TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99347	Metabotropic glutamate receptor 5	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	EC50 = 631000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B1U2ST	(2R,4R)-4-Amino-1-methylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302818	C7H12N2O4	188.18	CN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B1X8RG	(2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302608	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B29QMH	(2R)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine	Investigative	44569827	C9H13NO4	199.2	C1C2(CC1(C2)C(=O)O)C[C@H](C(=O)O)N	Ki = 336000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B3HQT6	(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid	Investigative	44322745	C6H9N3O5	203.15	C[C@](CN1C(=O)NOC1=O)(C(=O)O)N	Ki = 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B3O1FQ	(RS)-Apica	Investigative	4694355	C10H12NO5P	257.18	C1CC(C2=C1C=C(C=C2)P(=O)(O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B48TJE	(2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302605	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC(=CC=C2)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B4E2TO	4-(Amino-carboxy-methyl)-2-hydroxy-5-methyl-benzoic Acid	Investigative	10036599	C10H11NO5	225.2	CC1=CC(=C(C=C1C(C(=O)O)N)O)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B4SK1A	(2S)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569859	C10H15NO4	213.23	C1C2(CC1(C2)CC(=O)O)C[C@@H](C(=O)O)N	Ki = 293000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B4XAP2	2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyric acid	Investigative	9837114	C6H9N3O3S	203.22	C(C[C@H](C(=O)O)N)C1=NSNC1=O	EC50 > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B53OZS	(2R)-(3'-Phosphonomethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569862	C9H16NO5P	249.2	C1C2(CC1(C2)CP(=O)(O)O)C[C@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B54BWE	(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302609	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC3=CC=CC=C3C=C2)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B5T6CU	(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid	Investigative	10359073	C19H21NO4	327.4	C1=CC=C(C=C1)C(C[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B5XW4D	(2R)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569860	C10H15NO4	213.23	C1C2(CC1(C2)CC(=O)O)C[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B7TMV2	3-[(R)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Investigative	10241509	C8H11NO4	185.18	C1C2(CC1(C2)C(=O)O)[C@H](C(=O)O)N	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B8K6VC	(S)-4-(Amino(carboxy)methyl)cubane-1-carboxylic acid	Investigative	10198359	C11H11NO4	221.21	C12C3C4C1(C5C2C3(C45)C(=O)O)[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B9DR6Z	(S)-2-Amino-5-phosphonopentanoic acid	Investigative	1617110	C5H12NO5P	197.13	C(C[C@@H](C(=O)O)N)CP(=O)(O)O	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B9FH3U	Amino-(2-chloro-3,5-dihydroxy-phenyl)-acetic acid(S-CHPG)	Investigative	44322518	C8H8ClNO4	217.6	C1=C(C=C(C(=C1C(C(=O)O)N)Cl)O)O	Ki > 10000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	B9SVF3	N-(4-Chloro-2-((3,5-dichloro-N-ethylbenzamido)methyl)phenyl)picolinamide	Investigative	11351706	C22H18Cl3N3O2	462.8	CCN(CC1=C(C=CC(=C1)Cl)NC(=O)C2=CC=CC=N2)C(=O)C3=CC(=CC(=C3)Cl)Cl	EC50 = 470000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BA89FL	(2R,4R)-4-Amino-1-(naphthalen-1-ylmethyl)pyrrolidine-2,4-dicarboxylic Acid	Investigative	10358265	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC3=CC=CC=C32)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BB6KT7	(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302930	C14H18N2O4	278.3	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BBF7L9	(S)-Hibo	Investigative	10012356	C6H8N2O4	172.14	C1=C(ONC1=O)C[C@@H](C(=O)O)N	Ki = 490000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BC96JQ	(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid	Investigative	10330132	C6H11N3O4	189.17	C1[C@@H](N(C[C@]1(C(=O)O)N)N)C(=O)O	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BCYB02	(2R,4R)-4-Amino-1-(2,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302896	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=C(C=C(C=C2)Cl)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BD08XI	(2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302929	C15H20N2O4	292.33	C1[C@@H](N(C[C@]1(C(=O)O)N)CCCC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BF1ZB7	(2R,4R)-4-Amino-1-(4-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302932	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=C(C=C2)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BFEN08	(R)-1-Amino-indan-1,5-dicarboxylic acid	Investigative	6603702	C11H11NO4	221.21	C1C[C@@](C2=C1C=C(C=C2)C(=O)O)(C(=O)O)N	IC50 > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BGB5T3	(2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302931	C13H22N2O4	270.32	C1CCC(CC1)CN2C[C@](C[C@@H]2C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BGI1S7	alpha-Methyl-4-carboxyphenylglycine	Investigative	1222	C10H11NO4	209.2	CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N	Ki > 2000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BGQN61	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2S)-	Investigative	17758445	C5H9NO5S	195.2	C1[C@@H]([C@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BHS53B	(2R,4R)-4-Amino-1-benzhydrylpyrrolidine-2,4-dicarboxylic acid	Investigative	49799828	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BI56LB	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1R,2R)-	Investigative	17758556	C5H9NO5S	195.2	C1[C@@H]([C@@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BK8NL7	(1S,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid	Investigative	6604704	C7H11NO4	173.17	C1C[C@](C[C@H]1C(=O)O)(C(=O)O)N	EC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BKM51O	(2S)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine	Investigative	44569861	C9H16NO5P	249.2	C1C2(CC1(C2)CP(=O)(O)O)C[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BO1SZ9	(2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302913	C19H20N2O4	340.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BOCA73	(2R,4R)-4-Amino-1-ethylpyrrolidine-2,4-dicarboxylic acid	Investigative	44302837	C8H14N2O4	202.21	CCN1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BP9BL1	(2S)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine	Investigative	44569826	C9H13NO4	199.2	C1C2(CC1(C2)C(=O)O)C[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BP9I2D	(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10465017	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@H]2C(=O)O)(C(=O)O)N	EC50 > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BSWF59	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2S)-	Investigative	17758555	C5H9NO5S	195.2	C1[C@H]([C@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BUBT35	(1S,2S)-1-Amino-2-(carboxymethyl)cyclopropane-1-carboxylic acid	Investigative	11768848	C6H9NO4	159.14	C1[C@H]([C@@]1(C(=O)O)N)CC(=O)O	EC50 > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BWC90O	2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid	Investigative	44322843	C9H13NO4	199.2	C1C[C@](C2C1C[C@@H]2C(=O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BY4U5X	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2S)-	Investigative	17758450	C5H9NO5S	195.2	C1[C@H]([C@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BYE7U4	(2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302855	C21H24N2O4	368.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BYK29C	(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302856	C20H22N2O4	354.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BYWE14	(2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302686	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=C(C=CC=C2Cl)Cl)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BZ07DY	2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid	Investigative	6604795	C8H12N2O4	200.19	CC1=C(C(=O)NO1)CC[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BZ20RS	L-2-Aminoadipic acid	Investigative	92136	C6H11NO4	161.16	C(C[C@@H](C(=O)O)N)CC(=O)O	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	BZ5HB6	(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302819	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2Cl)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D04JKL	AIDA	Investigative	2071	C11H11NO4	221.21	C1CC(C2=C1C=C(C=C2)C(=O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D09AQK	(R,S)-4-phosphonophenylglycine	Investigative	4545574	C8H10NO5P	231.14	C1=CC(=CC=C1C(C(=O)O)N)P(=O)(O)O	Ki > 500000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D0D2GL	MPPG	Investigative	3972752	C9H12NO5P	245.17	CC(C1=CC=C(C=C1)P(=O)(O)O)(C(=O)O)N	Ki > 1000000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D0N0NJ	1-benzyl-APDC	Investigative	15508178	C13H16N2O4	264.28	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2)C(=O)O	IC50 > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D0OV2V	LY307452	Investigative	6324634	C21H25NO4	355.4	C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki > 300000 nM	Non binder
T99347	Metabotropic glutamate receptor 5	D0PN6Z	L-AP4	Investigative	179394	C4H10NO5P	183.1	C(CP(=O)(O)O)[C@@H](C(=O)O)N	Ki > 1000000 nM	Non binder