TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T00852	Serine/threonine-protein kinase cot	B09UAZ	2-[6-[4-(Methylcarbamoyl)phenyl]thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid	Investigative	56665622	C16H13N3O3S2	359.4	CNC(=O)C1=CC=C(C=C1)C2=CC3=C(S2)C(=NC=N3)SCC(=O)O	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B0RMH8	Thieno[2,3-c]pyridine-2-carboxamide,4-([1,1'-biphenyl]-4-yloxy)-	Investigative	9946185	C20H14N2O2S	346.4	C1=CC=C(C=C1)C2=CC=C(C=C2)OC3=CN=CC4=C3C=C(S4)C(=O)N	IC50 ~ 50000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B0T7GE	N-(4-(4-Iodophenoxy)thieno[2,3-c]pyridin-2-yl)acetamide	Investigative	44580627	C15H11IN2O2S	410.2	CC(=O)NC1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)I	IC50 ~ 50000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B2ALG5	N-[[4-Methyl-5-[3-(2H-tetrazol-5-yl)-1H-indazol-5-yl]pyridin-3-yl]methyl]ethanamine	Investigative	11186664	C17H18N8	334.4	CCNCC1=CN=CC(=C1C)C2=CC3=C(C=C2)NN=C3C4=NNN=N4	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B4B2TU	2-[6-(5-Chlorothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid	Investigative	56665623	C12H7ClN2O2S3	342.8	C1=C(SC(=C1)Cl)C2=CC3=C(S2)C(=NC=N3)SCC(=O)O	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B4OY7P	5-(3-(1H-Benzo[D]imidazol-2-YL)-1H-indazol-5-YL)-4-methylpyridin-3-OL	Investigative	135484456	C20H15N5O	341.4	CC1=C(C=NC=C1C2=CC3=C(C=C2)NN=C3C4=NC5=CC=CC=C5N4)O	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B74GXI	5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridine-3-carboxamide	Investigative	135532406	C21H16N6O	368.4	CC1=C(C=NC=C1C2=CC3=C(C=C2)NN=C3C4=NC5=CC=CC=C5N4)C(=O)N	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B79GRM	5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-N,4-dimethylpyridin-3-amine	Investigative	136086939	C21H18N6	354.4	CC1=C(C=NC=C1C2=CC3=C(C=C2)NN=C3C4=NC5=CC=CC=C5N4)NC	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B7RAI4	Ethyl 2-[6-(4-chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetate	Investigative	56682544	C16H13ClN2O2S2	364.9	CCOC(=O)CSC1=NC=NC2=C1SC(=C2)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B8K7EV	4-[[5-[3-(1H-Benzimidazol-2-yl)-1H-indazol-5-yl]-4-methylpyridin-3-yl]methyl]morpholine	Investigative	135433128	C25H24N6O	424.5	CC1=C(C=NC=C1CN2CCOCC2)C3=CC4=C(C=C3)NN=C4C5=NC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B9U2KO	4-(4-Iodophenoxy)thieno[2,3-c]pyridin-2-amine	Investigative	44580626	C13H9IN2OS	368.19	C1=CC(=CC=C1OC2=CN=CC3=C2C=C(S3)N)I	IC50 ~ 50000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	B9UC3Y	2-[[6-(4-Chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]amino]acetic acid	Investigative	56682661	C14H10ClN3O2S	319.8	C1=CC(=CC=C1C2=CC3=C(S2)C(=NC=N3)NCC(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BBCQ90	2-[[6-(4-Chlorophenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]acetic acid	Investigative	56669206	C15H12ClN3O2S	333.8	CN(CC(=O)O)C1=NC=NC2=C1SC(=C2)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BHRT64	3-(1H-Benzimidazol-2-yl)-5-(4,5-dimethylpyridin-3-yl)-1H-indazole	Investigative	135486151	C21H17N5	339.4	CC1=CN=CC(=C1C)C2=CC3=C(C=C2)NN=C3C4=NC5=CC=CC=C5N4	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BKB79F	2-[6-(4-Methylpiperidin-1-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid	Investigative	56658822	C14H17N3O2S2	323.4	CC1CCN(CC1)C2=CC3=C(S2)C(=NC=N3)SCC(=O)O	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BPI93B	2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-YL}amino)benzamide	Investigative	16058637	C17H15N5O2	321.33	C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T00852	Serine/threonine-protein kinase cot	BZF1C3	2-[6-(4-Phenylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylacetic acid	Investigative	56662166	C20H14N2O2S2	378.5	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC4=C(S3)C(=NC=N4)SCC(=O)O	IC50 ~ 100000 nM	Poor binder