TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T07740 Inward rectifier potassium channel Kir2.3 B0OW6Y 5-[2-[4-[2-[4-(Tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Investigative 57331209 C23H24N6O3 432.5 C1CN(CCN1CCC2=CC3=C(C=C2)C(=O)OC3)C(=O)CC4=CC=C(C=C4)N5C=NN=N5 IC50 ~ 50000 nM Poor binder T07740 Inward rectifier potassium channel Kir2.3 B3TL6G 6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile Investigative 59568656 C24H28N4O5 452.5 CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCN(CC3)C[C@@H](C4=NC=C(C(=C4)OC)C#N)O)O IC50 ~ 50000 nM Poor binder T07740 Inward rectifier potassium channel Kir2.3 BJC93H 1,4-Bis[2-(4-nitrophenyl)ethyl]piperazine Investigative 52337837 C20H24N4O4 384.4 C1CN(CCN1CCC2=CC=C(C=C2)[N+](=O)[O-])CCC3=CC=C(C=C3)[N+](=O)[O-] IC50 ~ 100000 nM Poor binder T07740 Inward rectifier potassium channel Kir2.3 BPFN07 1-[2-(4-Nitrophenyl)ethyl]piperazine Investigative 14985965 C12H17N3O2 235.28 C1CN(CCN1)CCC2=CC=C(C=C2)[N+](=O)[O-] IC50 ~ 100000 nM Poor binder T07740 Inward rectifier potassium channel Kir2.3 BPN5S3 4-Methyl-5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Investigative 57331668 C23H25N7O3 447.5 CC1=C(C=CC2=C1COC2=O)CCN3CCN(CC3)C(=O)CC4=CN=C(C=C4)N5C=NN=N5 IC50 ~ 50000 nM Poor binder