methylamino]-2-oxoethyl]-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]amino]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid	Investigative	45272952	C25H26F3N5O7S	597.6	C1[C@@H](C(=O)N(C2=CC=CC=C2S1)CC(=O)NCC3=CC=C(C=C3)C(=N)N)NC(=O)CCC(=O)O.C(=O)(C(F)(F)F)O	IC50 = 300000 nM	Non binder
T94033	Coagulation factor IIa	BH34BA	5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[2-[[4-(aminomethyl)phenyl]carbamoyl]-4-(methylamino)phenyl]benzoic acid	Investigative	16066741	C29H33N5O5	531.6	CC(C)C[C@@H](C(=O)N)NC(=O)C1=CC(=C(C=C1)C2=C(C=C(C=C2)NC)C(=O)NC3=CC=C(C=C3)CN)C(=O)O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BH3O5E	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(5,6,7,8-tetrahydroquinazolin-6-ylmethyl)pyrrolidine-2-carboxamide	Investigative	44378887	C30H41N5O4S	567.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC=NC=C4C3)NS(=O)(=O)CC5=CC=CC=C5	Ki = 289000 nM	Non binder
T94033	Coagulation factor IIa	BH70IN	Chembl47136	Investigative	73356326	C27H43N5O9	581.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 546000 nM	Non binder
T94033	Coagulation factor IIa	BH80DX	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[(2,5-dihydroxybenzoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]butanoic acid	Investigative	73353282	C29H48N8O8	636.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 273000 nM	Non binder
T94033	Coagulation factor IIa	BH82YG	Chembl48835	Investigative	73354794	C27H41N5O8S	595.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@@H]1CSCN1C(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 378000 nM	Non binder
T94033	Coagulation factor IIa	BH8LX1	Chembl295541	Investigative	73348720	C29H43N7O8	617.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 422000 nM	Non binder
T94033	Coagulation factor IIa	BH9ZO7	Benzyl N-[(2R)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	56676741	C40H46N6O5	690.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 = 560000 nM	Non binder
T94033	Coagulation factor IIa	BHA23T	Chembl4218188	Investigative	9882885	C14H10FN3O2S	303.31	CCSC1=NC=C2C(=N1)N=C(OC2=O)C3=CC=CC=C3F	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BHL85B	Chembl40441	Investigative	73348723	C27H41N5O10	595.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 680000 nM	Non binder
T94033	Coagulation factor IIa	BHM2Y5	4-Carbamimidoyl-N-[2-(3-carbamimidoylphenoxy)ethyl]benzamide	Investigative	9840270	C17H19N5O2	325.4	C1=CC(=CC(=C1)OCCNC(=O)C2=CC=C(C=C2)C(=N)N)C(=N)N	Ki = 710000 nM	Non binder
T94033	Coagulation factor IIa	BHM51N	3-[(4-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71456775	C15H18ClN3O3S	355.8	COC1=CC=C(C=C1)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 245000 nM	Non binder
T94033	Coagulation factor IIa	BHZ8X2	N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-(4-phenylmethanesulfonyl-piperazin-1-yl)-acetamide	Investigative	44375908	C22H31N7O4S2	521.7	C1CN(CCN1CC(=O)N[C@H](CCCN=C(N)N)C(=O)C2=NC=CS2)S(=O)(=O)CC3=CC=CC=C3	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BI0Q1C	4-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]butanamide;hydrochloride	Investigative	71453260	C20H27ClN4O5S	471	COC1=C(C=C(C=C1)CNC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BI5U3N	6-Amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide	Investigative	57392333	C42H60N8O7	789	CC[C@H](C)[C@@H]1C(=O)N[C@H](/C=C/C(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)N1)CC3=CC(=CC=C3)CN)NC(=O)CCCCCN)CC4=CC=C(C=C4)O	Ki = 330000 nM	Non binder
T94033	Coagulation factor IIa	BJ5GN1	3-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide	Investigative	44304192	C14H13ClN4O2	304.73	C1=CC(=C(C(=C1)Cl)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki = 450000 nM	Non binder
T94033	Coagulation factor IIa	BJ83EM	Chembl4207245	Investigative	145975446	C22H23NaO9S	486.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=CC=C(C=C3)OC(C)C)C.[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BJ85SG	Disodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-5-sulfonatooxy-1-benzofuran-6-yl] sulfate	Investigative	53391545	C25H22Na2O16S2	688.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OS(=O)(=O)[O-])OS(=O)(=O)[O-])C(=O)OCC)OC)C.[Na+].[Na+]	IC50 = 363078.05 nM	Non binder
T94033	Coagulation factor IIa	BJ9KU3	Chembl296297	Investigative	73347207	C26H41N5O8	551.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)CCNC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 821000 nM	Non binder
T94033	Coagulation factor IIa	BJF3R8	(S)-2-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester	Investigative	10071900	C25H33N3O4	439.5	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)N	IC50 > 333000 nM	Non binder
T94033	Coagulation factor IIa	BJF82O	3-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477533	C19H19F3N4O7S	504.4	C1=CC(=CC(=C1)NC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)C(=O)O.C(=O)(C(F)(F)F)O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BJL25U	Chembl416280	Investigative	73356334	C25H39N5O8	537.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 428000 nM	Non binder
T94033	Coagulation factor IIa	BKRT84	2-[2-[(3-Carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]-5-[[(1S)-1-carboxy-3-methylbutyl]carbamoyl]benzoic acid	Investigative	44421837	C29H30N4O7	546.6	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CC(=C(C=C1)C2=C(C=C(C=C2)NC)C(=O)NC3=CC=CC(=C3)C(=O)N)C(=O)O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BKS48Q	N-[2-(3-Amidinophenoxy)ethyl]-2'-sulfamoylbiphenyl-4-carboxamide	Investigative	9954812	C22H22N4O4S	438.5	C1=CC=C(C(=C1)C2=CC=C(C=C2)C(=O)NCCOC3=CC=CC(=C3)C(=N)N)S(=O)(=O)N	IC50 = 321000 nM	Non binder
T94033	Coagulation factor IIa	BKTV54	{(R)-1-[6-(4-Carbamimidoyl-benzylcarbamoyl)-6,7-dihydro-5H-[1]pyrindin-6-ylcarbamoyl]-2-methyl-propylamino}-acetic acid	Investigative	11849424	C24H30N6O4	466.5	CC(C)[C@H](C(=O)NC1(CC2=C(C1)N=CC=C2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 = 300000 nM	Non binder
T94033	Coagulation factor IIa	BL5A4M	3-Guanidinopropyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409734	C15H16ClN3O4	337.76	C1=CC2=C(C=C1CCl)C=C(C(=O)O2)C(=O)OCCCN=C(N)N	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BL5HO1	3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44303925	C24H23N5O3	429.5	CC(C)OC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CN=C(C=C4)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BMBF42	Methyl (2S,4S)-4-amino-2-[[(2S,4S)-4-amino-2-[3-[(1R,3R)-3-[[(2S,4S)-4-amino-2-[[(2S,4S)-4-amino-5-(1H-indol-3-yl)-3-oxo-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-2-oxocyclohexyl]propanoylamino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-5-(4-hydroxyphenyl)-3-oxopentanoate	Investigative	44404049	C68H74N12O14	1283.4	COC(=O)[C@H](C(=O)[C@H](CC1=CC=C(C=C1)O)N)NC(=O)[C@H](C(=O)[C@H](CC2=CNC3=CC=CC=C32)N)NC(=O)CC[C@H]4CCC[C@H](C4=O)NC(=O)[C@H](C(=O)[C@H](CC5=CNC6=CC=CC=C65)N)NC(=O)[C@H](C(=O)[C@H](CC7=CNC8=CC=CC=C87)N)NC(=O)OCC9=CC=CC=C9	IC50 > 400000 nM	Non binder
T94033	Coagulation factor IIa	BMBN07	(2S)-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-6-Amino-2-[(2,5-dihydroxybenzoyl)amino]hexanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]butanoic acid	Investigative	73345707	C29H47N5O8	593.7	CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 257000 nM	Non binder
T94033	Coagulation factor IIa	BMSV82	3-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477684	C20H21F3N4O7S	518.5	C1=CC(=CC(=C1)NC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)C(=O)O.C(=O)(C(F)(F)F)O	Ki = 201000 nM	Non binder
T94033	Coagulation factor IIa	BMX17B	Chembl297451	Investigative	73354795	C28H43N5O10	609.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 458000 nM	Non binder
T94033	Coagulation factor IIa	BMZC64	Sodium;[2-[(2-benzyl-3-ethoxycarbonyl-6-methoxy-1-benzofuran-5-yl)oxymethyl]-3-ethoxycarbonyl-1H-indol-5-yl] sulfate	Investigative	118723904	C31H28NNaO11S	645.6	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=C(N3)C=CC(=C4)OS(=O)(=O)[O-])C(=O)OCC)OC)CC5=CC=CC=C5.[Na+]	IC50 = 327000 nM	Non binder
T94033	Coagulation factor IIa	BN51BZ	(S)-2-[(3As,6S,6aR)-6-Methyl-4-((2R,3S)-2-(S)-methyl-3-methyl-cyclopropanecarbonyl)-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-pyrrolidine-1-carboxylic acid (4-isopropyl-phenyl)-amide	Investigative	511106	C28H38N4O4	494.6	C[C@@H]1[C@@H](C1C(=O)N2[C@H]3CCN([C@@H]3[C@@H](C2=O)C)C(=O)[C@@H]4CCCN4C(=O)NC5=CC=C(C=C5)C(C)C)C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BN5RQ7	Chembl298106	Investigative	73356330	C29H48N6O8	608.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 748000 nM	Non binder
T94033	Coagulation factor IIa	BN8G2W	Chembl4204101	Investigative	145976303	C17H12Na2O8S	422.3	CC1=C(C2=CC(=C(C=C2O1)OCC3=CC=CC=C3)OS(=O)(=O)[O-])C(=O)[O-].[Na+].[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BNIA67	(S)-2-((3As,6S,6aR)-4-Benzothiazol-2-yl-6-methyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-pyrrolidine-1-carboxylic acid (4-isopropyl-phenyl)-amide	Investigative	511111	C29H33N5O3S	531.7	C[C@H]1[C@@H]2[C@H](CCN2C(=O)[C@@H]3CCCN3C(=O)NC4=CC=C(C=C4)C(C)C)N(C1=O)C5=NC6=CC=CC=C6S5	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BNZ2W5	Chembl297329	Investigative	73350300	C27H43N5O8	565.7	CC[C@H](C)[C@@H](C(=O)NCCCC(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 262000 nM	Non binder
T94033	Coagulation factor IIa	BO0Y1D	3-Benzylbenzamidine	Investigative	12254250	C14H14N2	210.27	C1=CC=C(C=C1)CC2=CC(=CC=C2)C(=N)N	Ki = 398107.17 nM	Non binder
T94033	Coagulation factor IIa	BO3GS5	[4-[[3-[1,3-Dioxo-5-[(4-sulfooxyphenyl)carbamoyl]isoindol-2-yl]benzoyl]amino]phenyl] hydrogen sulfate	Investigative	71533477	C28H19N3O12S2	653.6	C1=CC(=CC(=C1)N2C(=O)C3=C(C2=O)C=C(C=C3)C(=O)NC4=CC=C(C=C4)OS(=O)(=O)O)C(=O)NC5=CC=C(C=C5)OS(=O)(=O)O	IC50 = 286000 nM	Non binder
T94033	Coagulation factor IIa	BO75ZM	Sodium;[3-carboxy-2-[(3-carboxy-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate	Investigative	53392975	C22H17NaO13S	544.4	CC1=C(C2=CC(=C(C=C2O1)OC)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)O)C(=O)O.[Na+]	IC50 = 371535.23 nM	Non binder
T94033	Coagulation factor IIa	BO7J8Y	4-Aminocyclohexyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409750	C17H18ClNO4	335.8	C1CC(CCC1N)OC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BOHI90	[4-(6-Chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-methanone	Investigative	11180045	C22H23ClN4O3S2	491	CN1CCC2=C(C1)SC(=N2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)C=C(C=C5)Cl	IC50 = 560000 nM	Non binder
T94033	Coagulation factor IIa	BP3N9J	(R)-5-[(S)-2-(4-Guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-4-(naphthalene-2-sulfonylamino)-5-oxo-pentanoic acid	Investigative	44363534	C25H34N6O6S	546.6	C1C[C@H](N(C1)C(=O)[C@@H](CCC(=O)O)NS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C(=O)NCCCCN=C(N)N	IC50 > 333000 nM	Non binder
T94033	Coagulation factor IIa	BPD92J	N-(4-Guanidino-phenyl)-2-hydroxy-5-methyl-benzamide	Investigative	44303839	C15H16N4O2	284.31	CC1=CC(=C(C=C1)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BPW2Q6	Chembl4211986	Investigative	16284785	C22H20N4O5	420.4	CC1=C(C(=NN1C2=CC=CC=C2)C)NC(=O)COC(=O)CN3C4=CC=CC=C4OC3=O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BPXO13	(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamide	Investigative	56673433	C39H46N6O5S	710.9	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NS(=O)(=O)CC4=CC=CC=C4	IC50 > 590000 nM	Non binder
T94033	Coagulation factor IIa	BQ57NV	(13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one	Investigative	134131084	C29H33N7O3	527.6	CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCCC/C=C\\CCOC2=CC(=N1)N)N=C3	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BQC43T	1,9-Di{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbonyl]hexahydro-1-pyrazinyl}-1,9-nonanedione	Investigative	44340086	C37H44N8O6	696.8	C1CN(CCN1C(=O)CCCCCCCC(=O)N2CCN(CC2)C(=O)C3=CC4=C(O3)C=CC(=C4)C(=N)N)C(=O)C5=CC6=C(O5)C=CC(=C6)C(=N)N	Ki = 230000 nM	Non binder
T94033	Coagulation factor IIa	BR1T4G	1,4-Bis[1,5-dioxo-5-(4-guanidinobenzylamino)pentylaminomethyl]benzene	Investigative	44315743	C34H44N10O4	656.8	C1=CC(=CC=C1CNC(=O)CCCC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CCCC(=O)NCC3=CC=C(C=C3)N=C(N)N	Ki = 492000 nM	Non binder
T94033	Coagulation factor IIa	BR1ZG9	2-Hydroxy-biphenyl-3-carboxylic acid (4-guanidino-phenyl)-amide	Investigative	44304105	C20H18N4O2	346.4	C1=CC=C(C=C1)C2=C(C(=CC=C2)C(=O)NC3=CC=C(C=C3)N=C(N)N)O	Ki > 450000 nM	Non binder
T94033	Coagulation factor IIa	BRV7J3	Chembl4215768	Investigative	145974171	C19H23NaO8S	434.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3CCCCC3)C.[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BS0RD1	3-Aminopropyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409710	C14H14ClNO4	295.72	C1=CC2=C(C=C1CCl)C=C(C(=O)O2)C(=O)OCCCN	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BS0W5Y	4-[5-Carbamimidoyl-2-(2-carboxy-2-oxo-ethyl)-phenoxy]-3-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzoylamino}-butyric acid	Investigative	10864710	C28H33N5O8	567.6	CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)C(=O)N[C@H](CC(=O)O)COC3=C(C=CC(=C3)C(=N)N)CC(=O)C(=O)O	Ki = 540000 nM	Non binder
T94033	Coagulation factor IIa	BS43PI	Chembl4203558	Investigative	145977781	C26H23NaO8S	518.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=CC(=CC=C3)S(=O)(=O)[O-])OCC4=CC=CC=C4)C.[Na+]	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BS5JV1	1,4-Bis[[2-oxo-2-[2-(1-amidino-4-piperidinyl)ethylamino]ethyl]carbamoyloxymethyl]benzene	Investigative	44289132	C30H48N10O6	644.8	C1CN(CCC1CCNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCCC3CCN(CC3)C(=N)N)C(=N)N	Ki = 423000 nM	Non binder
T94033	Coagulation factor IIa	BS6U2H	3-(7-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester	Investigative	10365461	C26H29N3O3	431.5	CCOC(=O)C(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3=CC=C(C=C3)O[C@H]4CCNC4	IC50 > 600000 nM	Non binder
T94033	Coagulation factor IIa	BSR58W	Chembl44935	Investigative	73348716	C28H44N6O9	608.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 300000 nM	Non binder
T94033	Coagulation factor IIa	BSTF30	4-[(3-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71453257	C15H18ClN3O3S	355.8	COC1=CC=CC(=C1)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	Ki = 223000 nM	Non binder
T94033	Coagulation factor IIa	BSV38P	Chembl46763	Investigative	73353286	C27H43N5O8	565.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 294000 nM	Non binder
T94033	Coagulation factor IIa	BSV60C	2-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)acetamide;hydrochloride	Investigative	71449632	C17H21ClN4O5S	428.9	COC1=C(C=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	Ki = 250000 nM	Non binder
T94033	Coagulation factor IIa	BT9P0N	2-[2-[(3-Carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]-5-(2-methylpropylcarbamoyl)benzoic acid	Investigative	44421826	C27H28N4O5	488.5	CC(C)CNC(=O)C1=CC(=C(C=C1)C2=C(C=C(C=C2)NC)C(=O)NC3=CC=CC(=C3)C(=O)N)C(=O)O	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BTJN37	1-(4-Chlorophenyl)-1H-tetrazole	Investigative	270006	C7H5ClN4	180.59	C1=CC(=CC=C1N2C=NN=N2)Cl	IC50 = 330000 nM	Non binder
T94033	Coagulation factor IIa	BTRI91	4-(2-Hydroxyethylamino)-pyridine	Investigative	17750368	C7H10N2O	138.17	C1=CN=CC=C1NCCO	Ki > 500000 nM	Non binder
T94033	Coagulation factor IIa	BU3J0C	Chembl4212332	Investigative	41583852	C24H24N4O3	416.5	CC1=CC2=CC=CC=C2N1CC(=O)OCC(=O)NC3=C(N(N=C3C)C4=CC=CC=C4)C	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BU9QB3	{(S)-1-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-ethylcarbamoyl]-4-guanidino-butyl}-carbamic acid tert-butyl ester	Investigative	44287260	C20H39N9O5	485.6	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCC(=O)NC(CCCN=C(N)N)C=O	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BV2UF1	alpha-(Benzyloxycarbonylamino)-4-guanidinobenzylphosphonic acid diphenyl ester	Investigative	11445130	C28H27N4O5P	530.5	C1=CC=C(C=C1)COC(=O)NC(C2=CC=C(C=C2)N=C(N)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 250000 nM	Non binder
T94033	Coagulation factor IIa	BV54EL	2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidine-1-carbonyl)-3-(pyridin-4-ylamino)-propyl]-acetamide	Investigative	44459496	C26H31N5O4S	509.6	C1CCN(CC1)C(=O)[C@H](CCNC2=CC=NC=C2)NC(=O)CNS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 300000 nM	Non binder
T94033	Coagulation factor IIa	BV58RB	{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-2,3-dihydro-1H-cyclopenta[b]naphthalen-2-ylcarbamoyl]-2-methyl-propylamino}-acetic acid	Investigative	11849427	C29H33N5O4	515.6	CC(C)[C@H](C(=O)NC1(CC2=CC3=CC=CC=C3C=C2C1)C(=O)NCC4=CC=C(C=C4)C(=N)N)NCC(=O)O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BV65UX	Chembl4213790	Investigative	10447733	C14H6F2N2O4	304.2	C1=CC(=C(C(=C1)F)C2=NC3=C(C=CC(=C3)[N+](=O)[O-])C(=O)O2)F	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BVS04D	(3R)-2-[2-(4-Chlorophenyl)acetyl]-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	66573845	C28H26ClN3O4	504	C1COCC(=O)N1C2=CC=C(C=C2)NC(=O)[C@H]3CC4=CC=CC=C4CN3C(=O)CC5=CC=C(C=C5)Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BW5DQ9	Chembl4217769	Investigative	145974035	C21H21NaO10S	488.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=CC(=CC=C3)OCOC)C.[Na+]	IC50 = 229000 nM	Non binder
T94033	Coagulation factor IIa	BW73KZ	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate	Investigative	9875345	C36H52N12O6	748.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N	Ki = 435000 nM	Non binder
T94033	Coagulation factor IIa	BWA4M5	(S)-N-(3-Chlorobenzyl)-1-(3,3-dimethylbutanoyl)pyrrolidine-2-carboxamide	Investigative	45141151	C18H25ClN2O2	336.9	CC(C)(C)CC(=O)N1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 484000 nM	Non binder
T94033	Coagulation factor IIa	BWI7Z9	4-(N-Benzylsulfamoyl)Benzamidinium Chloride	Investigative	71454984	C14H16ClN3O2S	325.8	C1=CC=C(C=C1)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl	Ki = 230000 nM	Non binder
T94033	Coagulation factor IIa	BWTM52	4-[(3,4-Dimethoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71462162	C16H20ClN3O4S	385.9	COC1=C(C=C(C=C1)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	IC50 > 500000 nM	Non binder
T94033	Coagulation factor IIa	BX62VE	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	56680052	C40H46N6O5	690.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN=C(N)N)C(=O)CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4	IC50 > 650000 nM	Non binder
T94033	Coagulation factor IIa	BXG6I0	2-(3,4-Dihydroxyphenyl)-5-[[4-[[2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxochromen-5-yl]oxymethyl]phenyl]methoxy]-3,7-dihydroxychromen-4-one	Investigative	137632528	C38H26O14	706.6	C1=CC(=CC=C1COC2=CC(=CC3=C2C(=O)C(=C(O3)C4=CC(=C(C=C4)O)O)O)O)COC5=CC(=CC6=C5C(=O)C(=C(O6)C7=CC(=C(C=C7)O)O)O)O	IC50 = 267000 nM	Non binder
T94033	Coagulation factor IIa	BY4Q7F	3-[3-(3-Benzyl-1H-indol-2-yl)-5-bromo-4-hydroxy-phenyl]-propionic acid	Investigative	44296078	C24H20BrNO3	450.3	C1=CC=C(C=C1)CC2=C(NC3=CC=CC=C32)C4=C(C(=CC(=C4)CCC(=O)O)Br)O	Ki = 700000 nM	Non binder
T94033	Coagulation factor IIa	BY56RN	(2S)-2-[[(2S)-2-[4-(Diaminomethylideneamino)butanoylamino]-3-(4-nitrophenyl)propanoyl]amino]-3-hydroxybutanamide	Investigative	44337970; 74999903	C18H27N7O6	437.5	CC([C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)CCCN=C(N)N)O	IC50 = 230000 nM	Non binder
T94033	Coagulation factor IIa	BY5AJ1	3-(Dimethylamino)benzenecarboximidamide;2,4,6-trinitrophenol	Investigative	118725262	C15H16N6O7	392.32	CN(C)C1=CC=CC(=C1)C(=N)N.C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-]	Ki = 794328.23 nM	Non binder
T94033	Coagulation factor IIa	BY6AZ9	1,4,7-Tribenzyl-1,4,7-triazacyclononane	Investigative	11307143	C27H33N3	399.6	C1CN(CCN(CCN1CC2=CC=CC=C2)CC3=CC=CC=C3)CC4=CC=CC=C4	Ki = 410000 nM	Non binder
T94033	Coagulation factor IIa	BYJ53B	2-{[(1R)-1-[(2-{[(4-Carbamimidoylphenyl)methyl]carbamoyl}-2,3-dihydro-1H-inden-2-yl)carbamoyl]propyl]amino}acetic acid	Investigative	11849333	C24H29N5O4	451.5	CC[C@H](C(=O)NC1(CC2=CC=CC=C2C1)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 = 300000 nM	Non binder
T94033	Coagulation factor IIa	BZ58YM	Chembl47291	Investigative	73351804	C25H39N5O8	537.6	CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 446000 nM	Non binder
T94033	Coagulation factor IIa	BZ6LO2	N-[3-(4-Aminothieno[3,2-c]pyridin-2-yl)-1-(4-methylpiperidin-1-yl)-1-oxopropan-2-yl]naphthalene-2-sulfonamide	Investigative	44328503	C26H28N4O3S2	508.7	CC1CCN(CC1)C(=O)C(CC2=CC3=C(S2)C=CN=C3N)NS(=O)(=O)C4=CC5=CC=CC=C5C=C4	IC50 = 209000 nM	Non binder
T94033	Coagulation factor IIa	BZ8Q2B	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-pyridin-4-ylsulfanylpropanoyl)piperazine-1-carboxylate	Investigative	44315912	C35H49N9O6S	723.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCSC5=CC=NC=C5	Ki = 741000 nM	Non binder
T94033	Coagulation factor IIa	BZE69R	Chembl4209061	Investigative	145964487	C25H22Na2O16S2	688.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)OS(=O)(=O)[O-])C.[Na+].[Na+]	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	BZK02C	5-Chlorothiophene-2-carboxamide	Investigative	5172545	C5H4ClNOS	161.61	C1=C(SC(=C1)Cl)C(=O)N	Ki = 431000 nM	Non binder
T94033	Coagulation factor IIa	BZSH38	N-(4-Guanidino-phenyl)-2-hydroxy-5-nitro-benzamide	Investigative	44303721	C14H13N5O4	315.28	C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])O)N=C(N)N	Ki = 315000 nM	Non binder
T94033	Coagulation factor IIa	BZT84A	{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-2,2-dimethyl-propylamino}-acetic acid	Investigative	11849334	C26H33N5O4	479.6	CC(C)(C)[C@H](C(=O)NC1(CC2=CC=CC=C2C1)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 = 300000 nM	Non binder
T94033	Coagulation factor IIa	BZYL38	(8e)-3-Amino-1-Methyl-15-[(1h-Pyrazol-1-Yl)methyl]-7,10,11,12,24,25-Hexahydro-6h,18h,23h-19,22-(Metheno)pyrido[4,3-J][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-One	Investigative	134131589	C29H33N7O3	527.6	CC1=C2CNC(=O)C3=CN(CC4=C(C=C(C=C4)CN5C=CC=N5)OCCC/C=C/CCOC2=CC(=N1)N)N=C3	IC50 > 200000 nM	Non binder
T94033	Coagulation factor IIa	BZYV69	2-[[(2R)-1-[[9-[(4-Carbamimidoylphenyl)methylcarbamoyl]-9-tricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaenyl]amino]-3-methyl-1-oxobutan-2-yl]amino]acetic acid	Investigative	11849429	C31H35N5O4	541.6	CC(C)[C@H](C(=O)NC1(CC2=CC=CC=C2C3=CC=CC=C3C1)C(=O)NCC4=CC=C(C=C4)C(=N)N)NCC(=O)O	IC50 > 300000 nM	Non binder
T94033	Coagulation factor IIa	D07SFI	Benzamidine	Investigative	2332	C7H8N2	120.15	C1=CC=C(C=C1)C(=N)N	Ki = 220000 nM	Non binder