TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15700	Caspase-8	D0J3SU	isatin sulfonamide 34	Clinical trial	9847835	C26H24N2O5S	476.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=CC=C4)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B01VUF	(S)-1-(4-Methoxybenzyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54587376	C25H23N3O6S	493.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CC[C@H]4COC5=CN=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B07OWV	4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic Acid	Investigative	4246483	C15H14O6	290.27	CCOC(=O)COC1=CC(=C(C2=CC=CC=C21)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T15700	Caspase-8	B0DVQ8	5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11509300	C18H17N3O5S	387.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)COC4=CN=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B0FU3L	2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-N-(furan-2-ylmethyl)-1,3-thiazole-4-carboxamide	Investigative	2821636	C17H14N2O4S	342.4	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)NCC4=CC=CO4	IC50 = 60000 nM	Poor binder
T15700	Caspase-8	B0NM9E	Isatin sulfonamide, 16a	Investigative	42618287	C18H16N2O4S	356.4	C1CN(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B0QM8N	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-tert-butylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide	Investigative	127037715	C25H30N4O4S	482.6	CC(C)(C)C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B0VXQ1	2-[1-[(4-Hydroxyphenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile	Investigative	16749163	C28H23N5O5S	541.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)O)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B1VD4S	2-[1-(3,4-Dichlorobenzyl)-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile	Investigative	42618286	C22H16Cl2N4O3S2	519.4	C1CSCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B2DS6Y	Nsci	Investigative	11591540	C26H25N3O6S	507.6	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CN=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B2DY7K	(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11525874	C24H20FN3O5S	481.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=NC(=CC=C5)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B2LO7C	2-[1-(Hydroxy-benzyl-2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile	Investigative	16749161	C29H24N4O5S	540.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)O)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B2R5AJ	(S)-5-(2-((2,4-Difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione	Investigative	54583925	C23H20F3N5O5S	535.5	C1CN([C@@H]1COC2=C(C=C(C=C2)F)F)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CN(N=N5)CCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B2X4CH	[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanone	Investigative	2821595	C16H11NO3S3	361.5	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)SC4=CC=CS4	IC50 = 62000 nM	Poor binder
T15700	Caspase-8	B38OVC	1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione	Investigative	5288850	C20H20N2O5S	400.4	CN1C2=C(C=C(C=C2)S(=O)(=O)N3CCC[C@H]3COC4=CC=CC=C4)C(=O)C1=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B3CA8I	(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dione	Investigative	11533326	C25H22FN3O5S	495.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CN=C(C=C4)F)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B3DFJ8	Isatin Michael acceptor (IMA) analogue, 19b	Investigative	42618292	C23H20N4O4S	448.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCCC4)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B3E1TI	(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11624920	C18H16N2O5S	372.4	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)NC(=O)C4=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B3TO9W	2-[1-[(4-Bromophenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile	Investigative	16749271	C28H22BrN5O4S	604.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)Br)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B4EF1K	2-[2-Oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile	Investigative	16749067	C22H18N4O4S	434.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=C(C#N)C#N)COC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B4MBT8	Isatin Michael acceptor (IMA) analogue, 12c	Investigative	42618283	C22H16Cl2N4O4S	503.4	C1COCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B5J6OB	(S)-1-(4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54586343	C31H33FN2O8S	612.7	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=C(C=C5)OCCOCCOCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B5MB1T	2-{1-Benzyl-2-oxo-5-[2-(pyridine-3-yloxymethyl)-pyrrolidine-1-sulfonyl]-1,2-dihydro-indol-3-yl-idene}-malononitrile	Investigative	16749162	C28H23N5O4S	525.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B62IWZ	Isatin Michael acceptor (IMA) analogue, 11b	Investigative	42618279	C24H22N4O4S	462.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCCCC4)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B65XSQ	1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione	Investigative	16749268	C25H22BrN3O5S	556.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)Br)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B6A7EZ	(S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin	Investigative	25179141	C24H22F3N5O5S	549.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CN(N=N4)CCF)COC5=C(C=C(C=C5)F)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B6EYA1	(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11684618	C26H24N2O6S	492.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CC[C@H]4COC5=CC=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B6LN1Y	5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	44304162	C20H21N3O4S	399.5	CN(CC1CCCN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T15700	Caspase-8	B7F4AM	(S)-2-(1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	54581987	C33H31FN4O6S	630.7	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)OCCOCCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B7L4DQ	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(2-isoquinolin-1-yloxyacetyl)amino]-4-methylpentanamide	Investigative	44332029	C21H25N3O6	415.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=NC=CC3=CC=CC=C32	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B7WIJ8	(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	25217030	C30H26FN5O5S	587.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)OCCF)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B7YR8F	2-[(1-Benzyl-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile	Investigative	42618284	C22H18N4O3S2	450.5	C1CSCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B83BOV	1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11576540	C25H23N3O5S	477.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=CC=C4)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B8EN4C	1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione	Investigative	11670894	C26H25N3O5S2	523.6	CSC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CN=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B8LZQ0	(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	9914167	C27H26N2O6S	506.6	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CC=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B8PRV6	Isatin Sulfonamide 26	Investigative	9800285	C19H19N3O4S	385.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)CNC4=CC=CC=C4	Ki = 80000 nM	Poor binder
T15700	Caspase-8	B8V9SH	1-(4-Bromo-benzyl)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	16749267	C26H23BrN2O5S	555.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)Br)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B8W7CY	(S)-1-(4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54582484	C32H35FN2O8S	626.7	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)OCCOCCOCCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B93XHP	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-4-yloxyacetyl)amino]pentanamide	Investigative	44332028	C21H25N3O6	415.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=CC=NC3=CC=CC=C32	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B97HDS	(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11576622	C24H20FN3O5S	481.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC(=NC=C5)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B9AW8I	1-Benzyl-5-thiomorpholinosulfonyl Isatin	Investigative	42618277	C19H18N2O4S2	402.5	C1CSCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B9U8MG	(S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin	Investigative	25179144	C24H24FN5O5S	513.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CN(N=N4)CCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	B9Z0NL	(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11634372	C25H21FN2O5S	480.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=CC=C5F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BA2RI6	(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11497112	C26H24N2O5S2	508.6	CSC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CC[C@H]4COC5=CC=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BA31BP	(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11584106	C25H22FN3O5S	495.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC(=NC=C4)F)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BAG21P	Isatin Michael acceptor (IMA) analogue, 19c	Investigative	42618293	C22H16Cl2N4O3S	487.4	C1CCN(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BAML21	(S)-5-(2-((2,4-Difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione	Investigative	54582924	C28H25F3N2O6S	574.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)OCCF)COC5=C(C=C(C=C5)F)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BB2XJ3	2-[(4-Methoxybenzyl)-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile	Investigative	42618285	C23H20N4O4S2	480.6	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCSCC4)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BBC1M4	Isatin Michael acceptor (IMA) analogue, 12a	Investigative	42618281	C22H18N4O4S	434.5	C1COCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BBEW23	Planktocyclin	Investigative	23655167	C39H60N8O8S	801	CC(C)C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)NCC(=O)N1)C(C)C)CC3=CC=CC=C3)CCSC)C(C)C	IC50 = 93000 nM	Poor binder
T15700	Caspase-8	BCK87P	(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	25217031	C29H24FN5O5S	573.6	C1CN([C@@H]1COC2=CN=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=C(C#N)C#N)CC5=CC=C(C=C5)OCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BD0LN5	2-[1-[(4-Methoxyphenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile	Investigative	16749164	C29H25N5O5S	555.6	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CN=CC=C5)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BDF3G5	5-(Morpholin-4-ylsulfonyl)-1H-indole-2,3-dione	Investigative	8027611	C12H12N2O5S	296.3	C1COCCN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BE65LN	(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	52918179	C22H21FN6O5S	500.5	C1CN([C@@H]1COC2=CN=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CN(N=N5)CCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BEQG27	1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione	Investigative	11705942	C25H22FN3O5S	495.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)F)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BFW4K9	(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11496333	C25H22N2O5S	462.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BFZN97	(S)-5-(2-((2,4-Difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione	Investigative	54583924	C27H23F3N2O6S	560.5	C1CN([C@@H]1COC2=C(C=C(C=C2)F)F)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=C(C=C5)OCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BGJ0Q4	(S)-2-(1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	54585834	C32H29FN4O6S	616.7	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=C(C#N)C#N)CC5=CC=C(C=C5)OCCOCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BH8J0Q	(S)-1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54581481	C30H31FN2O7S	582.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)OCCOCCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BHSC21	Isatin Michael acceptor (IMA) analogue, 18a	Investigative	42618288	C21H16N4O3S	404.4	C1CN(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BI2HX8	Phenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate	Investigative	2821640	C18H13NO4S	339.4	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)OC4=CC=CC=C4	IC50 = 60000 nM	Poor binder
T15700	Caspase-8	BI2O9T	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-(4-naphthalen-2-ylbutanoylamino)pentanamide	Investigative	44332128	C24H30N2O5	426.5	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)CCCC2=CC3=CC=CC=C3C=C2	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BI6Z0R	(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11509289	C19H18N2O5S	386.4	CN1C2=C(C=C(C=C2)S(=O)(=O)N3CC[C@H]3COC4=CC=CC=C4)C(=O)C1=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BIG40X	(3S)-4-[(2-Hydroxyphenyl)methylamino]-3-[[(2S)-2-[[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]amino]propanoyl]amino]butanoic acid	Investigative	45379628	C30H36N4O6	548.6	C[C@@H](C(=O)N[C@@H](CC(=O)O)CNCC1=CC=CC=C1O)NC(=O)[C@H](C(C)C)NC(=O)C2=CC3=CC=CC=C3C=C2	IC50 = 100000 nM	Poor binder
T15700	Caspase-8	BIXL90	Isatin Michael acceptor (IMA) analogue, 11c	Investigative	42618280	C23H18Cl2N4O3S	501.4	C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BJ7C9Q	5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11509301	C18H17N3O5S	387.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)COC4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BJV86F	(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11619968	C24H20FN3O5S	481.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CN=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BK9D7O	(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11519268	C27H26N2O5S2	522.6	CSC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CC=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BKX43R	2-(2,3-Dihydro-1,4-benzodioxin-2-YL)-1,3-thiazole-4-carboxylic acid	Investigative	2821593	C12H9NO4S	263.27	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)O	IC50 = 75000 nM	Poor binder
T15700	Caspase-8	BL3BO4	(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54584867	C23H22FN5O5S	499.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CN(N=N5)CCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BLT1F6	Isatin sulfonamide, 9c	Investigative	42618276	C19H16Cl2N2O5S	455.3	C1COCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BMKW18	Isatin Michael acceptor (IMA) analogue, 18b	Investigative	42618289	C22H18N4O4S	434.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC4)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BMZ39G	(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	25217032	C31H27FN4O5S	586.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)OCCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BNM1X6	Isatin Michael acceptor (IMA) analogue, 3	Investigative	16749269	C29H24N4O4S	524.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BO09VR	2-[1-[(4-Bromophenyl)methyl]-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile	Investigative	16749270	C29H23BrN4O4S	603.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=C(C=C4)Br)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BO0YM1	Isatin Michael acceptor (IMA) analogue, 19a	Investigative	42618291	C22H18N4O3S	418.5	C1CCN(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BO2FN3	1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dione	Investigative	11647018	C19H19N3O5S	401.4	CN1C2=C(C=C(C=C2)S(=O)(=O)N3CCC[C@H]3COC4=CN=CC=C4)C(=O)C1=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BOQ4G0	Acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester	Investigative	11512139	C28H26N2O7S	534.6	CC(=O)OC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCC[C@H]4COC5=CC=CC=C5)C(=O)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BP20VD	(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11712912	C26H24N2O6S	492.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)O)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BPCJ86	(S)-2-(1-(4-Methoxybenzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile	Investigative	25217029	C28H23N5O5S	541.6	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CC[C@H]4COC5=CN=CC=C5)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BPI2Y6	(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	9821545	C19H18N2O5S	386.4	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)COC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BPX1O4	Isatin Michael acceptor (IMA) analogue, 11a	Investigative	42618278	C23H20N4O3S	432.5	C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BQ3O2C	Isatin Michael acceptor (IMA) analogue, 18c	Investigative	42618290	C21H14Cl2N4O3S	473.3	C1CN(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=C(C#N)C#N)CC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BQG7Z2	Isatin Michael acceptor (IMA) analogue, 12b	Investigative	42618282	C23H20N4O5S	464.5	COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)S(=O)(=O)N4CCOCC4)C(=C(C#N)C#N)C2=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BQV91H	(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11583840	C25H21FN2O5S	480.5	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BR98MV	(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	52918177	C27H26FN3O6S	539.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)OCCF)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BS5A8Q	(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11634649	C25H22FN3O5S	495.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=NC(=CC=C4)F)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BSN5L4	(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	52918163	C26H24FN3O6S	525.5	C1CN([C@@H]1COC2=CN=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=C(C=C5)OCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BT3S0K	(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	52918178	C23H23FN6O5S	514.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CN(N=N4)CCF)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BT7K8E	1-(4-Hydroxy-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione	Investigative	16749068	C25H23N3O6S	493.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)O)COC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BTU01I	(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione	Investigative	11576852	C26H23FN2O5S	494.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)F)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BUM87T	(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	11533935	C28H27FN2O6S	538.6	C1C[C@H](N(C1)S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CC4=CC=C(C=C4)OCCF)COC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BV5MK3	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamide	Investigative	127042341	C21H22N4O4S	426.5	C1C[C@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BVM0H8	{(R)-1-[2-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-yl)-acetyl]-3-methyl-butyl}-carbamic acid benzyl ester	Investigative	44331963	C19H25NO6	363.4	CC(C)C[C@H](C(=O)C[C@H]1CC(=O)OC1O)NC(=O)OCC2=CC=CC=C2	IC50 = 50000 nM	Poor binder
T15700	Caspase-8	BW17HR	(S)-1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	54580470	C29H29FN2O7S	568.6	C1CN([C@@H]1COC2=CC=CC=C2)S(=O)(=O)C3=CC4=C(C=C3)N(C(=O)C4=O)CC5=CC=C(C=C5)OCCOCCF	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BW4DQ9	(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-methoxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide	Investigative	127042051	C22H24N4O5S	456.5	COC1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(=O)N)C#N	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	BWON84	7-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-sulfanyl-3,7-dihydro-1H-purine-2,6-dione	Investigative	3107941	C15H15ClN4O4S	382.8	CN1C2=C(C(=O)NC1=O)N(C(=S)N2)CC(COC3=CC=C(C=C3)Cl)O	IC50 = 76100 nM	Poor binder
T15700	Caspase-8	BZ1D7U	2-[1-Methyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile	Investigative	16749069	C23H20N4O4S	448.5	CN1C2=C(C=C(C=C2)S(=O)(=O)N3CCC[C@H]3COC4=CC=CC=C4)C(=C(C#N)C#N)C1=O	IC50 ~ 50000 nM	Poor binder
T15700	Caspase-8	D0N5MU	5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	4117381	C12H12N2O4S	280.3	C1CCN(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O	Ki ~ 50000 nM	Poor binder
T15700	Caspase-8	D0Q9XX	casp 4 inhib	Investigative	515950	C9H6N2O4	206.15	CN1C2=C(C=C(C=C2)[N+](=O)[O-])C(=O)C1=O	Ki ~ 50000 nM	Poor binder