TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T14731	NAD-dependent deacetylase sirtuin-1	D0M8FD	SNDX-275	Phase 2	4261	C21H20N4O3	376.4	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D00RNS	BDBM50363780	Patented	49847188	C21H25BrN4O2S	477.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)Br	IC50 = 62100 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D0V2UZ	BDBM50363773	Patented	49847196	C24H32N4O2S	440.6	CC(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C	IC50 = 64800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B09FPJ	4-Tert-butyl-N-[[4-[[2-[2-[2-[2-[2-[2-(dimethylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	57395074	C32H49ClN4O7S	669.3	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)COCCOCCOCCOCCOCCN(C)C.Cl	IC50 ~ 60000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B0A3DZ	US9365508, C6 (3-CF3,	Investigative	90936478	C23H27F3N4O3S	496.5	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C=C2)OC)C(F)(F)F	IC50 = 51700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B0B8GD	(2S)-6-Acetamido-2-[[(2S)-6-[[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134131282	C33H50N8O7S2	734.9	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CSC1=NC2=CC=CC=C2S1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 77500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B0BSF7	SirReal1-O-propargyl	Investigative	138319670	C21H20N4O2S2	424.5	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC#C)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B0ONU6	Chembl4287164	Investigative	145990906	C26H34N4O6S	530.6	CCOC(=O)CCNC(=S)NCCCC[C@@H](C(=O)NC1=CC(=CC=C1)O)NC(=O)OCC2=CC=CC=C2	IC50 = 177800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B0ZYR7	6-Chloro-N,N-diethyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	2859649	C17H21ClN2O	304.8	CCN(CC)C(=O)C1CCCC2=C1NC3=C2C=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B13CNX	(2S)-6-Acetamido-2-[[(2S)-6-[(2-benzylsulfanylacetyl)amino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130906	C33H53N7O7S	691.9	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CSCC1=CC=CC=C1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 171000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B14KAZ	3-(Furan-2-yl)-6-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	3163949	C15H12N4O2S	312.3	COC1=CC=C(C=C1)CC2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 76900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B16CHL	N-Methyl-2-(phenylamino)benzamide	Investigative	12476632	C14H14N2O	226.27	CNC(=O)C1=CC=CC=C1NC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B17KIE	Methyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	137658301	C21H22N4O4	394.4	CC1(CC(C2=C(O1)C=CC(=C2)NC(=O)OC)NC(=O)NC3=CC=CC(=C3)C#N)C	IC50 = 109900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1A9LW	3-(2-Furyl)-6-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	662768	C11H6N4OS2	274.3	C1=COC(=C1)C2=NN=C3N2N=C(S3)C4=CC=CS4	IC50 = 88600 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1FRS3	US9365508, D3 (3-Cl, 4-OMe,	Investigative	71664652	C22H26Cl2N4O3S	497.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C(=C2)Cl)OC)Cl	IC50 = 62500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1IXY5	(2S)-6-Acetamido-2-[[(2S)-6-(6-benzylsulfanylhexanoylamino)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130170	C37H61N7O7S	748	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CCCCCSCC1=CC=CC=C1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 57700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1J3WT	2-[3-[2-(2-Methylphenyl)ethoxy]anilino]benzamide	Investigative	60165506	C22H22N2O2	346.4	CC1=CC=CC=C1CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1LGI7	5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Investigative	3953303	C20H17ClN4O3	396.8	C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1OPK9	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	1096292	C22H20N4OS2	420.6	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1OYF4	6-(5-(4-Fluorophenyl)furan-2-yl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	1034419	C17H9FN4O2S	352.3	C1=COC(=C1)C2=NN=C3N2N=C(S3)C4=CC=C(O4)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1R5EG	1-[(4-Ethoxyphenyl)methyl]-5-[(2-methoxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one	Investigative	90666423	C31H28N2O3S	508.6	CCOC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=C(C=CC4=CC=CC=C43)OC)C5=CC=CC=C5	IC50 ~ 120000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1V7XZ	Sirtinol	Investigative	2827646	C26H22N2O2	394.5	CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2N=CC3=C(C=CC4=CC=CC=C43)O	IC50 = 68000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1XDO9	2-(4-Chloroanilino)benzamide	Investigative	901929	C13H11ClN2O	246.69	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)Cl	IC50 = 56000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1YJ3Z	4-(3-(4-(4-Fluorobenzyloxy)phenyl)acrylamido)-N-(2-(5-fluoro-1H-indol-3-yl)ethyl)piperidine-4-carboxamide	Investigative	5811220	C32H32F2N4O3	558.6	C1CNCCC1(C(=O)NCCC2=CNC3=C2C=C(C=C3)F)NC(=O)/C=C/C4=CC=C(C=C4)OCC5=CC=C(C=C5)F	IC50 = 73000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B1ZD0R	N-(2-(1-(Thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)pivalamide	Investigative	71654993	C18H26N4OS	346.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC=C3	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B2ASP0	(4-Bromophenyl)(5-hydroxynaphtho[1,2-b]furan-3-yl)methanone	Investigative	1211361	C19H11BrO3	367.2	C1=CC=C2C(=C1)C(=CC3=C2OC=C3C(=O)C4=CC=C(C=C4)Br)O	IC50 = 146000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B2IFP8	2-(3-Phenylsulfanylphenylamino)benzamide	Investigative	45267617	C19H16N2OS	320.4	C1=CC=C(C=C1)SC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 = 89000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B2IKF6	8-(3-Methylphenyl)-5-octyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2-carboxamide	Investigative	118283204	C27H35N3O	417.6	CCCCCCCCN1C2=C(CN(CC2)C(=O)N)C3=C1C=CC(=C3)C4=CC=CC(=C4)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B2JUG0	2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	Investigative	1183103	C24H14F3N3O2	433.4	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B2YI7T	Ethyl 2-[4-(dimethylamino)phenyl]-1-[3-(2-oxopyrrolidin-1-yl)propyl]benzimidazole-5-carboxylate	Investigative	90645142	C25H30N4O3	434.5	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)N(C)C)CCCN4CCCC4=O	IC50 = 60310 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B35VMK	5-[(2-Hydroxynaphthalen-1-yl)methyl]-1-[(4-methoxyphenyl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one	Investigative	90666431	C29H24N2O3S	480.6	COC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=C(C=CC4=CC=CC=C43)O)C5=CC=CC=C5	IC50 = 58200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B37GFS	2-(4-(Benzyloxy)Phenylamino)Benzamide	Investigative	71458450	C20H18N2O2	318.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3B7KC	5-Chloro-1H,2H,3H-imidazo[4,5-b]pyridine-2-thione	Investigative	56676724	C6H4ClN3S	185.64	C1=CC(=NC2=C1NC(=S)N2)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3JM9T	Nicotinamide	Investigative	936	C6H6N2O	122.12	C1=CC(=CN=C1)C(=O)N	IC50 = 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3K6MR	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-3,4,5-trifluorobenzamide	Investigative	49847268	C21H23F3N4O2S	452.5	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C(=C2)F)F)F	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3LNZ0	5-[(2-Hydroxynaphthalen-1-yl)methyl]-6-phenyl-1-[(4-propoxyphenyl)methyl]-2-sulfanylidenepyrimidin-4-one	Investigative	90666432	C31H28N2O3S	508.6	CCCOC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=C(C=CC4=CC=CC=C43)O)C5=CC=CC=C5	IC50 ~ 120000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3MU0W	Ethyl 2-(4-morpholinophenyl)-1H-benzimidazole-5-carboxylate	Investigative	127035147	C20H21N3O3	351.4	CCOC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N4CCOCC4	IC50 = 57500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B3U5TS	Cambinol analog, 6x	Investigative	42617968	C21H15FN2O2S	378.4	C1=CC=C2C(=C1)C=CC(=C2CC3=C(NC(=S)NC3=O)C4=CC=CC=C4F)O	IC50 = 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4BJI1	N-(5-{3-[(1-Benzyl-1h-1,2,3-Triazol-4-Yl)methoxy]benzyl}-1,3-Thiazol-2-Yl)-2-[(4,6-Dimethylpyrimidin-2-Yl)sulfanyl]acetamide	Investigative	112499922	C28H27N7O2S2	557.7	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CC5=CC=CC=C5)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4C5FO	2-[3-[Methyl-(2-phenylacetyl)amino]anilino]benzamide	Investigative	60165379	C22H21N3O2	359.4	CN(C1=CC=CC(=C1)NC2=CC=CC=C2C(=O)N)C(=O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4FT6G	2-[3-[2-(3-Chlorophenyl)ethoxy]anilino]benzamide	Investigative	60165795	C21H19ClN2O2	366.8	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4HY1G	Thiomyristoyl	Investigative	126843233	C34H51N3O3S	581.9	CCCCCCCCCCCCCC(=S)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 98000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4KSF8	N-[5-[(7-Chloronaphthalen-1-yl)methyl]-1,3-thiazol-2-yl]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide	Investigative	127028117	C22H19ClN4OS2	455	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=C3C=C(C=C4)Cl)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4P8AN	N-[4-(2-Carbamoylanilino)phenyl]pyridine-3-carboxamide	Investigative	60167418	C19H16N4O2	332.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)NC(=O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4Q7XE	5-[[3-(Naphthalene-2-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156563	C24H19N3O3	397.4	C1=CC=C2C=C(C=CC2=C1)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 = 52100 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4S3RL	Ethyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	137644691	C22H24N4O4	408.4	CCOC(=O)NC1=CC2=C(C=C1)OC(CC2NC(=O)NC3=CC=CC(=C3)C#N)(C)C	IC50 = 108700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B4T3YE	2-(4-Benzamidoanilino)benzamide	Investigative	60167271	C20H17N3O2	331.4	C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B54OBU	2-(4-Cyclohexanecarboxamidophenylamino)Benzamide	Investigative	60167274	C20H23N3O2	337.4	C1CCC(CC1)C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B58OXK	N-[4-(2-Carbamoylanilino)phenyl]pyridine-4-carboxamide	Investigative	60167419	C19H16N4O2	332.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)NC(=O)C3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5LND1	6,9-Dimethyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	2831741	C15H18N2O	242.32	CC1=CC2=C(C=C1)N(C3=C2CCCC3C(=O)N)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5PU2Y	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-(ethylcarbamothioylamino)hexanoyl]amino]hexanamide	Investigative	122184877	C27H50N8O6S	614.8	CCNC(=S)NCCCC[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 83400 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5RD4L	CCOC(=O)c1ccc2[nH]c(nc2c1)-c1ccc(cc1)N(C)C	Investigative	127035863	C18H19N3O2	309.4	CCOC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=C(C=C3)N(C)C	IC50 = 62900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5UKM2	2-[3-(Phenylcarbamoyl)anilino]benzamide	Investigative	60167420	C20H17N3O2	331.4	C1=CC=C(C=C1)NC(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5UQ0K	5-(5-Octyl-2-propan-2-yl-3,4-dihydro-1H-pyrido[4,3-b]indol-8-yl)pyrimidin-2-amine	Investigative	118283209	C26H37N5	419.6	CCCCCCCCN1C2=C(CN(CC2)C(C)C)C3=C1C=CC(=C3)C4=CN=C(N=C4)N	IC50 = 56000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5VKZ0	N-[1-(5-Carbamoyl-3-pyridyloxy)-5-naphthyl]benzamide	Investigative	101884808	C23H17N3O3	383.4	C1=CC=C(C=C1)C(=O)NC2=CC=CC3=C2C=CC=C3OC4=CN=CC(=C4)C(=O)N	IC50 = 52700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B5ZB0G	(2S)-6-Acetamido-2-[[(2S)-2-acetamidopropanoyl]amino]-N-[(2S)-1-(methylamino)-1-oxopropan-2-yl]hexanamide	Investigative	52949842	C17H31N5O5	385.5	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N[C@@H](C)C(=O)NC)NC(=O)C	IC50 = 88000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B62SAW	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-1,3-benzothiazole-2-carboxamide	Investigative	124156677	C21H16N4O3S	404.4	C1=CC=C2C(=C1)N=C(S2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 = 65200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B63MLJ	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-3-methylbenzamide;hydrochloride	Investigative	49847271	C22H29ClN4O2S	449	CC1=CC(=CC=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6AZ1B	3-(2-Carbamoylphenylamino)Benzoic Acid	Investigative	43358927	C14H12N2O3	256.26	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6P1BS	2-Thioxo-1,2-dihydro-5-[(biphenyl-4-yl)methylene]pyrimidine-4,6(3H,5H)-dione	Investigative	3610426	C17H12N2O2S	308.4	C1=CC=C(C=C1)C2=CC=C(C=C2)C=C3C(=O)NC(=S)NC3=O	IC50 = 50500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6QSN8	2-Benzoyl-1H-benzo[f]chromen-3(2H)-one	Investigative	16805603	C20H14O3	302.3	C1C(C(=O)OC2=C1C3=CC=CC=C3C=C2)C(=O)C4=CC=CC=C4	IC50 = 112000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6VDM1	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-propylbenzamide;hydrochloride	Investigative	57400269	C24H33ClN4O2S	477.1	CCCC1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 = 60200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6WC8A	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-thiophen-2-ylpyridine-3-carboxamide	Investigative	124156389	C23H18N4O3S	430.5	C1=CC(=CC(=C1)NC(=O)C2=CN=C(C=C2)C3=CC=CS3)COC4=CN=CC(=C4)C(=O)N	IC50 = 145000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6YX3L	2-[3-[2-[3-(Trifluoromethyl)phenyl]ethoxy]anilino]benzamide	Investigative	60165645	C22H19F3N2O2	400.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC(=CC=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B6Z8DE	2-(4-Isobutyramidophenylamino)Benzamide	Investigative	60167273	C17H19N3O2	297.35	CC(C)C(=O)NC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B79EXS	2-[3-[2-(3-Bromophenyl)ethoxy]anilino]benzamide	Investigative	60165798	C21H19BrN2O2	411.3	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC(=CC=C3)Br	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B7AM9Y	4-(Ethylamino)thieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654838	C9H10N4OS	222.27	CCNC1=NC=NC2=C1SC(=C2)C(=O)N	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B7EW0N	2-(Methyl(Phenyl)Amino)Benzamide	Investigative	67523832	C14H14N2O	226.27	CN(C1=CC=CC=C1)C2=CC=CC=C2C(=O)N	IC50 = 75000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B7IQ6X	2-[3-[Benzyl(methyl)carbamoyl]anilino]benzamide	Investigative	60167423	C22H21N3O2	359.4	CN(CC1=CC=CC=C1)C(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B7O6WZ	3,4-Dichloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	57398537	C21H25Cl3N4O2S	503.9	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C=C2)Cl)Cl.Cl	IC50 = 70900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B7R2QO	(2S)-6-Acetamido-2-[[(2S)-6-[[2-[[2-[[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino]acetyl]amino]acetyl]amino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130262	C37H56N10O9S2	849	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CNC(=O)CNC(=O)CSC1=NC2=CC=CC=C2S1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 116000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B84ZEY	1-Phenyl-2-(4-methylphenyl)-1H-benzoimidazole-5-carboxylic acid ethyl ester	Investigative	90645144	C23H20N2O2	356.4	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)C)C4=CC=CC=C4	IC50 = 79870 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8JE3K	2-(4-Phenylanilino)benzamide	Investigative	45267626	C19H16N2O	288.3	C1=CC=C(C=C1)C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8K9XL	1-[[3-(4-Tert-butylphenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-3-[3-(trifluoromethyl)phenyl]thiourea	Investigative	2743189	C21H20F3N5O2S	463.5	CC(C)(C)C1=CC=C(C=C1)C2=NOC(=N2)C(=O)NNC(=S)NC3=CC=CC(=C3)C(F)(F)F	IC50 = 192000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8NH6F	2-[3-[2-(2-Bromophenyl)ethoxy]anilino]benzamide	Investigative	60165797	C21H19BrN2O2	411.3	C1=CC=C(C(=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N)Br	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8NU5C	Tenovin-6	Investigative	24772043	C25H34N4O2S	454.6	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C	IC50 = 58100 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8OFS7	2-(P-Tolylamino)Benzamide	Investigative	71451256	C14H14N2O	226.27	CC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8PZ6T	5-[[3-[(2-Methylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124157048	C21H19N3O3	361.4	CC1=CC=CC=C1C(=O)NC2=CC=CC(=C2)COC3=CN=CC(=C3)C(=O)N	IC50 = 192000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8QG4F	Tert-butyl N-[4-[(4-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	72664790	C24H28N4O4	436.5	CC1(CC(C2=C(O1)C=CC(=C2)NC(=O)OC(C)(C)C)NC(=O)NC3=CC=C(C=C3)C#N)C	IC50 = 121200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8RA6N	Ethyl 1-(2-hydroxyethyl)-2-(4-piperidin-1-ylphenyl)benzimidazole-5-carboxylate	Investigative	73333808	C23H27N3O3	393.5	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)N4CCCCC4)CCO	IC50 = 74520 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B8S5DL	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-methylbenzamide;hydrochloride	Investigative	49847189	C22H29ClN4O2S	449	CC1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9BU4G	2-Phenoxybenzamide	Investigative	3290567	C13H11NO2	213.23	C1=CC=C(C=C1)OC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9OK7L	2-(3-Benzamidophenylamino)Benzamide	Investigative	60167424	C20H17N3O2	331.4	C1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9QN6I	(2S)-6-Acetamido-2-[[(2S)-6-[6-(1,3-benzoxazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134131255	C37H58N8O8S	775	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CCCCCSC1=NC2=CC=CC=C2O1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 133100 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9R1ZE	3-[3-(2-Carbamoylphenylamino)phenyl]acrylic acidmethyl ester	Investigative	45272735	C17H16N2O3	296.32	COC(=O)/C=C/C1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 = 65000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9UJI3	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamide	Investigative	49847039	C22H28N4O2S	412.6	CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	B9ZJ4P	N-[4-(2-Carbamoylanilino)phenyl]piperidine-4-carboxamide	Investigative	60167276	C19H22N4O2	338.4	C1CNCCC1C(=O)NC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA12XM	6-Chloro-N-ethyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	2858149	C15H17ClN2O	276.76	CCNC(=O)C1CCCC2=C1NC3=C2C=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA1M6U	2-(4-Acetamidophenylamino)Benzamide	Investigative	60167272	C15H15N3O2	269.3	CC(=O)NC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA28QK	2-[3-[1-(2-Cyclopentylethyl)-1H-1,2,3-triazole-4-yl]anilino]benzamide	Investigative	77461130	C22H25N5O	375.5	C1CCC(C1)CCN2C=C(N=N2)C3=CC(=CC=C3)NC4=CC=CC=C4C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA38WZ	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124157054	C24H19N3O3S	429.5	C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)C3=CC=CS3)COC4=CN=CC(=C4)C(=O)N	Ki ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA3T1X	6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid	Investigative	3148372	C13H12ClNO2	249.69	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BA93DJ	N-[1-(5-Carbamoyl-3-pyridyloxy)-5-naphthyl]-3-nitro-4-methylbenzamide	Investigative	101884812	C24H18N4O5	442.4	CC1=C(C=C(C=C1)C(=O)NC2=CC=CC3=C2C=CC=C3OC4=CN=CC(=C4)C(=O)N)[N+](=O)[O-]	IC50 = 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BAD54G	N-(4-Bromopyridine-3-yl)-3-(naphthalene-2-yl)benzamide	Investigative	118722847	C22H15BrN2O	403.3	C1=CC=C2C=C(C=CC2=C1)C3=CC(=CC=C3)C(=O)NC4=C(C=CN=C4)Br	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BAFL74	6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxamide	Investigative	11522166	C12H12BrN3O	294.15	C1CNC(C2=C1C3=C(N2)C=CC(=C3)Br)C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BAJD04	4-Chloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	49847123	C21H26Cl2N4O2S	469.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)Cl.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BAQ58M	2-Bromo-3-(3,5-difluorophenyl)benzofuran-4,6-diol	Investigative	54591048	C14H7BrF2O3	341.1	C1=C(C=C(C=C1F)F)C2=C(OC3=CC(=CC(=C32)O)O)Br	IC50 = 76300 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BB17DF	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	Investigative	53379498	C23H42N8O6S	558.7	CC(=O)NCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)N)NC(=O)[C@H](CCCNC(=O)C)NC(=O)C	IC50 = 89500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BB4RD9	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide	Investigative	1183106	C23H14ClN3O2	399.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4)Cl	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BBX06E	2-[3-(3-Fluorophenethyloxy)phenylamino]benzamide	Investigative	60148504	C21H19FN2O2	350.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC(=CC=C3)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BBZ5J0	(5E)-1-Ethyl-5-[(4-phenylmethoxyphenyl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	71453984	C20H18N2O3S	366.4	CCN1C(=O)/C(=C/C2=CC=C(C=C2)OCC3=CC=CC=C3)/C(=O)NC1=S	IC50 = 53200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BC0SU6	2-Anilino-N,N-dimethylbenzamide	Investigative	15701548	C15H16N2O	240.3	CN(C)C(=O)C1=CC=CC=C1NC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BC5FM3	3-[3-(2-Carbamoylanilino)phenyl]propanoic acid	Investigative	71451255	C16H16N2O3	284.31	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CCC(=O)O	IC50 = 93000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BCEX93	(S)-2-((S)-6-Acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoic acid	Investigative	52944947	C16H28N4O6	372.42	C[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)C	IC50 = 122000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BCPR48	3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide	Investigative	1328033	C19H21BrN2O3S	437.4	C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BCW4R6	Chembl4170094	Investigative	134820907	C26H26N6O3S	502.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CN(N=C4)C)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BD0K8Q	Propan-2-yl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate	Investigative	137634939	C23H26N4O4	422.5	CC(C)OC(=O)NC1=CC2=C(C=C1)OC(CC2NC(=O)NC3=CC=CC(=C3)C#N)(C)C	IC50 = 54800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BD3HP9	5-[5-(Pyridine-3-carbonylamino)naphthalen-1-yl]oxypyridine-3-carboxamide	Investigative	118717209	C22H16N4O3	384.4	C1=CC2=C(C=CC=C2OC3=CN=CC(=C3)C(=O)N)C(=C1)NC(=O)C4=CN=CC=C4	IC50 = 70700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BD8NQ3	N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]pyridazine-3-carboxamide	Investigative	124156885	C18H15N5O3	349.3	C1=CC(=CC(=C1)NC(=O)C2=NN=CC=C2)COC3=CN=CC(=C3)C(=O)N	IC50 = 90900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BDBM26	2-(3-Phenoxyphenylamino)benzamide	Investigative	44596233	C19H16N2O2	304.3	C1=CC=C(C=C1)OC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 = 58000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BDP59L	5-[[3-[(3-Fluoro-4-phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156666	C26H20FN3O3	441.5	C1=CC=C(C=C1)C2=C(C=C(C=C2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N)F	IC50 = 115000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BDUH35	2-[4-(Phenylcarbamoyl)anilino]benzamide	Investigative	60167129	C20H17N3O2	331.4	C1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BDV04T	2-(M-Tolylamino)Benzamide	Investigative	45268494	C14H14N2O	226.27	CC1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 = 68000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BE3YW2	3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one	Investigative	45168044	C28H26N4O2S	482.6	COC1=C(C2=CC=CC=C2C=C1)CN3C=NC4=C(C3=O)C5=C(S4)CC(CC5)NCC6=CN=CC=C6	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BE6W8N	6-Chloro-2,3,4,4a,9,9a-hexahydro-1H-carbazole-1-carboxamide	Investigative	44405122	C13H15ClN2O	250.72	C1CC2C(C(C1)C(=O)N)NC3=C2C=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BEFH63	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-(phenylcarbamothioylamino)hexanoyl]amino]hexanamide	Investigative	122184879	C31H50N8O6S	662.8	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)NC1=CC=CC=C1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 62900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BEJP62	Chembl4216559	Investigative	145973739	C39H46Br2N4O4	794.6	C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCNCCCCCCCCCNCCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O.Br.Br	IC50 = 97400 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BEM63D	6-Chloro-N-hydroxy-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	11687587	C13H13ClN2O2	264.71	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)NO	IC50 = 77600 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BEZV93	2-[3-[2-[4-(Trifluoromethyl)phenyl]ethoxy]anilino]benzamide	Investigative	60165646	C22H19F3N2O2	400.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BF1RL2	2-(2-Chlorobenzoyl)-1H-benzo[f]chromen-3(2H)-one	Investigative	44565975	C20H13ClO3	336.8	C1C(C(=O)OC2=C1C3=CC=CC=C3C=C2)C(=O)C4=CC=CC=C4Cl	IC50 = 89800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BF2G3N	2-[3-[2-(4-Bromophenyl)ethoxy]anilino]benzamide	Investigative	60165799	C21H19BrN2O2	411.3	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC=C(C=C3)Br	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BG24VS	2-Acetyl-6-chloro-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxamide	Investigative	11652227	C14H14ClN3O2	291.73	CC(=O)N1CCC2=C(C1C(=O)N)NC3=C2C=C(C=C3)Cl	IC50 = 79900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BG2E7D	N-[3-[(2-Oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide	Investigative	135659046	C26H22N2O2	394.5	CC(C1=CC=CC=C1)C(=O)NC2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O	IC50 = 76000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BGDA75	2-(4-Phenethylphenylamino)Benzamide	Investigative	60167127	C21H20N2O	316.4	C1=CC=C(C=C1)CCC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BGQR95	7-[(3,5-Dimethyl-1,2-oxazol-4-yl)methylamino]-3-[(4-methoxynaphthalen-1-yl)methyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	Investigative	137642096	C28H28N4O3S	500.6	CC1=C(C(=NO1)C)CNC2CCC3=C(C2)SC4=C3C(=O)N(C=N4)CC5=CC=C(C6=CC=CC=C56)OC	IC50 = 129000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BH2V8E	2-(4-Phenoxyphenylamino)benzamide	Investigative	45267627	C19H16N2O2	304.3	C1=CC=C(C=C1)OC2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BH3D9P	Chembl4288567	Investigative	121325102	C28H40N4O4	496.6	CCCCCCCNC(=O)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 64000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BH5MA8	Chembl4227437	Investigative	135397680	C24H27N7O3S2	525.7	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCOC)C	IC50 = 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BH9SN3	N-Methyl-4-(4-(2-pivalamidoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654992	C20H29N5O2S	403.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)NC	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BHM15B	N-[4-(2-Carbamoylanilino)phenyl]pyridine-2-carboxamide	Investigative	60167277	C19H16N4O2	332.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC=C(C=C2)NC(=O)C3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BI8D0L	2-Anilinobenzamide	Investigative	96455	C13H12N2O	212.25	C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 = 56000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BI9C4U	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide	Investigative	1183101	C23H14ClN3O2	399.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3N=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BIBW19	(5E)-1-Methyl-5-[(4-phenylmethoxyphenyl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	Investigative	71452171	C19H16N2O3S	352.4	CN1C(=O)/C(=C/C2=CC=C(C=C2)OCC3=CC=CC=C3)/C(=O)NC1=S	IC50 = 56500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BIPG89	2-Chloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	57392690	C21H26Cl2N4O2S	469.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=CC=C2Cl.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BIU06H	3,4-Dichloro-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide	Investigative	57398538	C21H24Cl2N4O2S	467.4	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC(=C(C=C2)Cl)Cl	IC50 = 70900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJ28GM	2-(4-Methoxyanilino)benzamide	Investigative	13505632	C14H14N2O2	242.27	COC1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJ3F7I	Chembl4217034	Investigative	145972149	C31H34N2O4	498.6	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC5=C(C=C4)OCO5	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJ5U4O	2-((3-Phenethoxyphenyl)Amino)Benzamide	Investigative	56935695	C21H20N2O2	332.4	C1=CC=C(C=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJ9OI1	Methyl 4-(2-Carbamoylphenylamino)Benzoate	Investigative	71451257	C15H14N2O3	270.28	COC(=O)C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJF54T	2-Phenylsulfanylbenzamide	Investigative	2728632	C13H11NOS	229.3	C1=CC=C(C=C1)SC2=CC=CC=C2C(=O)N	IC50 = 78000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJT39O	2-(3-Biphenylylamino)benzamide	Investigative	44596232	C19H16N2O	288.3	C1=CC=C(C=C1)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 = 52000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJV9P6	(2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone	Investigative	687118	C15H10O5	270.24	C1=CC(=C(C=C1O)C(=O)C2=COC3=C2C=C(C=C3)O)O	Ki = 174400 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BJYK97	5-[[3-(Naphthalene-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156591	C24H19N3O3	397.4	C1=CC=C2C(=C1)C=CC=C2C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 = 192000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BK15FT	3-(2-Furyl)-6-(2-pyrazinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	3163959	C11H6N6OS	270.27	C1=COC(=C1)C2=NN=C3N2N=C(S3)C4=NC=CN=C4	IC50 = 66600 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BK6Q2C	Ethyl 2-(1,3-benzodioxol-5-yl)-1-(2-hydroxyethyl)benzimidazole-5-carboxylate	Investigative	73333924	C19H18N2O5	354.4	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC4=C(C=C3)OCO4)CCO	IC50 = 80110 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BK80BA	3-(2-Furyl)-6-(1-phenylpropyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	6493842	C16H14N4OS	310.4	CCC(C1=CC=CC=C1)C2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 96200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL20QS	2-[3-[2-(4-Fluorophenyl)ethoxy]anilino]benzamide	Investigative	60165648	C21H19FN2O2	350.4	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL4KX9	2-[3-[2-[2-(Trifluoromethyl)phenyl]ethoxy]anilino]benzamide	Investigative	60165644	C22H19F3N2O2	400.4	C1=CC=C(C(=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL4T0U	2-[3-[2-(4-Methylphenyl)ethoxy]anilino]benzamide	Investigative	60165643	C22H22N2O2	346.4	CC1=CC=C(C=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL7IH0	2-[3-[Benzoyl(methyl)amino]anilino]benzamide	Investigative	60165377	C21H19N3O2	345.4	CN(C1=CC=CC(=C1)NC2=CC=CC=C2C(=O)N)C(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL83OY	2-Cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	Investigative	1183104	C24H14F3N3O2	433.4	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BL8J7Q	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-[[2-[[5-[(E)-2-phenylethenyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]hexanoyl]amino]hexanamide	Investigative	134130793	C36H54N10O7S	770.9	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CSC1=NNC(=N1)/C=C/C2=CC=CC=C2)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 149500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BLB6G7	3-(2-Furyl)-6-[(2-methoxyphenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	3163952	C15H12N4O3S	328.3	COC1=CC=CC=C1OCC2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 51200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BLG23W	Chembl4218670	Investigative	145967555	C32H39N3O2	497.7	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BLV4X7	(4-Chlorophenyl)-(5-hydroxy-6-methyl-1-benzofuran-3-yl)methanone	Investigative	71717361	C16H11ClO3	286.71	CC1=CC2=C(C=C1O)C(=CO2)C(=O)C3=CC=C(C=C3)Cl	IC50 = 88000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BLX9Y8	3-[[3-(Tert-Butoxycarbonylamino-phenyl)-1,2,4-oxadiazole-5-carbonyl]amino]-1-(4-(trifluoromethyl)phenyl)thiourea	Investigative	24949372	C22H21F3N6O4S	522.5	CC(C)(C)OC(=O)NC1=CC=CC(=C1)C2=NOC(=N2)C(=O)NNC(=S)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 168000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BM4V1E	[3-(2-Furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]methyl 3-methylphenyl ether	Investigative	6493843	C15H12N4O2S	312.3	CC1=CC(=CC=C1)OCC2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 75300 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BM7B5Q	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide;hydrochloride	Investigative	49847185	C21H27ClN4O2S	435	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=CC=C2.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BM8HL4	3-(2-Furyl)-6-(2-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	665718	C12H7N5OS	269.28	C1=CC=NC(=C1)C2=NN3C(=NN=C3S2)C4=CC=CO4	Ki = 58900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BMBY13	5-Benzyl-1-[(4-ethoxyphenyl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one	Investigative	90666436	C26H24N2O2S	428.5	CCOC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=CC=CC=C3)C4=CC=CC=C4	IC50 = 68100 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BMO69Y	4-Chlorothieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654770	C7H4ClN3OS	213.65	C1=C(SC2=C1N=CN=C2Cl)C(=O)N	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BMP5V2	1-[(4-Ethoxyphenyl)methyl]-5-[(2-hydroxynaphthalen-1-yl)methyl]-6-phenyl-2-sulfanylidenepyrimidin-4-one	Investigative	46856246	C30H26N2O3S	494.6	CCOC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=C(C=CC4=CC=CC=C43)O)C5=CC=CC=C5	IC50 ~ 120000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BMS08L	6-(2,3-Dihydro-1,4-benzodioxin-6-ylmethyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	4893498	C16H12N4O3S	340.4	C1COC2=C(O1)C=CC(=C2)CC3=NN4C(=NN=C4S3)C5=CC=CO5	IC50 = 67000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BMWN67	2-[3-(2-Hydroxylethyl)phenylamino]benzamide	Investigative	45270186	C15H16N2O2	256.3	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CCO	IC50 = 72000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BN05CU	(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	Investigative	45483031	C22H27N3O3S	413.5	CC(=S)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 = 140000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BN41FM	5-[[3-[(2-Phenylacetyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156054	C21H19N3O3	361.4	C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)COC3=CN=CC(=C3)C(=O)N	IC50 = 50800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BN4MS0	2-[4-[(Z)-2-Phenylethenyl]anilino]benzamide	Investigative	60167125	C21H18N2O	314.4	C1=CC=C(C=C1)/C=C\\C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BN8VG7	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-(propan-2-ylcarbamothioylamino)hexanoyl]amino]hexanamide	Investigative	122184878	C28H52N8O6S	628.8	CC(C)NC(=S)NCCCC[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 117900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BNO91Y	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-4-methoxybenzamide;hydrochloride	Investigative	49847191	C22H29ClN4O3S	465	CN(C)CCCCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)OC.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BOB20C	Chembl4211748	Investigative	145966202	C31H36N2O4	500.6	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC(=C(C=C4)O)OC	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BOC86J	2-[4-[(E)-2-Phenylethenyl]anilino]benzamide	Investigative	60167126	C21H18N2O	314.4	C1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BOH2B0	3-(1-Oxoisoindolin-2-yl)propanoic acid	Investigative	648461	C11H11NO3	205.21	C1C2=CC=CC=C2C(=O)N1CCC(=O)O	IC50 = 80000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BOX17P	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide	Investigative	1183108	C23H13Cl2N3O2	434.3	C1=CC(=C(C(=C1)Cl)Cl)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BP51EK	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	Investigative	121313586	C30H29N3O3S	511.6	COC1=CC=C(C=C1)CNC2CCC3=C(C2)SC4=C3C(=O)N(C=N4)CC5=C(C=CC6=CC=CC=C65)OC	IC50 = 119400 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BP8C7V	3-(Furan-2-yl)-6-(1-phenoxypropyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	6493847	C16H14N4O2S	326.4	CCC(C1=NN2C(=NN=C2S1)C3=CC=CO3)OC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BPD45V	N-(2-(1H-Indol-3-yl)ethyl)-4-(3-(4-(benzyloxy)phenyl)acrylamido)piperidine-4-carboxamide	Investigative	44427280	C32H34N4O3	522.6	C1CNCCC1(C(=O)NCCC2=CNC3=CC=CC=C32)NC(=O)/C=C/C4=CC=C(C=C4)OCC5=CC=CC=C5	IC50 = 52000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BPG0V6	N-[(E)-(3,5-Dibromo-2,4-dihydroxyphenyl)methylideneamino]quinoline-6-carboxamide	Investigative	136226207	C17H11Br2N3O3	465.1	C1=CC2=C(C=CC(=C2)C(=O)N/N=C/C3=CC(=C(C(=C3O)Br)O)Br)N=C1	EC50 = 55200 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BPS97O	5-[[3-[(4-Cyclohexylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124155894	C26H27N3O3	429.5	C1CCC(CC1)C2=CC=C(C=C2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 = 71500 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BPW73K	Cambinol analog, 6e	Investigative	42617970	C22H18N2O2S	374.5	CN1C(=C(C(=O)NC1=S)CC2=C(C=CC3=CC=CC=C32)O)C4=CC=CC=C4	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BPZ38A	N-(2-Amino-2-oxoethyl)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	609412	C15H16ClN3O2	305.76	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)NCC(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BQ3K4T	2-[3-[2-(2-Chlorophenyl)ethoxy]anilino]benzamide	Investigative	60165794	C21H19ClN2O2	366.8	C1=CC=C(C(=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BQ9O4R	2-[3-[(2-Phenylacetyl)amino]anilino]benzamide	Investigative	60165378	C21H19N3O2	345.4	C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BQZ6T1	5-(2-Methyl-5-octyl-3,4-dihydro-1H-pyrido[4,3-b]indol-8-yl)pyrimidin-2-amine	Investigative	72550526	C24H33N5	391.6	CCCCCCCCN1C2=C(CN(CC2)C)C3=C1C=CC(=C3)C4=CN=C(N=C4)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BR4MQ3	4-[[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]carbamoyl]benzoic acid	Investigative	124156580	C21H17N3O5	391.4	C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)C(=O)O)COC3=CN=CC(=C3)C(=O)N	IC50 = 142000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BR6S7E	(5-Hydroxy-1-benzofuran-3-yl)-(2-hydroxyphenyl)methanone	Investigative	71718571	C15H10O4	254.24	C1=CC=C(C(=C1)C(=O)C2=COC3=C2C=C(C=C3)O)O	IC50 = 71400 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BRQ52Y	5-[(2-Methoxynaphthalen-1-yl)methyl]-6-phenyl-1-[(4-propoxyphenyl)methyl]-2-sulfanylidenepyrimidin-4-one	Investigative	90666424	C32H30N2O3S	522.7	CCCOC1=CC=C(C=C1)CN2C(=C(C(=O)NC2=S)CC3=C(C=CC4=CC=CC=C43)OC)C5=CC=CC=C5	IC50 = 61900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BS05UX	Methanone, (4,6-dibromo-5-hydroxy-3-benzofuranyl)phenyl-	Investigative	1207797	C15H8Br2O3	396.03	C1=CC=C(C=C1)C(=O)C2=COC3=CC(=C(C(=C32)Br)O)Br	IC50 = 198000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BS14XY	1-(2-Hydroxyethyl)-2-[4-(dimethylamino)phenyl]-1H-benzoimidazole-5-carboxylic acid ethyl ester	Investigative	73333807	C20H23N3O3	353.4	CCOC(=O)C1=CC2=C(C=C1)N(C(=N2)C3=CC=C(C=C3)N(C)C)CCO	IC50 = 58430 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BS1A2Q	N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide	Investigative	1096276	C18H18N4OS2	370.5	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC=C3)C	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BT2R3E	3-Anilinobenzamide	Investigative	68509298	C13H12N2O	212.25	C1=CC=C(C=C1)NC2=CC=CC(=C2)C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BT57UJ	1-Ethyl-6-hydroxy-5-[(Z)-indol-3-ylidenemethyl]-2-sulfanylidenepyrimidin-4-one	Investigative	135469837	C15H13N3O2S	299.3	CCN1C(=C(C(=O)NC1=S)/C=C/2\\C=NC3=CC=CC=C32)O	IC50 = 89300 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BT61CY	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide	Investigative	2130402	C23H13Cl2N3O2	434.3	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C(=CC=C4)Cl)Cl)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BTJ69N	4-Tert-butyl-N-[[4-[[2-[2-[2-[2-[2-[2-(dimethylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]phenyl]carbamothioyl]benzamide	Investigative	57395075	C32H48N4O7S	632.8	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)COCCOCCOCCOCCOCCN(C)C	IC50 ~ 60000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BTW4M3	2-Benzyl-8-(3-methylphenyl)-5-octyl-3,4-dihydro-1H-pyrido[4,3-b]indole	Investigative	118283203	C33H40N2	464.7	CCCCCCCCN1C2=C(CN(CC2)CC3=CC=CC=C3)C4=C1C=CC(=C4)C5=CC=CC(=C5)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BU46BM	2-[3-(Benzylcarbamoyl)anilino]benzamide	Investigative	60167422	C21H19N3O2	345.4	C1=CC=C(C=C1)CNC(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BU4O7D	3-(2-Furyl)-6-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	662677	C14H10N4O2S	298.32	C1=CC=C(C=C1)OCC2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 61300 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BU6YX4	3-(2-Furyl)-6-(3,4,5-triethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	6493841	C19H20N4O4S	400.5	CCOC1=CC(=CC(=C1OCC)OCC)C2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 65700 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BUR2W6	3-(4-Fluorophenyl)benzofuran-4,6-diol	Investigative	54591047	C14H9FO3	244.22	C1=CC(=CC=C1C2=COC3=CC(=CC(=C32)O)O)F	IC50 = 192000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BUTM72	2-[3-[2-(4-Chlorophenyl)ethoxy]anilino]benzamide	Investigative	60165796	C21H19ClN2O2	366.8	C1=CC=C(C(=C1)C(=O)N)NC2=CC(=CC=C2)OCCC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BUVK80	Chembl4225505	Investigative	145967841	C55H84N10O15S3	1221.5	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCC5C6C(CS5)NC(=O)N6)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BV03QG	2-[4-[Methyl(phenyl)carbamoyl]anilino]benzamide	Investigative	60167128	C21H19N3O2	345.4	CN(C1=CC=CC=C1)C(=O)C2=CC=C(C=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BV96DU	N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]cyclopentanecarboxamide	Investigative	25232161	C22H27N5OS	409.5	C1CCC(C1)C(=O)NC2=CC=CC=C2C3=CN4C(=CSC4=N3)CN5CCNCC5	EC50 = 130000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BVAB15	N-[1-(5-Carbamoyl-3-pyridyloxy)-5-naphthyl]-3-nitrobenzamide	Investigative	101884803	C23H16N4O5	428.4	C1=CC(=CC(=C1)[N+](=O)[O-])C(=O)NC2=CC=CC3=C2C=CC=C3OC4=CN=CC(=C4)C(=O)N	IC50 = 64000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BVT7G8	2-(3-Hydroxymethylphenylamino)benzamide	Investigative	45269359	C14H14N2O2	242.27	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)CO	IC50 = 60000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BVW9Z7	6-(4-Chlorobenzyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	3163948	C14H9ClN4OS	316.8	C1=COC(=C1)C2=NN=C3N2N=C(S3)CC4=CC=C(C=C4)Cl	IC50 = 78000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BW0G9J	(2S)-6-Acetamido-2-[[(2S)-6-[6-(1H-benzimidazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide	Investigative	134130198	C37H59N9O7S	774	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CCCCCSC1=NC2=CC=CC=C2N1)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 187300 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BW27YL	4-[4-[2-(2,2-Dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxylic acid	Investigative	71654991	C19H26N4O3S	390.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BW2QK9	3-(Furan-2-yl)-6-(1-phenoxyethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	6493846	C15H12N4O2S	312.3	CC(C1=NN2C(=NN=C2S1)C3=CC=CO3)OC4=CC=CC=C4	IC50 = 67900 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BW3ZP1	N-[[4-[5-(Dimethylamino)pentanoylamino]phenyl]carbamothioyl]-2-methylbenzamide;hydrochloride	Investigative	49847038	C22H29ClN4O2S	449	CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BWET41	Bisindolylmaleimide v	Investigative	2400	C21H15N3O2	341.4	CN1C(=O)C(=C(C1=O)C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BWKU90	2-[3-[2-(3-Methylphenyl)ethoxy]anilino]benzamide	Investigative	60165642	C22H22N2O2	346.4	CC1=CC(=CC=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BWQP64	2-[3-[2-(2-Fluorophenyl)ethoxy]anilino]benzamide	Investigative	60165647	C21H19FN2O2	350.4	C1=CC=C(C(=C1)CCOC2=CC=CC(=C2)NC3=CC=CC=C3C(=O)N)F	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BX04NU	2-[3-[Methyl(phenyl)carbamoyl]anilino]benzamide	Investigative	60167421	C21H19N3O2	345.4	CN(C1=CC=CC=C1)C(=O)C2=CC(=CC=C2)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BX4P3L	3-(2-Furyl)-6-(3-pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole	Investigative	3163957	C12H7N5OS	269.28	C1=CC(=CN=C1)C2=NN3C(=NN=C3S2)C4=CC=CO4	IC50 = 78800 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BX8YB7	Methyl (2S)-2-[[(2S)-2-acetamido-6-(ethanethioylamino)hexanoyl]amino]propanoate	Investigative	54757799	C14H25N3O4S	331.43	C[C@@H](C(=O)OC)NC(=O)[C@H](CCCCNC(=S)C)NC(=O)C	IC50 = 51000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BXB50E	2-[4-[Benzoyl(methyl)amino]anilino]benzamide	Investigative	60167270	C21H19N3O2	345.4	CN(C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)N)C(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BXH2S8	Sirt2-PROTAC-1	Investigative	135397670	C40H40N10O8S2	852.9	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BXZC36	Ethyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate	Investigative	2915792	C15H16ClNO2	277.74	CCOC(=O)C1CCCC2=C1NC3=C2C=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BY3Q1S	8-(2-Aminopyrimidin-5-yl)-5-octyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2-carboxamide	Investigative	118283202	C24H32N6O	420.6	CCCCCCCCN1C2=C(CN(CC2)C(=O)N)C3=C1C=CC(=C3)C4=CN=C(N=C4)N	IC50 = 63000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BY56PN	SIRT2 Inhibitor, Inactive Control, AGK7	Investigative	1372572	C23H13Cl2N3O2	434.3	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BY94DE	2-[4-(1-Benzyl-1H-1,2,3-triazole-4-yl)anilino]benzamide	Investigative	77461131	C22H19N5O	369.4	C1=CC=C(C=C1)CN2C=C(N=N2)C3=CC=C(C=C3)NC4=CC=CC=C4C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BYB78T	Methyl 3-(2-Carbamoylphenylamino)Benzoate	Investigative	71451254	C15H14N2O3	270.28	COC(=O)C1=CC(=CC=C1)NC2=CC=CC=C2C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BYT6D5	3-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoic acid	Investigative	122184881	C28H50N8O8S	658.8	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)NCCC(=O)O)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BZ0WF4	Chembl4218205	Investigative	145970505	C35H43N3O2	537.7	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BZ81SU	2-(Naphthalen-2-ylamino)benzamide	Investigative	70089831	C17H14N2O	262.3	C1=CC=C2C=C(C=CC2=C1)NC3=CC=CC=C3C(=O)N	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BZL9G0	(6-Methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)methanamine	Investigative	2848181	C14H18N2	214.31	CC1=CC2=C(C=C1)NC3=C2CCCC3CN	IC50 ~ 100000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	BZT9W6	3-[3-(2-Carbamoylphenylamino)phenyl]acrylic acid	Investigative	45270178	C16H14N2O3	282.29	C1=CC=C(C(=C1)C(=O)N)NC2=CC=CC(=C2)/C=C/C(=O)O	IC50 = 58000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D03APP	diphenylamine-2-carboxylic acid	Investigative	4386	C13H11NO2	213.23	C1=CC=C(C=C1)NC2=CC=CC=C2C(=O)O	IC50 = 68000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D0D5ZL	PAULLONE	Investigative	369401	C16H12N2O	248.28	C1C2=C(C3=CC=CC=C3NC1=O)NC4=CC=CC=C24	IC50 = 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D0E3NT	AGK2	Investigative	2130404	C23H13Cl2N3O2	434.3	C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N	IC50 ~ 50000 nM	Poor binder
T14731	NAD-dependent deacetylase sirtuin-1	D0TO6S	Bisindolylmaleimide-I	Investigative	2396	C25H24N4O2	412.5	CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder