TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T12119	Voltage-gated sodium channel alpha Nav1.7	D0E4DW	Phenytoin	Approved	1775	C15H12N2O2	252.27	C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	D0TV6I	Safinamide	Approved	131682	C17H19FN2O2	302.34	C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F	IC50 = 100000 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	D0X0RI	Mexiletine	Approved	4178	C11H17NO	179.26	CC1=C(C(=CC=C1)C)OCC(C)N	IC50 = 56000 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	B0QX8B	N-(5-Chloro-6-(3,4-dichlorobenzyloxy)benzo[d]isoxazol-3-yl)methanesulfonamide	Investigative	86268555	C15H11Cl3N2O4S	421.7	CS(=O)(=O)NC1=NOC2=CC(=C(C=C21)Cl)OCC3=CC(=C(C=C3)Cl)Cl	IC50 = 74000 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	B7KZC5	[2-(4-Tert-Butyl-benzyloxy)-3-methoxy-phenyl]-pyrrolidin-1-yl-methanone	Investigative	44402703	C23H29NO3	367.5	CC(C)(C)C1=CC=C(C=C1)COC2=C(C=CC=C2OC)C(=O)N3CCCC3	IC50 = 90000 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	BULA89	4-[4-Chloro-2-(2-methylpyrazol-3-yl)phenoxy]-3-cyano-N-[5-(trifluoromethyl)pyrimidin-2-yl]benzenesulfonamide	Investigative	71719329	C22H14ClF3N6O3S	534.9	CN1C(=CC=N1)C2=C(C=CC(=C2)Cl)OC3=C(C=C(C=C3)S(=O)(=O)NC4=NC=C(C=N4)C(F)(F)F)C#N	IC50 = 51003.5 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	BW4X2V	3-Cyano-N-(5-fluoropyridin-2-yl)-4-[4-[(1,3,5-trimethylpyrazol-4-yl)methyl]phenoxy]benzenesulfonamide	Investigative	71720546	C25H22FN5O3S	491.5	CC1=C(C(=NN1C)C)CC2=CC=C(C=C2)OC3=C(C=C(C=C3)S(=O)(=O)NC4=NC=C(C=C4)F)C#N	IC50 = 54000.78 nM	Poor binder
T12119	Voltage-gated sodium channel alpha Nav1.7	BYB65T	N-[5-Chloro-6-[[3-chloro-4-(2-methylpropoxy)phenoxy]methyl]-1,2-benzoxazol-3-yl]methanesulfonamide	Investigative	86268159	C19H20Cl2N2O5S	459.3	CC(C)COC1=C(C=C(C=C1)OCC2=CC3=C(C=C2Cl)C(=NO3)NS(=O)(=O)C)Cl	IC50 = 86000 nM	Poor binder