TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B0VKA3	Lometrexol	Investigative	135413518	C21H25N5O6	443.5	C1[C@H](CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B1HPO6	(2S)-2-[[4-[(1S)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methoxybutyl]benzoyl]amino]pentanedioic acid	Investigative	135924171	C21H27N5O7	461.5	CO[C@@H](CCCC1=C(N=C(NC1=O)N)N)C2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B31UOH	(2S)-2-[[4-[(1R)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-hydroxybutyl]benzoyl]amino]pentanedioic acid	Investigative	135924168	C20H25N5O7	447.4	C1=CC(=CC=C1[C@@H](CCCC2=C(N=C(NC2=O)N)N)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B3ZYH7	4-Cyano-N-phenylbenzenesulfonamide	Investigative	7033676	C13H10N2O2S	258.3	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C#N	IC50 ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B4J3TO	2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(3-fluoro-4-nitro-benzyl)-amino]-benzoylamino}-pentanedioic acid	Investigative	136002210	C28H25FN6O8	592.5	C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N(CC2=CC3=C(C=C2)N=C(NC3=O)N)CC4=CC(=C(C=C4)[N+](=O)[O-])F	Ki = 52000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B6S3HY	N-[4-[1-(Trifluoroacetyl)-4-(2,6-diamino-4-oxo-3,4-dihydropyrimidine-5-yl)butyl]benzoyl]-L-glutamic acid	Investigative	135474781	C22H24F3N5O7	527.4	C1=CC(=CC=C1C(CCCC2=C(N=C(NC2=O)N)N)C(=O)C(F)(F)F)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B7BVP0	2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887148	C21H26N6O6	458.5	CN(CC1=CC=C(C=C1)C(=O)NC(CCC(=O)O)C(=O)O)C2CC3=C(NC2)N=C(NC3=O)N	IC50 = 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	B87QHO	1,5-Dihydroimidazo[4,5-C][1,2,6]thiadiazin-4(3h)-One 2,2-Dioxide	Investigative	12413165	C4H4N4O3S	188.17	C1=NC2=C(N1)C(=O)NS(=O)(=O)N2	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BA6E3K	(2S)-2-[[4-[(1S)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-hydroxybutyl]benzoyl]amino]pentanedioic acid	Investigative	135924167	C20H25N5O7	447.4	C1=CC(=CC=C1[C@H](CCCC2=C(N=C(NC2=O)N)N)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BCS56B	2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid	Investigative	135436405	C21H25N5O6	443.5	C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	IC50 = 130000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BEJX69	N-({4-[(1s)-4-(2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-1-(Methylsulfanyl)butyl]phenyl}carbonyl)-L-Glutamic Acid	Investigative	135566721	C21H27N5O6S	477.5	CS[C@@H](CCCC1=C(N=C(NC1=O)N)N)C2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BERJ32	2-[[4-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887147	C20H24N6O6	444.4	C1C(CNC2=C1C(=O)NC(=N2)N)NCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BHM71S	2-[[4-[[(2-Amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887126	C20H20N6O6	440.4	C1=CC(=CC=C1CNC2=CC3=C(N=C2)N=C(NC3=O)N)C(=O)NC(CCC(=O)O)C(=O)O	IC50 = 62800 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BI8G0N	(2S)-2-[[4-[(1R)-4-(2,4-Diamino-6-oxo-1H-pyrimidin-5-yl)-1-methoxybutyl]benzoyl]amino]pentanedioic acid	Investigative	135924169	C21H27N5O7	461.5	CO[C@H](CCCC1=C(N=C(NC1=O)N)N)C2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BIE9L2	3-[(4-Cyanophenyl)sulfonylamino]benzamide	Investigative	18084678	C14H11N3O3S	301.32	C1=CC(=CC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C#N)C(=O)N	IC50 = 90000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BKHM82	N-((1H-Tetrazol-5-yl)methyl)-4-(6-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl)benzamide	Investigative	135491785	C19H20F3N9O3	479.4	C1=CC(=CC=C1C(CCCC2=C(N=C(NC2=O)N)N)C(=O)C(F)(F)F)C(=O)NCC3=NNN=N3	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BLP31I	[3,4-Dihydroxy-5r-(2,2,4-Trioxo-1,2r,3s,4r-Tetrahydro-2l6-Imidazo[4,5-C][1,2,6]thiadiazin-7-Yl)tetrahydrofuran-2-Yl]methyl Dihydrogen Phosphate	Investigative	11963492	C9H13N4O10PS	400.26	C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)NS(=O)(=O)NC2=O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BML70V	N-[4-(Quinoxalin-2-ylsulfamoyl)phenyl]acetamide	Investigative	95887	C16H14N4O3S	342.4	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2	IC50 = 54700 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BN7GV4	7-(3,4-Dihydroxy-5r-Hydroxymethyltetrahydrofuran-2-Yl)-2,2-Dioxo-1,2r,3r,7-Tetrahydro-2l6-Imidazo[4,5-C][1,2,6]thiadiazin-4s-One	Investigative	11963491	C9H12N4O7S	320.28	C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)NS(=O)(=O)NC2=O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BPF4D3	7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one	Investigative	135469335	C12H13N5O	243.26	CC1=C2C=NC3=C(C2=C(N1C)C)C(=O)NC(=N3)N	IC50 ~ 95000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BQK2A1	N-({4-[(1r)-4-(2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-1-(Methylsulfanyl)butyl]phenyl}carbonyl)-L-Glutamic Acid	Investigative	135566722	C21H27N5O6S	477.5	CS[C@H](CCCC1=C(N=C(NC1=O)N)N)C2=CC=C(C=C2)C(=O)N[C@@H](CCC(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BR4B0T	2-{4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid	Investigative	135746097	C25H24N4O6	476.5	CC1=NC2=C(C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1	IC50 ~ 60000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BW8ZJ2	2-[[4-[[(2-Amino-4-oxo-3H-pyrido[2,3-d]pyrimidin-6-yl)-methylamino]methyl]benzoyl]amino]pentanedioic acid	Investigative	135887127	C21H22N6O6	454.4	CN(CC1=CC=C(C=C1)C(=O)NC(CCC(=O)O)C(=O)O)C2=CC3=C(N=C2)N=C(NC3=O)N	IC50 = 141000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BX51IL	N-(4-((3-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid	Investigative	135407589	C19H24N6O6	432.4	C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCCCC2=C(N=C(NC2=O)N)N	IC50 = 94000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BX7C3I	2-(4-(6-(2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,1,1-trifluoro-2-oxohexan-3-yl)benzamido)acetic acid	Investigative	135513031	C19H20F3N5O5	455.4	C1=CC(=CC=C1C(CCCC2=C(N=C(NC2=O)N)N)C(=O)C(F)(F)F)C(=O)NCC(=O)O	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	BYH6P4	2,6-Diamino-5-[6-(1,3-benzoxazol-2-yl)-6-oxohexyl]pyrimidin-4(1H)-one	Investigative	136152909	C17H19N5O3	341.4	C1=CC=C2C(=C1)N=C(O2)C(=O)CCCCCC3=C(N=C(NC3=O)N)N	Ki ~ 100000 nM	Poor binder
T04741	Phosphoribosylaminoimidazolecarboxamide formyltransferase	D0F2WA	10-trifluoroacetyl-DDACTHF	Investigative	135929093	C22H24F3N5O7	527.4	.	Ki ~ 100000 nM	Poor binder