TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T13863 Transmembrane protease serine 6 B24JMU Tert-butyl 4-[[2-[(3-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid Investigative 71477380 C22H25F3N4O7S 546.5 CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O Ki = 137000 nM Poor binder T13863 Transmembrane protease serine 6 B2B8TM 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)acetamide;hydrochloride Investigative 71453262 C17H21ClN4O5S 428.9 COC1=C(C=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl Ki = 82000 nM Poor binder T13863 Transmembrane protease serine 6 B3OT1L 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-cyclohexylacetamide;2,2,2-trifluoroacetic acid Investigative 71476910 C17H23F3N4O5S 452.5 C1CCC(CC1)NC(=O)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O Ki = 64000 nM Poor binder T13863 Transmembrane protease serine 6 B3PB0M 3-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)propanamide;hydrochloride Investigative 71454987 C18H23ClN4O5S 442.9 COC1=C(C=C(C=C1)NC(=O)CCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl Ki = 132000 nM Poor binder T13863 Transmembrane protease serine 6 B6O8WQ 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-naphthalen-2-ylacetamide;2,2,2-trifluoroacetic acid Investigative 71476909 C21H19F3N4O5S 496.5 C1=CC=C2C=C(C=CC2=C1)NC(=O)CNS(=O)(=O)C3=CC=CC(=C3)C(=N)N.C(=O)(C(F)(F)F)O Ki = 50000 nM Poor binder T13863 Transmembrane protease serine 6 B86ELK N-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid Investigative 71477066 C21H19F3N4O5S 496.5 C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NCC(=O)NC3=CC=CC(=C3)C(=N)N.C(=O)(C(F)(F)F)O Ki = 163000 nM Poor binder T13863 Transmembrane protease serine 6 B9LU5N 4-(N-Phenylsulfamoyl)Benzamidinium Chloride Investigative 71449631 C13H14ClN3O2S 311.79 C1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)C(=N)N.Cl Ki = 88000 nM Poor binder T13863 Transmembrane protease serine 6 B9MVJ2 (1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,41S,44S,50S)-50-Benzyl-4-[(2S)-butan-2-yl]-25,34-bis[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-3,6,12,18,21,24,27,30,33,36,39,43,49,52-tetradecaoxo-54,55-dithia-2,5,11,17,20,23,26,29,32,35,38,42,48,51-tetradecazapentacyclo[29.21.4.07,11.013,17.044,48]hexapentacontane-41-carboxylic acid Investigative 122192784 C70H102N20O19S2 1591.8 CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N4CCC[C@H]4C(=O)N1)CC5=CC=C(C=C5)O)CO)CCCN=C(N)N)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)C[C@H](NC(=O)[C@@H]6CCCN6C(=O)[C@@H](NC2=O)CC7=CC=CC=C7)C(=O)O)CCCN=C(N)N Ki ~ 50000 nM Poor binder T13863 Transmembrane protease serine 6 B9XGZ1 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-phenylacetamide;2,2,2-trifluoroacetic acid Investigative 71476908 C17H17F3N4O5S 446.4 C1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O Ki = 65000 nM Poor binder T13863 Transmembrane protease serine 6 BB16JQ 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-propan-2-ylacetamide;2,2,2-trifluoroacetic acid Investigative 71477064 C14H19F3N4O5S 412.39 CC(C)NC(=O)CNS(=O)(=O)C1=CC=CC(=C1)C(=N)N.C(=O)(C(F)(F)F)O Ki = 148000 nM Poor binder T13863 Transmembrane protease serine 6 BD4YQ2 Tert-butyl 3-[3-[(3-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid Investigative 71477383 C23H27F3N4O7S 560.5 CC(C)(C)OC(=O)C1=CC(=CC=C1)NC(=O)CCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O Ki = 65000 nM Poor binder T13863 Transmembrane protease serine 6 BH5Z2C 3-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]propanamide;hydrochloride Investigative 71454989 C19H25ClN4O5S 456.9 COC1=C(C=C(C=C1)CNC(=O)CCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl Ki = 187000 nM Poor binder T13863 Transmembrane protease serine 6 BIYW57 N-(3-Carbamimidoylphenyl)-2-(naphthalen-1-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid Investigative 71477067 C21H19F3N4O5S 496.5 C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)NCC(=O)NC3=CC=CC(=C3)C(=N)N.C(=O)(C(F)(F)F)O Ki = 163000 nM Poor binder T13863 Transmembrane protease serine 6 BJG12Y 2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]acetamide;hydrochloride Investigative 71458637 C18H23ClN4O5S 442.9 COC1=C(C=C(C=C1)CNC(=O)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl Ki = 155000 nM Poor binder T13863 Transmembrane protease serine 6 BO0C9M 4-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid Investigative 71477687 C19H19F3N4O7S 504.4 C1=CC(=CC(=C1)S(=O)(=O)NCCC(=O)NC2=CC=C(C=C2)C(=O)O)C(=N)N.C(=O)(C(F)(F)F)O Ki = 52000 nM Poor binder T13863 Transmembrane protease serine 6 BO29IH N-(3-Carbamimidoylphenyl)-2-[(3,4-dimethoxyphenyl)sulfonylamino]acetamide;2,2,2-trifluoroacetic acid Investigative 71477065 C19H21F3N4O7S 506.5 COC1=C(C=C(C=C1)S(=O)(=O)NCC(=O)NC2=CC=CC(=C2)C(=N)N)OC.C(=O)(C(F)(F)F)O Ki = 196000 nM Poor binder T13863 Transmembrane protease serine 6 BR4GB6 4-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid Investigative 71477685 C18H17F3N4O7S 490.4 C1=CC(=CC(=C1)S(=O)(=O)NCC(=O)NC2=CC=C(C=C2)C(=O)O)C(=N)N.C(=O)(C(F)(F)F)O Ki = 139000 nM Poor binder T13863 Transmembrane protease serine 6 BSV60C 2-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)acetamide;hydrochloride Investigative 71449632 C17H21ClN4O5S 428.9 COC1=C(C=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl Ki = 115000 nM Poor binder T13863 Transmembrane protease serine 6 BYB45R Tert-butyl 4-[4-[(3-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid Investigative 71477384 C24H29F3N4O7S 574.6 CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CCCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O Ki = 70000 nM Poor binder