TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05387	Tissue transglutaminase	B01HMJ	Benzyl 4-[4-[(E)-4-ethoxy-4-oxobut-2-enyl]phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954722	C24H28N2O6S	472.6	CCOC(=O)/C=C/CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OCC3=CC=CC=C3	IC50 = 91000 nM	Poor binder
T05387	Tissue transglutaminase	B03TEA	Benzyl N-[4-[(3R)-3-(prop-2-enoylamino)piperidin-1-yl]sulfonylphenyl]carbamate	Investigative	71451225	C22H25N3O5S	443.5	C=CC(=O)N[C@@H]1CCCN(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B0ENF6	(2S)-2-[(4-Nitrophenyl)methoxycarbonylamino]-6-(prop-2-enoylamino)hexanoic acid	Investigative	71450344	C17H21N3O7	379.4	C=CC(=O)NCCCC[C@@H](C(=O)O)NC(=O)OCC1=CC=C(C=C1)[N+](=O)[O-]	IC50 = 62000 nM	Poor binder
T05387	Tissue transglutaminase	B0LA4F	N-(2-Bromophenyl)prop-2-enamide	Investigative	13593050	C9H8BrNO	226.07	C=CC(=O)NC1=CC=CC=C1Br	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B0LG9D	Tert-butyl 4-[4-(cyanomethylcarbamoyl)phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954612	C18H24N4O5S	408.5	CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NCC#N	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B1A0ZH	Chembl4174000	Investigative	145951882	C15H12N2O3	268.27	C1C(O1)(/C=C/C2=CC(=CC=C2)[N+](=O)[O-])C3=CN=CC=C3	IC50 = 151000 nM	Poor binder
T05387	Tissue transglutaminase	B1QJ7T	(E)-3-(2-Oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one	Investigative	17578027	C15H10N2O2	250.25	C1=CC=C2C(=C1)/C(=C\\C(=O)C3=CN=CC=C3)/C(=O)N2	Ki = 86000 nM	Poor binder
T05387	Tissue transglutaminase	B28FAD	Benzyl (S)-1-(((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylcarbamate	Investigative	14159824	C21H22BrN3O5	476.3	C1[C@H](ON=C1Br)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)OCC3=CC=CC=C3	Ki = 68000 nM	Poor binder
T05387	Tissue transglutaminase	B2ANX8	alpha-N-Carbobenzyloxy-epsilon-N-acryloyl-L-lysine	Investigative	71457507	C17H22N2O5	334.4	C=CC(=O)NCCCC[C@@H](C(=O)O)NC(=O)OCC1=CC=CC=C1	Ki = 60300 nM	Poor binder
T05387	Tissue transglutaminase	B2K8MF	Chembl4165260	Investigative	145962928	C16H8N4O5	336.26	C1=CC=C2C(=C1)N=NN2C(=O)C3=CC4=C(C=CC(=C4)[N+](=O)[O-])OC3=O	IC50 = 145000 nM	Poor binder
T05387	Tissue transglutaminase	B2QH3D	Tert-butyl 4-[4-[[(E)-2-methylbut-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954504	C20H29N3O5S	423.5	C/C=C(\\C)/C(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B2ZV5J	(2S)-2-(Methoxycarbonylamino)-6-(prop-2-enoylamino)hexanoic acid	Investigative	71452150	C11H18N2O5	258.269	COC(=O)N[C@@H](CCCCNC(=O)C=C)C(=O)O	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B42BYA	2-[(3-Bromo-4,5-dihydroisoxazol-5-ylmethyl)carbamoyl]-2,3-dihydroindole-1-carboxylic acid benzyl ester	Investigative	11626706	C21H20BrN3O4	458.3	C1C(ON=C1Br)CNC(=O)C2CC3=CC=CC=C3N2C(=O)OCC4=CC=CC=C4	Ki = 138000 nM	Poor binder
T05387	Tissue transglutaminase	B5KGP0	5-Bromoisatin	Investigative	6889	C8H4BrNO2	226.03	C1=CC2=C(C=C1Br)C(=O)C(=O)N2	IC50 = 65000 nM	Poor binder
T05387	Tissue transglutaminase	B7B8XS	Benzyl N-[4-[(3S)-3-(prop-2-enoylamino)piperidin-1-yl]sulfonylphenyl]carbamate	Investigative	71449435	C22H25N3O5S	443.5	C=CC(=O)N[C@H]1CCCN(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B7YE6B	(S)-3-(1-Acryloylpiperidin-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid	Investigative	71457506	C16H26N2O5	326.39	CC(C)(C)OC(=O)N[C@@H](CC1CCN(CC1)C(=O)C=C)C(=O)O	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B93JXQ	Tert-butyl 4-(4-cyanophenyl)sulfonylpiperazine-1-carboxylate	Investigative	6736443	C16H21N3O4S	351.4	CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C#N	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	B9KOZ1	Tert-butyl 4-[4-(cyanomethylcarbamoylamino)phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954610	C18H25N5O5S	423.5	CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NCC#N	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BAO67V	Chembl4227629	Investigative	145967697	C27H37N5O3	479.6	CCC(=O)NCCCC[C@@H](C(=O)N1CCN(CC1)C2=CC=CC(=N2)C)NC(=O)CC3=CC=CC=C3	Ki = 64300 nM	Poor binder
T05387	Tissue transglutaminase	BBMI65	Benzyl N-[4-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]sulfonylphenyl]carbamate	Investigative	71451226	C21H23N3O5S	429.5	C=CC(=O)N[C@H]1CCN(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)OCC3=CC=CC=C3	IC50 = 55000 nM	Poor binder
T05387	Tissue transglutaminase	BC2W1E	Indirubin	Investigative	10177	C16H10N2O2	262.26	C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T05387	Tissue transglutaminase	BC9XG1	Tert-butyl 4-[4-[(2-cyanoacetyl)amino]phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954613	C18H24N4O5S	408.5	CC(C)(C)OC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CC#N	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BD7T3F	Chembl4167132	Investigative	145955913	C20H14N8O3	414.4	C1=CC(=CC=C1CN2C=C(N=N2)C(=O)C3=CN(N=N3)CC4=CC=C(C=C4)[N+](=O)[O-])C#N	IC50 ~ 100000 nM	Poor binder
T05387	Tissue transglutaminase	BEM61J	Chembl4164796	Investigative	145960783	C20H14F3N7O4	473.4	C1=CC(=CC=C1CN2C=C(N=N2)C(=O)C3=CN(N=N3)CC4=CC=C(C=C4)OC(F)(F)F)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T05387	Tissue transglutaminase	BF5UZ4	Tert-butyl 4-[4-[(2-ethoxy-2-oxoethyl)amino]phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954611	C19H29N3O6S	427.5	CCOC(=O)CNC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BF8H5C	5,7-Difluoroindoline-2,3-dione	Investigative	16794671	C8H3F2NO2	183.11	C1=C(C=C(C2=C1C(=O)C(=O)N2)F)F	IC50 = 65000 nM	Poor binder
T05387	Tissue transglutaminase	BFO4Y1	N-(4-Methoxyphenyl)acrylamide	Investigative	82197	C10H11NO2	177.2	COC1=CC=C(C=C1)NC(=O)C=C	IC50 = 58000 nM	Poor binder
T05387	Tissue transglutaminase	BI24HO	(S)-Quinolin-3-ylmethyl 2-(((3-bromo-4,5-dihydroisoxazol-5-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate	Investigative	16094746	C20H21BrN4O4	461.3	C1C[C@H](N(C1)C(=O)NCC2CC(=NO2)Br)C(=O)OCC3=NC4=CC=CC=C4C=C3	Ki = 62000 nM	Poor binder
T05387	Tissue transglutaminase	BIP17B	N-[2-(4-Phenylphenyl)ethyl]-4-[4-(prop-2-enoylamino)piperidin-1-yl]sulfonylbenzamide	Investigative	71454791	C29H31N3O4S	517.6	C=CC(=O)NC1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NCCC3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 57000 nM	Poor binder
T05387	Tissue transglutaminase	BJC4G6	Benzyl 4-[3-[methyl(2-methylpropyl)amino]-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954825	C26H34N4O5S	514.6	CC(C)CN(C)C1=C(C=CC(=C1)S(=O)(=O)N2CCN(CC2)C(=O)OCC3=CC=CC=C3)NC(=O)C=C	IC50 = 76000 nM	Poor binder
T05387	Tissue transglutaminase	BJW5M0	Chembl4168680	Investigative	145955756	C15H12N2O3	268.27	C1[C@@H]([C@H]1C(=O)C2=CC=NC=C2)C3=CC(=CC=C3)[N+](=O)[O-]	IC50 = 147000 nM	Poor binder
T05387	Tissue transglutaminase	BK1CB2	Chembl4165391	Investigative	145954920	C19H14N8O5	434.4	C1=CC=C(C(=C1)CN2C=C(N=N2)C(=O)C3=CN(N=N3)CC4=CC=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]	IC50 = 64100 nM	Poor binder
T05387	Tissue transglutaminase	BKCS35	(S)-3-(4-Acrylamidophenyl)-2-(((benzyloxy)methyl)amino)propanoic acid	Investigative	71450339	C20H22N2O4	354.4	C=CC(=O)NC1=CC=C(C=C1)C[C@@H](C(=O)O)NCOCC2=CC=CC=C2	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BKW8H7	Quinolin-3-ylmethyl 1-((3-bromo-4,5-dihydroisoxazol-5-yl)methylamino)-3-(5-methoxy-1H-indol-3-yl)-1-oxopropan-2-ylcarbamate	Investigative	11512608	C27H26BrN5O5	580.4	COC1=CC2=C(C=C1)NC=C2CC(C(=O)NCC3CC(=NO3)Br)NC(=O)OCC4=CC5=CC=CC=C5N=C4	Ki = 51000 nM	Poor binder
T05387	Tissue transglutaminase	BMW1X7	Tert-butyl 4-[4-(2-methylprop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954418	C19H27N3O5S	409.5	CC(=C)C(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BNU69A	Chembl4160319	Investigative	145959648	C19H14N8O5	434.4	C1=CC(=CC(=C1)[N+](=O)[O-])CN2C=C(N=N2)C(=O)C3=CN(N=N3)CC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T05387	Tissue transglutaminase	BNU98V	Benzyl 4-[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954721	C23H26N2O6S	458.5	CCOC(=O)/C=C/C1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OCC3=CC=CC=C3	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BOF72S	5-Iodoisatin	Investigative	88695	C8H4INO2	273.03	C1=CC2=C(C=C1I)C(=O)C(=O)N2	IC50 = 65000 nM	Poor binder
T05387	Tissue transglutaminase	BR7A2J	[4-(4-Aminophenyl)sulfonylpiperazin-1-yl]-cyclopropylmethanone	Investigative	61113906	C14H19N3O3S	309.39	C1CC1C(=O)N2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BTR3I6	(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-4-Carbamoyl-2-[(2S)-pyrrolidin-2-ylformamido]butanoyl]pyrrolidin-2-yl]formamido}-5-(2-oxoacetamido)pentanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid	Investigative	44437814	C42H61N9O11	868	CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCNC(=O)C=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]4CCCN4	Ki = 200000 nM	Poor binder
T05387	Tissue transglutaminase	BU2O9W	[1-[(3-Bromo-4,5-dihydroisoxazol-5-ylmethyl)carbamoyl]-2-(4-fluoro-1H-indol-3-yl)ethyl]carbamic acid benzyl ester	Investigative	11526422	C23H22BrFN4O4	517.299	C1C(ON=C1Br)CNC(=O)C(CC2=CNC3=C2C(=CC=C3)F)NC(=O)OCC4=CC=CC=C4	Ki = 99000 nM	Poor binder
T05387	Tissue transglutaminase	BWQ2B4	Tert-butyl 4-[4-(2-oxopropanoylamino)phenyl]sulfonylpiperazine-1-carboxylate	Investigative	56954614	C18H25N3O6S	411.5	CC(=O)C(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	BWYL12	Benzyl N-[(2S)-1-(4-acetylpiperazin-1-yl)-1-oxo-6-(prop-2-enoylamino)hexan-2-yl]carbamate	Investigative	137650985	C23H32N4O5	444.5	CC(=O)N1CCN(CC1)C(=O)[C@H](CCCCNC(=O)C=C)NC(=O)OCC2=CC=CC=C2	Ki = 52100 nM	Poor binder
T05387	Tissue transglutaminase	BYNP32	N-(4-Bromophenyl)propionamide	Investigative	346184	C9H10BrNO	228.09	CCC(=O)NC1=CC=C(C=C1)Br	IC50 ~ 80000 nM	Poor binder
T05387	Tissue transglutaminase	D03TPH	5-chloro-1H-indole-2,3-dione	Investigative	87203	C8H4ClNO2	181.57	C1=CC2=C(C=C1Cl)C(=O)C(=O)N2	IC50 = 65000 nM	Poor binder
T05387	Tissue transglutaminase	D0N6BC	LDN-91946	Investigative	950368	C15H10N2O4S	314.3	C1=CC=C(C=C1)C(=O)C2=C(C3=C(S2)NC(=O)C(=C3)C(=O)O)N	Ki = 100000 nM	Poor binder