TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T00176	Ubiquitin-protein ligase E3 Mdm2	B07LFI	7-Chloro-10-(2-fluorophenyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697857	C17H9ClFN3O2	341.7	C1=CC=C(C(=C1)N2C3=C(C=C(C=C3)Cl)C=C4C2=NC(=O)NC4=O)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B0DXP3	10-(4-Chlorophenyl)-8-methylpyrimido[4,5-b]quinoline-2,4-dione	Investigative	73355682	C18H12ClN3O2	337.8	CC1=CC2=C(C=C1)C=C3C(=O)NC(=O)N=C3N2C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B0KD8A	Ethyl 6-chloro-3-[1-[(4-chlorophenyl)methyl-formylamino]-2-(cyclohexylamino)-2-oxoethyl]-1H-indole-2-carboxylate	Investigative	56942854	C27H29Cl2N3O4	530.4	CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC3CCCCC3)N(CC4=CC=C(C=C4)Cl)C=O	Ki = 50000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B1B0VO	1-[2-[7-[(2R)-Butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]-3-methylurea	Investigative	53262649	C30H35ClN4O4	551.1	CC[C@@H](C)OC1=C(C=C2CC(=O)N(C(C2=C1)C3=C(C=C(C=C3)Cl)NC(=O)NC)C4=CC=C(C=C4)N(C)C)OC	IC50 = 71187.8 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B2GK7P	Dimethyl 2-[[1-(4-chlorophenyl)-2,5-diphenylpyrrol-3-yl]methylidene]propanedioate	Investigative	90666833	C28H22ClNO4	471.9	COC(=O)C(=CC1=C(N(C(=C1)C2=CC=CC=C2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C(=O)OC	IC50 ~ 50000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B2KJW5	Methyl 2-(4-chlorophenyl)-2-[3-(4-chlorophenyl)-7,8-difluoro-5-oxo-2-sulfanylidene-1,3-dihydro-1,4-benzodiazepin-4-yl]acetate	Investigative	70684931	C24H16Cl2F2N2O3S	521.4	COC(=O)C(C1=CC=C(C=C1)Cl)N2C(C(=S)NC3=CC(=C(C=C3C2=O)F)F)C4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B2M9YA	1,4-Benzodiazepine-2,5-dione antagonist, 22	Investigative	11952817	C29H25ClF3IN2O5	700.9	C[C@H](C1=CC=C(C=C1)Cl)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)OC(F)(F)F	IC50 = 67000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B3E6RU	4-((1-(4-Chlorophenyl)-1-hydroxy-3-oxoisoindolin-2-yl)methyl)benzoic acid	Investigative	51350114	C22H16ClNO4	393.8	C1=CC=C2C(=C1)C(=O)N(C2(C3=CC=C(C=C3)Cl)O)CC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B4BMV9	Methyl 2-[9-chloro-3-(4-chlorophenyl)-5-oxo-2-sulfanylidene-1,3-dihydro-1,4-benzodiazepin-4-yl]-2-(4-chlorophenyl)acetate	Investigative	70697491	C24H17Cl3N2O3S	519.799	COC(=O)C(C1=CC=C(C=C1)Cl)N2C(C(=S)NC3=C(C2=O)C=CC=C3Cl)C4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B4SEZ8	5-[[6-Amino-1-[[(2S)-1-[(3-amino-3-oxopropyl)-[5-(4-fluorophenyl)pentyl]amino]-4-carboxybutan-2-yl]-[4-(4-bromophenyl)butyl]amino]hexan-2-yl]-(2-spiro[5.5]undecan-3-ylethyl)amino]-4-(4-methylpentanoylamino)pentanoic acid	Investigative	46227513	C59H96BrFN6O6	1084.3	CC(C)CCC(=O)NC(CCC(=O)O)CN(CCC1CCC2(CCCCC2)CC1)C(CCCCN)CN(CCCCC3=CC=C(C=C3)Br)[C@@H](CCC(=O)O)CN(CCCCCC4=CC=C(C=C4)F)CCC(=O)N	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B4T6UW	(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[4-[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]triazol-1-yl]pentanoic acid	Investigative	122192876	C33H35N5O6	597.7	CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CN(N=N2)CCC[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35	IC50 = 57360 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B4VQF9	9-Chloro-10-(3-fluorophenyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	73351169	C17H9ClFN3O2	341.7	C1=CC(=CC(=C1)F)N2C3=C(C=CC=C3Cl)C=C4C2=NC(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B5IO3P	US9079913, MI-743B	Investigative	58254334	C35H39Cl2FN4O4	669.6	CC(C)(C)C[C@@H]1[C@]2([C@H]([C@@H](N1)C(=O)N3CCN(CC3)C(=O)C4CC4)C5=CC(=CC=C5)Cl)C6=CC(=C(C=C6N(C2=O)C(=O)C7CC7)Cl)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B5RY3C	10-(4-Chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione	Investigative	1114145	C17H9ClN4O4	368.7	C1=CC(=CC=C1N2C3=C(C=C(C=C3)[N+](=O)[O-])C=C4C2=NC(=O)NC4=O)Cl	IC50 ~ 75000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B5S7NU	N-Acylpolyamine (NAPA) scaffold, 12	Investigative	44472960	C47H75BrN10O10	1020.1	CC(C)CCCNC(=O)N(CC(CCC(=O)O)NC(=O)N)C(CCCCN)CN(C(CCC(=O)O)CN(CCC(=O)N)C(=O)NCCCC1=CC=C(C=C1)OC)C(=O)NCCC2=CC=C(C=C2)Br	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B6QS9V	Nutlin-3A	Investigative	11433190	C30H30Cl2N4O4	581.5	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl	IC50 ~ 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B6VWI3	3-Benzoyl-2-(4-bromophenyl)-4-propan-2-yloxy-1-[[2-propan-2-yloxy-4-(trifluoromethyl)phenyl]methyl]-2H-pyrrol-5-one	Investigative	90644127	C31H29BrF3NO4	616.5	CC(C)OC1=C(C=CC(=C1)C(F)(F)F)CN2C(C(=C(C2=O)OC(C)C)C(=O)C3=CC=CC=C3)C4=CC=C(C=C4)Br	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B7LB6W	2-[(4-Benzoylphenyl)methyl]-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]isoindol-1-one	Investigative	51351128	C33H28ClNO4	538	C1CC1(CO)COC2(C3=CC=CC=C3C(=O)N2CC4=CC=C(C=C4)C(=O)C5=CC=CC=C5)C6=CC=C(C=C6)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B93OWN	Lissoclinidine B	Investigative	25147779	C18H15N3OS	321.4	C1OC2=C(S1)C(=C3C4=C(C=CN=C42)C5=CC=CC=C5N3)CCN	IC50 = 58600 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	B94ESP	9-Bromo-10-phenylpyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697859	C17H10BrN3O2	368.2	C1=CC=C(C=C1)N2C3=C(C=CC=C3Br)C=C4C2=NC(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BAOC74	3-(4-Chlorophenyl)-3-hydroxy-2-(4-(methylsulfonyl)benzyl)isoindolin-1-one	Investigative	51349973	C22H18ClNO4S	427.9	CS(=O)(=O)C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BAUF90	N,N-Dimethyl-5-methylvaracin	Investigative	44588490	C13H19NO2S5	381.6	CC1=C(C2=C(C(=C1OC)OC)SSSSS2)CCN(C)C	IC50 = 120800 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BCB3T7	2-[7-[(2R)-Butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorobenzamide	Investigative	58437689	C29H32ClN3O4	522	CC[C@@H](C)OC1=C(C=C2CC(=O)N(C(C2=C1)C3=C(C=C(C=C3)Cl)C(=O)N)C4=CC=C(C=C4)N(C)C)OC	IC50 = 70257.7 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BD5A7L	3-Hydroxy-2-(4-nitrobenzyl)-3-phenyl-2,3-dihydroisoindol-1-one	Investigative	51349702	C21H16N2O4	360.4	C1=CC=C(C=C1)C2(C3=CC=CC=C3C(=O)N2CC4=CC=C(C=C4)[N+](=O)[O-])O	IC50 = 87000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BD6Y8I	6-Chloro-10-(4-chlorophenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione	Investigative	1883338	C17H9Cl2N3O2	358.2	C1=CC2=C(C=C3C(=O)NC(=O)N=C3N2C4=CC=C(C=C4)Cl)C(=C1)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BES53P	N-Acylpolyamine (NAPA) scaffold, 2	Investigative	44472950	C45H71ClN10O9	931.6	CC(C)CCCNC(=O)N(CC(CCC(=O)O)NC(=O)N)C(CCCCN)CN(C(CCC(=O)O)CN(CCC(=O)N)C(=O)NCCC1=CC=CC=C1)C(=O)NCCC2=CC=C(C=C2)Cl	IC50 = 85000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BGB70R	(4-Chlorophenyl)[3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-YL]acetic acid	Investigative	656933	C23H15Cl2IN2O4	581.2	C1=CC(=CC=C1[C@H]2C(=O)NC3=C(C=C(C=C3)I)C(=O)N2[C@@H](C4=CC=C(C=C4)Cl)C(=O)O)Cl	IC50 = 128000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BGC6Z4	Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione,9-chloro-10-phenyl-	Investigative	71818716	C17H10ClN3O2	323.7	C1=CC=C(C=C1)N2C3=C(C=CC=C3Cl)C=C4C2=NC(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BGI9A1	2-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)-N-cyclohexyl-3-phenylpropanamide	Investigative	71722565	C22H24ClN3O2	397.9	C1CCC(CC1)NC(=O)C(CC2=CC=CC=C2)N3C4=C(C=C(C=C4)Cl)NC3=O	Ki ~ 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BH4D0L	(+/-)-4-((1-(4-Chlorophenyl)-1-((1-(hydroxymethyl)cyclopropyl)methoxy)-3-oxoisoindolin-2-yl)methyl)benzamide	Investigative	51351007	C27H25ClN2O4	476.9	C1CC1(CO)COC2(C3=CC=CC=C3C(=O)N2CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BHZ4J9	CID 51350115	Investigative	51350115	C23H18ClNO3	391.8	CC(=O)C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O	IC50 = 88000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BI2W6U	9-Chloro-10-(3-chlorophenyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697858	C17H9Cl2N3O2	358.2	C1=CC(=CC(=C1)Cl)N2C3=C(C=CC=C3Cl)C=C4C2=NC(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BJ4K2C	5-{(3S)-3-(4-Chlorophenyl)-4-[(R)-1-(4-chlorophenyl)-ethyl]-7-iodo-2,5-dioxo-2,3,4,5-tetrahydro-benzo[e][1,4]diazepin-1-yl}-pentanoic acid	Investigative	11952815	C28H25Cl2IN2O4	651.3	C[C@H](C1=CC=C(C=C1)Cl)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)Cl	IC50 = 67000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BJ7B3U	3-(4-Chlorophenyl)-3-hydroxy-2-naphthalen-1-ylmethyl-2,3-dihydroisoindol-1-one	Investigative	51349839	C25H18ClNO2	399.9	C1=CC=C2C(=C1)C=CC=C2CN3C(=O)C4=CC=CC=C4C3(C5=CC=C(C=C5)Cl)O	IC50 = 96000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BJG7K8	2-(4-Bromophenyl)-2-(5-chloro-2-oxo-3H-benzimidazol-1-yl)-N-cyclohexylacetamide	Investigative	71722718	C21H21BrClN3O2	462.8	C1CCC(CC1)NC(=O)C(C2=CC=C(C=C2)Br)N3C4=C(C=C(C=C4)Cl)NC3=O	Ki = 54000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BK1Q7X	4-((1-(4-Chlorophenyl)-1-hydroxy-3-oxoisoindolin-2-yl)methyl)benzenesulfonamide	Investigative	51349974	C21H17ClN2O4S	428.9	C1=CC=C2C(=C1)C(=O)N(C2(C3=CC=C(C=C3)Cl)O)CC4=CC=C(C=C4)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BK2J8Z	1,4-Benzodiazepine-2,5-dione antagonist, 5	Investigative	44176188	C28H24Cl2IN3O5	680.3	C1=CC(=CC=C1[C@H]2C(=O)NC3=C(C=C(C=C3)I)C(=O)N2[C@@H](C4=CC=C(C=C4)Cl)C(=O)NCCCCC(=O)O)Cl	IC50 = 90000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BL27KS	2-(3-Bromobenzyl)-3-(4-chlorophenyl)-3-hydroxy-2,3-dihydroisoindol-1-one	Investigative	51349840	C21H15BrClNO2	428.7	C1=CC=C2C(=C1)C(=O)N(C2(C3=CC=C(C=C3)Cl)O)CC4=CC(=CC=C4)Br	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BLJ6F2	(3S,4S)-3-(4-Chlorophenyl)-2-[(4-chlorophenyl)methyl]-N-(2-methoxyethyl)-1-oxo-3,4-dihydroisoquinoline-4-carboxamide	Investigative	46894143	C26H24Cl2N2O3	483.4	COCCNC(=O)[C@@H]1[C@H](N(C(=O)C2=CC=CC=C12)CC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl	IC50 = 62500 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BLZ3X7	1,4-Benzodiazepine-2,5-dione scaffold, 2	Investigative	11952783	C28H26Cl2IN3O4	666.3	C[C@H](C1=C(C=C(C=C1)Cl)N)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)Cl	IC50 = 80000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BM2XB3	1,4-Benzodiazepine-2,5-dione antagonist, 18	Investigative	44176200	C28H25Cl2IN2O4	651.3	C[C@@H](C1=CC=C(C=C1)Cl)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)Cl	IC50 = 128000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BMD57O	2-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)-3-phenyl-N-(2-phenylethyl)propanamide	Investigative	71723197	C24H22ClN3O2	419.9	C1=CC=C(C=C1)CCNC(=O)C(CC2=CC=CC=C2)N3C4=C(C=C(C=C4)Cl)NC3=O	Ki = 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BOB73F	6-Chloro-3-[1-[(4-chlorophenyl)methyl]-3-phenylindol-2-yl]-N-(2-morpholin-4-ylethyl)-1H-indole-2-carboxamide	Investigative	127035702	C36H32Cl2N4O2	623.6	C1COCCN1CCNC(=O)C2=C(C3=C(N2)C=C(C=C3)Cl)C4=C(C5=CC=CC=C5N4CC6=CC=C(C=C6)Cl)C7=CC=CC=C7	Ki ~ 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BPW3V7	3-Benzoyl-2-(4-bromophenyl)-1-[[2-methoxy-4-(trifluoromethyl)phenyl]methyl]-4-[[(1R)-1-phenylethyl]amino]-2H-pyrrol-5-one	Investigative	90644135	C34H28BrF3N2O3	649.5	C[C@H](C1=CC=CC=C1)NC2=C(C(N(C2=O)CC3=C(C=C(C=C3)C(F)(F)F)OC)C4=CC=C(C=C4)Br)C(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BQT39X	3-(4-Chlorophenyl)-3-hydroxy-2-propylisoindolin-1-one	Investigative	51349561	C17H16ClNO2	301.8	CCCN1C(=O)C2=CC=CC=C2C1(C3=CC=C(C=C3)Cl)O	IC50 = 69000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BQUV73	3-Benzoyl-2-(4-bromophenyl)-1-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-[[(1R)-1-phenylethyl]amino]-2H-pyrrol-5-one	Investigative	90644136	C33H25BrF4N2O2	637.5	C[C@H](C1=CC=CC=C1)NC2=C(C(N(C2=O)CC3=C(C=C(C=C3)C(F)(F)F)F)C4=CC=C(C=C4)Br)C(=O)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BR0SE9	10-(4-Chlorophenyl)-6-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697717	C18H9ClF3N3O2	391.7	C1=CC(=C2C=C3C(=O)NC(=O)N=C3N(C2=C1)C4=CC=C(C=C4)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BR8FS5	10-Benzyl-9-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697719	C19H12F3N3O2	371.3	C1=CC=C(C=C1)CN2C3=C(C=CC=C3C(F)(F)F)C=C4C2=NC(=O)NC4=O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BR8J9H	1,4-Benzodiazepine-2,5-dione antagonist, 17	Investigative	44176199	C27H23Cl2IN2O4	637.3	C1=CC(=CC=C1CN2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)Cl)Cl	IC50 = 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BRD5O6	N-Acylpolyamine (NAPA) scaffold, 1	Investigative	44472949	C44H69ClN10O9	917.5	CC(C)CCNC(=O)N(CC(CCC(=O)O)NC(=O)N)C(CCCCN)CN(C(CCC(=O)O)CN(CCC(=O)N)C(=O)NCCC1=CC=CC=C1)C(=O)NCCC2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BRNH94	Methyl 2-(4-chlorophenyl)-2-[3-(4-chlorophenyl)-8-methoxy-5-oxo-2-sulfanylidene-1,3-dihydro-1,4-benzodiazepin-4-yl]acetate	Investigative	70689182	C25H20Cl2N2O4S	515.4	COC1=CC2=C(C=C1)C(=O)N(C(C(=S)N2)C3=CC=C(C=C3)Cl)C(C4=CC=C(C=C4)Cl)C(=O)OC	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BS6CP5	10-(2-Fluorophenyl)-9-nitropyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697714	C17H9FN4O4	352.28	C1=CC=C(C(=C1)N2C3=C(C=CC=C3[N+](=O)[O-])C=C4C2=NC(=O)NC4=O)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BSH51R	Methyl 2-[8-chloro-3-(4-chlorophenyl)-2-methylsulfanyl-5-oxo-3H-1,4-benzodiazepin-4-yl]-2-(4-chlorophenyl)acetate	Investigative	70682884	C25H19Cl3N2O3S	533.9	COC(=O)C(C1=CC=C(C=C1)Cl)N2C(C(=NC3=C(C2=O)C=CC(=C3)Cl)SC)C4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BSQ46C	Methyl 2-(4-chlorophenyl)-2-[3-(4-chlorophenyl)-9-methyl-5-oxo-2-sulfanylidene-1,3-dihydro-1,4-benzodiazepin-4-yl]acetate	Investigative	70695482	C25H20Cl2N2O3S	499.4	CC1=C2C(=CC=C1)C(=O)N(C(C(=S)N2)C3=CC=C(C=C3)Cl)C(C4=CC=C(C=C4)Cl)C(=O)OC	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BT5D8O	5-[(3S)-3-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-2-methoxy-2-oxoethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid	Investigative	44412055	C29H25Cl2IN2O6	695.3	COC(=O)C(C1=CC=C(C=C1)Cl)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCCCC(=O)O)C4=CC=C(C=C4)Cl	IC50 = 67000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BT6VM0	5-[(3S)-3-(4-Chlorophenyl)-4-[(1R)-1-(4-chlorophenyl)ethyl]-7-ethynyl-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid	Investigative	11706629	C30H26Cl2N2O4	549.4	C[C@H](C1=CC=C(C=C1)Cl)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)C#C)CCCCC(=O)O)C4=CC=C(C=C4)Cl	IC50 = 69000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BTUP53	Ethyl 6-chloro-3-[[1-(4-chlorophenyl)tetrazol-5-yl]-(cyclohexylmethylamino)methyl]-1H-indole-2-carboxylate	Investigative	137658613	C26H28Cl2N6O2	527.4	CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C3=NN=NN3C4=CC=C(C=C4)Cl)NCC5CCCCC5	Ki = 117000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BUA21I	(3S,4S)-3-(4-Chlorophenyl)-2-[(4-chlorophenyl)methyl]-1-oxo-3,4-dihydroisoquinoline-4-carboxylic acid	Investigative	24813118	C23H17Cl2NO3	426.3	C1=CC=C2C(=C1)[C@@H]([C@H](N(C2=O)CC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)C(=O)O	IC50 ~ 60000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BV07OP	3-(4-Chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-methylsulfanylphenyl)methyl]isoindol-1-one	Investigative	51351004	C27H26ClNO3S	480	CSC1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)OCC5(CC5)CO	IC50 = 175000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BV76SO	3-Benzoyl-2-(4-bromophenyl)-1-[[2-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-propan-2-yloxy-2H-pyrrol-5-one	Investigative	90644130	C28H22BrF4NO3	576.4	CC(C)OC1=C(C(N(C1=O)CC2=C(C=C(C=C2)C(F)(F)F)F)C3=CC=C(C=C3)Br)C(=O)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BV97NE	3-(4-Chlorophenyl)-3-hydroxy-2-(4-(methylsulfinyl)benzyl)isoindolin-1-one	Investigative	51349972	C22H18ClNO3S	411.9	CS(=O)C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BVG1E2	10-(2-Fluorophenyl)-8-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697716	C18H9F4N3O2	375.3	C1=CC=C(C(=C1)N2C3=C(C=CC(=C3)C(F)(F)F)C=C4C2=NC(=O)NC4=O)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BVO31Q	10-(4-Chlorophenyl)-8-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697718	C18H9ClF3N3O2	391.7	C1=CC(=CC=C1N2C3=C(C=CC(=C3)C(F)(F)F)C=C4C2=NC(=O)NC4=O)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BW12NF	3-(4-Chlorophenyl)-3-hydroxy-2-(4-(trifluoromethyl)benzyl)isoindolin-1-one	Investigative	51349975	C22H15ClF3NO2	417.8	C1=CC=C2C(=C1)C(=O)N(C2(C3=CC=C(C=C3)Cl)O)CC4=CC=C(C=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BW6RL0	3-(4-Chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[[4-(trifluoromethylsulfonyl)phenyl]methyl]isoindol-1-one	Investigative	53318521	C27H23ClF3NO5S	566	C1CC1(CO)COC2(C3=CC=CC=C3C(=O)N2CC4=CC=C(C=C4)S(=O)(=O)C(F)(F)F)C5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BW9N1Z	Chembl4203765	Investigative	145978249	C79H116BrN23O28	1915.8	C[C@H]([C@H](C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)NC(C)(C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=C(C=C3)Br)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@@H](CC(=O)O)N)O	Ki = 93000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BWZ2V6	N-Acylpolyamine (NAPA) scaffold, 3	Investigative	44472951	C45H70Cl2N10O9	966	CC(C)CCCNC(=O)N(CC(CCC(=O)O)NC(=O)N)C(CCCCN)CN(C(CCC(=O)O)CN(CCC(=O)N)C(=O)NCCC1=CC=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)Cl	IC50 = 63000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BX2LJ7	1,4-Benzodiazepine-2,5-dione antagonist, 2	Investigative	44176185	C24H17Cl2IN2O4	595.2	C1=CC(=CC=C1[C@H]2C(=O)NC3=C(C=C(C=C3)I)C(=O)N2[C@H](CC(=O)O)C4=CC=C(C=C4)Cl)Cl	IC50 = 70000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BXKI48	1,4-Benzodiazepine-2,5-dione scaffold, 21	Investigative	9917797	C28H28Cl2IN3O4	668.3	C[C@H](C1=C(C=C(C=C1)Cl)N)N2[C@H](C(=O)N(C3=C(C2=O)C=C(C=C3)I)CCOCCOC)C4=CC=C(C=C4)Cl	IC50 = 57000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BY6JI0	N-[2-[7-[(2R)-Butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]acetamide	Investigative	53262650	C30H34ClN3O4	536.1	CC[C@@H](C)OC1=C(C=C2CC(=O)N(C(C2=C1)C3=C(C=C(C=C3)Cl)NC(=O)C)C4=CC=C(C=C4)N(C)C)OC	IC50 = 50653.6 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BYT7C0	5-[4-[Carboxy-(4-chlorophenyl)methyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid	Investigative	22046762	C28H23Cl2IN2O6	681.3	C1=CC(=CC=C1C2C(=O)N(C3=C(C=C(C=C3)I)C(=O)N2C(C4=CC=C(C=C4)Cl)C(=O)O)CCCCC(=O)O)Cl	IC50 = 128000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BYV95Q	10-(4-Chlorophenyl)-9-nitropyrimido[4,5-b]quinoline-2,4-dione	Investigative	72697715	C17H9ClN4O4	368.7	C1=CC2=C(C(=C1)[N+](=O)[O-])N(C3=NC(=O)NC(=O)C3=C2)C4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BYZ23J	10-(4-Chlorophenyl)-7-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4-dione	Investigative	44421760	C18H9ClF3N3O2	391.7	C1=CC(=CC=C1N2C3=C(C=C(C=C3)C(F)(F)F)C=C4C2=NC(=O)NC4=O)Cl	IC50 ~ 100000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BZS1C5	3-(4-Chlorophenyl)-3-hydroxy-2-(3-nitrobenzyl)isoindolin-1-one	Investigative	51349835	C21H15ClN2O4	394.8	C1=CC=C2C(=C1)C(=O)N(C2(C3=CC=C(C=C3)Cl)O)CC4=CC(=CC=C4)[N+](=O)[O-]	IC50 = 54000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BZUG65	3-(4-Chlorophenyl)-3-hydroxy-2-benzylisoindolin-1-one	Investigative	3608080	C21H16ClNO2	349.8	C1=CC=C(C=C1)CN2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)Cl)O	IC50 = 74000 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	BZW70A	Isolissoclinotoxin B	Investigative	44588489	C11H15NO2S5	353.6	CN(C)CCC1=CC(=C(C2=C1SSSSS2)O)OC	IC50 = 58600 nM	Poor binder
T00176	Ubiquitin-protein ligase E3 Mdm2	D07QJJ	CATECHOL	Investigative	289	C6H6O2	110.11	C1=CC=C(C(=C1)O)O	IC50 ~ 100000 nM	Poor binder