TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T07173	Tropomyosin-related kinase A	D0Y5UG	Amitriptyline	Approved	2160	C20H23N	277.4	CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31	IC50 = 60000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B05YET	1-(4-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea	Investigative	127030123	C21H17N5O2	371.4	COC1=CC=C(C=C1)NC(=O)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B06POE	N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030426	C25H25N5O	411.5	COC1=CC=CC(=C1)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B08NAQ	Benz[b]indeno[1,2-e]pyran-6,11-dione	Investigative	10422105	C16H8O3	248.23	C1=CC=C2C(=C1)C3=C(C2=O)OC4=CC=CC=C4C3=O	IC50 = 55800 nM	Poor binder
T07173	Tropomyosin-related kinase A	B1TV6D	3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine	Investigative	127031368	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=CC(=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B2CME9	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127033165	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=C3C(=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B2NRQ3	1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea	Investigative	53239374	C19H20N4O3	352.4	CCNC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B4NZ6S	3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide	Investigative	46934144	C24H20ClN3O3	433.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B4YQZ3	1-(3-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea	Investigative	127034308	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B51FNC	2-(2-Pyridin-3-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide	Investigative	137652057	C21H18N4O	342.4	C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=CN=CC=C4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	B5JDG2	N-[(1-Methylimidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide	Investigative	137638843	C19H18N4OS	350.4	CN1C=CN=C1CNC(=O)CN2C3=CC=CC=C3C=C2C4=CC=CS4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	B6K0AZ	2-(2-Phenylpyrrolo[3,2-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide	Investigative	137656463	C21H18N4O	342.4	C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=CC=N3	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	B6TCU4	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127031677	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=C(C=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B73ECX	N-(Pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamine	Investigative	137656818	C20H19N3S	333.5	C1=CC=C2C(=C1)C=C(N2CCNCC3=CC=CC=N3)C4=CC=CS4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	B76FRE	1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	53239375	C21H24N4O3	380.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B78VZH	N-(2-Pyridin-2-ylethyl)-2-thiophen-2-ylindole-1-carboxamide	Investigative	137641283	C20H17N3OS	347.4	C1=CC=C2C(=C1)C=C(N2C(=O)NCCC3=CC=CC=N3)C4=CC=CS4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	B7P4NU	N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031076	C21H14N4	322.4	C#CC1=CC(=CC=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B7W6FE	Chembl4204606	Investigative	118189493	C24H23F4N5O4	521.5	CN1C=C(N=C1)C2=CC(=C(N=C2)O[C@@H]3CCN(C[C@H]3F)C(=O)CC4=CC=C(C=C4)OC(F)(F)F)C(=O)N	IC50 = 74000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B7YZA8	5-Methyl-3-(trifluoromethyl)indeno[2,1-b]quinoline-6,11-dione	Investigative	122194426	C18H10F3NO2	329.3	CN1C2=C(C=CC(=C2)C(F)(F)F)C(=O)C3=C1C(=O)C4=CC=CC=C43	IC50 = 117000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B9ND4E	6-[3-[(5-Carbamoyl-2-phenylpyrazol-3-yl)carbamoyl]-4-chlorophenyl]pyridine-2-carboxamide	Investigative	118505219	C23H17ClN6O3	460.9	C1=CC=C(C=C1)N2C(=CC(=N2)C(=O)N)NC(=O)C3=C(C=CC(=C3)C4=NC(=CC=C4)C(=O)N)Cl	IC50 = 50000 nM	Poor binder
T07173	Tropomyosin-related kinase A	B9QD5X	N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-carboxamide	Investigative	137644894	C20H17N3OS	347.4	C1=CC=C2C(=C1)C=C(N2CCNC(=O)C3=CC=CC=N3)C4=CC=CS4	IC50 = 74020 nM	Poor binder
T07173	Tropomyosin-related kinase A	B9S0YQ	1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127031075	C16H15N5O	293.32	CCNC(=O)NC1=NC=CC2=NC(=CN=C21)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BA20XY	1-[[3-(1,3-Thiazol-2-yl)phenyl]methyl]-3-[4-(trifluoromethoxy)phenyl]urea	Investigative	90645512	C18H14F3N3O2S	393.4	C1=CC(=CC(=C1)C2=NC=CS2)CNC(=O)NC3=CC=C(C=C3)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BB4I1G	1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127030427	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BB65DH	N-(Pyridin-2-ylmethyl)-2-thiophen-2-ylindole-1-carboxamide	Investigative	137647123	C19H15N3OS	333.4	C1=CC=C2C(=C1)C=C(N2C(=O)NCC3=CC=CC=N3)C4=CC=CS4	IC50 = 64320 nM	Poor binder
T07173	Tropomyosin-related kinase A	BBFY93	1-(3-Phenylpyrido[3,4-b]pyrazin-8-yl)-3-prop-2-enylurea	Investigative	127032542	C17H15N5O	305.33	C=CCNC(=O)NC1=C2C(=CN=C1)N=C(C=N2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BD6YR7	N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030425	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)C3=NC4=CN=CC(=C4N=C3)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BFP59Z	1-(5-Tert-butyl-1,2-oxazol-3-yl)-3-[3-(6-chloropyrazin-2-yl)oxyphenyl]urea	Investigative	122183071	C18H18ClN5O3	387.8	CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=CN=CC(=N3)Cl	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BGVU25	N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide	Investigative	16723801	C23H20ClN3O	389.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BH9N3O	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127033758	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BK5HQ8	N-(2-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031383	C20H16N4O	328.4	COC1=CC=CC=C1NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BK7WV4	N-Pyridin-2-yl-2-(2-thiophen-2-ylindol-1-yl)acetamide	Investigative	137660376	C19H15N3OS	333.4	C1=CC=C2C(=C1)C=C(N2CC(=O)NC3=CC=CC=N3)C4=CC=CS4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	BL4AJ5	Chembl4216925	Investigative	118665628	C25H28F4N2O6	528.5	CC(C)(COC1=CC(=C(C=C1)C(=O)N)O[C@H]2CCN(C[C@@H]2F)C(=O)CC3=CC=C(C=C3)OC(F)(F)F)O	IC50 = 61000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BM26ZO	1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-	Investigative	2826530	C14H11N3O5	301.25	C1=CC2=CC(=CC3=C2C(=C1)C(=O)N(C3=O)NCCO)[N+](=O)[O-]	IC50 = 149000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BMC31A	1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea	Investigative	52936268	C20H18N6O	358.4	CN1C=C(C=N1)C2=CC3=C(C=CC(=N3)NC(=O)NCC4=CC=CC=C4)N=C2	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BMD27F	2-(2-Phenylpyrrolo[2,3-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide	Investigative	137643316	C21H18N4O	342.4	C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)N=CC=C3	IC50 = 99820 nM	Poor binder
T07173	Tropomyosin-related kinase A	BNY6E0	3-Chloro-5-methylindeno[2,1-b]quinoline-6,11-dione	Investigative	122194424	C17H10ClNO2	295.7	CN1C2=C(C=CC(=C2)Cl)C(=O)C3=C1C(=O)C4=CC=CC=C43	IC50 = 88500 nM	Poor binder
T07173	Tropomyosin-related kinase A	BO2J1K	5,7-Dimethylindeno[2,1-b]quinoline-6,11-dione	Investigative	122194427	C18H13NO2	275.3	CC1=C2C(=CC=C1)C3=C(C2=O)N(C4=CC=CC=C4C3=O)C	IC50 = 73300 nM	Poor binder
T07173	Tropomyosin-related kinase A	BOKJ71	N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine	Investigative	127030124	C19H12ClFN4	350.8	C1=CC=C(C=C1)C2=NC3=CN=CC(=C3N=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BRG63H	7-Hydroxy-5-methylindeno[2,1-b]quinoline-6,11-dione	Investigative	122194429	C17H11NO3	277.27	CN1C2=CC=CC=C2C(=O)C3=C1C(=O)C4=C3C=CC=C4O	IC50 = 141000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BS9Q0L	N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-sulfonamide	Investigative	137633612	C19H17N3O2S2	383.5	C1=CC=C2C(=C1)C=C(N2CCNS(=O)(=O)C3=CC=CC=N3)C4=CC=CS4	IC50 ~ 81010 nM	Poor binder
T07173	Tropomyosin-related kinase A	BT3H1C	N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031384	C20H16N4O	328.4	COC1=CC=C(C=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BU9QK8	1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-phenylurea	Investigative	53236671	C19H16N6O	344.4	CN1C=C(C=N1)C2=CC3=C(C=CC(=N3)NC(=O)NC4=CC=CC=C4)N=C2	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BXT68J	1-Ethyl-3-[7-(4-methoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	53239373	C18H18N4O2	322.4	CCNC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BXTV61	1-(3-Tert-butylphenyl)-3-[3-(6-chloropyrazin-2-yl)oxyphenyl]urea	Investigative	122183072	C21H21ClN4O2	396.9	CC(C)(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=CC=C2)OC3=CN=CC(=N3)Cl	IC50 ~ 100000 nM	Poor binder
T07173	Tropomyosin-related kinase A	BYA5E9	1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	136065882	C20H22N4O3	366.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)O)OC	IC50 = 80630 nM	Poor binder