TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T07663	Phosphodiesterase 5A	D0Y9ZE	Milrinone	Approved	4197	C12H9N3O	211.22	CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	D03QJL	Ibudilast	Phase 2	3671	C14H18N2O	230.31	CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C	IC50 = 103000 nM	Poor binder
T07663	Phosphodiesterase 5A	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	D0A0ZU	AC1MOZOL	Patented	3403301	C16H18N2OS2	318.5	CCC(C)SC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	D0Z7YQ	AC1M1SP5	Patented	2155273	C16H18N2O2S2	334.5	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	D05VLN	Isomazole	Terminated	55690	C14H13N3O2S	287.34	COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=NC=C3	IC50 = 58000 nM	Poor binder
T07663	Phosphodiesterase 5A	B05TXO	5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968471	C17H24ClN3O3	353.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCOCCN	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B0IL3G	Moracin C	Investigative	155248	C19H18O4	310.3	CC(=CCC1=C(C=C(C=C1O)C2=CC3=C(O2)C=C(C=C3)O)O)C	IC50 ~ 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	B0LMZ1	1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]butan-1-one	Investigative	23654252	C16H22O4	278.34	CCCC(=O)C1=CC(=C(C=C1)OC)OC2CCOCC2	IC50 ~ 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	B17IYK	N-[4-(Diethylaminomethyl)-2-[2-(diethylamino)-2-oxoacetyl]phenyl]benzamide	Investigative	137631637	C24H31N3O3	409.5	CCN(CC)CC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2)C(=O)C(=O)N(CC)CC	IC50 = 157510 nM	Poor binder
T07663	Phosphodiesterase 5A	B1C0EV	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one	Investigative	9859898	C14H16N4O	256.3	CC(C)C1=NN2C=CC=CC2=C1C3=NNC(=O)CC3	IC50 = 78000 nM	Poor binder
T07663	Phosphodiesterase 5A	B1TXR4	Lorneic acid B	Investigative	44605342	C17H24O3	276.4	CCCCCC(C1=C(C=CC(=C1)C)/C=C/CC(=O)O)O	IC50 = 87100 nM	Poor binder
T07663	Phosphodiesterase 5A	B21MFB	4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9836643	C15H12ClN3OS	317.8	CN1C(=NC2=CC=C(C=C2)O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B2S3MG	6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one	Investigative	15606258	C17H15N3O2	293.32	COC1=NC2=C3C(=C1)CCN3C(=O)CN=C2C4=CC=CC=C4	IC50 = 91000 nM	Poor binder
T07663	Phosphodiesterase 5A	B2UP0G	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl]pyridine-3-carboxamide	Investigative	11742456	C23H19N5O3	413.4	COC1=NC2=C3C(=C1)CCN3C(=O)[C@@H](N=C2C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B42GIH	3-[5-[(Diethylamino)methyl]-2-furyl]-1-benzyl-1H-indazole	Investigative	10291967	C23H25N3O	359.5	CCN(CC)CC1=CC=C(O1)C2=NN(C3=CC=CC=C32)CC4=CC=CC=C4	IC50 = 63000 nM	Poor binder
T07663	Phosphodiesterase 5A	B45PMI	2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetonitrile	Investigative	9922545	C15H16ClN3O2	305.76	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC#N	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B47OKJ	5-Methyl-1-[(2-nitrophenyl)methyl]indole-2,3-dione	Investigative	43826154	C16H12N2O4	296.28	CC1=CC2=C(C=C1)N(C(=O)C2=O)CC3=CC=CC=C3[N+](=O)[O-]	IC50 = 200000 nM	Poor binder
T07663	Phosphodiesterase 5A	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B4B5KL	3-Cyclopentyloxy-4-methoxy-N-(2-nitrophenyl)benzamide	Investigative	10089597	C19H20N2O5	356.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2[N+](=O)[O-])OC3CCCC3	IC50 = 65000 nM	Poor binder
T07663	Phosphodiesterase 5A	B4G9AQ	8-Chloro-5-(2-morpholin-4-ylethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	6918800	C19H26ClN3O3	379.9	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCN4CCOCC4	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B4GU0D	2-[2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetic acid	Investigative	10270352	C17H22ClN3O4	367.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCNCC(=O)O	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B4JF8H	8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9880288	C16H22ClN3O2	323.82	CNCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B57NKZ	2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol	Investigative	9880010	C15H12ClN3OS	317.8	CN1C(=NC2=CC=CC=C2O)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B5QEJ4	[3-Hydroxymethyl-1-(3-methanesulfonyl-4,5-dimethoxy-phenyl)-6,7-dimethoxy-naphthalen-2-yl]-methanol	Investigative	10479468	C23H26O8S	462.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)S(=O)(=O)C)OC)OC)CO)CO	IC50 = 53000 nM	Poor binder
T07663	Phosphodiesterase 5A	B5XLR9	6-Phenyl-8-chlorospiro[quinazoline-4(3H),1'-cyclohexane]-2(1H)-one	Investigative	6918667	C19H19ClN2O	326.8	C1CCC2(CC1)C3=C(C(=CC(=C3)C4=CC=CC=C4)Cl)NC(=O)N2	IC50 = 69800 nM	Poor binder
T07663	Phosphodiesterase 5A	B6THY8	4-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[3-(dimethylamino)propyl]benzamide	Investigative	6918797	C25H31ClN4O2	455	CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 ~ 50700 nM	Poor binder
T07663	Phosphodiesterase 5A	B6WCG2	2-Bromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one	Investigative	44384345	C11H7BrN4O	291.1	C1=CC=C(C=C1)C2=NNC(=O)N3C2=NC(=C3)Br	IC50 = 66700 nM	Poor binder
T07663	Phosphodiesterase 5A	B73SGZ	3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzamide	Investigative	9968005	C16H13ClN4OS	344.8	CN1C(=NC2=CC=CC(=C2)C(=O)N)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B7H3NC	5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9966830	C15H11ClFN3S	319.8	CN1C(=NC2=CC(=CC=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B7UE1J	1-Benzoyl-5-[(4-methoxyanilino)methyl]indole-2,3-dione	Investigative	137637339	C23H18N2O4	386.4	COC1=CC=C(C=C1)NCC2=CC3=C(C=C2)N(C(=O)C3=O)C(=O)C4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B7VK8X	(2S,8R)-2-(2-Bromophenyl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione	Investigative	46193244	C21H18BrN3O2	424.3	CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@@H]2C4=CC=CC=C4Br)NC5=CC=CC=C35	IC50 = 88000 nM	Poor binder
T07663	Phosphodiesterase 5A	B7Z5IB	8-Chloro-5-(2H-tetrazol-5-ylmethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9924468	C15H17ClN6O2	348.79	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC4=NNN=N4	IC50 ~ 88000 nM	Poor binder
T07663	Phosphodiesterase 5A	B8KD9T	1,3-Bis(cyclopropylmethyl)-7-methyl-8-[[(4-methoxyphenyl)sulfonyl]amino]xanthine	Investigative	10456913	C21H25N5O5S	459.5	CN1C2=C(N=C1NS(=O)(=O)C3=CC=C(C=C3)OC)N(C(=O)N(C2=O)CC4CC4)CC5CC5	IC50 = 54000 nM	Poor binder
T07663	Phosphodiesterase 5A	B8OSL6	5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine	Investigative	9901606	C15H11ClFN3S	319.8	CN1C(=NC2=CC=C(C=C2)F)SC(=N1)C3=CC=C(C=C3)Cl	IC50 = 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B8RJ4T	2-Isopropyl-3-(6-chloropyridazine-3-yl)pyrazolo[1,5-a]pyridine	Investigative	24751991	C14H13ClN4	272.73	CC(C)C1=NN2C=CC=CC2=C1C3=NN=C(C=C3)Cl	IC50 = 65000 nM	Poor binder
T07663	Phosphodiesterase 5A	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	B92BKO	1,3-Bis(cyclopropylmethyl)-7-methyl-8-[(phenylsulfonyl)amino]xanthine	Investigative	10252045	C20H23N5O4S	429.5	CN1C2=C(N=C1NS(=O)(=O)C3=CC=CC=C3)N(C(=O)N(C2=O)CC4CC4)CC5CC5	IC50 = 53000 nM	Poor binder
T07663	Phosphodiesterase 5A	B94ENV	8-Chloro-6-pyridin-2-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10268304	C18H18ClN3O	327.8	C1CCC2(CC1)C3=C(C(=CC(=C3)C4=CC=CC=N4)Cl)NC(=O)N2	IC50 = 68400 nM	Poor binder
T07663	Phosphodiesterase 5A	B97HAY	6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	662965	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC)OC	IC50 ~ 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	B9B6QD	3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[3-(dimethylamino)propyl]benzamide	Investigative	6918668	C25H31ClN4O2	455	CN(C)CCCNC(=O)C1=CC=CC(=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 ~ 84900 nM	Poor binder
T07663	Phosphodiesterase 5A	B9FN2U	3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzonitrile	Investigative	21920370	C16H11ClN4S	326.8	CN1C(=NC2=CC=CC(=C2)C#N)SC(=N1)C3=CC=C(C=C3)Cl	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	B9W7HS	5-(2-Aminoethoxy)-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9922691	C15H20ClN3O2	309.79	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCN	IC50 = 73200 nM	Poor binder
T07663	Phosphodiesterase 5A	BAR03O	Ethyl 5-[(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylate	Investigative	44394047	C21H23ClN2O5	418.9	CCOC(=O)C1=CC=C(O1)COC2=C3C(=C(C=C2)Cl)NC(=O)NC34CCCCC4	IC50 = 80000 nM	Poor binder
T07663	Phosphodiesterase 5A	BBQ31S	(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol	Investigative	10729204	C14H16O4	248.27	COC1=CC2=CC(=C(C=C2C=C1OC)CO)CO	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BBZS05	8-Chloro-6-[2-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	44393651	C25H29ClN4O2	453	CN1CCN(CC1)C(=O)C2=CC=CC=C2C3=CC4=C(C(=C3)Cl)NC(=O)NC45CCCCC5	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BC3MU2	3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[2-(dimethylamino)ethyl]benzamide	Investigative	6918796	C24H29ClN4O2	441	CN(C)CCNC(=O)C1=CC=CC(=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BCE62K	3,4,11,12-Tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one	Investigative	54580521	C13H12N4O	240.26	C1CC2=NN3C=CC=CC3=C2C4=NNC(=O)CC41	IC50 = 145000 nM	Poor binder
T07663	Phosphodiesterase 5A	BD0XY9	8-Chloro-5-[2-hydroxy-3-(methylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9924709	C17H24ClN3O3	353.8	CNCC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BD76NM	N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide	Investigative	11373312	C23H19N5O3	413.4	COC1=NC2=C3C(=C1)CCN3C(=O)C(N=C2C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 = 95000 nM	Poor binder
T07663	Phosphodiesterase 5A	BF48VA	8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10109572	C18H26ClN3O3	367.9	CN(C)CC(COC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3)O	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BG6OC1	3-Bromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one	Investigative	44384546	C11H7BrN4O	291.1	C1=CC=C(C=C1)C2=NNC(=O)N3C2=NC=C3Br	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BG87XN	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one	Investigative	24751843	C14H14N4O	254.29	CC(C)C1=NN2C=CC=CC2=C1C3=NNC(=O)C=C3	IC50 = 79000 nM	Poor binder
T07663	Phosphodiesterase 5A	BG8MJ2	3-Cyclopentyloxy-N-(2-hydroxy-phenyl)-4-methoxy-benzamide	Investigative	10359077	C19H21NO4	327.4	COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2O)OC3CCCC3	IC50 = 175000 nM	Poor binder
T07663	Phosphodiesterase 5A	BGE8O1	5,6-Dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one	Investigative	54582527	C13H10N4O	238.24	C1CC2=NN3C=CC=CC3=C2C4=NNC(=O)C=C41	IC50 = 156000 nM	Poor binder
T07663	Phosphodiesterase 5A	BGP76O	8-Chloro-5-[2-(dimethylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9967652	C17H24ClN3O2	337.8	CN(C)CCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 = 74000 nM	Poor binder
T07663	Phosphodiesterase 5A	BH4JT6	8-Chloro-5-[3-(dimethylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	9968370	C18H26ClN3O2	351.9	CN(C)CCCOC1=C2C(=C(C=C1)Cl)NC(=O)NC23CCCCC3	IC50 = 98000 nM	Poor binder
T07663	Phosphodiesterase 5A	BJ69KQ	2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetic acid	Investigative	6918798	C15H17ClN2O4	324.76	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC(=O)O	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BJA3Z5	4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one	Investigative	25179287	C25H22N2O3	398.5	CC(=O)CC(C1=CC(=C(C=C1)OC2=CC=CC=N2)OC)C3=CC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	BKP81M	PDE4 inhibitor intermediate 1	Investigative	9842576	C21H29NO5	375.5	CC(=O)[C@@]1(CN(C[C@H]1C2=CC(=C(C=C2)OC)OC3CCCC3)C(=O)OC)C	Ki ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BKUG45	5-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylic acid	Investigative	10200432	C19H19ClN2O5	390.8	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC4=CC=C(O4)C(=O)O	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BM4S2C	1-Benzoyl-5-(piperidin-1-ylmethyl)indole-2,3-dione	Investigative	137648482	C21H20N2O3	348.4	C1CCN(CC1)CC2=CC3=C(C=C2)N(C(=O)C3=O)C(=O)C4=CC=CC=C4	IC50 = 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	BN6KZ0	(2,4,6-Trimethoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl)-amine	Investigative	18796640	C21H25N3O6	415.4	COC1=CC(=C(C(=C1)OC)CNC2=NC=NC3=C(C(=C(C=C32)OC)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BO7ZA1	6-Methoxy-3,8-Dimethyl-4-(Piperazin-1-Yl)-1h-Pyrazolo[3,4-B]quinoline	Investigative	46239840	C17H21N5O	311.4	CC1=CC(=CC2=C(C3=C(NN=C3N=C12)C)N4CCNCC4)OC	Ki ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BP3JF1	2,3-Dichloro-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one	Investigative	44384713	C11H6Cl2N4O	281.09	C1=CC=C(C=C1)C2=NNC(=O)N3C2=NC(=C3Cl)Cl	IC50 = 56100 nM	Poor binder
T07663	Phosphodiesterase 5A	BP9FG5	2-[2-(2-Hydroxyethoxy)phenyl]-1H-imidazo[4,5-b]pyridine	Investigative	9992525	C14H13N3O2	255.27	C1=CC=C(C(=C1)C2=NC3=C(N2)C=CC=N3)OCCO	IC50 = 64000 nM	Poor binder
T07663	Phosphodiesterase 5A	BQES71	N-[5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-phenyl]-acetamide	Investigative	10646809	C24H27NO7	441.5	CC(=O)NC1=C(C(=CC(=C1)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC)OC)OC	IC50 = 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BRV5I3	1,3-Di(cyclopropylmethyl)-8-(4-methoxybenzenesulphonylamino)xanthine	Investigative	10343476	C20H23N5O5S	445.5	COC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=C(N2)C(=O)N(C(=O)N3CC4CC4)CC5CC5	IC50 = 68000 nM	Poor binder
T07663	Phosphodiesterase 5A	BS5U0E	N'-[1,3-Bis(cyclopropylmethyl)-2,6-dioxo-7H-purin-8-yl]-N,N-dimethylmethanimidamide	Investigative	10404378	C16H22N6O2	330.38	CN(C)/C=N/C1=NC2=C(N1)C(=O)N(C(=O)N2CC3CC3)CC4CC4	IC50 = 56000 nM	Poor binder
T07663	Phosphodiesterase 5A	BTJF29	8-Chloro-6-[3-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	10182563	C25H29ClN4O2	453	CN1CCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC4=C(C(=C3)Cl)NC(=O)NC45CCCCC5	IC50 = 52400 nM	Poor binder
T07663	Phosphodiesterase 5A	BTQ28A	4-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[2-(dimethylamino)ethyl]benzamide	Investigative	6918795	C24H29ClN4O2	441	CN(C)CCNC(=O)C1=CC=C(C=C1)C2=CC3=C(C(=C2)Cl)NC(=O)NC34CCCCC4	IC50 ~ 67300 nM	Poor binder
T07663	Phosphodiesterase 5A	BU98RW	1-Benzoyl-5-methyl-3H-indol-2-one	Investigative	134908214	C16H13NO2	251.28	CC1=CC2=C(C=C1)N(C(=O)C2)C(=O)C3=CC=CC=C3	IC50 = 91200 nM	Poor binder
T07663	Phosphodiesterase 5A	BVF8N3	3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxypropane-1-sulfonic acid	Investigative	10221904	C16H21ClN2O5S	388.9	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCCS(=O)(=O)O	IC50 = 60000 nM	Poor binder
T07663	Phosphodiesterase 5A	BVGM70	5-Bromo-1-[(4-bromophenyl)methyl]indole-2,3-dione	Investigative	4352680	C15H9Br2NO2	395.04	C1=CC(=CC=C1CN2C3=C(C=C(C=C3)Br)C(=O)C2=O)Br	IC50 = 130620 nM	Poor binder
T07663	Phosphodiesterase 5A	BX47WE	1-[4-(Difluoromethoxy)-3-(oxolan-3-yloxy)phenyl]-3-methylbutan-1-one	Investigative	25147798	C16H20F2O4	314.32	CC(C)CC(=O)C1=CC(=C(C=C1)OC(F)F)OC2CCOC2	IC50 ~ 50000 nM	Poor binder
T07663	Phosphodiesterase 5A	BXJ1K4	4-[(3-Chloro-4-methoxyphenyl)methylamino]-1-(4-hydroxypiperidin-1-yl)-N,N-dimethylphthalazine-6-carboxamide;hydrochloride	Investigative	45264712	C24H29Cl2N5O3	506.4	CN(C)C(=O)C1=CC2=C(C=C1)C(=NN=C2NCC3=CC(=C(C=C3)OC)Cl)N4CCC(CC4)O.Cl	IC50 = 58000 nM	Poor binder
T07663	Phosphodiesterase 5A	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BXVA98	8-Chloro-5-(2-hydroxyethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one	Investigative	6918799	C15H19ClN2O3	310.77	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCCO	IC50 ~ 91000 nM	Poor binder
T07663	Phosphodiesterase 5A	BY6CJ5	6,7,8-Trimethoxy-n-[(4-nitrophenyl)methyl]-4-quinazolinamine	Investigative	18796725	C18H18N4O5	370.4	COC1=C(C(=C2C(=C1)C(=NC=N2)NCC3=CC=C(C=C3)[N+](=O)[O-])OC)OC	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BZB5T3	3-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]-4H-1,2,4-oxadiazol-5-one	Investigative	135482260	C16H17ClN4O4	364.78	C1CCC2(CC1)C3=C(C=CC(=C3NC(=O)N2)Cl)OCC4=NOC(=O)N4	IC50 ~ 101000 nM	Poor binder
T07663	Phosphodiesterase 5A	BZG1V9	N,N,5-Trimethyl-2,3-dioxoindole-1-carboxamide	Investigative	137662139	C12H12N2O3	232.23	CC1=CC2=C(C=C1)N(C(=O)C2=O)C(=O)N(C)C	IC50 = 100000 nM	Poor binder
T07663	Phosphodiesterase 5A	BZU7T5	6-(2-Isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)pyridazin-3(2H)-one	Investigative	53248667	C15H16N4O2	284.31	CC(C)C1=NN2C(=CC=C(C2=C1)C3=NNC(=O)C=C3)OC	IC50 ~ 100000 nM	Poor binder