TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T01280	Beta-site APP-cleaving enzyme 2	B0AI2N	(4S)-4-[5-(Ethylaminomethyl)-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137637780	C14H19F2N3S	299.38	CCNCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 = 75700 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B1M0EZ	N1-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-ethynyl-N3-((R)-1-phenylethyl)isophthalamide	Investigative	44570174	C31H33N3O3	495.6	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C#C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B3BEJ6	3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2R,3S)-2-hydroxy-1-[(3-methoxyphenyl)methylamino]-4-methylpentan-3-yl]benzamide	Investigative	44447299	C27H40N4O5S	532.7	CCNC1=CC(=CC(=C1)C(=O)N[C@H]([C@@H](CNCC2=CC(=CC=C2)OC)O)C(C)C)N3CCCCS3(=O)=O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B3EFP0	N1-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)-5-(thiophen-3-yl)isophthalamide	Investigative	44570207	C33H35N3O3S	553.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C3=CSC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B3SZ1C	N1-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-methoxy-N3-((R)-1-phenylethyl)isophthalamide	Investigative	44570173	C30H35N3O4	501.6	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)OC)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B4HS8N	N-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide	Investigative	44441703	C31H37N3O5S	563.7	CCCN(C1=CC2=CC(=C1)C(=O)N[C@H](CCC3=CC(=CC=C3)C[C@@](C(=O)OC2)(C)N)C4=CC=CC=C4)S(=O)(=O)C	IC50 = 54000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B4IW2Q	N5-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N7-((R)-1-phenylethyl)chroman-5,7-dicarboxamide	Investigative	44570302	C32H37N3O4	527.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=C3CCCOC3=C2)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B57UJA	(4S)-4-[2,4-Difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137646316	C15H18F5N3S	367.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCC(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B5HCQ7	(4S)-4-[2,4-Difluoro-5-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137640486	C17H23F2N3OS	355.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN3CC[C@H](C3)OC)F)F	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B7U4EB	(R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one	Investigative	45488108	C22H29N3O2	367.5	CC1=C(C=CC(=C1)[C@@]2(C(=O)N(C(=N2)N)C)C34CC5CC(C3)CC(C5)C4)OC	IC50 = 73580 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B8KYV1	3-{2-[(5-Aminopentyl)amino]-2-oxoethoxy}-5-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl phenylmethanesulfonate	Investigative	448772	C29H34FN3O6S	571.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)OS(=O)(=O)CC3=CC=CC=C3)OCC(=O)NCCCCCN	IC50 = 137000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B8M9PZ	3-[Benzyl(methyl)sulfamoyl]-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	49863030	C34H44N4O5S	620.8	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)S(=O)(=O)N(C)CC4=CC=CC=C4)O	IC50 = 200000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B8X6AV	N4-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methyl-N6-((R)-1-phenylethyl)benzofuran-4,6-dicarboxamide	Investigative	44570263	C32H35N3O4	525.6	CC1=CC2=C(C=C(C=C2O1)C(=O)N[C@H](C)C3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B94TIS	(4S)-4-[2,4-Difluoro-5-[(3-methoxypropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137635828	C16H23F2N3OS	343.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCCOC)F)F	IC50 = 62900 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B9GHI3	(4S)-4-[2,4-Difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137654633	C18H20F2N4S	362.4	CC1=CN=C(C=C1)NCC2=CC(=C(C=C2F)F)[C@@]3(CCSC(=N3)N)C	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	B9XZ0F	N-((2S,3R)-4-((S)-1-(Cyclohexylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(2-oxopyrrolidin-1-yl)benzamide	Investigative	44454541	C30H40N4O4	520.7	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)N4CCCC4=O)O	IC50 = 78530 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BA4E7V	(4S)-4-[2,4-Difluoro-5-[[methyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137657646	C15H18F5N3S	367.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN(C)CC(F)(F)F)F)F	IC50 ~ 84000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BALO21	(6R,8As)-8a-(2,4-difluorophenyl)-6-(2-methylpyrimidin-4-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	91819730	C18H18F2N4OS	376.4	CC1=NC=CC(=N1)[C@H]2CC3CSC(=N[C@]3(CO2)C4=C(C=C(C=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BBFQ67	N1-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-hydroxy-N3-((R)-1-phenylethyl)isophthalamide	Investigative	44570172	C29H33N3O4	487.6	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)O)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BBP90W	N1-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)-5-(2-phenylethynyl)isophthalamide	Investigative	44570209	C37H37N3O3	571.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C#CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BE9V1A	(4S)-4-[5-[(Dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137662127	C14H19F2N3S	299.38	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN(C)C)F)F	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BF09KQ	N-((2S,3R)-4-(Cyclohexylmethylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Investigative	44446199	C30H42N4O3	506.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3CCCCC3)O)N4CCCC4=O	IC50 = 57540 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BFLK57	N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide	Investigative	11290116	C19H18N4O	318.4	C1=CC=C(C=C1)C2=CC=C(N2CC(=O)N=C(N)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BFN8B9	3-Benzylsulfonyl-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	49863029	C33H41N3O5S	591.8	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)S(=O)(=O)CC4=CC=CC=C4)O	IC50 = 117000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BI1JW7	4-Imidazolidinone, 2-imino-5,5-diphenyl-	Investigative	213731	C15H13N3O	251.28	C1=CC=C(C=C1)C2(C(=O)NC(=N2)N)C3=CC=CC=C3	IC50 = 87190 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BI3VT0	N-[[4-(Aminomethyl)phenyl]methyl]-3-methyl-2-(4-phenylphenyl)butanamide	Investigative	71584648	C25H28N2O	372.5	CC(C)C(C1=CC=C(C=C1)C2=CC=CC=C2)C(=O)NCC3=CC=C(C=C3)CN	IC50 = 100500 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BIUT74	(4S)-4-[2,4-Difluoro-5-[(propan-2-ylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137648425	C15H21F2N3S	313.4	CC(C)NCC1=CC(=C(C=C1F)F)[C@@]2(CCSC(=N2)N)C	IC50 ~ 94000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BK8FY7	3-(Ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-isobutoxy-2-methylpropan-2-ylamino)-1-phenylbutan-2-yl)-5-(2-oxopyrrolidin-1-yl)benzamide	Investigative	44446202	C31H46N4O4	538.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNC(C)(C)COCC(C)C)O)N3CCCC3=O	IC50 = 69010 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BKQ3X4	4-Acetamido-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	44454542	C28H38N4O4	494.6	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC=C(C=C3)NC(=O)C)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BKX5E4	(2R)-N-[[4-(Aminomethyl)phenyl]methyl]-2-(3-fluoro-4-phenylphenyl)propanamide	Investigative	71584647	C23H23FN2O	362.4	C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)NCC3=CC=C(C=C3)CN	IC50 = 193800 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BL62CN	3-(Benzylsulfonylamino)-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	49863026	C33H42N4O5S	606.8	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)NS(=O)(=O)CC4=CC=CC=C4)O	IC50 = 132000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BM08WG	5-(1-Benzyl-1H-1,2,3-triazol-4-yl)-N1-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-phenylethyl)isophthalamide	Investigative	44570210	C38H40N6O3	628.8	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C3=CN(N=N3)CC4=CC=CC=C4)C(=O)N[C@@H](CC5=CC=CC=C5)[C@@H](CNC6CC6)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BN03VI	(4S)-4-[5-[(Cyclopropylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137641491	C15H19F2N3S	311.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNC3CC3)F)F	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BO4BC3	Hydroxy ethylamine (HEA), 19	Investigative	25190497	C28H38N6O5S	570.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CN2C=CC=N2)[C@@H](CNCC3=CC(=CC=C3)OC)O)N4CCCCS4(=O)=O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BOAF03	N6-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methyl-N4-((R)-1-phenylethyl)benzofuran-4,6-dicarboxamide	Investigative	44570213	C32H35N3O4	525.6	CC1=CC2=C(C=C(C=C2O1)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O)C(=O)N[C@H](C)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BP3GR1	N7-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N5-((R)-1-phenylethyl)chroman-5,7-dicarboxamide	Investigative	25181420	C32H37N3O4	527.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=C3CCCOC3=CC(=C2)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BRL6I0	N8-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N6-((R)-1-phenylethyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-6,8-dicarboxamide	Investigative	25181421	C33H39N3O4	541.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=C3CCCCOC3=CC(=C2)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BV51WT	3-(Benzenesulfonamido)-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	49863025	C32H40N4O5S	592.8	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CC=C4)O	IC50 = 79400 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BW6D5J	N6-((2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-N8-((R)-1-phenylethyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-6,8-dicarboxamide	Investigative	44570303	C33H39N3O4	541.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=C3CCCCOC3=C2)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BX09KW	5-(4-Chlorophenyl)-3-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	Investigative	44570208	C35H36ClN3O3	582.1	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)C3=CC=C(C=C3)Cl)C(=O)N[C@@H](CC4=CC=CC=C4)[C@@H](CNC5CC5)O	IC50 ~ 100000 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BX5G3H	N-((2S,3R)-4-(Benzylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Investigative	10391277	C30H36N4O3	500.6	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC=CC=C3)O)N4CCCC4=O	IC50 = 63100 nM	Poor binder
T01280	Beta-site APP-cleaving enzyme 2	BXA2G8	N-((2S,3R)-4-((R)-2,3-Dihydro-1H-inden-1-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide	Investigative	44446207	C32H38N4O3	526.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CN[C@@H]3CCC4=CC=CC=C34)O)N5CCCC5=O	IC50 = 93330 nM	Poor binder