TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02719	Metabotropic glutamate receptor 3	B91OPF	(1R,2S)-2-Amino-2-carboxycyclopropane-1-acetic acid	Investigative	45082292	C6H9NO4	159.14	C1[C@@H]([C@@]1(C(=O)O)N)CC(=O)O	Ki = 199526.23 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	BB6KT7	(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302930	C14H18N2O4	278.3	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC2=CC=CC=C2)C(=O)O	IC50 = 166000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	BC96JQ	(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid	Investigative	10330132	C6H11N3O4	189.17	C1[C@@H](N(C[C@]1(C(=O)O)N)N)C(=O)O	Ki = 52000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	BPWR93	(1R,2R,4S,5S,6R)-2-Amino-4-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Investigative	11481048	C9H13NO4	199.2	C[C@H]1C[C@@]([C@@H]2[C@H]1[C@H]2C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	BS8Y6V	2-[[2,4-Dicarboxybutyl(hydroxy)phosphoryl]methyl]pentanedioic acid	Investigative	4408	C12H19O10P	354.25	C(CC(=O)O)C(CP(=O)(CC(CCC(=O)O)C(=O)O)O)C(=O)O	EC50 = 51000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	BYK29C	(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302856	C20H22N2O4	354.4	C1[C@@H](N(C[C@]1(C(=O)O)N)CC(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 = 63600 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	D09UBS	Ro64-5229	Investigative	10428048	C17H19Cl2N3O	352.3	C1CCCC(CC1)O/C(=C\\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl	Ki ~ 100000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	D0IO8J	2-methyl-6-(phenylethynyl)pyridine	Investigative	3025961	C14H11N	193.24	CC1=NC(=CC=C1)C#CC2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T02719	Metabotropic glutamate receptor 3	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder