TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02546	Voltage-gated sodium channel alpha Nav1.4	D04MSM	Carbamazepine	Approved	2554	C15H12N2O	236.27	C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N	Ki = 52000 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	B1PCG2	CID 127046597	Investigative	127046597	C175H267N53O46S7	4074	CC[C@H](C)[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)C(C)C)CC(C)C)CC(=O)N)CCCNC(=N)N)NC3=O)NC(=O)[C@H](CC(=O)O)N)CC(C)C)CC6=CC=CC=C6)CCSC)CCCNC(=N)N)CCCCN)CO)CCCNC(=N)N)[C@@H](C)O)CC7=CN=CN7)CCC(=O)N)CC8=CNC9=CC=CC=C98)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)CCCCN)CC(=O)O)CC(=O)N)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	B42WTJ	3-(4-Methoxyphenyl)-1H-pyrazole	Investigative	599984	C10H10N2O	174.2	COC1=CC=C(C=C1)C2=CC=NN2	Ki = 81000 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	B8EO1C	(2S)-N-(2,6-Dimethylphenyl)-N,1-dimethylpyrrolidine-2-carboxamide	Investigative	10752970	C15H22N2O	246.35	CC1=C(C(=CC=C1)C)N(C)C(=O)[C@@H]2CCCN2C	EC50 = 199526.23 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	BHJ43T	N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide	Investigative	52920492	C22H19N7O2	413.4	C1=CC=C(C=C1)C(=O)NCC2=NOC(=N2)C3=NN(C4=CC=CC=C43)CCN5C=CN=C5	IC50 = 56000 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	BTY7V2	3-Phenyl-1H-pyrazole	Investigative	17155	C9H8N2	144.17	C1=CC=C(C=C1)C2=CC=NN2	Ki = 61000 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	BV84LQ	(2S)-N-(2,6-Dimethylphenyl)-N-methylpyrrolidine-2-carboxamide	Investigative	10681102	C14H20N2O	232.32	CC1=C(C(=CC=C1)C)N(C)C(=O)[C@@H]2CCCN2	EC50 = 67608.3 nM	Poor binder
T02546	Voltage-gated sodium channel alpha Nav1.4	BW75NQ	(2R)-N-(2,6-Dimethylphenyl)-1-methylpyrrolidine-2-carboxamide	Investigative	10609631	C14H20N2O	232.32	CC1=C(C(=CC=C1)C)NC(=O)[C@H]2CCCN2C	EC50 = 67608.3 nM	Poor binder