TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T08391	Janus kinase 2	D0J9ZR	Niclosamide	Approved	4477	C13H8Cl2N2O4	327.12	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B0D2SQ	COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=CCN(C)C)c1	Investigative	117652419	C27H27FN4O2	458.5	CC1=CC(=C(C=C1F)OC)C2=CNC3=C2C=C(C=N3)C4=CC(=CC=C4)NC(=O)/C=C/CN(C)C	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B0FD3P	CN(C)CC=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(C)c2c1	Investigative	117652572	C20H22N4O	334.4	CC1=CNC2=C1C=C(C=N2)C3=CC(=CC=C3)NC(=O)/C=C/CN(C)C	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B0NZT4	4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide	Investigative	46917073	C18H16ClN3O	325.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCCl	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B18GAM	2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46917070	C18H18N4O	306.4	CN(C)CC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B1E3KY	Disodium;2-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	76325323	C19H16FN6Na2O3P	472.3	CN1C(=C(N=C1C2=CN(N=N2)CCP(=O)([O-])[O-])C3=CC=C(C=C3)F)C4=CC=NC=C4.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B1NM0O	3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide	Investigative	46916410	C17H14ClN3O	311.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCl	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B1S4YF	Chembl4279618	Investigative	118911552	C20H23N5	333.4	CN([C@H]1CN(CC12CC2)CC3=CC=CC=C3)C4=NC=NC5=C4C=CN5	IC50 = 98000 nM	Poor binder
T08391	Janus kinase 2	B21NGY	6-Phenyl-1H-indazol-3-amine	Investigative	11658542	C13H11N3	209.25	C1=CC=C(C=C1)C2=CC3=C(C=C2)C(=NN3)N	IC50 = 145300 nM	Poor binder
T08391	Janus kinase 2	B24FDH	Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate	Investigative	118707523	C21H14FN8NaO2S	484.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CC(=O)[O-])C5=CC=C(C=C5)F.[Na+]	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B2DO4T	4-[5-(4-Fluorophenyl)-3-methyl-2-(2H-triazol-4-yl)imidazol-4-yl]pyridine	Investigative	76325315	C17H13FN6	320.32	CN1C(=C(N=C1C2=NNN=C2)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B2X6MP	N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide	Investigative	46917074	C18H14N6O	330.3	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CN4C=NC=N4	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B3H7WV	2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine	Investigative	9798589	C17H13FN6S	352.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)N)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B3K2IF	4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol	Investigative	9796455	C16H21N3O3	303.36	COC1=C(C=C2C(=C1)N=CC(=N2)NC3CCC(CC3)O)OC	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B4I1TG	N-Tert-butyl-3-[[5-cyano-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide	Investigative	134130282	C27H34N8O2S	534.7	CC1=C(C=CC(=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)S(=O)(=O)NC(C)(C)C)C#N)N4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B4NZ6S	3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide	Investigative	46934144	C24H20ClN3O3	433.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=C(C=C4)[N+](=O)[O-]	IC50 = 106700 nM	Poor binder
T08391	Janus kinase 2	B51RCZ	6-Bromo-1H-indazol-3-amine	Investigative	2786631	C7H6BrN3	212.05	C1=CC2=C(C=C1Br)NN=C2N	IC50 = 131000 nM	Poor binder
T08391	Janus kinase 2	B5QA4G	Chembl4285755	Investigative	145993080	C18H20N6O	336.4	CC1=CC(=CC(=C1)NC2=NN3C(=CN=C3C(=C2)NC4CC4)C(=O)N)C	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B64LHM	(2R,3R,4R,5S,6R)-3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]-6-(hydroxymethyl)oxane-2,4,5-triol	Investigative	118707521	C23H23FN6O5	482.5	CN1C(=C(N=C1C2=CN(N=N2)[C@@H]3[C@H]([C@@H]([C@H](O[C@H]3O)CO)O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B6BAX3	Chembl4228653	Investigative	145969804	C43H49N11O5S	832	CCNC(=O)C1=CC2=C(N=C(N=C2S1)N)C3=CC(=CC=C3)OCCCCCCOC4=CC=C(C=C4)NC5=NC(=C6C=CNC6=N5)C7=CN(N=C7)CCCCCCC(=O)NO	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B6SO8N	1-[(3-Methyl-1-{2-[(1,2,3-Trimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol	Investigative	71698379	C23H27N7O	417.5	CC1=C(N(C2=C1C=C(C=C2)NC3=NC=CC(=N3)N4C=C(C(=N4)C)CN5CC(C5)O)C)C	IC50 = 138200 nM	Poor binder
T08391	Janus kinase 2	B73IWP	2-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethanol	Investigative	76314414	C19H17FN6O	364.4	CN1C(=C(N=C1C2=CN(N=N2)CCO)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B7LQ4K	2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46916408	C21H23N5O	361.4	CN1CCN(CC1)CC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	B7WL9S	(3R)-1-[[1-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-4-methylpyrrol-3-yl]methyl]pyrrolidin-3-ol	Investigative	53232414	C22H27N5O	377.5	CC1=CC(=CC(=C1)NC2=NC=CC(=N2)N3C=C(C(=C3)CN4CC[C@H](C4)O)C)C	IC50 = 115300 nM	Poor binder
T08391	Janus kinase 2	B81JYI	Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	118707526	C21H16FN8Na2O3PS	556.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CCP(=O)([O-])[O-])C5=CC=C(C=C5)F.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B82CPS	4-[4-(4-Fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazol-2-yl]phenol	Investigative	136987005	C20H15FN4OS	378.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B8WI1Y	COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1	Investigative	117652433	C24H20FN3O2	401.4	CC1=CC(=C(C=C1F)OC)C2=CNC3=C2C=C(C=N3)C4=CC(=CC=C4)NC(=O)C=C	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	B97OTQ	7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707522	C19H12FN5S	361.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BAL19S	(E)-N-[3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]-4-(dimethylamino)but-2-enamide	Investigative	117652519	C19H19ClN4O	354.8	CN(C)C/C=C/C(=O)NC1=CC=CC(=C1)C2=CC3=C(NC=C3Cl)N=C2	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BALX83	1-[(1-{2-[(3-Chloro-1,2-Dimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-3-Methyl-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol	Investigative	71698376	C22H24ClN7O	437.9	CC1=C(C2=C(N1C)C=CC(=C2)NC3=NC=CC(=N3)N4C=C(C(=N4)C)CN5CC(C5)O)Cl	IC50 = 111900 nM	Poor binder
T08391	Janus kinase 2	BB7T4M	4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine	Investigative	118707543	C22H15FN4S	386.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BCVE73	N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide	Investigative	1485420	C18H13N3O2S2	367.4	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4	IC50 = 55500 nM	Poor binder
T08391	Janus kinase 2	BD5O9Y	2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine	Investigative	44124695	C24H20FN7	425.5	C[C@@H](C1=CC=CC=C1)NC2=NC=CC(=N2)C3=C(N=C4N3C=CC(=N4)N)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BD5TM1	5-[4-(1,1-Dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine	Investigative	67479440	C17H19N5O2S	357.4	C1CS(=O)(=O)CCN1CC2=CC=C(C=C2)C3=CC=CC4=NC(=NN43)N	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BDM21A	4-[5-(4-Fluorophenyl)-2-[1-[(3S,4S)-3-fluoropiperidin-4-yl]triazol-4-yl]-3-methylimidazol-4-yl]pyridine;hydrochloride	Investigative	76317978	C22H22ClF2N7	457.9	CN1C(=C(N=C1C2=CN(N=N2)[C@H]3CCNC[C@@H]3F)C4=CC=C(C=C4)F)C5=CC=NC=C5.Cl	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BG9Z4J	N-(3-(2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)acrylamide	Investigative	86300420	C16H13N3O2	279.29	C=CC(=O)NC1=CC=CC(=C1)C2=CC3=C(NC(=O)C3)N=C2	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BGD0S5	3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76332540	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=CC(=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BGVU25	N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide	Investigative	16723801	C23H20ClN3O	389.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=NC=C4	IC50 = 133600 nM	Poor binder
T08391	Janus kinase 2	BHYL12	Cc1cccc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c1F	Investigative	117652502	C23H18FN3O	371.4	CC1=C(C(=CC=C1)C2=CNC3=C2C=C(C=N3)C4=CC(=CC=C4)NC(=O)C=C)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BKG16O	4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine	Investigative	76310785	C23H26FN6O3P	484.5	CCOP(=O)(CCN1C=C(N=N1)C2=NC(=C(N2C)C3=CC=NC=C3)C4=CC=C(C=C4)F)OCC	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BMJZ59	2-Morpholino-N-(3-(quinoxalin-2-yl)phenyl)acetamide	Investigative	46916411	C20H20N4O2	348.4	C1COCCN1CC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	BNK7H2	7-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707525	C25H26FN8O3PS	568.6	CCOP(=O)(CCN1C=C(N=N1)C2=NC3=NC(=C(N3C=C2)C4=NC(=NC=C4)SC)C5=CC=C(C=C5)F)OCC	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BPD53O	Chembl4289149	Investigative	145987719	C18H14F3N7O	401.3	C1CC1NC2=CC(=NN3C2=NC=C3C(=O)N)NC4=CC(=CC(=C4)C(F)(F)F)C#N	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	BQX3F8	2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol	Investigative	137659496	C19H19N5O	333.4	CC1=CC=C(C=C1)CNC2=NC(=NC3=C2C4=C(N3)C=C(C(=C4)O)C)N	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BQZ92A	(E)-4-(Dimethylamino)-N-[3-[3-(2-fluoro-3-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]but-2-enamide	Investigative	117652348	C26H25FN4O	428.5	CC1=C(C(=CC=C1)C2=CNC3=C2C=C(C=N3)C4=CC(=CC=C4)NC(=O)/C=C/CN(C)C)F	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BRQ36B	2-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide	Investigative	58200382	C17H14ClN3O	311.8	CC(C(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2)Cl	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	BSH4V3	N-(3-Quinoxalin-2-ylphenyl)propanamide	Investigative	952076	C17H15N3O	277.32	CCC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	BU4J9Y	(E)-N-[3-[3-(3,5-Difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-fluorophenyl]-4-(dimethylamino)but-2-enamide	Investigative	86300416	C26H23F3N4O2	480.5	CN(C)C/C=C/C(=O)NC1=CC(=C(C=C1)F)C2=CC3=C(NC=C3C4=C(C(=CC(=C4)F)F)OC)N=C2	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	BU8V1Y	(3R)-1-[[1-[2-[(3-Chloro-1,2-dimethylindol-5-yl)amino]pyrimidin-4-yl]-3-methylpyrazol-4-yl]methyl]pyrrolidin-3-ol	Investigative	89708625	C23H26ClN7O	452	CC1=C(C2=C(N1C)C=CC(=C2)NC3=NC=CC(=N3)N4C=C(C(=N4)C)CN5CC[C@H](C5)O)Cl	IC50 = 162400 nM	Poor binder
T08391	Janus kinase 2	BWV26C	N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea	Investigative	1485415	C22H18N4O2	370.4	COC1=CC=C(C=C1)NC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T08391	Janus kinase 2	BYZ38E	4-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76310788	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=C(C=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T08391	Janus kinase 2	D0VC0I	Oxindole 94	Investigative	5169	C20H14FN3O	331.3	C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O	IC50 ~ 100000 nM	Poor binder