TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T02728	Neurotensin receptor type 1	B09RDO	(2S)-2-{[2-(2,6-Dimethoxyphenyl)-1-(4-pyridyl)imidazol-4-yl]carbonylamino}-4-methylpentanoic acid	Investigative	49837921	C23H26N4O5	438.5	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=C(C=CC=C2OC)OC)C3=CC=NC=C3	EC50 = 66000 nM	Poor binder
T02728	Neurotensin receptor type 1	B0F7GT	(2R)-4-Methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoic acid	Investigative	118708054	C26H26N2O3	414.5	CC(C)C[C@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC=CC4=CC=CC=C43	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	B1ASO8	(2S)-2-[[2-(2,6-Dimethoxyphenyl)-1-(4-methylphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	49837922	C25H29N3O5	451.5	CC1=CC=C(C=C1)N2C=C(N=C2C3=C(C=CC=C3OC)OC)C(=O)N[C@@H](CC(C)C)C(=O)O	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B1NJT3	(R)-4-Methyl-2-(2-(5-(quinoline-8-sulfonamido)-1H-indol-1-yl)acetamido)pentanoic acid	Investigative	44581036	C25H26N4O5S	494.6	CC(C)C[C@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)NS(=O)(=O)C3=CC=CC4=C3N=CC=C4	EC50 = 178000 nM	Poor binder
T02728	Neurotensin receptor type 1	B3JG9B	4-[4-(2-Fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline	Investigative	1920221	C26H25FN4O2	444.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5F)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B3P2VQ	(2S)-2-[[3-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-2-(4-bromophenyl)oxolane-3-carbonyl]amino]-4-methylpentanoic acid	Investigative	134146201	C34H54BrN9O7	780.8	CC(C)C[C@@H](C(=O)O)NC(=O)C1(CCOC1C2=CC=C(C=C2)Br)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N	Ki = 70500 nM	Poor binder
T02728	Neurotensin receptor type 1	B5ZDI8	2-Cyclopropyl-6,7-dimethoxy-4-piperazin-1-ylquinazoline	Investigative	56593292	C17H22N4O2	314.4	COC1=C(C=C2C(=C1)C(=NC(=N2)C3CC3)N4CCNCC4)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B60AFQ	6,7-Dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline	Investigative	1951822	C26H26N4O2	426.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B68PLQ	(2S)-2-[[1-(7-Chloroquinolin-4-yl)-2-phenylimidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	49837919	C25H23ClN4O3	462.9	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2)C3=C4C=CC(=CC4=NC=C3)Cl	EC50 = 72000 nM	Poor binder
T02728	Neurotensin receptor type 1	B6J9AN	4-[4-(4-Fluorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline	Investigative	1941471	C26H25FN4O2	444.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=C(C=C5)F)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B82WNO	1-(2-Cyclopropyl-6,7-dimethoxyquinazolin-4-yl)-4-(phenylsulfonyl)piperazine	Investigative	56593283	C23H26N4O4S	454.5	COC1=C(C=C2C(=C1)C(=NC(=N2)C3CC3)N4CCN(CC4)S(=O)(=O)C5=CC=CC=C5)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B8HNE2	(2S)-4-Methyl-2-[[2-[5-(quinoline-4-carbonylamino)indol-1-yl]acetyl]amino]pentanoic acid	Investigative	118708036	C26H26N4O4	458.5	CC(C)C[C@@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)NC(=O)C3=CC=NC4=CC=CC=C34	EC50 = 55070 nM	Poor binder
T02728	Neurotensin receptor type 1	B8JEF7	2-Cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline	Investigative	53245590	C24H28N4O3	420.5	COC1=CC=CC=C1N2CCN(CC2)C3=NC(=NC4=CC(=C(C=C43)OC)OC)C5CC5	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	B8TJ3E	N-[(2S)-1-Hydroxy-4-methylpentan-2-yl]-2-(5-quinolin-3-ylindol-1-yl)acetamide	Investigative	118708043	C25H27N3O2	401.5	CC(C)C[C@@H](CO)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	B9DK5C	(2S)-2-[[3-[[(2S)-1-[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-2-(4-bromophenyl)oxolane-3-carbonyl]amino]-4-methylpentanoic acid	Investigative	134143837	C34H54BrN11O7	808.8	CC(C)C[C@@H](C(=O)O)NC(=O)C1(CCOC1C2=CC=C(C=C2)Br)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)N	Ki = 72500 nM	Poor binder
T02728	Neurotensin receptor type 1	B9UI1N	(2S)-2-[[2-(4-Bromophenyl)-3-[[(2S)-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]oxolane-3-carbonyl]amino]-4-methylpentanoic acid	Investigative	134138287	C34H54BrN9O7	780.8	CC(C)C[C@@H](C(=O)O)NC(=O)C1(CCOC1C2=CC=C(C=C2)Br)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N	Ki = 53000 nM	Poor binder
T02728	Neurotensin receptor type 1	B9W0TI	6-Ethoxy-7-methoxy-4-[4-(2-nitrophenyl)piperazin-1-yl]-2-phenylquinazoline	Investigative	73352405	C27H27N5O4	485.5	CCOC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5[N+](=O)[O-])OC	EC50 = 75000 nM	Poor binder
T02728	Neurotensin receptor type 1	BAL56S	(2R)-4-Methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoic acid	Investigative	118708049	C25H25N3O3	415.5	CC(C)C[C@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BC09PI	Methyl (2S)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoate	Investigative	118708042	C26H27N3O3	429.5	CC(C)C[C@@H](C(=O)OC)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BC2D0N	(2S)-2-[[2-[[3-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-2-(4-bromophenyl)oxolane-3-carbonyl]amino]acetyl]amino]-4-methylpentanoic acid	Investigative	134134595	C36H57BrN8O8	809.8	CC(C)C[C@@H](C(=O)O)NC(=O)CNC(=O)C1(CCOC1C2=CC=C(C=C2)Br)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N	Ki ~ 50000 nM	Poor binder
T02728	Neurotensin receptor type 1	BC97ZX	(2S)-4-Methyl-2-[(2-phenyl-1-quinolin-4-ylimidazole-4-carbonyl)amino]pentanoic acid	Investigative	49837907	C25H24N4O3	428.5	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2)C3=CC=NC4=CC=CC=C43	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BCTE07	Methyl (2R)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoate	Investigative	118708055	C27H28N2O3	428.5	CC(C)C[C@H](C(=O)OC)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC=CC4=CC=CC=C43	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BD07IT	6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline	Investigative	10339735	C21H24N4O3	380.4	COC1=CC=CC=C1N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BD97YN	2-[[2-(5-Quinolin-3-ylindol-1-yl)acetyl]amino]acetic acid	Investigative	118708045	C21H17N3O3	359.4	C1=CC=C2C(=C1)C=C(C=N2)C3=CC4=C(C=C3)N(C=C4)CC(=O)NCC(=O)O	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BDL1B5	(2S)-2-[[2-(2-Methoxyphenyl)-1-pyridin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	49837905	C22H24N4O4	408.4	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2OC)C3=CC=NC=C3	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BEV3F5	Methyl (2R)-4-methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]pentanoate	Investigative	118708050	C26H27N3O3	429.5	CC(C)C[C@H](C(=O)OC)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BH51SC	Chembl4292651	Investigative	145987656	C36H55N7O10	745.9	CC(C)C[C@@H](C(=O)O)NC(=O)[C@@H]1COCC=CCOC[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N1)CC3=CC=C(C=C3)O)CCCCN)N	IC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BH9S6W	(2S)-2-[[2-(2-Methoxyphenyl)-1-quinolin-4-ylimidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	49837913	C26H26N4O4	458.5	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2OC)C3=CC=NC4=CC=CC=C43	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BH9UF3	6-Ethoxy-7-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline	Investigative	73353870	C28H30N4O3	470.6	CCOC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5OC)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BHV8X9	(2S)-2-[[1-(7-Chloroquinolin-4-yl)-2-(2-methoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	49837903	C26H25ClN4O4	493	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2OC)C3=C4C=CC(=CC4=NC=C3)Cl	EC50 = 56000 nM	Poor binder
T02728	Neurotensin receptor type 1	BJY69G	[4-(2-Cyclopropyl-6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]-(2-methoxyphenyl)methanone	Investigative	56593279	C25H28N4O4	448.5	COC1=CC=CC=C1C(=O)N2CCN(CC2)C3=NC(=NC4=CC(=C(C=C43)OC)OC)C5CC5	EC50 = 68000 nM	Poor binder
T02728	Neurotensin receptor type 1	BK7B2G	4-[4-(2-Chlorophenyl)piperazin-1-yl]-6,7-dimethoxy-2-phenylquinazoline	Investigative	73347807	C26H25ClN4O2	461	COC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5Cl)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BLY20R	2-[6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazolin-2-yl]-N,N-dimethylethanamine	Investigative	56593274	C25H33N5O3	451.6	CN(C)CCC1=NC2=CC(=C(C=C2C(=N1)N3CCN(CC3)C4=CC=CC=C4OC)OC)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BP2H1O	(2S)-3-Methyl-2-[[2-(5-quinolin-3-ylindol-1-yl)acetyl]amino]butanoic acid	Investigative	118708047	C24H23N3O3	401.5	CC(C)[C@@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BP5XH6	Chembl4294560	Investigative	145993831	C34H51N7O8	685.8	CC[C@H](C)[C@H]1C(=O)N[C@@H](CC=CC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N1)CC3=CC=C(C=C3)O)NC(=O)[C@H](CCCCN)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BR3L0P	4-[4-(2,6-Dimethylphenyl)piperazin-1-yl]-6-ethoxy-7-methoxy-2-phenylquinazoline	Investigative	73356947	C29H32N4O2	468.6	CCOC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=C(C=CC=C5C)C)OC	EC50 = 61000 nM	Poor binder
T02728	Neurotensin receptor type 1	BR8M3X	(2S)-2-[[2-(5-Quinolin-3-ylindol-1-yl)acetyl]amino]propanoic acid	Investigative	118708046	C22H19N3O3	373.4	C[C@@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC4=CC=CC=C4N=C3	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BS2P8J	(2S)-3-Methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]butanoic acid	Investigative	118708053	C25H24N2O3	400.5	CC(C)[C@@H](C(=O)O)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC=CC4=CC=CC=C43	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BU0J1D	Methyl (2S)-4-methyl-2-[[2-(5-naphthalen-1-ylindol-1-yl)acetyl]amino]pentanoate	Investigative	118708051	C27H28N2O3	428.5	CC(C)C[C@@H](C(=O)OC)NC(=O)CN1C=CC2=C1C=CC(=C2)C3=CC=CC4=CC=CC=C43	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BU58PD	6,7-Dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methylquinazoline	Investigative	52914826	C22H26N4O3	394.5	CC1=NC2=CC(=C(C=C2C(=N1)N3CCN(CC3)C4=CC=CC=C4OC)OC)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BUID02	(2S)-2-[[3-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-2-(4-bromophenyl)oxolane-3-carbonyl]amino]-4-methylpentanoic acid	Investigative	134136231	C34H54BrN7O7	752.7	CC(C)C[C@@H](C(=O)O)NC(=O)C1(CCOC1C2=CC=C(C=C2)Br)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N	Ki = 67000 nM	Poor binder
T02728	Neurotensin receptor type 1	BVEF72	2-[[2-(5-Naphthalen-1-ylindol-1-yl)acetyl]amino]acetic acid	Investigative	118708052	C22H18N2O3	358.4	C1=CC=C2C(=C1)C=CC=C2C3=CC4=C(C=C3)N(C=C4)CC(=O)NCC(=O)O	EC50 ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BVNQ60	(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-1-[(2S)-6-Amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]-[2-(4-hydroxyphenyl)ethyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid	Investigative	52951476	C39H66N10O8	803	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)CN(CCC1=CC=C(C=C1)O)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N	Ki = 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BVTC49	(2S)-2-[[(2S,3S)-2-[[2-[(5R)-1-[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-6-oxo-1,7-diazaspiro[4.4]nonan-7-yl]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid	Investigative	44396910	C40H66N12O8	843	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)N2CC[C@@]3(C2=O)CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)N	Ki ~ 100000 nM	Poor binder
T02728	Neurotensin receptor type 1	BWI04R	6-Ethoxy-7-methoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline	Investigative	73356948	C27H28N4O2	440.5	CCOC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BY80TD	6-Ethoxy-4-[4-(2-fluorophenyl)piperazin-1-yl]-7-methoxy-2-phenylquinazoline	Investigative	73346308	C27H27FN4O2	458.5	CCOC1=C(C=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3)N4CCN(CC4)C5=CC=CC=C5F)OC	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BZ2XO9	(2S)-4-Methyl-2-[(2-phenyl-1-(4-pyridyl)imidazol-4-yl)carbonylamino]pentanoic acid	Investigative	49837915	C21H22N4O3	378.4	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=CC=CC=C2)C3=CC=NC=C3	EC50 ~ 80000 nM	Poor binder
T02728	Neurotensin receptor type 1	BZSN46	(2S)-2-[[1-(7-Chloroquinolin-4-yl)-2-(2,4-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid	Investigative	50919373	C27H27ClN4O5	523	CC(C)C[C@@H](C(=O)O)NC(=O)C1=CN(C(=N1)C2=C(C=C(C=C2)OC)OC)C3=C4C=CC(=CC4=NC=C3)Cl	EC50 ~ 80000 nM	Poor binder