TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02001	Phosphodiesterase 4D	D0BK6B	CI-930	Discontinued in Phase 2	3021729	C14H14N4O	254.29	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	Ki ~ 50000 nM	Poor binder
T02001	Phosphodiesterase 4D	B05TXO	5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968471	C17H24ClN3O3	353.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCOCCN	IC50 = 99000 nM	Poor binder
T02001	Phosphodiesterase 4D	B0Z2TQ	5-(4-Chlorophenyl)-N-cyclohexyl-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9857760	C15H18ClN3S	307.8	CN1C(=NC2CCCCC2)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 57000 nM	Poor binder
T02001	Phosphodiesterase 4D	B14WZE	5-(4-Chlorophenyl)-N-cyclopentyl-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9835752	C14H16ClN3S	293.8	CN1C(=NC2CCCC2)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 81500 nM	Poor binder
T02001	Phosphodiesterase 4D	B1FYM3	7-(5-Cyclohexylimino-4-methyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine	Investigative	6918791	C17H20N6S	340.4	CN1C(=NC2CCCCC2)SC(=N1)C3=CC4=C(C=C3)C(=NC=N4)N	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B1PUI5	4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-N-(2-dimethylamino-ethyl)-N-methyl-benzamide	Investigative	21920369	C21H31N5OS	401.6	CN1C(=NC2CCCCC2)SC(=N1)C3=CC=C(C=C3)C(=O)N(C)CCN(C)C	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B1XH2D	4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]cyclohexan-1-amine	Investigative	9836880	C15H19ClN4S	322.9	CN1C(=NC2CCC(CC2)N)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B28ZOQ	2-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-phenol	Investigative	135856794	C15H19N3OS	289.4	CN1C(=NC2CCCCC2)SC(=N1)C3=CC=CC=C3O	IC50 = 71000 nM	Poor binder
T02001	Phosphodiesterase 4D	B2J8RL	Cyclopentyl(4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)methanone	Investigative	46884170	C29H33FN6O	500.6	C1CCC(C1)C(=O)N2CCN(CC2)CCCNC3=NN=C(C4=C3C=C5N4C=CC=C5)C6=CC(=CC=C6)F	Ki = 61000 nM	Poor binder
T02001	Phosphodiesterase 4D	B2LF7S	Chembl4174666	Investigative	27659581	C20H16N2O4	348.4	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=CC=C(C=C4)[N+](=O)[O-]	IC50 = 88300 nM	Poor binder
T02001	Phosphodiesterase 4D	B2MGU0	Chembl4167151	Investigative	145952944	C21H19NO2	317.4	CC1=CC=C(C=C1)C2=CC=C(O2)C(=O)N3CCCC4=CC=CC=C43	IC50 = 50100 nM	Poor binder
T02001	Phosphodiesterase 4D	B3QKX6	4-(3-Fluorophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)pyridazino[4,5-b]indolizin-1-amine	Investigative	46884097	C27H27FN8	482.6	C1CN(CCN1CCCNC2=NN=C(C3=C2C=C4N3C=CC=C4)C5=CC(=CC=C5)F)C6=NC=CC=N6	Ki = 83000 nM	Poor binder
T02001	Phosphodiesterase 4D	B3ZXS7	Chembl4172684	Investigative	2566813	C20H16N2O4	348.4	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=CC=C(C=C4)[N+](=O)[O-]	IC50 = 77200 nM	Poor binder
T02001	Phosphodiesterase 4D	B4JF8H	8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9880288	C16H22ClN3O2	323.82	CNCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 = 53200 nM	Poor binder
T02001	Phosphodiesterase 4D	B4M6RX	5-(3-Chlorophenyl)-N-cyclohexyl-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	21920329	C15H18ClN3S	307.8	CN1C(=NC2CCCCC2)SC(=N1)C3=CC(=CC=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B50WTU	Chembl4204765	Investigative	145976583	C22H24ClNO3	385.9	COC1=C(C=C2CN(CCC2=C1)C(=O)C3=CC=C(C=C3)Cl)OC4CCCC4	IC50 = 92580 nM	Poor binder
T02001	Phosphodiesterase 4D	B57NKZ	2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9880010	C15H12ClN3OS	317.8	CN1C(=NC2=CC=CC=C2O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B5F0KA	Chembl4164011	Investigative	145959784	C21H19NO2	317.4	CC1=CC=C(C=C1)C2=CC=C(O2)C(=O)N3CCC4=CC=CC=C4C3	IC50 = 56800 nM	Poor binder
T02001	Phosphodiesterase 4D	B5S2NX	Chembl4160331	Investigative	145960159	C20H15F2NO2	339.3	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=C(C=CC=C4F)F	IC50 = 81300 nM	Poor binder
T02001	Phosphodiesterase 4D	B6E2KY	(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridazin-4-yl)methanone	Investigative	46884368	C26H29N9O3	515.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=CN=NC=C4)C5=CC(=CC=C5)[N+](=O)[O-]	Ki = 51200 nM	Poor binder
T02001	Phosphodiesterase 4D	B6HBD1	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-one	Investigative	25178735	C16H22O4	278.34	CCCC(=O)C1=CC(=C(C=C1)OC2CCOCC2)OC	IC50 = 60000 nM	Poor binder
T02001	Phosphodiesterase 4D	B6M1HS	(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridin-4-yl)methanone	Investigative	46884257	C27H30N8O3	514.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=CC=NC=C4)C5=CC(=CC=C5)[N+](=O)[O-]	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	B72YKV	N-(1-Azabicyclo[2.2.1]heptan-3-yl)-5-(4-chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	44393929	C15H17ClN4S	320.8	CN1C(=NC2CN3CCC2C3)SC(=N1)C4=CC=C(C=C4)Cl	IC50 = 79000 nM	Poor binder
T02001	Phosphodiesterase 4D	B7CDZ0	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-one	Investigative	25178736	C17H24O4	292.4	CCCCC(=O)C1=CC(=C(C=C1)OC2CCOCC2)OC	IC50 = 70794.58 nM	Poor binder
T02001	Phosphodiesterase 4D	B7GR4Y	1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-one	Investigative	25178738	C16H22O4	278.34	CCCCC(=O)C1=CC(=C(C=C1)OC2CCOC2)OC	IC50 = 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	B7H3NC	5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9966830	C15H11ClFN3S	319.8	CN1C(=NC2=CC(=CC=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B8D2LK	1-(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)ethanone	Investigative	46884135	C25H27FN6O	446.5	CC(=O)N1CCN(CC1)CCCNC2=NN=C(C3=C2C=C4N3C=CC=C4)C5=CC(=CC=C5)F	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	B8OSL6	5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9901606	C15H11ClFN3S	319.8	CN1C(=NC2=CC=C(C=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B91LIR	5-(4-Chlorophenyl)-N-cyclooctyl-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	44393959	C17H22ClN3S	335.9	CN1C(=NC2CCCCCCC2)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	B9MJY2	Chembl4281168	Investigative	145981967	C17H16N2O2	280.32	CC1=CC=C(C=C1)C2=CC=C(O2)C(=O)N3C(=CC(=N3)C)C	IC50 = 52900 nM	Poor binder
T02001	Phosphodiesterase 4D	BAG60F	(4-(3-(1,2-Dimethyl-7-phenyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone	Investigative	46884218	C26H30N8O	470.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=NC=CC=N4)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BB82QW	1-[4-Methoxy-3-(piperidin-4-yloxy)phenyl]pentan-1-one	Investigative	25178916	C17H25NO3	291.4	CCCCC(=O)C1=CC(=C(C=C1)OC)OC2CCNCC2	IC50 = 102000 nM	Poor binder
T02001	Phosphodiesterase 4D	BBL4O3	7-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2-methyl-quinazolin-4-ylamine	Investigative	6918792	C18H22N6S	354.5	CC1=NC2=C(C=CC(=C2)C3=NN(C(=NC4CCCCC4)S3)C)C(=N1)N	IC50 = 92330 nM	Poor binder
T02001	Phosphodiesterase 4D	BBSR20	5-(4-Chlorophenyl)-3-methyl-N-pentan-3-yl-1,3,4-thiadiazol-2-imine	Investigative	21920385	C14H18ClN3S	295.8	CCC(CC)N=C1N(N=C(S1)C2=CC=C(C=C2)Cl)C	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BC25TG	(4-(3-(4-Phenylpyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(pyrazin-2-yl)methanone	Investigative	46830337	C28H28N8O	492.6	C1CN(CCN1CCCNC2=NN=C(C3=C2C=C4N3C=CC=C4)C5=CC=CC=C5)C(=O)C6=NC=CN=C6	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BC9B4R	Chembl4162324	Investigative	145957727	C20H16ClNO2	337.8	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=CC(=CC=C4)Cl	IC50 = 96800 nM	Poor binder
T02001	Phosphodiesterase 4D	BCOU91	4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-2-methoxy-benzamide	Investigative	21920341	C17H22N4O2S	346.4	CN1C(=NC2CCCCC2)SC(=N1)C3=CC(=C(C=C3)C(=O)N)OC	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BCR67U	Ethyl 2-[4-[3,5-bis(cyclopropylmethoxy)phenyl]-6-methoxy-2-methylquinazolin-7-yl]oxyacetate	Investigative	44329685	C28H32N2O6	492.6	CCOC(=O)COC1=C(C=C2C(=C1)N=C(N=C2C3=CC(=CC(=C3)OCC4CC4)OCC5CC5)C)OC	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BD3I9Y	(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(isoxazol-5-yl)methanone	Investigative	46884300	C25H28N8O4	504.5	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=CC=NO4)C5=CC(=CC=C5)[N+](=O)[O-]	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BD5FL3	1-(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)propan-1-one	Investigative	46884136	C26H29FN6O	460.5	CCC(=O)N1CCN(CC1)CCCNC2=NN=C(C3=C2C=C4N3C=CC=C4)C5=CC(=CC=C5)F	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BDP8I0	Chembl4206447	Investigative	145975414	C21H24ClNO4S	421.9	COC1=C(C=C2CN(CCC2=C1)S(=O)(=O)C3=CC=C(C=C3)Cl)OC4CCCC4	IC50 = 133560 nM	Poor binder
T02001	Phosphodiesterase 4D	BDW7G1	N-(3-(4-(Pyrimidin-2-yl)piperazin-1-yl)propyl)-4-m-tolylpyridazino[4,5-b]indolizin-1-amine	Investigative	46884094	C28H30N8	478.6	CC1=CC(=CC=C1)C2=NN=C(C3=C2N4C=CC=CC4=C3)NCCCN5CCN(CC5)C6=NC=CC=N6	Ki = 54400 nM	Poor binder
T02001	Phosphodiesterase 4D	BF48BP	(4-(3-(4-(3-Fluorophenyl)pyridazino[4,5-b]indolizin-1-ylamino)propyl)piperazin-1-yl)(1-methyl-1H-pyrrol-2-yl)methanone	Investigative	46884172	C29H30FN7O	511.6	CN1C=CC=C1C(=O)N2CCN(CC2)CCCNC3=NN=C(C4=C3C=C5N4C=CC=C5)C6=CC(=CC=C6)F	Ki = 65000 nM	Poor binder
T02001	Phosphodiesterase 4D	BF48VA	8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10109572	C18H26ClN3O3	367.9	CN(C)CC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 = 55000 nM	Poor binder
T02001	Phosphodiesterase 4D	BG6YU5	1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]butan-1-ol	Investigative	25181021	C15H22O4	266.33	CCCC(C1=CC(=C(C=C1)OC2CCOC2)OC)O	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BGM86U	(3,4,5-Trimethoxyphenyl)methyl 5-phenylfuran-2-carboxylate	Investigative	57385767	C21H20O6	368.4	COC1=CC(=CC(=C1OC)OC)COC(=O)C2=CC=C(O2)C3=CC=CC=C3	IC50 = 66300 nM	Poor binder
T02001	Phosphodiesterase 4D	BHL63Q	2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]-3-hydroxybenzoic acid	Investigative	44393950	C16H12ClN3O3S	361.8	CN1C(=NC2=C(C=CC=C2O)C(=O)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 58250 nM	Poor binder
T02001	Phosphodiesterase 4D	BHXG73	Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate	Investigative	215436	C8H12N2O2	168.19	CCOC(=O)C1=C(NN=C1C)C	IC50 = 82000 nM	Poor binder
T02001	Phosphodiesterase 4D	BI34MR	[1-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]cyclopentyl]methanol	Investigative	21920253	C15H18ClN3OS	323.8	CN1C(=NC2(CCCC2)CO)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BJ89QB	2-[4-[3,5-Bis(cyclopropylmethoxy)phenyl]-2-ethyl-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol	Investigative	44329633	C28H34N2O6	494.6	CCC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC(=C3)OCC4CC4)OCC5CC5)OCCO)OCCO	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BLM9B3	Chembl4281304	Investigative	145980160	C23H18F4N6O	470.4	C1CC1NC2=CC(=NN3C2=NC=C3C(=O)N)NC4=CC=CC(=C4)C5=C(C=C(C=C5)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BM21LG	(4-(3-(7-(3-Fluorophenyl)-1,2-dimethyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone	Investigative	46884255	C26H29FN8O	488.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=NC=CC=N4)C5=CC(=CC=C5)F	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BN6D2F	Chembl4165955	Investigative	145953102	C20H15F2NO2	339.3	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=C(C=CC=C4F)F	IC50 = 89200 nM	Poor binder
T02001	Phosphodiesterase 4D	BN8KE9	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-ol	Investigative	25180832	C16H24O4	280.36	CCCC(C1=CC(=C(C=C1)OC2CCOCC2)OC)O	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BP0F3I	Chembl4283822	Investigative	145990536	C16H12F2N2O2	302.27	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=C(C=CC=C3F)F)C	IC50 = 88200 nM	Poor binder
T02001	Phosphodiesterase 4D	BP4FX7	Chembl4289060	Investigative	145987253	C16H13N3O4	311.29	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])C	IC50 = 87300 nM	Poor binder
T02001	Phosphodiesterase 4D	BP8KM9	1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-ol	Investigative	25181022	C16H24O4	280.36	CCCCC(C1=CC(=C(C=C1)OC2CCOC2)OC)O	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BQ15DL	N-(3-Bicyclo[2.2.1]heptanyl)-5-(4-chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9966833	C16H18ClN3S	319.9	CN1C(=NC2CC3CCC2C3)SC(=N1)C4=CC=C(C=C4)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BSK4L9	4-(2-Methoxy-4-pentanoylphenoxy)piperidine-1-carboxylic Acidtert-Butyl Ester	Investigative	25178733	C22H33NO5	391.5	CCCCC(=O)C1=CC(=C(C=C1)OC2CCN(CC2)C(=O)OC(C)(C)C)OC	IC50 = 93000 nM	Poor binder
T02001	Phosphodiesterase 4D	BSO0M8	4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid	Investigative	136132229	C29H33N5O5	531.6	CC(C)(COC1=CC=C(C=C1)C(=O)O)C2=NC3=C(N2)C(=N)N=CN3CC4=CC(=C(C=C4)OC)OC5CCCC5	Ki ~ 50000 nM	Poor binder
T02001	Phosphodiesterase 4D	BSR6U4	7-Benzyloxy-4-(3,5-bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazoline	Investigative	44329482	C32H34N2O4	510.6	CCC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC(=C3)OCC4CC4)OCC5CC5)OC)OCC6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BT95NB	3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9966737	C15H12ClN3OS	317.8	CN1C(=NC2=CC(=CC=C2)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BTDO10	4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzoic Acid	Investigative	9968050	C16H12ClN3O2S	345.8	CN1C(=NC2=CC=C(C=C2)C(=O)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T02001	Phosphodiesterase 4D	BTFK81	(4-(3-(7-(3-Chlorophenyl)-1,2-dimethyl-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone	Investigative	46884219	C26H29ClN8O	505	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=NC=CC=N4)C5=CC(=CC=C5)Cl	Ki = 80900 nM	Poor binder
T02001	Phosphodiesterase 4D	BTR15E	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-ol	Investigative	25181020	C17H26O4	294.4	CCCCC(C1=CC(=C(C=C1)OC2CCOCC2)OC)O	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BTY3I8	7-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-pyridin-3-ylpyrazolo[1,5-a]pyrimidine	Investigative	24775191	C22H18F2N4O2	408.4	C1CC1COC2=C(C=CC(=C2)C3=CC=NC4=CC(=NN34)C5=CN=CC=C5)OC(F)F	EC50 = 66900 nM	Poor binder
T02001	Phosphodiesterase 4D	BUM9N1	4-{5-[(Z)-Cyclohexylimino]-4-methyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl}-benzoic acid methyl ester	Investigative	44394060	C17H21N3O2S	331.4	CN1C(=NC2CCCCC2)SC(=N1)C3=CC=C(C=C3)C(=O)OC	IC50 = 95500 nM	Poor binder
T02001	Phosphodiesterase 4D	BVK69Q	(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyrimidin-2-yl)methanone	Investigative	46884256	C26H29N9O3	515.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=NC=CC=N4)C5=CC(=CC=C5)[N+](=O)[O-]	Ki ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	BW4GZ0	4-Phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propyl)pyridazino[4,5-b]indolizin-1-amine	Investigative	46884033	C27H28N8	464.6	C1CN(CCN1CCCNC2=NN=C(C3=C2C=C4N3C=CC=C4)C5=CC=CC=C5)C6=NC=CC=N6	Ki = 59000 nM	Poor binder
T02001	Phosphodiesterase 4D	BZWK74	4-(4-Hydroxy-3-methoxyphenyl]-4-pyridin-3-ylbutan-2-one	Investigative	44588185	C16H17NO3	271.31	CC(=O)CC(C1=CC(=C(C=C1)O)OC)C2=CN=CC=C2	IC50 = 79432.82 nM	Poor binder
T02001	Phosphodiesterase 4D	D05UMA	(R)-DULOXETINE	Investigative	10334821	C18H19NOS	297.4	CNCC[C@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	D08AWN	(S)-Norfluoxetine	Investigative	3058751	C16H16F3NO	295.3	C1=CC=C(C=C1)[C@H](CCN)OC2=CC=C(C=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	D0I4TO	(S)-NORDULOXETINE	Investigative	10107888	C17H17NOS	283.4	C1=CC=C2C(=C1)C=CC=C2O[C@@H](CCN)C3=CC=CS3	IC50 ~ 100000 nM	Poor binder
T02001	Phosphodiesterase 4D	D0WB6P	R-NORDULOXETINE	Investigative	46227262	C17H17NOS	283.4	C1=CC=C2C(=C1)C=CC=C2O[C@H](CCN)C3=CC=CS3	IC50 ~ 100000 nM	Poor binder