TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15882	Leukocyte proteinase-3	D0FT4R	Sivelestat	Phase 4	107706	C20H22N2O7S	434.5	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O	IC50 ~ 100000 nM	Poor binder
T15882	Leukocyte proteinase-3	B2H8JQ	1-Phenyl-2-(5-carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-1,4-dihydropyridine-4-one	Investigative	72793778	C25H22N2O6S	478.5	CC(C)(C)C(=O)OC1=CN(C(=CC1=O)CSC2=NC3=C(O2)C=CC(=C3)C(=O)O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T15882	Leukocyte proteinase-3	B9RI7L	(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797573	C19H18F3N3O3S	425.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T15882	Leukocyte proteinase-3	BNHQ54	cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide	Investigative	24822701	C17H17N3OS	311.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T15882	Leukocyte proteinase-3	BQD61L	2-[(5-Amino-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dichlorophenyl)-2-phenylacetamide	Investigative	5236960	C16H13Cl2N5OS	394.3	C1=CC=C(C=C1)C(C(=O)NC2=CC(=CC(=C2)Cl)Cl)SC3=NNC(=N3)N	IC50 ~ 139000 nM	Poor binder
T15882	Leukocyte proteinase-3	BVP1Q6	(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanone	Investigative	102323332	C12H13IN4O2	372.16	C1=CC(=CC=C1C[C@@H](C(=O)C=[N+]=[N-])NC(=O)CN)I	IC50 ~ 50000 nM	Poor binder
T15882	Leukocyte proteinase-3	BZ9P3H	6-(((5-(Cyclopropanecarboxamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-fluorobenzoate	Investigative	18572952	C19H14FN3O5S2	447.5	C1CC1C(=O)NC2=NN=C(S2)SCC3=CC(=O)C(=CO3)OC(=O)C4=CC(=CC=C4)F	IC50 ~ 134000 nM	Poor binder