TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T03279	Ribosomal protein S6 kinase alpha-3	B14THE	2-[(Z)-[6-(4-Fluorophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57390270	C14H14ClFN6S	352.8	CC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)F)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B1DH3E	2-[(E)-[2-Chloro-6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770690	C13H11Cl2FN6S	373.2	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)F.Cl	IC50 = 86000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B3IXZ4	2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395515	C13H11ClFN7O2S	383.79	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])F.Cl	IC50 = 53750 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B3O1HQ	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2,3-dimethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572631	C15H14Cl3N7O2S	462.7	CC1=C(SC2=NC(=C(N12)/C=N/N=C(N)N)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])C.Cl	IC50 = 98500 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B46URL	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770916	C11H10Cl3N7S2	410.7	CC1=NN2C(=C(N=C2S1)C3=C(SC(=C3)Cl)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B4BPE9	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24205071	C13H12Cl2N8O2S	415.3	CC1=NN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 94000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B4I5KM	2-[(Z)-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395511	C13H12ClFN6S	338.79	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B50OTR	2-[(E)-(2-Chloro-6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	54770688	C13H12Cl2N6S	355.2	C1=CC=C(C=C1)C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B5XJA0	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-ethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	16099329	C15H14Cl3N7O2S	462.7	CCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 = 83000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B65URH	2-[(Z)-[6-(2-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395517	C13H11ClFN7O2S	383.79	C1=CC(=C(C(=C1)[N+](=O)[O-])F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B85EIP	N-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrobromide	Investigative	54771593	C17H13BrCl2N6S2	516.299	C1CN=C(N1)N/N=C/C2=C(N=C3N2C4=CC=CC=C4S3)C5=C(SC(=C5)Cl)Cl.Br	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	B9FZ2T	2-[(Z)-[6-(2,5-Dimethoxy-4-nitrophenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57400760	C15H17ClN8O4S	440.9	CC1=NN2C(=C(N=C2S1)C3=CC(=C(C=C3OC)[N+](=O)[O-])OC)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BCYB54	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204555	C11H9Cl3N6S2	395.7	C1=CSC2=NC(=C(N21)/C=N/N=C(N)N)C3=C(SC(=C3)Cl)Cl.Cl	IC50 = 79000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BEWX31	2-[(E)-(3-Methyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	24203624	C13H14ClN7S	335.82	CC1=CSC2=NC(=C(N12)/C=N/N=C(N)N)C3=CN=CC=C3.Cl	IC50 = 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BG16US	2-[(Z)-[6-(4-Bromo-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57394412	C13H11BrClN7O2S	444.7	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])Br.Cl	IC50 = 56730 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BI0R8C	2-[(Z)-[6-[3-(Trifluoromethyl)phenyl]imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395519	C14H12ClF3N6S	388.8	C1=CC(=CC(=C1)C(F)(F)F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BJ97CS	2-[(Z)-[6-(2,4,5-Trifluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57399028	C13H10ClF3N6S	374.77	C1=CSC2=NC(=C(N21)/C=N\\N=C(N)N)C3=CC(=C(C=C3F)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BMK8L2	N-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrobromide	Investigative	54771823	C15H13BrCl2N6S	460.2	C1CN=C(N1)N/N=C/C2=C(N=C3N2C=CC=C3)C4=C(SC(=C4)Cl)Cl.Br	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BQN3M8	2-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771819	C13H11Cl3N6S	389.7	C1=CC2=NC(=C(N2C=C1)/C=N/N=C(N)N)C3=C(SC(=C3)Cl)Cl.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BQU31L	N-Methyl-4-(2-(piperidin-4-yl)-5-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)pyrimidin-2-amine	Investigative	11502255	C20H21F3N6	402.4	CNC1=NC=CC(=N1)C2=C(N=C(N2)C3CCNCC3)C4=CC(=CC=C4)C(F)(F)F	IC50 = 76000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BRH13F	2-[(E)-(2,3-Dimethyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	24203147	C14H16ClN7S	349.8	CC1=C(SC2=NC(=C(N12)/C=N/N=C(N)N)C3=CN=CC=C3)C.Cl	IC50 = 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BS0E7X	N-[(E)-[2-Chloro-6-(2,5-dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrobromide	Investigative	54771373	C13H10BrCl3N6S2	500.7	C1CN=C(N1)N/N=C/C2=C(N=C3N2C=C(S3)Cl)C4=C(SC(=C4)Cl)Cl.Br	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BT4X2J	2-[(Z)-[6-(2,6-Difluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395513	C13H11ClF2N6S	356.78	C1=CC(=C(C(=C1)F)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BTV83Z	2-[(Z)-[6-(2-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57400762	C13H12ClFN6S	338.79	C1=CC=C(C(=C1)C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BVJD91	N-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrobromide	Investigative	54771374	C15H14BrClN8O2S	485.7	CC1=NN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/NC4=NCCN4.Br	IC50 ~ 100000 nM	Poor binder
T03279	Ribosomal protein S6 kinase alpha-3	BYX1R8	2-[(Z)-[6-(3,4-Difluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57402526	C13H11ClF2N6S	356.78	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F)F.Cl	IC50 ~ 100000 nM	Poor binder