TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T15023 Neuropilin-1 B0MK4V 5-Chloro-3-(2,6-dimethylphenylamino)-2-phenylindolizine-1-carbonitrile Investigative 44415068 C23H18ClN3 371.9 CC1=C(C(=CC=C1)C)NC2=C(C(=C3N2C(=CC=C3)Cl)C#N)C4=CC=CC=C4 IC50 = 60000 nM Poor binder T15023 Neuropilin-1 B1MG0L 5-Chloro-3-(phenethylamino)-2-(piperidin-4-yl)indolizine-1-carbonitrile Investigative 44415160 C22H23ClN4 378.9 C1CNCCC1C2=C(N3C(=C2C#N)C=CC=C3Cl)NCCC4=CC=CC=C4 IC50 = 95000 nM Poor binder T15023 Neuropilin-1 B4EPW0 5-Chloro-3-(3-(dimethylamino)propylamino)-2-phenylindolizine-1-carbonitrile Investigative 44415067 C20H21ClN4 352.9 CN(C)CCCNC1=C(C(=C2N1C(=CC=C2)Cl)C#N)C3=CC=CC=C3 IC50 = 62000 nM Poor binder T15023 Neuropilin-1 BFV0Y8 (S)-2-{[3-(4-Nitro-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acid Investigative 24815571 C17H20N6O7S2 484.5 C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)NC2=C(SC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O IC50 = 52000 nM Poor binder T15023 Neuropilin-1 BN5B2R 3,6-Anhydro-2-deoxy-4,5-O-isopropylidene-7-[N-(aminoiminomethyl)-N-(2-guanidinoethyl)amino]-N-[2-(1Hindol-3-yl)ethyl]-L-galacto-heptonoamide Investigative 46888232 C24H36N8O4 500.6 CC1(O[C@H]2[C@H](O[C@H]([C@H]2O1)CN(CCN=C(N)N)C(=N)N)CC(=O)NCCC3=CNC4=CC=CC=C43)C IC50 = 92000 nM Poor binder T15023 Neuropilin-1 BQT5K2 3-(Cyclohexylamino)-5-(3-(dimethylamino)propoxy)-2-phenylindolizine-1-carbonitrile Investigative 44415284 C26H32N4O 416.6 CN(C)CCCOC1=CC=CC2=C(C(=C(N21)NC3CCCCC3)C4=CC=CC=C4)C#N IC50 = 79000 nM Poor binder T15023 Neuropilin-1 BWI74A 3-(3-Aminophenylamino)-5-chloro-2-phenylindolizine-1-carbonitrile Investigative 44415045 C21H15ClN4 358.8 C1=CC=C(C=C1)C2=C(N3C(=C2C#N)C=CC=C3Cl)NC4=CC=CC(=C4)N IC50 = 80000 nM Poor binder