TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T16347	Protein-tyrosine phosphatase 1B	D0Z3DY	Benzbromarone	Approved	2333	C17H12Br2O3	424.1	CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br	IC50 = 53800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0W8WB	Berberine	Phase 4	2353	C20H18NO4+	336.4	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC	IC50 = 67000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0T8QB	GLYCYRRHIZIN	Phase 3	14982	C42H62O16	822.9	C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B01YET	2-Bromoacetophenone	Investigative	6259	C8H7BrO	199.04	C1=CC=C(C=C1)C(=O)CBr	Ki = 81000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B02JCZ	[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]methylphosphonic acid	Investigative	44450333	C23H22N3O5PS2	515.5	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)CP(=O)(O)O)CC3=CC=C(C=C3)C4=CSN=N4	IC50 = 123000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0AG3X	Chembl4216013	Investigative	145973266	C17H22O2	258.35	CC1=CC(=CC2=C1[C@H]3[C@@H]4[C@H](C3(C)C)CC[C@@]4(O2)C)O	IC50 = 58200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0E2WQ	Licoflavone A	Investigative	5319000	C20H18O4	322.4	CC(=CCC1=CC2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)C	IC50 = 54500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0GX5R	N-(4,5-Diphenyl-2-thiazolyl)-2-(2-furyl)ethenesulfonamide	Investigative	44337799	C21H16N2O3S2	408.5	C1=CC=C(C=C1)C2=C(SC(=N2)NS(=O)(=O)/C=C/C3=CC=CO3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0INB7	(2S)-7-Hydroxy-2-(3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one	Investigative	73354070	C25H28O5	408.5	CC(=CCC1=C(C=CC2=C1O[C@@H](CC2=O)C3=CC4=C(C=C3)OC(C(C4)O)(C)C)O)C	IC50 = 52200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0MIT9	Chembl4280516	Investigative	145982366	C24H19N3S	381.5	C1=CC=C(C=C1)C2=CC=C(C=C2)/C=N/NC(=S)NC3=CC=CC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0NL1U	Azane;[(3S)-3-(methylcarbamoyl)-2-(3-phenylpropanoyl)-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797141	C20H26N4O5S	434.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC=CC=C3)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 64400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0O7WX	Estramustine phosphate	Investigative	259329	C23H32Cl2NO6P	520.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2OP(=O)(O)O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl	IC50 = 62400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0PIR1	Sulfuric acid mono-[1-(naphthalen-1-ylmethoxymethyl)-3-phenyl-propyl] ester	Investigative	44303684	C21H22O5S	386.5	C1=CC=C(C=C1)CCC(COCC2=CC=CC3=CC=CC=C32)OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0U3JV	Azane;[(3S)-3-(methylcarbamoyl)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797139	C16H26N4O6S	402.5	CC(C)(C)OC(=O)N1CC2=C(C[C@H]1C(=O)NC)C=CC(=C2)NS(=O)(=O)O.N	IC50 = 134800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0W4ZV	CID 58746680	Investigative	58746680	C29H30N4O7S	578.6	C1C(S(=O)(=O)NC1=O)C2=CC=C(C=C2)C[C@@H](C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CC4=CC=C(C=C4)O	IC50 = 169824.37 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0W6FB	(2S)-N-[(2S)-1-Amino-1-oxo-3-[4-(1,1,3-trioxo-1,2-thiazolidin-5-yl)phenyl]propan-2-yl]-3-phenyl-2-[(2-phenylacetyl)amino]propanamide	Investigative	58746519	C29H30N4O6S	562.6	C1C(S(=O)(=O)NC1=O)C2=CC=C(C=C2)C[C@@H](C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CC4=CC=CC=C4	IC50 = 179887.09 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0W8ID	2-[(3,4-Dichlorobenzyl)sulfanyl]-4-(4-Hydroxybut-1-Yn-1-Yl)benzoic Acid	Investigative	54751679	C18H14Cl2O3S	381.3	C1=CC(=C(C=C1CSC2=C(C=CC(=C2)C#CCCO)C(=O)O)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0WNO9	Gypensapogenin C	Investigative	57395175	C30H46O2	438.7	CC(=C1CC=C(C1=O)[C@H]2CC[C@@]3([C@@H]2CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)C)C	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0X9UM	Ethyl (E)-2-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]ethenesulfonate	Investigative	70691129	C22H23NO5S	413.5	CCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B0ZUY7	1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]but-3-yn-2-yl hydrogen sulfate	Investigative	44303433	C18H28O4S	340.5	CC1=CC[C@@H]2[C@@]([C@H]1CC(C#C)OS(=O)(=O)O)(CCCC2(C)C)C	IC50 = 160000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B12KGR	alpha,alpha-Difluoro-3-[bis(methylsulfonyl)amino]-4-[(E)-styryl]benzylphosphonic acid	Investigative	15486042	C17H18F2NO7PS2	481.4	CS(=O)(=O)N(C1=C(C=CC(=C1)C(F)(F)P(=O)(O)O)/C=C/C2=CC=CC=C2)S(=O)(=O)C	IC50 = 57900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B12MWQ	3-[3-[4-[[(2R,3R,4S,5R,6S)-3,4,5-Tribenzoyloxy-6-methoxyoxan-2-yl]methoxymethyl]triazol-1-yl]propoxy]benzoic acid	Investigative	56671798	C41H39N3O12	765.8	CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COCC2=CN(N=N2)CCCOC3=CC=CC(=C3)C(=O)O)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5)OC(=O)C6=CC=CC=C6	IC50 = 64600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B13SCI	(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-12-[(2S)-butan-2-yl]-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid	Investigative	11844603	C46H66N8O8	859.1	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)NCCCC[C@@H](C(=O)N1)NC(=O)N[C@@H]([C@@H](C)CC)C(=O)O)CC2=CC=CC=C2)CC3=CNC4=CC=CC=C43)C)CC(C)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1EL4N	(S)-4-Benzyloxycarbonylamino-4-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-(4-carboxymethoxy-phenyl)-ethylcarbamoyl]-butyric acid benzyl ester	Investigative	44320886	C37H44N4O10	704.8	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 = 72000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1FQ7T	4-[[(4E)-3-Benzyl-4-[(4-hydroxyphenyl)methylidene]-2,5-dioxoimidazolidin-1-yl]methyl]benzoic acid	Investigative	122193548	C25H20N2O5	428.4	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)O)/C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)O	IC50 = 104000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1K2AI	2-[4-[[4-(Carboxymethylsulfanyl)phenyl]methyl-[[4-(thiadiazol-4-yl)phenyl]methyl]sulfamoyl]phenoxy]acetic acid	Investigative	44450251	C26H23N3O7S3	585.7	C1=CC(=CC=C1CN(CC2=CC=C(C=C2)SCC(=O)O)S(=O)(=O)C3=CC=C(C=C3)OCC(=O)O)C4=CSN=N4	IC50 = 114000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1K8ZQ	2-[4-[(2S,5R)-5-Carbamoyl-2-[[(2S)-2-[[2-[2-[(4-methoxyphenyl)methyl]tetrazol-5-yl]acetyl]amino]-5-oxo-5-phenylmethoxypentanoyl]amino]-7-methyl-3-oxooctyl]phenoxy]acetic acid	Investigative	44397525	C41H49N7O10	799.9	CC(C)C[C@H](CC(=O)[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)CC3=NN(N=N3)CC4=CC=C(C=C4)OC)C(=O)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1LC8H	Butyl (E)-2-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]ethenesulfonate	Investigative	70695329	C24H27NO5S	441.5	CCCCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1LEQ5	2-[4-[(2S,5R)-5-Carbamoyl-7-methyl-2-[[(2S)-2-[[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]-5-oxo-5-phenylmethoxypentanoyl]amino]-3-oxooctyl]phenoxy]acetic acid	Investigative	44397524	C37H45N5O11	735.8	CC1=CN(C(=O)NC1=O)CC(=O)N[C@@H](CCC(=O)OCC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)OCC(=O)O)C(=O)C[C@@H](CC(C)C)C(=O)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1N7MR	[4-({[(Benzyl-methyl-carbamoyl)-methyl]-[4-(difluoro-phosphono-methyl)-benzyl]-amino}-methyl)-phenoxy]-acetic acid	Investigative	44404306	C27H29F2N2O7P	562.5	CN(CC1=CC=CC=C1)C(=O)CN(CC2=CC=C(C=C2)C(F)(F)P(=O)(O)O)CC3=CC=C(C=C3)OCC(=O)O	IC50 = 67500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1NSO3	5-(1-Hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione	Investigative	54706178	C10H14O5	214.21	CC(C)C(=C1C(=O)OC(OC1=O)(C)C)O	IC50 = 72700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1NY9O	[1-(2-Methyl-2,3-dihydrobenzimidazol-1-yl)-4-phenylbutan-2-yl] hydrogen sulfate	Investigative	44303685	C18H22N2O4S	362.4	CC1NC2=CC=CC=C2N1CC(CCC3=CC=CC=C3)OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1OQ3C	Kanzonol U	Investigative	10542808	C19H16O4	308.3	CC1(C=CC2=C(C=CC(=C2O1)C3=CC4=C(O3)C=C(C=C4)O)O)C	IC50 = 62700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1PCX9	Cefsulodin sodium salt	Investigative	57514697	C22H20N4O8S2	532.6	C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)O)C[N+]4=CC=C(C=C4)C(=O)N	IC50 = 190000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B1PF7V	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	136069445	C28H43NO5	473.6	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1O)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B23FOA	2-Amino-4,5-diphenyl-6-(methylthio)benzene-1,3-dicarbonitrile	Investigative	44138095	C21H15N3S	341.4	CSC1=C(C(=C(C(=C1C#N)N)C#N)C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 58000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B24ERC	[Fluoro-[7-[fluoro(phosphono)methyl]naphthalen-2-yl]methyl]phosphonic acid	Investigative	44344614	C12H12F2O6P2	352.16	C1=CC(=CC2=C1C=CC(=C2)C(F)P(=O)(O)O)C(F)P(=O)(O)O	IC50 = 130000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B25EQX	CID 58746630	Investigative	58746630	C30H32N4O7S	592.7	COC1=CC=C(C=C1)CC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)C4CC(=O)NS4(=O)=O)C(=O)N	IC50 = 169824.37 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B27PNV	2-[2-Ethyl-N-(2-oxopropanoyl)anilino]benzoic acid	Investigative	76326107	C18H17NO4	311.3	CCC1=CC=CC=C1N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)C	Ki = 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2AF9S	Nakitriol	Investigative	10420098	C11H12O3	192.21	C=C/C=C(/CO)\\C1=C(C=CC(=C1)O)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2BKD3	9-Ethoxymethyl-4-methyl-9-(4-methyl-piperazin-1-ylmethyl)-8,9-dihydro-pyrano[2,3-f]chromene-2,10-dione	Investigative	46879575	C22H28N2O5	400.5	CCOCC1(COC2=C(C1=O)C3=C(C=C2)C(=CC(=O)O3)C)CN4CCN(CC4)C	IC50 = 65500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2D5GF	3-Benzyl-5-bromo-2-hydroxybenzoic acid	Investigative	13922432	C14H11BrO3	307.14	C1=CC=C(C=C1)CC2=C(C(=CC(=C2)Br)C(=O)O)O	IC50 = 148000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2F5EC	2-[4-[[[4-(Carboxymethoxy)phenyl]sulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]-2-methylpropanedioic acid	Investigative	44450310	C28H25N3O9S2	611.6	CC(C1=CC=C(C=C1)CN(CC2=CC=C(C=C2)C3=CSN=N3)S(=O)(=O)C4=CC=C(C=C4)OCC(=O)O)(C(=O)O)C(=O)O	IC50 = 74200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2GL0D	[1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-3-phenylpropan-2-yl] hydrogen sulfate	Investigative	44303451	C23H34O4S	406.6	CC1=CC[C@@H]2[C@@]([C@H]1CC(CC3=CC=CC=C3)OS(=O)(=O)O)(CCCC2(C)C)C	IC50 = 87000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2GSE5	5-(3-Butyramidophenyl)isoxazole-3-carboxylic acid	Investigative	44344024	C14H14N2O4	274.27	CCCC(=O)NC1=CC=CC(=C1)C2=CC(=NO2)C(=O)O	Ki = 125892.54 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2H1US	5-{[4-(Phenylmethoxy)phenyl]methylene}-1,3-diazolidine-2,4-dione	Investigative	6377130	C17H14N2O3	294.3	C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C/3\\C(=O)NC(=O)N3	IC50 = 170000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2L1TR	5-{2-Fluoro-5-[3-(3-hydroxy-2-methoxycarbonyl-phenoxy)-propenyl]-phenyl}-isoxazole-3-carboxylic acid	Investigative	447994	C21H16FNO7	413.4	COC(=O)C1=C(C=CC=C1OC/C=C/C2=CC(=C(C=C2)F)C3=CC(=NO3)C(=O)O)O	IC50 = 110000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2LEY1	Ethyl 2-[(5E)-5-[[4-(2-ethoxy-2-oxoethoxy)phenyl]methylidene]-2,4-dioxoimidazolidin-1-yl]acetate	Investigative	60152176	C18H20N2O7	376.4	CCOC(=O)CN1/C(=C/C2=CC=C(C=C2)OCC(=O)OCC)/C(=O)NC1=O	IC50 = 133000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2RFT5	2-[2,3-Dihydro-1,4-benzodioxin-6-yl(oxalo)amino]benzoic acid	Investigative	45267803	C17H13NO7	343.29	C1COC2=C(O1)C=CC(=C2)N(C3=CC=CC=C3C(=O)O)C(=O)C(=O)O	Ki = 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2T3VF	5-[(E)-2-(4-Carboxy-5-hydroxyphenyl)vinyl]-3-(furan-2-yl)-2-methoxybenzoic acid	Investigative	44563617	C21H16O7	380.3	COC1=C(C=C(C=C1C(=O)O)/C=C/C2=CC(=C(C=C2)C(=O)O)O)C3=CC=CO3	IC50 = 194000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2U5FR	Azane;[(3S)-3-(methylcarbamoyl)-2-(2-phenoxyacetyl)-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797140	C19H24N4O6S	436.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)COC3=CC=CC=C3)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 95300 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2VDZ3	4-(N-Benzyl-C-pentadecylcarbonimidoyl)-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	135955126	C28H43NO4	457.6	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B2XVS3	2-(3-Bromoanilino)-5-hydroxybenzothiazole-6-carboxylic acid	Investigative	101884098	C14H9BrN2O3S	365.2	C1=CC(=CC(=C1)Br)NC2=NC3=C(S2)C=C(C(=C3)O)C(=O)O	IC50 = 65000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B34LZC	3-Hydroxybenzoic acid	Investigative	7420	C7H6O3	138.12	C1=CC(=CC(=C1)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B36FIB	3-(2,4-Dimethoxyphenyl)-5-pyridin-2-yl-4,5-dihydro-1,2-oxazole	Investigative	76326418	C16H16N2O3	284.31	COC1=CC(=C(C=C1)C2=NOC(C2)C3=CC=CC=N3)OC	Ki = 170000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B36JDQ	(S)-2-(4-(Benzamidomethyl)-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid	Investigative	53320581	C19H18N4O4	366.4	C1=CC=C(C=C1)C(=O)NCC2=CN(N=N2)[C@@H](CC3=CC=C(C=C3)O)C(=O)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B36NGB	2-[4-[(2S,5R)-5-Carbamoyl-2-[[(2S)-2-[4-(1H-indol-3-yl)butanoylamino]-5-oxo-5-phenylmethoxypentanoyl]amino]-7-methyl-3-oxooctyl]phenoxy]acetic acid	Investigative	44397523	C42H50N4O9	754.9	CC(C)C[C@H](CC(=O)[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)CCCC3=CNC4=CC=CC=C43)C(=O)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B36NLR	3-(3,4-Dichlorobenzyloxy)thiophene-2-carboxylic acid	Investigative	54757811	C12H8Cl2O3S	303.2	C1=CC(=C(C=C1COC2=C(SC=C2)C(=O)O)Cl)Cl	IC50 = 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B37DAX	2-[4-[[4-(Carboxymethoxy)-3-methylphenyl]methyl-[[4-(thiadiazol-4-yl)phenyl]methyl]sulfamoyl]phenoxy]acetic acid	Investigative	44450265	C27H25N3O8S2	583.6	CC1=C(C=CC(=C1)CN(CC2=CC=C(C=C2)C3=CSN=N3)S(=O)(=O)C4=CC=C(C=C4)OCC(=O)O)OCC(=O)O	IC50 = 76200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B37QCE	2-[(5,7-Diamino-pyrimido[5,4-e][1,2,4]triazin-3-ylmethyl)-(2-hydroxy-ethyl)-amino]-ethanol	Investigative	44329967	C10H16N8O2	280.29	C(CO)N(CCO)CC1=NC2=C(N=C(N=C2N=N1)N)N	IC50 = 97000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3BPG6	3-(4,7-Dimethoxybenzofuran-5-yl)-5-phenyl-4,5-dihydroisoxazole	Investigative	11948628	C19H17NO4	323.3	COC1=C2C(=C(C(=C1)C3=NOC(C3)C4=CC=CC=C4)OC)C=CO2	IC50 = 76000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3C0QR	6-(1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)-1-cyanoindolizine-3-carboxylic acid	Investigative	44405951	C25H25N3O5	447.5	CC(C)CC(C1=CN2C(=C(C=C2C(=O)O)C#N)C=C1)C(=O)NC(CC(=O)O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3DOU5	3-(3,4-Dichlorobenzylsulfonyl)thiophene-2-carboxylic acid	Investigative	54757813	C12H8Cl2O4S2	351.2	C1=CC(=C(C=C1CS(=O)(=O)C2=C(SC=C2)C(=O)O)Cl)Cl	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3F1RW	Methyl 2-[(4E)-3-benzyl-2,5-dioxo-4-[(4-phenylmethoxyphenyl)methylidene]imidazolidin-1-yl]acetate	Investigative	122193486	C27H24N2O5	456.5	COC(=O)CN1C(=O)/C(=C\\C2=CC=C(C=C2)OCC3=CC=CC=C3)/N(C1=O)CC4=CC=CC=C4	IC50 = 110000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3MTA2	(2S)-7-Hydroxy-2-(3,4,8-trihydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)-2,3-dihydrochromen-4-one	Investigative	44589233	C20H20O7	372.4	CC1(C(C(C2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(O3)C=C(C=C4)O)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3NTF7	Chembl4217308	Investigative	145973093	C22H13Cl2NO4	426.2	C1=CC=C(C=C1)C2=C(C(=NO2)C(=O)O)C3=CC=CC(=C3)C4=CC(=C(C(=C4)Cl)O)Cl	IC50 = 127000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3O6SE	4-(3-(4-Acetoxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)acryloyl)phenyl acetate	Investigative	11069872	C25H26O6	422.5	CC(=O)OC1=CC=C(C=C1)C(=O)/C=C/C2=CC(=C(C=C2OC)OC(=O)C)C(C)(C)C=C	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3SOV2	Tetrahydroisoquinoline (TIQ) deriv. 9c	Investigative	11155758	C23H29N3O6S	475.6	CC(C)(C)OC(=O)N1CC2=C(C[C@H]1C(=O)NCCC3=CC=CC=C3)C=CC(=C2)NS(=O)(=O)O	IC50 = 51400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3SXE5	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-(benzoylsulfamoyl)ethyl]anilino]-2-oxoacetic acid	Investigative	71602705	C24H19N3O7S	493.5	C1=CC=C(C=C1)C(=O)NS(=O)(=O)C(CC2=CC=C(C=C2)NC(=O)C(=O)O)C3=NC4=CC=CC=C4O3	Ki = 125000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3U6ZR	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]sulfinylacetic acid	Investigative	44450245	C24H21N3O5S3	527.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)S(=O)CC(=O)O	IC50 = 173000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3UY2T	3-(4-Methyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	18003344	C11H17N9	275.31	CN1CCN(CC1)CC2=NC3=C(N=C(N=C3N=N2)N)N	IC50 = 87000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3VYR4	5-(1H-Indol-3-ylmethyl)-3-[5-(3-methylphenyl)thiophen-2-yl]-1,2,4-oxadiazole	Investigative	127025572	C22H17N3OS	371.5	CC1=CC(=CC=C1)C2=CC=C(S2)C3=NOC(=N3)CC4=CNC5=CC=CC=C54	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B3XOU1	2-[4-[2-(1H-Benzimidazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602468	C23H19FN4O5S	482.5	C1=CC=C2C(=C1)NC(=N2)C(CC3=CC=C(C=C3)NC(=O)C(=O)O)S(=O)(=O)NC4=CC=C(C=C4)F	Ki = 67500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B47VWI	cis-4-(4-(Hydroxymethyl)styryl)benzene-1,2-diol	Investigative	44432621	C15H14O3	242.27	C1=CC(=CC=C1CO)/C=C\\C2=CC(=C(C=C2)O)O	IC50 = 137500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B48BQE	2-[4-[[4-(Phosphonomethyl)phenyl]methyl-[[4-(thiadiazol-4-yl)phenyl]methyl]sulfamoyl]phenoxy]acetic acid	Investigative	44450344	C25H24N3O8PS2	589.6	C1=CC(=CC=C1CN(CC2=CC=C(C=C2)C3=CSN=N3)S(=O)(=O)C4=CC=C(C=C4)OCC(=O)O)CP(=O)(O)O	IC50 = 96800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B49HDV	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenoxy]acetic acid	Investigative	44450321	C24H21N3O5S2	495.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)OCC(=O)O	IC50 = 54100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4AT5M	2-Bromo-1-(naphthalen-1-yl)ethanone	Investigative	3830513	C12H9BrO	249.1	C1=CC=C2C(=C1)C=CC=C2C(=O)CBr	Ki = 92000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4B6XZ	(-)-Moracin P	Investigative	25208124	C19H18O5	326.3	CC1([C@@H](CC2=C(O1)C=C3C(=C2)C=C(O3)C4=CC(=CC(=C4)O)O)O)C	IC50 ~ 80000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4BN2A	Glabridin	Investigative	124052	C20H20O4	324.4	CC1(C=CC2=C(O1)C=CC3=C2OC[C@H](C3)C4=C(C=C(C=C4)O)O)C	IC50 = 73400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4DKT2	2-[2-Bromo-4-[[[4-(carboxymethoxy)phenyl]sulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenoxy]-2,2-difluoroacetic acid	Investigative	44450331	C26H20BrF2N3O8S2	684.5	C1=CC(=CC=C1CN(CC2=CC(=C(C=C2)OC(C(=O)O)(F)F)Br)S(=O)(=O)C3=CC=C(C=C3)OCC(=O)O)C4=CSN=N4	IC50 = 77900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4H2QN	Globuxanthone	Investigative	60148490	C18H16O5	312.3	CC(C)(C=C)C1=CC(=C(C2=C1OC3=C(C2=O)C=CC=C3O)O)O	IC50 = 73200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4P2VO	(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S,5S)-2,5-Dihydroxy-6-methylhept-6-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol	Investigative	71718556	C30H52O4	476.7	CC(=C)[C@H](CC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C)O)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4PQ5Z	2-Hydroxy-3,5-diphenylbenzoic acid	Investigative	25101399	C19H14O3	290.3	C1=CC=C(C=C1)C2=CC(=C(C(=C2)C(=O)O)O)C3=CC=CC=C3	IC50 = 84000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4S0YM	2-Bromo-4'-nitroacetophenone	Investigative	66840	C8H6BrNO3	244.04	C1=CC(=CC=C1C(=O)CBr)[N+](=O)[O-]	Ki = 195000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4U1GW	2-Amino-4-(4-methoxyphenyl)-5-phenyl-6-(methylthio)benzene-1,3-dicarbonitrile	Investigative	44138096	C22H17N3OS	371.5	COC1=CC=C(C=C1)C2=C(C(=C(C(=C2C3=CC=CC=C3)SC)C#N)N)C#N	IC50 = 86000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4XBD1	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]-2-chlorophenoxy]acetic acid	Investigative	44450274	C24H20ClN3O5S2	530	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC(=C(C=C4)OCC(=O)O)Cl	IC50 = 53800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4XW5G	N-[2-(4-Methoxyphenyl)ethyl]-2-naphthalen-1-yl-acetamide	Investigative	2710079	C21H21NO2	319.4	COC1=CC=C(C=C1)CCNC(=O)CC2=CC=CC3=CC=CC=C32	IC50 = 69000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4Y3FZ	Glabone	Investigative	11346860	C18H12O4	292.3	COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C4C(=C3)C=CO4	IC50 = 68800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B4YU3R	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-[(4-propan-2-yloxyphenyl)sulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602754	C26H25N3O7S	523.6	CC(C)OC1=CC=C(C=C1)NS(=O)(=O)C(CC2=CC=C(C=C2)NC(=O)C(=O)O)C3=NC4=CC=CC=C4O3	Ki = 92000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B53DXY	5-(1-Hydroxybutylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione	Investigative	68122136	C10H14O5	214.21	CCCC(=C1C(=O)OC(OC1=O)(C)C)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B56XED	4-[N-[(3-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	135797392	C28H42ClNO4	492.1	CCCCCCCCCCCCCCCC(=NCC1=CC(=CC=C1)Cl)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B57GHE	Dithiolan-4-yl furan-3-carboxylate	Investigative	72163424	C8H8O3S2	216.3	C1C(CSS1)OC(=O)C2=COC=C2	IC50 = 78190 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B57YDQ	5-[({3-[(3,4-Dichlorobenzyl)sulfanyl]thiophen-2-Yl}carbonyl)sulfamoyl]-2-Methoxybenzoic Acid	Investigative	54751678	C20H15Cl2NO6S3	532.4	COC1=C(C=C(C=C1)S(=O)(=O)NC(=O)C2=C(C=CS2)SCC3=CC(=C(C=C3)Cl)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B58ZFG	7-(((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-1-cyanoindolizine-3-carboxylic acid	Investigative	44405932	C26H26N4O6	490.5	CC(C)C[C@@H](C(=O)NC(CC(=O)O)C1=CC=CC=C1)NC(=O)C2=CC3=C(C=C(N3C=C2)C(=O)O)C#N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5B1GW	4-(Hydroxymethyl)-5-(3-iodophenyl)-1,2-oxazole-3-carboxylic acid	Investigative	45268794	C11H8INO4	345.09	C1=CC(=CC(=C1)I)C2=C(C(=NO2)C(=O)O)CO	Ki = 125892.54 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5D3BQ	2-[4-[2-(1H-Benzimidazol-2-yl)-2-[(4-fluorophenyl)-methylsulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602470	C24H21FN4O5S	496.5	CN(C1=CC=C(C=C1)F)S(=O)(=O)C(CC2=CC=C(C=C2)NC(=O)C(=O)O)C3=NC4=CC=CC=C4N3	Ki = 125000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5DAY4	2-[(S)-(4-Bromoanilino)-diethoxyphosphorylmethyl]phenol	Investigative	57397768	C17H21BrNO4P	414.2	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=C(C=C2)Br)OCC	IC50 = 91700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5FRD7	7-[(1-Hydroxy-1-phenylpropan-2-yl)amino]quinoline-5,8-dione	Investigative	386231	C18H16N2O3	308.3	CC(C(C1=CC=CC=C1)O)NC2=CC(=O)C3=C(C2=O)N=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5M0IY	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenoxy]-2,2-difluoroacetic acid	Investigative	44450295	C24H19F2N3O5S2	531.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)OC(C(=O)O)(F)F	IC50 = 97100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5N3CH	2-Bromo-1-(pyridin-2-yl)ethanone	Investigative	38384	C7H6BrNO	200.03	C1=CC=NC(=C1)C(=O)CBr	Ki = 173000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5NYZ0	Tetrahydroisoquinoline (TIQ) deriv. 10g	Investigative	23646404	C21H23N3O9S	493.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)COC3=CC=CC(=C3C(=O)OC)O)C=C(C=C2)NS(=O)(=O)O	IC50 = 93400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5WN4V	3-((S)-2-(3-Benzoyl-1-cyanoindolizin-5-yloxy)-4-methylpentanamido)-3-phenylpropanoic acid	Investigative	11678073	C31H29N3O5	523.6	CC(C)C[C@@H](C(=O)NC(CC(=O)O)C1=CC=CC=C1)OC2=CC=CC3=C(C=C(N32)C(=O)C4=CC=CC=C4)C#N	IC50 = 85100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B5Z0EG	Chembl4211055	Investigative	145965718	C17H22O2	258.35	CC1=CC(=CC2=C1C[C@@H]3[C@@H](CC[C@@]3(O2)C)C(=C)C)O	IC50 = 61000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B61ACQ	4-[N-[[2-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254280	C30H48N2O4	500.7	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1N(C)C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B64DYN	4-[[(4E)-3-Benzyl-2,5-dioxo-4-[(4-phenylmethoxyphenyl)methylidene]imidazolidin-1-yl]methyl]benzoic acid	Investigative	122193546	C32H26N2O5	518.6	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC4=CC=CC=C4)/C(=O)N(C2=O)CC5=CC=C(C=C5)C(=O)O	IC50 = 96000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B65FIV	5-((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yloxy)-1-cyanoindolizine-3-carboxylic acid	Investigative	44405958	C25H25N3O6	463.5	CC(C)C[C@@H](C(=O)NC(CC(=O)O)C1=CC=CC=C1)OC2=CC=CC3=C(C=C(N32)C(=O)O)C#N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6BR0N	(E)-3-(2,4-Dinitrostyryl)benzene-1,2-diol	Investigative	44432625	C14H10N2O6	302.24	C1=CC(=C(C(=C1)O)O)/C=C/C2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]	IC50 = 168000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6CWA0	Erythribyssin K	Investigative	56659163	C16H12O5	284.26	C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC(=C(C=C3)O)C=O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6EQC0	Azane;4-[(3S)-3-(methylcarbamoyl)-7-(sulfoamino)-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxobutanoic acid	Investigative	49797135	C15H22N4O7S	402.4	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC(=O)O)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 153500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6F9GS	2-[4-[[4-(Carboxymethoxy)-3-chlorophenyl]methyl-[[4-(thiadiazol-4-yl)phenyl]methyl]sulfamoyl]phenoxy]acetic acid	Investigative	44450283	C26H22ClN3O8S2	604.1	C1=CC(=CC=C1CN(CC2=CC(=C(C=C2)OCC(=O)O)Cl)S(=O)(=O)C3=CC=C(C=C3)OCC(=O)O)C4=CSN=N4	IC50 = 57700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6G1HU	3-(4-Hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one	Investigative	12458245	C17H14O5	298.29	COC1=CC2=C(C(=C1)OC)C(=O)C(=CO2)C3=CC=C(C=C3)O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6H2DV	2-[4-[(2S,5R)-5-Carbamoyl-2-[[(2S)-2-[3-(1H-indol-3-yl)propanoylamino]-5-oxo-5-phenylmethoxypentanoyl]amino]-7-methyl-3-oxooctyl]phenoxy]acetic acid	Investigative	44397522	C41H48N4O9	740.8	CC(C)C[C@H](CC(=O)[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)CCC3=CNC4=CC=CC=C43)C(=O)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6MI4U	4-[2-[3-[(2-Aminoacetyl)amino]phenyl]ethynyl]-2-[(3,4-dichlorophenyl)methylsulfanyl]benzoic acid	Investigative	54758004	C24H18Cl2N2O3S	485.4	C1=CC(=CC(=C1)NC(=O)CN)C#CC2=CC(=C(C=C2)C(=O)O)SCC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6OSK4	5-(1-Hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione	Investigative	54693142	C8H10O5	186.16	CC(=C1C(=O)OC(OC1=O)(C)C)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6Q7TJ	5-(1H-Indol-3-ylmethyl)-3-[3-(4-propylphenyl)phenyl]-1,2,4-oxadiazole	Investigative	127027706	C26H23N3O	393.5	CCCC1=CC=C(C=C1)C2=CC(=CC=C2)C3=NOC(=N3)CC4=CNC5=CC=CC=C54	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6QX9G	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]-2-bromophenoxy]-2,2-difluoroacetic acid	Investigative	44450318	C24H18BrF2N3O5S2	610.5	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC(=C(C=C4)OC(C(=O)O)(F)F)Br	IC50 = 52100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6SDC3	5-(3-((Tert-Butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylic acid	Investigative	45270378	C15H16N2O5	304.3	CC(C)(C)OC(=O)NC1=CC=CC(=C1)C2=CC(=NO2)C(=O)O	Ki = 199526.23 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6TNJ9	3-(3-Chlorobenzylthio)thiophene-2-carboxylic acid	Investigative	54757715	C12H9ClO2S2	284.8	C1=CC(=CC(=C1)Cl)CSC2=C(SC=C2)C(=O)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6UD9J	4-[2-(3-Chlorophenyl)ethynyl]-2-[(3,4-dichlorophenyl)methylsulfanyl]benzoic acid	Investigative	54758005	C22H13Cl3O2S	447.8	C1=CC(=CC(=C1)Cl)C#CC2=CC(=C(C=C2)C(=O)O)SCC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B6Z9IW	2-Bromo-1-(4-fluorophenyl)ethanone	Investigative	96749	C8H6BrFO	217.03	C1=CC(=CC=C1C(=O)CBr)F	Ki = 56000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B70HQG	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	135797387	C29H45NO4	471.7	CCCCCCCCCCCCCCCC(=NCC1=CC=CC(=C1)C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B76RDG	5-Benzyl-3-Bromo-2-hydroxybenzoic acid	Investigative	25101398	C14H11BrO3	307.14	C1=CC=C(C=C1)CC2=CC(=C(C(=C2)Br)O)C(=O)O	IC50 = 153000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B78VKF	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]-2-methylphenoxy]acetic acid	Investigative	44450263	C25H23N3O5S2	509.6	CC1=C(C=CC(=C1)CN(CC2=CC=C(C=C2)C3=CSN=N3)S(=O)(=O)C4=CC=CC=C4)OCC(=O)O	IC50 = 80700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7BU5X	3-Morpholin-4-ylmethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	12109539	C10H14N8O	262.27	C1COCCN1CC2=NC3=C(N=C(N=C3N=N2)N)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7CK5T	1,2,7-Trihydroxyxanthen-9-one	Investigative	137638732	C13H8O5	244.2	C1=CC2=C(C=C1O)C(=O)C3=C(O2)C=CC(=C3O)O	IC50 = 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7CL2G	(E)-N-(5-Ethyl-4-phenyl-1,3-thiazol-2-yl)-2-naphthalen-2-ylethenesulfonamide	Investigative	44337562	C23H20N2O2S2	420.6	CCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC3=CC=CC=C3C=C2)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7D2WZ	Azane;[(3S)-3-(methylcarbamoyl)-2-(5-phenylpentanoyl)-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797138	C22H30N4O5S	462.6	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCCCC3=CC=CC=C3)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 148000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7JV5Q	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	136254275	C29H45NO5	487.7	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)OC)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7MT5Q	3-[(3,4-Dimethylphenyl)methylsulfanyl]thiophene-2-carboxylic acid	Investigative	54757717	C14H14O2S2	278.4	CC1=C(C=C(C=C1)CSC2=C(SC=C2)C(=O)O)C	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7QX1F	2-[4-(Methylthio)-2-pyridinylmethylsulfinyl]-5-isopropoxy-1H-benzimidazole	Investigative	9863756	C17H19N3O2S2	361.5	CC(C)OC1=CC2=C(C=C1)N=C(N2)S(=O)CC3=NC=CC(=C3)SC	IC50 = 55200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7TK4I	5-(2-(3-Chloropropoxy)-4-methoxyphenyl)-3-phenylisoxazole	Investigative	54585350	C19H18ClNO3	343.8	COC1=CC(=C(C=C1)C2=CC(=NO2)C3=CC=CC=C3)OCCCCl	IC50 = 56780 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7UHW4	3-[1-(2-Methylbenzylamino)hexadecane-1-ylidene]-5-(hydroxymethyl)tetrahydrofuran-2,4-dione	Investigative	135797386	C29H45NO4	471.7	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7W6FS	6-[(2E)-3,7-Dimethylocta-2,6-dienyl]-4,8-dihydroxy-7-methoxyfuro[3,2-b]xanthen-5-one	Investigative	137642206	C26H26O6	434.5	CC(=CCC/C(=C/CC1=C(C(=CC2=C1C(=O)C3=C(O2)C=C4C(=C3O)C=CO4)O)OC)/C)C	IC50 = 55100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7XCP2	2-(7-(Benzyloxy)-1-(methoxymethyl)-1H-indol-3-yl)-3,3,3-trifluoro-2-hydroxypropanoic acid	Investigative	44444622	C20H18F3NO5	409.4	COCN1C=C(C2=C1C(=CC=C2)OCC3=CC=CC=C3)C(C(=O)O)(C(F)(F)F)O	IC50 = 176000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B7XOS2	2-[4-(2-Bromoacetyl)phenoxy]acetic Acid	Investigative	4966	C10H9BrO4	273.08	C1=CC(=CC=C1C(=O)CBr)OCC(=O)O	Ki = 193000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B80UNQ	5-Benzyl-2-hydroxybiphenyl-3-carboxylic acid	Investigative	19779154	C20H16O3	304.3	C1=CC=C(C=C1)CC2=CC(=C(C(=C2)C(=O)O)O)C3=CC=CC=C3	IC50 = 65000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B83DGR	Azane;[(3S)-2-(benzylcarbamoyl)-3-(methylcarbamoyl)-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797134	C19H25N5O5S	435.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)NCC3=CC=CC=C3)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 164000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B83HXZ	2-[4-[2-(Acetylsulfamoyl)-2-(1,3-benzoxazol-2-yl)ethyl]anilino]-2-oxoacetic acid	Investigative	73348832	C19H17N3O7S	431.4	CC(=O)NS(=O)(=O)C(CC1=CC=C(C=C1)NC(=O)C(=O)O)C2=NC3=CC=CC=C3O2	Ki = 63000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8BHM6	2-Naphthylglyoxylic acid	Investigative	9834233	C12H8O3	200.19	C1=CC=C2C=C(C=CC2=C1)C(=O)C(=O)O	IC50 = 190000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8CHW5	Chembl4210458	Investigative	102036608	C27H28O12	544.5	COC1=C(C=CC(=C1)/C=C/C(=O)O[C@@H]2C[C@](C[C@H]([C@@H]2OC(=O)/C=C/C3=CC(=C(C=C3)O)OC)O)(C(=O)O)O)O	IC50 = 67100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8F2JY	3-[[3-Carboxy-5-(furan-2-yl)-2-hydroxyphenyl]methyl]-5-(furan-2-yl)-2-hydroxybenzoic acid	Investigative	25101548	C23H16O8	420.4	C1=COC(=C1)C2=CC(=C(C(=C2)C(=O)O)O)CC3=C(C(=CC(=C3)C4=CC=CO4)C(=O)O)O	IC50 = 67000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8G0EQ	2-[2-[(Z)-(2,4-Dioxo-1,3-thiazolidin-5-ylidene)methyl]-5-phenylmethoxyphenoxy]acetic acid	Investigative	56679984	C19H15NO6S	385.4	C1=CC=C(C=C1)COC2=CC(=C(C=C2)/C=C\\3/C(=O)NC(=O)S3)OCC(=O)O	IC50 = 136000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8JZ0B	2-{4-[(S)-2-[(S)-4-Benzyloxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-2-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethyl]-phenoxy}-malonic acid	Investigative	44320456	C45H48N4O12	836.9	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)OC(C(=O)O)C(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35	IC50 = 116000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8MSX2	Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-hydroxypropanoate	Investigative	57380433	C12H17NNaO7P	341.23	CCOP(=O)(C(C1=CC=CC=C1O)N[C@@H](CO)C(=O)[O-])O.[Na+]	IC50 = 135000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8PU3Y	9-(Ethoxymethyl)-4-methyl-9-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46879577	C26H29N3O5	463.5	CCOCC1(COC2=C(C1=O)C3=C(C=C2)C(=CC(=O)O3)C)CN4CCN(CC4)C5=CC=CC=N5	IC50 = 76200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8QJ6V	2-(5-Phenyl-2-(2H-tetrazol-5-yl)thiophen-3-yloxy)acetic acid	Investigative	44439132	C13H10N4O3S	302.31	C1=CC=C(C=C1)C2=CC(=C(S2)C3=NNN=N3)OCC(=O)O	Ki = 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8QW2O	N-(4,5-Diphenyl-2-thiazolyl)-2-(4-nitrophenyl)ethenesulfonamide	Investigative	44337574	C23H17N3O4S2	463.5	C1=CC=C(C=C1)C2=C(SC(=N2)NS(=O)(=O)/C=C/C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4	IC50 = 58000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8RW4Z	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl]-2-hydroxyphenoxy]acetic acid	Investigative	71602532	C23H19FN2O7S	486.5	C1=CC=C2C(=C1)N=C(O2)C(CC3=CC(=C(C=C3)OCC(=O)O)O)S(=O)(=O)NC4=CC=C(C=C4)F	Ki = 66500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8T4DB	4-[2-(3-Aminophenyl)ethynyl]-2-[(3,4-dichlorophenyl)methylsulfanyl]benzoic acid	Investigative	54758003	C22H15Cl2NO2S	428.3	C1=CC(=CC(=C1)N)C#CC2=CC(=C(C=C2)C(=O)O)SCC3=CC(=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8TK9P	4-[5-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]thiophen-2-yl]aniline	Investigative	118722143	C21H16N4OS	372.4	C1=CC=C2C(=C1)C(=CN2)CC3=NC(=NO3)C4=CC=C(S4)C5=CC=C(C=C5)N	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8TXS7	[Difluoro-(2-methylquinolin-7-yl)methyl]phosphonic acid	Investigative	44449658	C11H10F2NO3P	273.17	CC1=NC2=C(C=C1)C=CC(=C2)C(F)(F)P(=O)(O)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8V7LI	Methyl 3-(2,4-dimethoxyphenyl)-5-phenyl-4,5-dihydro-1,2-oxazole-4-carboxylate	Investigative	76311979	C19H19NO5	341.4	COC1=CC(=C(C=C1)C2=NOC(C2C(=O)OC)C3=CC=CC=C3)OC	Ki = 135000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8XL7U	Subelliptenone G	Investigative	9916414	C13H8O5	244.2	C1=CC2=C(C(=C1)O)OC3=C(C=CC(=C3C2=O)O)O	IC50 = 148300 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8XPK4	3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	10172292	C17H21N9	351.4	C1CN(CCN1CC2=CC=CC=C2)CC3=NC4=C(N=C(N=C4N=N3)N)N	IC50 = 98000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B8Y5WS	3-Formyl-6-nitrochromone	Investigative	1268078	C10H5NO5	219.15	C1=CC2=C(C=C1[N+](=O)[O-])C(=O)C(=CO2)C=O	IC50 = 91000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B93IHM	2-[(Carboxycarbonyl)(1-naphthyl)amino]benzoic acid	Investigative	447411	C19H13NO5	335.3	C1=CC=C2C(=C1)C=CC=C2N(C3=CC=CC=C3C(=O)O)C(=O)C(=O)O	Ki = 158489.32 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B95SUQ	Methyl 2-[(4E)-3-benzyl-4-[(4-hydroxyphenyl)methylidene]-2,5-dioxoimidazolidin-1-yl]acetate	Investigative	122193482	C20H18N2O5	366.4	COC(=O)CN1C(=O)/C(=C\\C2=CC=C(C=C2)O)/N(C1=O)CC3=CC=CC=C3	IC50 = 136000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B95UHR	Narirutin	Investigative	442431	C27H32O14	580.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC=C(C=C5)O)O)O)O)O)O)O)O	IC50 = 56500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B96PFA	3-{2-[(3Z)-5-{[(3-Chloro-4-fluorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid	Investigative	135924018	C22H16ClFN4O5S	502.9	C1=CC(=CC(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)NCC4=CC(=C(C=C4)F)Cl)O)C(=O)O	IC50 = 54900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B96SHM	N-[4-(2-Naphthyl)-5-propyl-2-thiazolyl]-2-(2-naphthyl)ethenesulfonamide	Investigative	44337440	C28H24N2O2S2	484.6	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC3=CC=CC=C3C=C2)C4=CC5=CC=CC=C5C=C4	IC50 = 98000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B97CPZ	(E)-2-(2-Chlorophenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337607	C26H23ClN2O2S2	495.1	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=CC=C2Cl)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B98RTA	3-Ethynyl-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	Investigative	71597177	C17H10O4	278.26	C#CC1=C(OC2=CC(=C(C=C21)C(=O)O)O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9BYT7	(2S)-7-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-2,3-dihydrochromen-4-one	Investigative	56669529	C16H14O5	286.28	COC1=C(C=CC(=C1)[C@@H]2CC(=O)C3=C(O2)C=C(C=C3)O)O	IC50 = 98100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9EKY8	Ethyl (E)-2-[4-[4-[4-[(E)-2-ethoxysulfonylethenyl]phenoxy]butoxy]phenyl]ethenesulfonate	Investigative	137634422	C24H30O8S2	510.6	CCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCCCCOC2=CC=C(C=C2)/C=C/S(=O)(=O)OCC	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9GD1N	(2S)-2-(3,8-Dihydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)-7-hydroxy-2,3-dihydrochromen-4-one	Investigative	44589232	C20H20O6	356.4	CC1(C(CC2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(O3)C=C(C=C4)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9GDN4	2-Amino-4,5-bis(4-methoxyphenyl)-6-methylsulfanylbenzene-1,3-dicarbonitrile	Investigative	44591657	C23H19N3O2S	401.5	COC1=CC=C(C=C1)C2=C(C(=C(C(=C2C3=CC=C(C=C3)OC)SC)C#N)N)C#N	IC50 = 72000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9GJ0L	5-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]-1-benzofuran-2-carboxylic acid	Investigative	44450221	C25H19N3O5S2	505.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC5=C(C=C4)OC(=C5)C(=O)O	IC50 = 63600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9GT2I	3-(2,4-Dimethoxyphenyl)-5-phenyl-4,5-dihydro-1,2-oxazole	Investigative	76319197	C17H17NO3	283.32	COC1=CC(=C(C=C1)C2=NOC(C2)C3=CC=CC=C3)OC	IC50 = 69000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9H0DY	N-(4-Fluoro-1,3-benzothiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine	Investigative	7158830	C16H11FN4O2S	342.3	COC1=CC=C(C=C1)C2=NN=C(O2)NC3=NC4=C(C=CC=C4S3)F	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9H1WU	Chembl4218731	Investigative	145969860	C19H18O7	358.3	CC1(C(OC2=C1C3=C(C(=C2)O)C(=O)C4=C(O3)C(=C(C=C4)O)OC)CO)C	IC50 = 52500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9I0DV	(4-(4-Bromo-3,5-bis(trifluoromethyl)phenylcarbamoyl)phenyl)difluoromethylphosphonic acid	Investigative	46186815	C16H9BrF8NO4P	542.11	C1=CC(=CC=C1C(=O)NC2=CC(=C(C(=C2)C(F)(F)F)Br)C(F)(F)F)C(F)(F)P(=O)(O)O	Ki ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9IR4K	[(4-Hydroxy-2-naphthyl)difluoromethyl]phosphonic acid	Investigative	10468556	C11H9F2O4P	274.16	C1=CC=C2C(=C1)C=C(C=C2O)C(F)(F)P(=O)(O)O	Ki = 93000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9J7KO	4-[3-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]phenyl]aniline	Investigative	118722144	C23H18N4O	366.4	C1=CC=C2C(=C1)C(=CN2)CC3=NC(=NO3)C4=CC=CC(=C4)C5=CC=C(C=C5)N	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9MS1Z	3-[2-(3-Fluorophenyl)ethyl]-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid	Investigative	71561818	C23H17FO4	376.4	C1=CC=C(C=C1)C2=C(C3=CC(=C(C=C3O2)O)C(=O)O)CCC4=CC(=CC=C4)F	IC50 = 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9MVG1	3,3,3-Trifluoro-2-hydroxy-2-(5-(2-(3-hydroxy-2-(methoxycarbonyl)phenoxy)ethoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-3-yl)propanoic acid	Investigative	44444623	C27H32F3NO9Si	599.6	COC(=O)C1=C(C=CC=C1OCCOC2=CC3=C(C=C2)N(C=C3C(C(=O)O)(C(F)(F)F)O)COCC[Si](C)(C)C)O	IC50 = 123000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9NUQ0	(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[[1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]triazol-4-yl]methoxy]propanoic acid	Investigative	56670423	C17H28N4O10	448.4	CC(C)(C)OC(=O)N[C@@H](COCC1=CN(N=N1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9OP5H	Erythribyssin I	Investigative	56673038	C20H20O5	340.4	CC1(C(CC2=C(O1)C=CC(=C2)[C@@H]3CC(=O)C4=C(O3)C=C(C=C4)O)O)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9PNV5	(2S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid	Investigative	56660070	C39H48N4O10	732.8	CC(C)(C)OC(=O)N[C@@H](COCC1=CN(N=N1)C[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)OC)OCC3=CC=CC=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5)C(=O)O	IC50 = 67800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9THJ1	Ethyl (E)-2-[4-[(5-phenyl-1,2-oxazol-3-yl)methoxy]phenyl]ethenesulfonate	Investigative	70691145	C20H19NO5S	385.4	CCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCC2=NOC(=C2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9WSU3	[(3-Bromonaphthalen-2-yl)-difluoromethyl]phosphonic acid	Investigative	44449592	C11H8BrF2O3P	337.05	C1=CC=C2C=C(C(=CC2=C1)C(F)(F)P(=O)(O)O)Br	Ki = 179000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	B9WVP4	3-{2-[(3Z)-5-({[4-Chloro-3-(trifluoromethyl)phenyl]methyl}sulfamoyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid	Investigative	135924020	C23H16ClF3N4O5S	552.9	C1=CC(=CC(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)NCC4=CC(=C(C=C4)Cl)C(F)(F)F)O)C(=O)O	IC50 = 63100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BA17YK	2-[3-Oxo-3-phenyl-1-((4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl)-propyl]-malonic acid	Investigative	44303453	C27H36O5	440.6	CC1=C([C@]2(CCCC([C@@H]2CC1)(C)C)C)CC(CC(=O)C3=CC=CC=C3)C(C(=O)O)C(=O)O	IC50 = 68000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BA4S2T	Sulfuric acid mono-(1-naphthalen-1-ylmethyl-3-phenyl-propyl) ester	Investigative	44303518	C20H20O4S	356.4	C1=CC=C(C=C1)CCC(CC2=CC=CC3=CC=CC=C32)OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BA6U2Q	Sodium; 3-hydroxy-4-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)-naphthalene-1-sulfonate	Investigative	65235	C20H16N4O5S	424.4	CC1=C(C(=O)N(N1)C2=CC=CC=C2)N=NC3=C(C=C(C4=CC=CC=C43)S(=O)(=O)O)O	IC50 = 150000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BA7TK2	3-[(4-Chlorobenzyl)sulfanyl]-2-thiophenecarboxylic acid	Investigative	2765069	C12H9ClO2S2	284.8	C1=CC(=CC=C1CSC2=C(SC=C2)C(=O)O)Cl	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BA84YR	CID 58746753	Investigative	58746753	C30H29F3N4O6S	630.6	C1C(S(=O)(=O)NC1=O)C2=CC=C(C=C2)C[C@@H](C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CC4=CC=C(C=C4)C(F)(F)F	IC50 = 169824.37 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BACN73	4-[N-[(2-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254277	C28H42ClNO4	492.1	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1Cl)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BAFY26	4-[N-[(4-Chlorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254273	C28H42ClNO4	492.1	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)Cl)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BAKB17	3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	10198815	C10H16N8	248.29	CCN(CC)CC1=NC2=C(N=C(N=C2N=N1)N)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BAOQ07	2-[(4E)-3-Benzyl-2,5-dioxo-4-[(4-phenylmethoxyphenyl)methylidene]imidazolidin-1-yl]acetic acid	Investigative	122193543	C26H22N2O5	442.5	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC4=CC=CC=C4)/C(=O)N(C2=O)CC(=O)O	IC50 = 113000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BAWI57	2-Hydroxy-5-[[(2-thioxo-2,3-dihydro-1H-benzimidazole-1-yl)methyl]amino]benzoic acid	Investigative	15520072	C15H13N3O3S	315.3	C1=CC=C2C(=C1)NC(=S)N2CNC3=CC(=C(C=C3)O)C(=O)O	Ki = 61000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BAY2C9	Tetrahydroisoquinoline (TIQ) deriv. 10c	Investigative	11327911	C21H25N3O5S	431.5	CC1=CC=C(C=C1)CCC(=O)N2CC3=C(C[C@H]2C(=O)NC)C=CC(=C3)NS(=O)(=O)O	IC50 = 198000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BB17YK	3-(Phenylethynyl)-alpha,alpha-difluorobenzylphosphonic acid	Investigative	44366440	C15H11F2O3P	308.22	C1=CC=C(C=C1)C#CC2=CC(=CC=C2)C(F)(F)P(=O)(O)O	IC50 = 135900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BB35EK	Sodium;difluoro-(3-phenylphenyl)methanesulfonate	Investigative	23673589	C13H9F2NaO3S	306.26	C1=CC=C(C=C1)C2=CC(=CC=C2)C(F)(F)S(=O)(=O)[O-].[Na+]	IC50 = 115000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BB54WL	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-(butylsulfamoyl)ethyl]anilino]-2-oxoacetic acid	Investigative	71602534	C21H23N3O6S	445.5	CCCCNS(=O)(=O)C(CC1=CC=C(C=C1)NC(=O)C(=O)O)C2=NC3=CC=CC=C3O2	Ki = 82400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BB6J7V	1-(2,5-Dimethoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one	Investigative	7947894	C21H18O3	318.4	COC1=CC(=C(C=C1)OC)C(=O)/C=C/C2=CC3=CC=CC=C3C=C2	IC50 = 144540 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BBD6E4	3-(2,3-Dichlorobenzylthio)thiophene-2-carboxylic acid	Investigative	54757716	C12H8Cl2O2S2	319.2	C1=CC(=C(C(=C1)Cl)Cl)CSC2=C(SC=C2)C(=O)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BBF4O8	3-(2,4-Dimethoxyphenyl)-5-imidazol-1-yl-4,5-dihydro-1,2-oxazole	Investigative	76319196	C14H15N3O3	273.29	COC1=CC(=C(C=C1)C2=NOC(C2)N3C=CN=C3)OC	Ki = 63000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BBU4W0	6-(((S)-1-(2-Carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-1-cyanoindolizine-3-carboxylic acid	Investigative	44405933	C26H26N4O6	490.5	CC(C)C[C@@H](C(=O)NC(CC(=O)O)C1=CC=CC=C1)NC(=O)C2=CN3C(=C(C=C3C(=O)O)C#N)C=C2	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BBW19O	Glabrone	Investigative	5317652	C20H16O5	336.3	CC1(C=CC2=C(O1)C=CC(=C2O)C3=COC4=C(C3=O)C=CC(=C4)O)C	IC50 = 66300 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC13LH	6-Fluoro-3-formylchromone	Investigative	688893	C10H5FO3	192.14	C1=CC2=C(C=C1F)C(=O)C(=CO2)C=O	IC50 = 55000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC2L0Z	2-(4-Methyl-5-phenyl-2-(2H-tetrazol-5-yl)thiophen-3-yloxy)acetic acid	Investigative	44439131	C14H12N4O3S	316.34	CC1=C(SC(=C1OCC(=O)O)C2=NNN=N2)C3=CC=CC=C3	Ki = 170000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC2V3Q	Oxalylarylaminobenzoic Acid Analog 8d	Investigative	11001493	C17H15NO5	313.3	CCC1=CC=CC=C1N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)O	Ki = 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC5T0I	(E)-2-(4-Cyano-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide	Investigative	44337581	C24H17N3O2S2	443.5	C1=CC=C(C=C1)C2=C(SC(=N2)NS(=O)(=O)/C=C/C3=CC=C(C=C3)C#N)C4=CC=CC=C4	IC50 = 58000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC76KX	9-Ethoxymethyl-4-methyl-9-(4-phenyl-piperazin-1-yl-methyl)-8,9-dihydro-pyrano[2,3-f]chromene-2,10-dione	Investigative	46879576	C27H30N2O5	462.5	CCOCC1(COC2=C(C1=O)C3=C(C=C2)C(=CC(=O)O3)C)CN4CCN(CC4)C5=CC=CC=C5	IC50 = 70600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BC7GI1	4-[(E)-2-(4,5-Diphenyl-thiazol-2-ylsulfamoyl)-vinyl]-benzoic acid methyl ester	Investigative	44337604	C25H20N2O4S2	476.6	COC(=O)C1=CC=C(C=C1)/C=C/S(=O)(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 59000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BCK05V	3-(2,4-Dimethoxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1,2-oxazole	Investigative	76330041	C18H19NO4	313.3	COC1=CC=C(C=C1)C2CC(=NO2)C3=C(C=C(C=C3)OC)OC	IC50 = 67000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BCN68R	5-[3-[(E)-4-Hydroxy-3-(3-hydroxy-2-methoxycarbonylphenoxy)but-1-enyl]phenyl]-1,2-oxazole-3-carboxylic acid	Investigative	11189464	C22H19NO8	425.4	COC(=O)C1=C(C=CC=C1OC(CO)/C=C/C2=CC(=CC=C2)C3=CC(=NO3)C(=O)O)O	Ki = 50118.72 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BCZ8J1	2-(Carboxyformamido)thiophene-3-carboxylic acid	Investigative	44359237	C7H5NO5S	215.19	C1=CSC(=C1C(=O)O)NC(=O)C(=O)O	Ki = 107151.93 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BD26PI	PTP1B Inhibitor, 6	Investigative	71463480	C22H23NO4	365.4	CC1(C=CC2=C(O1)C=CC(=C2OC)C3=NOC(C3)C4=CC=C(C=C4)OC)C	Ki = 56000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BD4J1Z	Ethyl (E)-3-[6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzofuran-2-yl]prop-1-ene-1-sulfonate	Investigative	70697356	C25H25NO6S	467.5	CCOS(=O)(=O)/C=C/CC1=CC2=C(O1)C=C(C=C2)OCCC3=C(OC(=N3)C4=CC=CC=C4)C	IC50 = 84600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BD4UX9	4-[N-[(3-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254281	C28H42FNO4	475.6	CCCCCCCCCCCCCCCC(=NCC1=CC(=CC=C1)F)C2=C(C(OC2=O)CO)O	IC50 = 83700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BD9YH1	Chembl4206173	Investigative	145975895	C24H19NO4	385.4	CC1=CC(=CC(=C1O)C)C2=CC(=CC=C2)C3=C(ON=C3C(=O)O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BDA15T	5-[(2,3-Dioxoindol-1-yl)methyl]furan-2-carbaldehyde	Investigative	71452583	C14H9NO4	255.22	C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(O3)C=O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BDC19Y	PTP1B Inhibitor, 19	Investigative	71463488	C19H17NO5	339.3	CC(=O)OC1=CC(=C(C=C1)C2=NOC(C2)C3=CC=CC=C3)OC(=O)C	IC50 = 62700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BDN74I	N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-(4-nitrophenyl)ethenesulfonamide	Investigative	44337596	C19H17N3O4S2	415.5	CCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3	IC50 = 83000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BDR68Y	Ethyl (E)-2-[2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-4-phenylmethoxyphenyl]ethenesulfonate	Investigative	70686949	C29H29NO6S	519.6	CCOS(=O)(=O)/C=C/C1=C(C=C(C=C1)OCC2=CC=CC=C2)OCCC3=C(OC(=N3)C4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BE0I1X	Moracin O	Investigative	14539883	C19H18O5	326.3	CC(C)(C1CC2=C(O1)C=C3C(=C2)C=C(O3)C4=CC(=CC(=C4)O)O)O	IC50 ~ 80000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BE0PC8	Echinatin	Investigative	6442675	C16H14O4	270.28	COC1=C(C=CC(=C1)O)/C=C/C(=O)C2=CC=C(C=C2)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BE8M1Q	3-(4-Methoxybenzofuran-5-yl)-5-phenyl-4,5-dihydroisoxazole	Investigative	11266347	C18H15NO3	293.3	COC1=C(C=CC2=C1C=CO2)C3=NOC(C3)C4=CC=CC=C4	IC50 = 76000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BE8S7U	(2S,3S)-2-[[(3S,6R,9S,12S,15S)-3-Benzyl-6-[2-[2-(carbamoylamino)phenyl]-2-oxoethyl]-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid	Investigative	44415112	C45H65N9O10	892.1	CC[C@H](C)[C@@H](C(=O)O)NC(=O)N[C@H]1CCCCNC(=O)[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)CC(C)C)C)CC(=O)C2=CC=CC=C2NC(=O)N)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BE9X4D	Sigmoidin D	Investigative	129362	C20H20O7	372.4	CC1([C@H](CC2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BEF67A	3-(6-Bromopyridin-2-yl)-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole	Investigative	127027724	C16H11BrN4O	355.19	C1=CC=C2C(=C1)C(=CN2)CC3=NC(=NO3)C4=NC(=CC=C4)Br	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BEI0W4	Chromone-3-carboxaldehyde	Investigative	87112	C10H6O3	174.15	C1=CC=C2C(=C1)C(=O)C(=CO2)C=O	IC50 = 73000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BEKB42	4-({4-[(E)-(1-Ethyl-2,5-dioxoimidazolidin-4-ylidene)methyl]-2-iodophenoxy}methyl)benzoic acid	Investigative	6504357	C20H17IN2O5	492.3	CCN1C(=O)/C(=C\\C2=CC(=C(C=C2)OCC3=CC=C(C=C3)C(=O)O)I)/NC1=O	IC50 = 63800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BEM64F	Benzarone	Investigative	255968	C17H14O3	266.29	CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC=C(C=C3)O	IC50 ~ 150000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BEVX34	9-(Hydroxymethyl)-4-methyl-9-(pyrrolidin-1-ylmethyl)-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46882183	C19H21NO5	343.4	CC1=CC(=O)OC2=C1C=CC3=C2C(=O)C(CO3)(CN4CCCC4)CO	IC50 = 56700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BF0ZP8	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	135797397	C28H43NO5	473.6	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)O)C2=C(C(OC2=O)CO)O	IC50 = 68100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BF2OY9	N-[4-(4-Chlorophenyl)-5-methyl-2-thiazolyl]-2-(3,4-difluorophenyl)ethenesulfonamide	Investigative	44337423	C18H13ClF2N2O2S2	426.9	CC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC(=C(C=C2)F)F)C3=CC=C(C=C3)Cl	IC50 = 51000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BF37VR	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	135797389	C29H45NO5	487.7	CCCCCCCCCCCCCCCC(=NCC1=CC(=CC=C1)OC)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BF7ZA0	Methyl 4-[4-[5-[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]thiophen-2-yl]phenoxy]butanoate	Investigative	127025578	C26H23N3O4S	473.5	COC(=O)CCCOC1=CC=C(C=C1)C2=CC=C(S2)C3=NOC(=N3)CC4=CNC5=CC=CC=C54	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFC8A3	4-[N-[[4-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254276	C30H48N2O4	500.7	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)N(C)C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFL43Q	3-(Carboxyformamido)isonicotinic acid	Investigative	10998288	C8H6N2O5	210.14	C1=CN=CC(=C1C(=O)O)NC(=O)C(=O)O	Ki = 158489.32 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFL8C1	3,4-Dichloro-N-[4-(4-chloro-benzenesulfonyl)-5-methylsulfanyl-2H-pyrazol-3-yl]-benzamide	Investigative	2819267	C17H12Cl3N3O3S2	476.8	CSC1=NNC(=C1S(=O)(=O)C2=CC=C(C=C2)Cl)NC(=O)C3=CC(=C(C=C3)Cl)Cl	IC50 = 63900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFM4Y6	2-[2,3-Dimethyl-N-(2-oxopropanoyl)anilino]benzoic acid	Investigative	76308036	C18H17NO4	311.3	CC1=C(C(=CC=C1)N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)C)C	Ki = 93000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFN0G1	2-[2-[(E)-3-Hydroxyprop-1-enyl]-N-oxaloanilino]benzoic acid	Investigative	45268796	C18H15NO6	341.3	C1=CC=C(C(=C1)/C=C/CO)N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)O	Ki = 50118.72 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFTO82	(2S,3S)-2-[[(3S,6S,9S,12S,15S)-3-Benzyl-6-(1H-indol-3-ylmethyl)-7-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazacyclononadec-15-yl]carbamoylamino]-3-methylpentanoic acid	Investigative	11844604	C45H64N8O8	845	CC[C@H](C)[C@@H](C(=O)O)NC(=O)N[C@H]1CCCCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)CC(C)C)C)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BFV82U	Euxanthone	Investigative	5281631	C13H8O4	228.2	C1=CC(=C2C(=C1)OC3=C(C2=O)C=C(C=C3)O)O	IC50 = 149900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG0R4I	4-[(E)-2-(5-Bromo-3-carboxy-4-hydroxyphenyl)vinyl]-2-hydroxybenzoic acid	Investigative	44563592	C16H11BrO6	379.16	C1=CC(=C(C=C1/C=C/C2=CC(=C(C(=C2)Br)O)C(=O)O)O)C(=O)O	IC50 = 64000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG1B5O	2-[(3,4-Dichlorophenyl)methylsulfanyl]-N-methylsulfonylbenzamide	Investigative	54757905	C15H13Cl2NO3S2	390.3	CS(=O)(=O)NC(=O)C1=CC=CC=C1SCC2=CC(=C(C=C2)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG1IS9	(S)-4-[(S)-1-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-2-(4-carboxymethoxy-phenyl)-ethylcarbamoyl]-4-phenethyloxycarbonylamino-butyric acid benzyl ester	Investigative	10327524	C38H46N4O10	718.8	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)OCC(=O)O)NC(=O)[C@H](CCC(=O)OCC2=CC=CC=C2)NC(=O)OCCC3=CC=CC=C3	IC50 = 58200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG1M7E	3-((S)-2-(1-Cyano-3-(ethoxycarbonyl)indolizin-5-yloxy)-4-methylpentanamido)-3-phenylpropanoic acid	Investigative	44405959	C27H29N3O6	491.5	CCOC(=O)C1=CC(=C2N1C(=CC=C2)O[C@@H](CC(C)C)C(=O)NC(CC(=O)O)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG25EQ	4-Bromo-2-[(3,4-dichlorophenyl)methylsulfanyl]benzoic acid	Investigative	54757906	C14H9BrCl2O2S	392.1	C1=CC(=C(C=C1CSC2=C(C=CC(=C2)Br)C(=O)O)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG30SO	(E)-2-(3,4-Difluorophenyl)-N-(4,5-diphenyl-1,3-thiazol-2-yl)ethenesulfonamide	Investigative	44337392	C23H16F2N2O2S2	454.5	C1=CC=C(C=C1)C2=C(SC(=N2)NS(=O)(=O)/C=C/C3=CC(=C(C=C3)F)F)C4=CC=CC=C4	IC50 = 85000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG65MT	2,5-Dihydroxybenzoic acid	Investigative	3469	C7H6O4	154.12	C1=CC(=C(C=C1O)C(=O)O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BG9Y0N	1-(2-Hydroxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one	Investigative	7729033	C19H14O2	274.3	C1=CC=C2C(=C1)C=CC=C2/C=C/C(=O)C3=CC=CC=C3O	IC50 = 158490 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGEL02	4-[5-(4-Carboxymethoxybenzylidene)-2,4-dioxothiazolidin-3-yl]methylbenzoic acid	Investigative	18864298	C20H15NO7S	413.4	C1=CC(=CC=C1CN2C(=O)/C(=C/C3=CC=C(C=C3)OCC(=O)O)/SC2=O)C(=O)O	IC50 = 85000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGFE50	7-Phenyl-furo[3,2-g]chromen-5-one	Investigative	44422146	C17H10O3	262.26	C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C4C(=C3)C=CO4	Ki = 57000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGM62E	Glyinflanin H	Investigative	15233562	C19H16O4	308.3	CC1(C=CC2=C(O1)C=CC(=C2O)C3=CC4=C(O3)C=C(C=C4)O)C	IC50 = 64900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGQ5Z0	4-[6-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl]phenol	Investigative	137174949	C22H16N4O2	368.4	C1=CC=C2C(=C1)C(=CN2)CC3=NC(=NO3)C4=CC=CC(=N4)C5=CC=C(C=C5)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGTH52	Benzoic acid, 3,3'-methylenebis[5-bromo-2-hydroxy-	Investigative	268455	C15H10Br2O6	446.04	C1=C(C=C(C(=C1CC2=C(C(=CC(=C2)Br)C(=O)O)O)O)C(=O)O)Br	IC50 = 149000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BGVD32	Tetrahydroisoquinoline (TIQ) deriv. 10e	Investigative	23646403	C21H22F3N3O5S	485.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC(=CC=C3)C(F)(F)F)C=C(C=C2)NS(=O)(=O)O	IC50 = 146000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BH17PW	3-(4-Phenyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	44329839	C16H19N9	337.38	C1CN(CCN1CC2=NC3=C(N=C(N=C3N=N2)N)N)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BH1L7C	Oxalylarylaminobenzoic Acid Analog 8c	Investigative	11046051	C19H17NO5	339.3	C1CCC2=C(C1)C=CC=C2N(C3=CC=CC=C3C(=O)O)C(=O)C(=O)O	Ki = 74000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BH7F5P	2-[(4E)-3-Benzyl-4-[[4-(carboxymethoxy)phenyl]methylidene]-2,5-dioxoimidazolidin-1-yl]acetic acid	Investigative	122193542	C21H18N2O7	410.4	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC(=O)O)/C(=O)N(C2=O)CC(=O)O	IC50 = 122000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BH9D2P	(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337409	C18H14Cl2N2O2S2	425.4	CC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=CC=C2Cl)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BHP9D7	(E)-4-(2,4-Dinitrostyryl)benzene-1,2-diol	Investigative	44432624	C14H10N2O6	302.24	C1=CC(=C(C=C1/C=C/C2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-])O)O	IC50 = 190000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BHU1V7	9-(Hydroxymethyl)-4-methyl-9-(morpholin-4-ylmethyl)-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46882139	C19H21NO6	359.4	CC1=CC(=O)OC2=C1C=CC3=C2C(=O)C(CO3)(CN4CCOCC4)CO	IC50 = 52400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BI58WQ	4-(Carboxyformamido)thiophene-3-carboxylic acid	Investigative	11745998	C7H5NO5S	215.19	C1=C(C(=CS1)NC(=O)C(=O)O)C(=O)O	Ki = 75000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BI93BZ	3-(Naphthalen-2-ylmethylsulfanyl)thiophene-2-carboxylic acid	Investigative	54757809	C16H12O2S2	300.4	C1=CC=C2C=C(C=CC2=C1)CSC3=C(SC=C3)C(=O)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BIC16G	4-[N-[(2-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254278	C28H42FNO4	475.6	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1F)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BIC1F2	[1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]-3-methylbutan-2-yl] hydrogen sulfate	Investigative	44303580	C19H34O4S	358.5	CC1=CC[C@@H]2[C@@]([C@H]1CC(C(C)C)OS(=O)(=O)O)(CCCC2(C)C)C	IC50 = 110000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BID8O3	6-[(2S)-5,7-Dihydroxy-4-oxo-2,3-dihydrochromen-2-yl]-8-hydroxy-2,2-dimethyl-3H-chromen-4-one	Investigative	44589231	C20H18O7	370.4	CC1(CC(=O)C2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BIGW90	(5-Benzyloxy-3-hydroxy-biphenyl-4-yloxy)-acetic acid	Investigative	44434674	C21H18O5	350.4	C1=CC=C(C=C1)COC2=CC(=CC(=C2OCC(=O)O)O)C3=CC=CC=C3	IC50 = 93000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BIH12T	(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(2S)-2-Hydroxy-6-methylhept-6-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol	Investigative	71719758	C30H52O3	460.7	CC(=C)CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BIMR52	2-(2-Allyl-4,5-dibromothiophen-3-yloxy)acetic acid	Investigative	44439124	C9H8Br2O3S	356.03	C=CCC1=C(C(=C(S1)Br)Br)OCC(=O)O	IC50 = 165000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ13ED	N-(4,5-Diphenyl-2-thiazolyl)-2-(3,4-dimethoxyphenyl)ethenesulfonamide	Investigative	44337726	C25H22N2O4S2	478.6	COC1=C(C=C(C=C1)/C=C/S(=O)(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC=CC=C4)OC	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ3EU4	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]sulfanylacetic acid	Investigative	44450252	C24H21N3O4S3	511.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)SCC(=O)O	IC50 = 115000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ4L2D	6-Benzyl-2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid	Investigative	9863691	C17H16N2O5S	360.4	C1CN(CC2=C1C(=C(S2)NC(=O)C(=O)O)C(=O)O)CC3=CC=CC=C3	Ki = 63095.73 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ5P8S	Glycyrrhisoflavone	Investigative	5317764	C20H18O6	354.4	CC(=CCC1=C(C(=CC(=C1)C2=COC3=CC(=CC(=C3C2=O)O)O)O)O)C	IC50 = 58700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ73YB	6-Hydroxy-3-[2-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethynyl]-2-phenyl-1-benzofuran-5-carboxylic acid	Investigative	71717989	C36H36O6	564.7	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C#CC5=C(OC6=CC(=C(C=C65)C(=O)O)O)C7=CC=CC=C7)O)C	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJ7QR5	(Z)-5-[4-(4-Fluorobenzyloxy)benzylidene]thiazolidine-2,4-dione	Investigative	5605148	C17H12FNO3S	329.3	C1=CC(=CC=C1COC2=CC=C(C=C2)/C=C\\3/C(=O)NC(=O)S3)F	IC50 = 68000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJAG79	3-[2-(2-Nitrophenyl)hydrazinyl]-2-oxoindole-5-sulfonic acid	Investigative	3246406	C14H10N4O6S	362.32	C1=CC=C(C(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)O)O)[N+](=O)[O-]	IC50 = 96700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJPW06	5-[(5-Methyl-2,3-dioxoindol-1-yl)methyl]furan-2-carbaldehyde	Investigative	71456090	C15H11NO4	269.25	CC1=CC2=C(C=C1)N(C(=O)C2=O)CC3=CC=C(O3)C=O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJQ3V6	1-[2-(7-Acetyl-6-hydroxy-1-benzofuran-3-yl)-6-hydroxy-1-benzofuran-7-yl]ethanone	Investigative	44422179	C20H14O6	350.3	CC(=O)C1=C(C=CC2=C1OC(=C2)C3=COC4=C3C=CC(=C4C(=O)C)O)O	Ki = 54000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BJY3R0	3-Piperazin-1-ylmethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	12109536	C10H15N9	261.29	C1CN(CCN1)CC2=NC3=C(N=C(N=C3N=N2)N)N	IC50 = 91000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK16DQ	Glycycoumarin	Investigative	5317756	C21H20O6	368.4	CC(=CCC1=C(C2=C(C=C1O)OC(=O)C(=C2)C3=C(C=C(C=C3)O)O)OC)C	IC50 = 183900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK1DP0	9-(Hydroxymethyl)-4-methyl-9-(piperidin-1-ylmethyl)-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46882140	C20H23NO5	357.4	CC1=CC(=O)OC2=C1C=CC3=C2C(=O)C(CO3)(CN4CCCCC4)CO	IC50 = 62100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK37HB	5-[(5-Chloro-2,3-dioxoindol-1-yl)methyl]furan-2-carbaldehyde	Investigative	71457901	C14H8ClNO4	289.67	C1=CC2=C(C=C1Cl)C(=O)C(=O)N2CC3=CC=C(O3)C=O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK5UV3	Methyl 4-[4-[3-[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]phenyl]phenoxy]butanoate	Investigative	127028347	C28H25N3O4	467.5	COC(=O)CCCOC1=CC=C(C=C1)C2=CC(=CC=C2)C3=NOC(=N3)CC4=CNC5=CC=CC=C54	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK67XD	Macroantoin F	Investigative	10392218	C26H26O12	530.5	COC(=O)[C@@]1(C[C@H]([C@H]([C@@H](C1)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)O)O	IC50 = 56000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK6JX3	Ethyl (E)-2-[4-[2-[(4-phenyl-1,3-thiazol-2-yl)amino]ethoxy]phenyl]ethenesulfonate	Investigative	70693259	C21H22N2O4S2	430.5	CCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCCNC2=NC(=CS2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK71IF	2-[4-[2-Amino-3-oxo-3-(pentylamino)propyl]-N-oxaloanilino]benzoic acid	Investigative	44306768	C23H27N3O6	441.5	CCCCCNC(=O)C(CC1=CC=C(C=C1)N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)O)N	Ki ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK7L3U	3-(4-Methoxybenzofuran-5-yl)-5-(4-methoxyphenyl)-4,5-dihydroisoxazole	Investigative	44410095	C19H17NO4	323.3	COC1=CC=C(C=C1)C2CC(=NO2)C3=C(C4=C(C=C3)OC=C4)OC	IC50 = 81000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK7XE1	Naringin	Investigative	442428	C27H32O14	580.5	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK89PN	5-(3-(((1-Acetylpiperidin-4-yl)carbonyl)amino)phenyl)isoxazole-3-carboxylic Acid	Investigative	9998434	C18H19N3O5	357.4	CC(=O)N1CCC(CC1)C(=O)NC2=CC=CC(=C2)C3=CC(=NO3)C(=O)O	Ki = 79432.82 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BK9D0Q	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]-2-oxoacetic acid	Investigative	44450343	C24H19N3O5S2	493.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)C(=O)C(=O)O	IC50 = 60300 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKA1U9	4-Bromo-3-(carboxymethoxy)thiophene-2-carboxylic acid	Investigative	9547975	C7H5BrO5S	281.08	C1=C(C(=C(S1)C(=O)O)OCC(=O)O)Br	Ki = 160000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKE48O	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-[(4-methylphenyl)sulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602708	C24H21N3O6S	479.5	CC1=CC=C(C=C1)NS(=O)(=O)C(CC2=CC=C(C=C2)NC(=O)C(=O)O)C3=NC4=CC=CC=C4O3	Ki = 62000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKL73U	Tetrahydroisoquinoline (TIQ) deriv. 10h	Investigative	11316438	C20H23N3O6S	433.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC(=CC=C3)O)C=C(C=C2)NS(=O)(=O)O	IC50 = 82100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKNE09	Difluoro(1-naphthyl)methylphosphonic acid	Investigative	10332717	C11H9F2O3P	258.16	C1=CC=C2C(=C1)C=CC=C2C(F)(F)P(=O)(O)O	IC50 = 112000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKR01D	N-[4-(4-Biphenylyl)-5-propyl-2-thiazolyl]-2-[4-(trifluoromethyl)phenyl]ethenesulfonamide	Investigative	44337454	C27H23F3N2O2S2	528.6	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKRQ36	6-Hydroxy-3-(3-hydroxyprop-1-ynyl)-2-phenyl-benzofuran-5-carboxylic acid	Investigative	71561559	C18H12O5	308.3	C1=CC=C(C=C1)C2=C(C3=CC(=C(C=C3O2)O)C(=O)O)C#CCO	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BKV5M7	Methyl 3-(4-methoxybenzofuran-5-yl)-5-phenyl-4,5-dihydroisoxazole-4-carboxylate	Investigative	44410062	C20H17NO5	351.4	COC1=C(C=CC2=C1C=CO2)C3=NOC(C3C(=O)OC)C4=CC=CC=C4	Ki = 72500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BL1SR7	Chembl4214128	Investigative	145971302	C8H5N3S	175.21	C#CC1=CC2=NSN=C2C=C1N	IC50 = 50230 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BL2B6F	alpha,alpha-Difluoro-3-[bis(methylsulfonyl)amino]-4-(phenylethynyl)benzylphosphonic acid	Investigative	15486041	C17H16F2NO7PS2	479.4	CS(=O)(=O)N(C1=C(C=CC(=C1)C(F)(F)P(=O)(O)O)C#CC2=CC=CC=C2)S(=O)(=O)C	IC50 = 88700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BL4TW6	beta-Amyrin	Investigative	73145	C30H50O	426.7	C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)[C@@H]1CC(CC2)(C)C)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BL79YF	3-[(3,4-Dichlorobenzyl)sulfanyl]-2-thiophenecarboxylic acid	Investigative	2765033	C12H8Cl2O2S2	319.2	C1=CC(=C(C=C1CSC2=C(SC=C2)C(=O)O)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BLHZ17	N-(4,5-Diphenyl-2-thiazolyl)-2-(4-methylphenyl)ethenesulfonamide	Investigative	44337816	C24H20N2O2S2	432.6	CC1=CC=C(C=C1)/C=C/S(=O)(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BLO8D3	Butyl (E)-2-[4-[2-(2-phenyl-1,3-thiazol-4-yl)ethoxy]phenyl]ethenesulfonate	Investigative	70686947	C23H25NO4S2	443.6	CCCCOS(=O)(=O)/C=C/C1=CC=C(C=C1)OCCC2=CSC(=N2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BLQO37	Ethyl (E)-2-[2-[2-(5-methyl-2-phenyl-1,3-thiazol-4-yl)ethoxy]-4-phenylmethoxyphenyl]ethenesulfonate	Investigative	70691144	C29H29NO5S2	535.7	CCOS(=O)(=O)/C=C/C1=C(C=C(C=C1)OCC2=CC=CC=C2)OCCC3=C(SC(=N3)C4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BLUP17	Isoliquiritigenin	Investigative	638278	C15H12O4	256.25	C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BLV3O9	2-Butyl-3-(4-hydroxybenzoyl)benzofuran	Investigative	96670	C19H18O3	294.3	CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC=C(C=C3)O	IC50 = 71400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BM10KZ	Ethyl (E)-3-(5-methyl-2-phenyl-1,3-thiazol-4-yl)prop-1-ene-1-sulfonate	Investigative	70689036	C15H17NO3S2	323.4	CCOS(=O)(=O)/C=C/CC1=C(SC(=N1)C2=CC=CC=C2)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BM2W7E	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]-2,6-difluorophenoxy]acetic acid	Investigative	44450285	C24H19F2N3O5S2	531.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC(=C(C(=C4)F)OCC(=O)O)F	IC50 = 137000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BM5L6G	3-Piperidin-1-ylmethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine	Investigative	12109538	C11H16N8	260.3	C1CCN(CC1)CC2=NC3=C(N=C(N=C3N=N2)N)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BMH2R4	2-[(S)-(2-Chloroanilino)-diethoxyphosphorylmethyl]phenol	Investigative	57390693	C17H21ClNO4P	369.8	CCOP(=O)([C@@H](C1=CC=CC=C1O)NC2=CC=CC=C2Cl)OCC	IC50 = 137000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BMH6Y5	2-(3-(2-(2-(4-Chlorophenyl)-4-methylthiazol-5-yl)ethoxy)-4-hydroxyphenyl)-3,3,3-trifluoro-2-hydroxypropanoic acid	Investigative	44444636	C21H17ClF3NO5S	487.9	CC1=C(SC(=N1)C2=CC=C(C=C2)Cl)CCOC3=C(C=CC(=C3)C(C(=O)O)(C(F)(F)F)O)O	IC50 = 105000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BMHF17	(E)-4-(3,4-Dihydroxystyryl)benzaldehyde	Investigative	44432619	C15H12O3	240.25	C1=CC(=CC=C1/C=C/C2=CC(=C(C=C2)O)O)C=O	IC50 = 101000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BN1D2E	(2S)-N-[(1S)-1-Carbamoyl-2-[4-(1,1,3-trioxo-1$l^{6},2-thiazolidin-5-yl)phenyl]ethyl]-3-phenyl-2-(phenylformamido)propanamide	Investigative	23646521	C28H28N4O6S	548.6	C1C(S(=O)(=O)NC1=O)C2=CC=C(C=C2)C[C@@H](C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)C4=CC=CC=C4	IC50 = 149968.48 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BN86GK	Dess-Martin periodinane	Investigative	159087	C13H13IO8	424.14	CC(=O)OI1(C2=CC=CC=C2C(=O)O1)(OC(=O)C)OC(=O)C	IC50 = 130000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNA5G2	(3Z)-3-[2-(2-Nitrophenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide	Investigative	135924010	C14H11N5O5S	361.33	C1=CC=C(C(=C1)N=NC2=C(NC3=C2C=C(C=C3)S(=O)(=O)N)O)[N+](=O)[O-]	IC50 = 156600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNAV56	2-[2-Oxopropanoyl(5,6,7,8-tetrahydronaphthalen-1-yl)amino]benzoic acid	Investigative	76308038	C20H19NO4	337.4	CC(=O)C(=O)N(C1=CC=CC=C1C(=O)O)C2=CC=CC3=C2CCCC3	Ki = 74000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNGY53	2-Bromo-4'-methoxyacetophenone	Investigative	4965	C9H9BrO2	229.07	COC1=CC=C(C=C1)C(=O)CBr	Ki = 128000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNIF90	(E)-2-(3,4-Difluorophenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337719	C26H22F2N2O2S2	496.6	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC(=C(C=C2)F)F)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 77000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNU0K8	4-[[4-[(E)-[3-Benzyl-1-(carboxymethyl)-2,5-dioxoimidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid	Investigative	122193541	C27H22N2O7	486.5	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC4=CC=C(C=C4)C(=O)O)/C(=O)N(C2=O)CC(=O)O	IC50 = 103000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BNWH26	(5E)-5-[(4-Phenacyloxyphenyl)methylidene]imidazolidine-2,4-dione	Investigative	60151894	C18H14N2O4	322.3	C1=CC=C(C=C1)C(=O)COC2=CC=C(C=C2)/C=C/3\\C(=O)NC(=O)N3	IC50 = 155000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO0JM4	Licoagrochalcone C	Investigative	5318990	C21H22O5	354.4	CC(=CCC1=C(C=CC(=C1OC)/C=C/C(=O)C2=CC(=C(C=C2)O)O)O)C	IC50 = 59500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO34WG	3-(3-Stibonophenyl)Propanoic Acid	Investigative	24204784	C9H11O5Sb	320.94	C1=CC(=CC(=C1)[Sb](=O)(O)O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO4E3M	N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-[4-(methylsulfonyl)phenyl]ethenesulfonamide	Investigative	44337575	C20H20N2O4S3	448.6	CCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=C(C=C2)S(=O)(=O)C)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO7DW9	5-Benzyl-4-hydroxybiphenyl-3-carboxylic acid	Investigative	19880831	C20H16O3	304.3	C1=CC=C(C=C1)CC2=C(C(=CC(=C2)C3=CC=CC=C3)C(=O)O)O	IC50 = 57000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO82HV	Butyl (E)-2-[2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-4-phenylmethoxyphenyl]ethenesulfonate	Investigative	70691143	C31H33NO6S	547.7	CCCCOS(=O)(=O)/C=C/C1=C(C=C(C=C1)OCC2=CC=CC=C2)OCCC3=C(OC(=N3)C4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO95DM	Methyl 5-[[3-[(3,4-dichlorophenyl)methylsulfanyl]thiophene-2-carbonyl]sulfamoyl]-2-methoxybenzoate	Investigative	54757904	C21H17Cl2NO6S3	546.5	COC1=C(C=C(C=C1)S(=O)(=O)NC(=O)C2=C(C=CS2)SCC3=CC(=C(C=C3)Cl)Cl)C(=O)OC	IC50 = 73000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BO9ZU7	Difluoro(naphthalen-2-yl)methanesulfonate	Investigative	10706701	C11H8F2O3S	258.24	C1=CC=C2C=C(C=CC2=C1)C(F)(F)S(=O)(=O)O	IC50 = 175000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BOA52J	3-[(3,4-Dichlorobenzyl)sulfanyl]-N-(Methylsulfonyl)thiophene-2-Carboxamide	Investigative	54751676	C13H11Cl2NO3S3	396.3	CS(=O)(=O)NC(=O)C1=C(C=CS1)SCC2=CC(=C(C=C2)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BOFG48	Vignafuran	Investigative	441958	C16H14O4	270.28	COC1=CC2=C(C=C1)C=C(O2)C3=C(C=C(C=C3)O)OC	IC50 = 74100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BOT7G6	3-(3,4-Dichlorobenzylamino)thiophene-2-carboxylic acid	Investigative	54757812	C12H9Cl2NO2S	302.2	C1=CC(=C(C=C1CNC2=C(SC=C2)C(=O)O)Cl)Cl	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BOVW62	Methyl 2-[(4E)-3-benzyl-4-[[4-(2-methoxy-2-oxoethoxy)phenyl]methylidene]-2,5-dioxoimidazolidin-1-yl]acetate	Investigative	122193485	C23H22N2O7	438.4	COC(=O)CN1C(=O)/C(=C\\C2=CC=C(C=C2)OCC(=O)OC)/N(C1=O)CC3=CC=CC=C3	IC50 = 114000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BP1C2D	Gypensapogenin D	Investigative	57403824	C30H46O3	454.7	CC(=C[C@H]1C=C(C(=O)O1)[C@H]2CC[C@@]3([C@@H]2CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)O)C)C)C)C	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BP1JD4	2-[4-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]-2,2-difluoroacetic acid	Investigative	44450352	C24H19F2N3O4S2	515.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC=C(C=C4)C(C(=O)O)(F)F	IC50 = 51800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BP2C7O	3-(2,4-Dimethoxyphenyl)-5-pyridin-4-yl-4,5-dihydro-1,2-oxazole	Investigative	76322853	C16H16N2O3	284.31	COC1=CC(=C(C=C1)C2=NOC(C2)C3=CC=NC=C3)OC	Ki = 150000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BP5Z8W	(5Z)-5-[(4-Phenylmethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione	Investigative	5939774	C17H13NO3S	311.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C\\3/C(=O)NC(=O)S3	IC50 = 64000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPB3Z9	5-(3-((2-(3-Hydroxy-2-(methoxycarbonyl)phenoxy)ethyl)amino)phenyl)isoxazole-3-carboxylic Acid	Investigative	10250245	C20H18N2O7	398.4	COC(=O)C1=C(C=CC=C1OCCNC2=CC=CC(=C2)C3=CC(=NO3)C(=O)O)O	Ki = 50118.72 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPE19G	N-(1-Benzyl-3-cyano-1H-pyrrolo[3,2-b]quinoxalin-2-yl)benzenesulfonamide	Investigative	1921859	C24H17N5O2S	439.5	C1=CC=C(C=C1)CN2C(=C(C3=NC4=CC=CC=C4N=C32)C#N)NS(=O)(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPHW67	(E)-2-(4-Butylphenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337400	C30H32N2O2S2	516.7	CCCCC1=CC=C(C=C1)/C=C/S(=O)(=O)NC2=NC(=C(S2)CCC)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPKD80	Licochalcone C	Investigative	9840805	C21H22O4	338.4	CC(=CCC1=C(C=CC(=C1OC)/C=C/C(=O)C2=CC=C(C=C2)O)O)C	IC50 = 57000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPN43O	(E)-2-(2-Chlorophenyl)-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337410	C17H12Cl2N2O2S2	411.3	C1=CC=C(C(=C1)/C=C/S(=O)(=O)NC2=NC(=CS2)C3=CC=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPQH08	(2S)-7-Hydroxy-2-[3-[(E)-3-hydroxy-3-methylbut-1-enyl]-4-methoxy-5-(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one	Investigative	11995581	C26H30O5	422.5	CC(=CCC1=C(C(=CC(=C1)[C@@H]2CC(=O)C3=C(O2)C=C(C=C3)O)/C=C/C(C)(C)O)OC)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BPX16G	5-[1-[2-(3-Hydroxy-2-methoxycarbonylphenoxy)ethyl]indol-6-yl]-1,2-oxazole-3-carboxylic acid	Investigative	11362207	C22H18N2O7	422.4	COC(=O)C1=C(C=CC=C1OCCN2C=CC3=C2C=C(C=C3)C4=CC(=NO4)C(=O)O)O	Ki = 50118.72 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ01XA	{4-[3-(4-Oxalyl-phenoxymethyl)-benzyloxy]-phenyl}-oxo-acetic acid	Investigative	10094446	C24H18O8	434.4	C1=CC(=CC(=C1)COC2=CC=C(C=C2)C(=O)C(=O)O)COC3=CC=C(C=C3)C(=O)C(=O)O	IC50 = 53000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ15KX	3,5-Dibenzyl-2-hydroxybenzoic acid	Investigative	25101400	C21H18O3	318.4	C1=CC=C(C=C1)CC2=CC(=C(C(=C2)C(=O)O)O)CC3=CC=CC=C3	IC50 = 91000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ1I6Y	4,5-Diphenylisoxazole-3-carboxylic acid	Investigative	58537218	C16H11NO3	265.26	C1=CC=C(C=C1)C2=C(ON=C2C(=O)O)C3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ40FD	2-(Furan-2-yl)-2-oxoacetic acid	Investigative	73846	C6H4O4	140.09	C1=COC(=C1)C(=O)C(=O)O	Ki = 79000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ47EX	2-(3-Methoxy-N-oxaloanilino)benzoic acid	Investigative	45271202	C16H13NO6	315.28	COC1=CC=CC(=C1)N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)O	Ki = 158489.32 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ5I3W	1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]pent-4-en-2-yl hydrogen sulfate	Investigative	44303523	C19H32O4S	356.5	CC1=CC[C@@H]2[C@@]([C@H]1CC(CC=C)OS(=O)(=O)O)(CCCC2(C)C)C	IC50 = 185000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ7S5C	9-(Ethoxymethyl)-4-methyl-9-(pyrrolidin-1-ylmethyl)-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46882186	C21H25NO5	371.4	CCOCC1(COC2=C(C1=O)C3=C(C=C2)C(=CC(=O)O3)C)CN4CCCC4	IC50 = 82700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ9E2A	2-(4-Methoxyphenyl)-2-oxoacetic acid	Investigative	584714	C9H8O4	180.16	COC1=CC=C(C=C1)C(=O)C(=O)O	IC50 = 150000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQ9PK6	9-(Diethylaminomethyl)-9-(ethoxymethyl)-4-methyl-8H-pyrano[2,3-f]chromene-2,10-dione	Investigative	46882187	C21H27NO5	373.4	CCN(CC)CC1(COC2=C(C1=O)C3=C(C=C2)C(=CC(=O)O3)C)COCC	IC50 = 90400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQF9M0	Tetrahydroisoquinoline (TIQ) deriv. 9b	Investigative	11236561	C22H27N3O6S	461.5	CC(C)(C)OC(=O)N1CC2=C(C[C@H]1C(=O)NCC3=CC=CC=C3)C=CC(=C2)NS(=O)(=O)O	IC50 = 120200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQG3K7	1-(4-Hydroxy-3-methoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one	Investigative	9448597	C20H16O3	304.3	COC1=C(C=CC(=C1)C(=O)/C=C/C2=CC3=CC=CC=C3C=C2)O	IC50 = 123030 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BQO32M	(5E)-5-{4-[(4-Chlorobenzyl)oxy]benzylidene}imidazolidine-2,4-dione	Investigative	21213049	C17H13ClN2O3	328.7	C1=CC(=CC=C1COC2=CC=C(C=C2)/C=C/3\\C(=O)NC(=O)N3)Cl	IC50 = 122000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR03FQ	3-(1,3-Benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one	Investigative	5383850	C16H11NO5	297.26	C1OC2=C(O1)C=C(C=C2)/C=C/C(=O)C3=CC(=CC=C3)[N+](=O)[O-]	IC50 = 107000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR4M2F	5-Biphenyl-3-yl-1,1-dioxo-1lambda*6*-[1,2,5]thiadiazolidin-3-one	Investigative	44399816	C14H12N2O3S	288.32	C1C(=O)NS(=O)(=O)N1C2=CC=CC(=C2)C3=CC=CC=C3	IC50 = 132000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR5TF9	4-Ethynyl-alpha,alpha-difluorobenzylphosphonic acid	Investigative	44366691	C9H7F2O3P	232.12	C#CC1=CC=C(C=C1)C(F)(F)P(=O)(O)O	IC50 = 77500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR72IS	1,4,5,6-Tetrahydroxy-2-(2-methylbut-3-en-2-yl)xanthen-9-one	Investigative	10426622	C18H16O6	328.3	CC(C)(C=C)C1=CC(=C2C(=C1O)C(=O)C3=C(O2)C(=C(C=C3)O)O)O	IC50 = 53000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR7SN2	5-(2-Methoxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one	Investigative	44399820	C9H10N2O4S	242.25	COC1=CC=CC=C1N2CC(=O)NS2(=O)=O	IC50 = 138000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR8V6T	2-(Oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine-3-carboxylic acid	Investigative	444766	C10H10N2O5S	270.26	C1CNCC2=C1C(=C(S2)NC(=O)C(=O)O)C(=O)O	Ki = 50118.72 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BR94YB	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(4-methylphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	135797388	C29H45NO4	471.7	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BRE2Y9	Abyssinones III	Investigative	10408069	C25H26O4	390.5	CC(=CCC1=CC(=CC2=C1OC(C=C2)(C)C)[C@@H]3CC(=O)C4=C(O3)C=C(C=C4)O)C	IC50 = 72900 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BRHP24	4-[N-[(4-Fluorophenyl)methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	136254274	C28H42FNO4	475.6	CCCCCCCCCCCCCCCC(=NCC1=CC=C(C=C1)F)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BRI42G	2-[(4E)-3-Benzyl-4-[(4-hydroxyphenyl)methylidene]-2,5-dioxoimidazolidin-1-yl]acetic acid	Investigative	122193547	C19H16N2O5	352.3	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)O)/C(=O)N(C2=O)CC(=O)O	IC50 = 142000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BRVG81	(E)-1-(5-Chloro-2-thienyl)-3-(2-naphthyl)prop-2-en-1-one	Investigative	56945877	C17H11ClOS	298.8	C1=CC=C2C=C(C=CC2=C1)/C=C/C(=O)C3=CC=C(S3)Cl	IC50 = 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BS9Q0R	(E)-2-(4-Butyl-phenyl)-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide	Investigative	44337589	C27H26N2O2S2	474.6	CCCCC1=CC=C(C=C1)/C=C/S(=O)(=O)NC2=NC(=C(S2)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSB5E3	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(2-methoxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	136254279	C29H45NO5	487.7	CCCCCCCCCCCCCCCC(=NCC1=CC=CC=C1OC)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSJ68E	Naringenin	Investigative	439246	C15H12O5	272.25	C1[C@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O	IC50 = 130100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSM9H4	4-[(3Ar,7aS)-7-methyl-1,3-dioxo-4,7a-dihydro-3aH-4,7-epoxyisoindol-2-yl]-N-[(E)-(4-bromophenyl)methylideneamino]benzenesulfonamide	Investigative	90667494	C22H18BrN3O5S	516.4	CC12C=CC(O1)[C@H]3[C@@H]2C(=O)N(C3=O)C4=CC=C(C=C4)S(=O)(=O)N/N=C/C5=CC=C(C=C5)Br	IC50 = 88000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSMJ21	3-(3,4-Dibromobenzylthio)thiophene-2-carboxylic acid	Investigative	54757810	C12H8Br2O2S2	408.1	C1=CC(=C(C=C1CSC2=C(SC=C2)C(=O)O)Br)Br	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSP2Y1	Ethyl 2-[4-[(E)-(2,5-dioxoimidazolidin-4-ylidene)methyl]phenoxy]acetate	Investigative	60152037	C14H14N2O5	290.27	CCOC(=O)COC1=CC=C(C=C1)/C=C/2\\C(=O)NC(=O)N2	IC50 = 172000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSV9K0	Tetrahydroisoquinoline (TIQ) deriv. 10f	Investigative	11236319	C20H22ClN3O5S	451.9	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC(=CC=C3)Cl)C=C(C=C2)NS(=O)(=O)O	IC50 = 101100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSVY97	2-[4-[[[4-(Carboxymethoxy)phenyl]sulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenoxy]acetic acid	Investigative	44450335	C26H23N3O8S2	569.6	C1=CC(=CC=C1CN(CC2=CC=C(C=C2)OCC(=O)O)S(=O)(=O)C3=CC=C(C=C3)OCC(=O)O)C4=CSN=N4	IC50 = 59600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSX0Z1	N-[2-(4-Methoxyphenyl)ethyl]-2-phenoxyacetamide	Investigative	2711328	C17H19NO3	285.34	COC1=CC=C(C=C1)CCNC(=O)COC2=CC=CC=C2	IC50 = 74000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BSZ63J	3-Hydroxy-2-(hydroxymethyl)-4-[N-[(3-hydroxyphenyl)methyl]-C-pentadecylcarbonimidoyl]-2H-furan-5-one	Investigative	135797381	C28H43NO5	473.6	CCCCCCCCCCCCCCCC(=NCC1=CC(=CC=C1)O)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BT1HE9	PTP1B Inhibitor, 7	Investigative	71463481	C20H20N2O3	336.4	CC1(C=CC2=C(O1)C=CC(=C2OC)C3=NOC(C3)C4=CC=CC=N4)C	IC50 = 87000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BT9Z5A	1-[(1S,4As,8aS)-2,5,5,8a-tetramethyl-1,4,4a,6,7,8-hexahydronaphthalen-1-yl]hexan-2-yl hydrogen sulfate	Investigative	44303463	C20H36O4S	372.6	CCCCC(C[C@H]1C(=CC[C@@H]2[C@@]1(CCCC2(C)C)C)C)OS(=O)(=O)O	IC50 = 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BTC7N3	Sigmoidin C	Investigative	44424648	C20H18O6	354.4	CC1(C=CC2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BTD81A	(2-Methoxy-2-oxoethyl) 2-[(4E)-3-benzyl-4-[[4-(2-methoxy-2-oxoethoxy)phenyl]methylidene]-2,5-dioxoimidazolidin-1-yl]acetate	Investigative	122193550	C25H24N2O9	496.5	COC(=O)COC1=CC=C(C=C1)/C=C/2\\C(=O)N(C(=O)N2CC3=CC=CC=C3)CC(=O)OCC(=O)OC	IC50 = 101000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BTJX15	Licocoumarone	Investigative	503731	C20H20O5	340.4	CC(=CCC1=C(C2=C(C=C1O)OC(=C2)C3=C(C=C(C=C3)O)O)OC)C	IC50 = 71200 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BTS87P	2-{[6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-1,3-benzothiazol-2-yl]sulfanyl}-N-{5-[(3-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}acetamide	Investigative	3433760	C27H19N5O3S4	589.7	CC1=CC(=CC=C1)CSC2=NN=C(S2)NC(=O)CSC3=NC4=C(S3)C=C(C=C4)N5C(=O)C6=CC=CC=C6C5=O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU48IR	Chembl4159605	Investigative	145957853	C16H11BrN2O5S	423.2	C1=CC(=CC=C1OC(=O)CSC2=NN=C(O2)C3=CC(=C(C=C3)O)O)Br	IC50 = 115340 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU65CJ	3-[4-[4-[[(2R,3R,4S,5R,6S)-3,4,5-Tribenzoyloxy-6-methoxyoxan-2-yl]methoxymethyl]triazol-1-yl]butoxy]benzoic acid	Investigative	56681853	C42H41N3O12	779.8	CO[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COCC2=CN(N=N2)CCCCOC3=CC=CC(=C3)C(=O)O)OC(=O)C4=CC=CC=C4)OC(=O)C5=CC=CC=C5)OC(=O)C6=CC=CC=C6	IC50 = 60100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU6KM5	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-[(4-chlorobenzoyl)sulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602706	C24H18ClN3O7S	527.9	C1=CC=C2C(=C1)N=C(O2)C(CC3=CC=C(C=C3)NC(=O)C(=O)O)S(=O)(=O)NC(=O)C4=CC=C(C=C4)Cl	Ki = 82400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU8VI7	PTP1B Inhibitor, 5	Investigative	71463479	C21H21NO3	335.4	CC1(C=CC2=C(O1)C=CC(=C2OC)C3=NOC(C3)C4=CC=CC=C4)C	IC50 = 70000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU95DM	N-(1-Benzyl-1H-pyrrolo[3,2-b]quinoxalin-2-yl)benzenesulfonamide	Investigative	1933357	C23H18N4O2S	414.5	C1=CC=C(C=C1)CN2C(=CC3=NC4=CC=CC=C4N=C32)NS(=O)(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BU9A6P	Azane;[[7-[difluoro(phosphono)methyl]naphthalen-1-yl]-difluoromethyl]phosphonic acid	Investigative	49796578	C12H13F4NO6P2	405.18	C1=CC2=C(C=C(C=C2)C(F)(F)P(=O)(O)O)C(=C1)C(F)(F)P(=O)(O)O.N	IC50 = 118000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUB2C6	1-[2-(5-Acetyl-6-hydroxy-1-benzofuran-3-yl)-6-hydroxy-1-benzofuran-5-yl]ethanone	Investigative	44422131	C20H14O6	350.3	CC(=O)C1=C(C=C2C(=C1)C=C(O2)C3=COC4=CC(=C(C=C43)C(=O)C)O)O	Ki = 61000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUBF69	2-[4-[[[4-(Carboxymethoxy)phenyl]sulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenyl]propanoic acid	Investigative	44450308	C27H25N3O7S2	567.6	CC(C1=CC=C(C=C1)CN(CC2=CC=C(C=C2)C3=CSN=N3)S(=O)(=O)C4=CC=C(C=C4)OCC(=O)O)C(=O)O	IC50 = 153000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUE1N5	N-[2-(4-Methoxyphenyl)ethyl]-2-(2-nitrophenyl)-acetamide	Investigative	4471649	C17H18N2O4	314.34	COC1=CC=C(C=C1)CCNC(=O)CC2=CC=CC=C2[N+](=O)[O-]	IC50 = 87000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUO47G	Symphoxanthone	Investigative	15292820	C18H16O6	328.3	CC(C)(C=C)C1=CC(=C(C2=C1OC3=C(C2=O)C=CC(=C3O)O)O)O	IC50 = 85500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BURG65	alpha,alpha-Difluoro-3-(methylsulfonylamino)-4-[(E)-styryl]benzylphosphonic acid	Investigative	44366499	C16H16F2NO5PS	403.3	CS(=O)(=O)NC1=C(C=CC(=C1)C(F)(F)P(=O)(O)O)/C=C/C2=CC=CC=C2	IC50 = 175700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUT85K	2',4'-Dihydroxy-4-methoxychalcone	Investigative	5711223	C16H14O4	270.28	COC1=CC=C(C=C1)/C=C/C(=O)C2=C(C=C(C=C2)O)O	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BUW7D6	Chembl4212452	Investigative	145964831	C22H15NO4	357.4	C1=CC=C(C=C1)C2=C(C(=NO2)C(=O)O)C3=CC=CC(=C3)C4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BV57YN	5-[(E)-2-(3-Carboxy-4-hydroxyphenyl)ethenyl]-2-hydroxy-3-phenylbenzoic acid	Investigative	44563618	C22H16O6	376.4	C1=CC=C(C=C1)C2=C(C(=CC(=C2)/C=C/C3=CC(=C(C=C3)O)C(=O)O)C(=O)O)O	IC50 = 125000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BV7K8P	3-(Benzylthio)thiophene-2-carboxylic acid	Investigative	14024697	C12H10O2S2	250.3	C1=CC=C(C=C1)CSC2=C(SC=C2)C(=O)O	IC50 ~ 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BV9P2W	alpha,alpha-Difluoro-3-(methylsulfonylamino)-4-(phenylethynyl)benzylphosphonic acid	Investigative	15486040	C16H14F2NO5PS	401.3	CS(=O)(=O)NC1=C(C=CC(=C1)C(F)(F)P(=O)(O)O)C#CC2=CC=CC=C2	IC50 = 167100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BVL20U	N-(4-Phenyl-5-ethyl-2-thiazolyl)-2-(2-chlorophenyl)ethenesulfonamide	Investigative	44337612	C19H17ClN2O2S2	404.9	CCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=CC=C2Cl)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BVLJ14	Benzoic acid, 3,3'-methylenebis[5-bromo-6-hydroxy-	Investigative	14785818	C15H10Br2O6	446.04	C1=C(C=C(C(=C1C(=O)O)O)Br)CC2=CC(=C(C(=C2)Br)O)C(=O)O	IC50 = 78000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BVOC29	Benzoic acid, 2-[(carboxycarbonyl)(2,3-dimethylphenyl)amino]-	Investigative	9836432	C17H15NO5	313.3	CC1=C(C(=CC=C1)N(C2=CC=CC=C2C(=O)O)C(=O)C(=O)O)C	Ki = 93000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BVR0D6	3-(4,7-Dimethoxybenzofuran-5-yl)-5-(4-methoxyphenyl)-4,5-dihydroisoxazole	Investigative	11948629	C20H19NO5	353.4	COC1=CC=C(C=C1)C2CC(=NO2)C3=CC(=C4C(=C3OC)C=CO4)OC	IC50 = 81000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BVWG31	(2S)-2-(3,4-Dihydroxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)-5,7-dihydroxy-2,3-dihydrochromen-4-one	Investigative	44589217	C20H20O7	372.4	CC1(C(C(C2=C(O1)C=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW0IP2	4,5-Di-O-caffeoylquinic acid	Investigative	6474309	C25H24O12	516.4	C1[C@H]([C@@H]([C@@H](C[C@]1(C(=O)O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)O	IC50 = 59400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW0IQ7	4-[[(4E)-3-Benzyl-4-[[4-(carboxymethoxy)phenyl]methylidene]-2,5-dioxoimidazolidin-1-yl]methyl]benzoic acid	Investigative	122193545	C27H22N2O7	486.5	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC(=O)O)/C(=O)N(C2=O)CC4=CC=C(C=C4)C(=O)O	IC50 = 103000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW7VS3	4-[Acetyl(6,7,8,9-tetrahydrodibenzofuran-2-yl)sulfamoyl]benzoic acid	Investigative	2964738	C21H19NO6S	413.4	CC(=O)N(C1=CC2=C(C=C1)OC3=C2CCCC3)S(=O)(=O)C4=CC=C(C=C4)C(=O)O	IC50 = 120000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW85AO	5-{(S)-2-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-2-[(S)-4-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-ethyl}-2-carboxymethoxy-benzoic acid	Investigative	44320455	C38H42N4O12	746.8	CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC(=C(C=C1)OCC(=O)O)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24	IC50 = 54700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW9ID3	Phosphonic acid, (difluoro-2-naphthalenylmethyl)-	Investigative	10422621	C11H9F2O3P	258.16	C1=CC=C2C=C(C=CC2=C1)C(F)(F)P(=O)(O)O	IC50 = 95000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BW9X2R	(3S,5R,8R,9R,10R,12R,13R,14R,17S)-17-[(Z)-6-Hydroxy-6-methylhept-2-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol	Investigative	71719757	C30H52O3	460.7	C/C(=C/CCC(C)(C)O)/[C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)O)C	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BWD37G	(1S,2S,17S,19R)-12-Hydroxy-19-[(Z)-3-hydroxy-2-methylprop-1-enyl]-8,8,21,21-tetramethyl-5-(3-methylbut-2-enyl)-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaene-14,18-dione	Investigative	137631809	C32H36O7	532.6	CC(=CCC1=C2C(=C(C3=C1O[C@@]45[C@H]6C[C@@H](C=C4C3=O)C(=O)[C@@]5(OC6(C)C)/C=C(/C)\\CO)O)C=CC(O2)(C)C)C	IC50 = 70250 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BWK09B	Kanzonol Y	Investigative	10001604	C25H30O5	410.5	CC(=CCC1=CC(=C(C=C1O)O)C(=O)[C@@H](CC2=CC(=C(C=C2)O)CC=C(C)C)O)C	IC50 = 90500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BWK6O9	Chembl4210532	Investigative	145966877	C22H14FNO4	375.3	C1=CC=C(C=C1)C2=C(C(=NO2)C(=O)O)C3=CC=CC(=C3)C4=CC(=C(C=C4)O)F	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BWMZ48	Euchrestaflavanone A	Investigative	484588	C25H28O5	408.5	CC(=CCC1=C(C=CC(=C1)[C@@H]2CC(=O)C3=C(C=C(C(=C3O2)CC=C(C)C)O)O)O)C	IC50 = 62400 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BWR7S0	2-[4-[2-(1H-Benzimidazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl]-2-hydroxyphenoxy]acetic acid	Investigative	71602597	C23H20FN3O6S	485.5	C1=CC=C2C(=C1)NC(=N2)C(CC3=CC(=C(C=C3)OCC(=O)O)O)S(=O)(=O)NC4=CC=C(C=C4)F	Ki = 162000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BX0GS5	4-[N-[[3-(Dimethylamino)phenyl]methyl]-C-pentadecylcarbonimidoyl]-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one	Investigative	135797380	C30H48N2O4	500.7	CCCCCCCCCCCCCCCC(=NCC1=CC(=CC=C1)N(C)C)C2=C(C(OC2=O)CO)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BX1HZ3	4-[[(4E)-3-Benzyl-4-[[4-[(4-carboxyphenyl)methoxy]phenyl]methylidene]-2,5-dioxoimidazolidin-1-yl]methyl]benzoic acid	Investigative	122193544	C33H26N2O7	562.6	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)OCC4=CC=C(C=C4)C(=O)O)/C(=O)N(C2=O)CC5=CC=C(C=C5)C(=O)O	IC50 = 89000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BX3W6A	Tetrahydroisoquinoline (TIQ) deriv. 10d	Investigative	23646402	C22H25F3N4O7S2	578.6	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCC3=CC(=CC(=C3)NS(=O)(=O)C)C(F)(F)F)C=C(C=C2)NS(=O)(=O)O	IC50 = 183700 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BX45TR	Chembl4212874	Investigative	145967464	C22H15NO4	357.4	C1=CC=C(C=C1)C2=C(C(=NO2)C(=O)O)C3=CC=CC(=C3)C4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BXE2T8	N-[4-Phenyl-5-decyl-2-thiazolyl]-2-(2-chlorophenyl)ethenesulfonamide	Investigative	44337441	C27H33ClN2O2S2	517.1	CCCCCCCCCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=CC=C2Cl)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BXHT84	1-[2-(5-Acetyl-4-hydroxy-1-benzofuran-3-yl)-4-hydroxy-1-benzofuran-5-yl]ethanone	Investigative	44422132	C20H14O6	350.3	CC(=O)C1=C(C2=C(C=C1)OC(=C2)C3=COC4=C3C(=C(C=C4)C(=O)C)O)O	IC50 = 58800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BXLM27	2-(5-(2-(2-(4-Chlorophenyl)-4-methylthiazol-5-yl)ethoxy)-1-(methoxymethyl)-1H-indol-3-yl)-3,3,3-trifluoro-2-hydroxypropanoic acid	Investigative	44444624	C25H22ClF3N2O5S	555	CC1=C(SC(=N1)C2=CC=C(C=C2)Cl)CCOC3=CC4=C(C=C3)N(C=C4C(C(=O)O)(C(F)(F)F)O)COC	IC50 = 59000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY1RZ6	3-(2-(4-((3-Benzoyl-1-cyanoindolizin-5-yl)methoxy)phenyl)-4-methylpentanamido)-3-phenylpropanoic acid	Investigative	44406035	C38H35N3O5	613.7	CC(C)CC(C1=CC=C(C=C1)OCC2=CC=CC3=C(C=C(N32)C(=O)C4=CC=CC=C4)C#N)C(=O)NC(CC(=O)O)C5=CC=CC=C5	IC50 = 80600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY2DJ8	2-[(3,4-Dichlorobenzyl)sulfanyl]benzoic Acid	Investigative	4584157	C14H10Cl2O2S	313.2	C1=CC=C(C(=C1)C(=O)O)SCC2=CC(=C(C=C2)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY3N8X	Methyl (2S)-2-[4-(benzamidomethyl)triazol-1-yl]-3-(4-hydroxyphenyl)propanoate	Investigative	53319270	C20H20N4O4	380.4	COC(=O)[C@H](CC1=CC=C(C=C1)O)N2C=C(N=N2)CNC(=O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY5OC8	Odoratin	Investigative	13965473	C17H14O6	314.29	COC1=C(C=C(C=C1)C2=COC3=CC(=C(C=C3C2=O)OC)O)O	IC50 = 70000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY81GQ	Sodium;5-[difluoro-(3-phenylphenyl)methyl]-1,2,3-triaza-4-azanidacyclopenta-2,5-diene	Investigative	23675509	C14H9F2N4Na	294.23	C1=CC=C(C=C1)C2=CC(=CC=C2)C(C3=NN=N[N-]3)(F)F.[Na+]	Ki = 98000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY9Z0J	Sodium;difluoro(naphthalen-2-yl)methanesulfonate	Investigative	44340098	C11H7F2NaO3S	280.22	C1=CC=C2C=C(C=CC2=C1)C(F)(F)S(=O)(=O)[O-].[Na+]	IC50 = 175000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BY9ZD6	4-(Phenylethynyl)-alpha,alpha-difluorobenzylphosphonic acid	Investigative	44366478	C15H11F2O3P	308.22	C1=CC=C(C=C1)C#CC2=CC=C(C=C2)C(F)(F)P(=O)(O)O	IC50 = 128300 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BYJU42	2-[3-[[Benzenesulfonyl-[[4-(thiadiazol-4-yl)phenyl]methyl]amino]methyl]phenoxy]-2,2-difluoroacetic acid	Investigative	44450292	C24H19F2N3O5S2	531.6	C1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(C=C2)C3=CSN=N3)CC4=CC(=CC=C4)OC(C(=O)O)(F)F	IC50 = 198000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BYOK51	Azane;[(3S)-3-(methylcarbamoyl)-2-(3-phenoxypropanoyl)-3,4-dihydro-1H-isoquinolin-7-yl]sulfamic acid	Investigative	49797133	C20H26N4O6S	450.5	CNC(=O)[C@@H]1CC2=C(CN1C(=O)CCOC3=CC=CC=C3)C=C(C=C2)NS(=O)(=O)O.N	IC50 = 83600 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BYV89S	5-(3'-(3-(Carboxy)isoxazol-5-yl)-1,1'-biphenyl-3-yl)isoxazole-3-carboxylic acid	Investigative	10429577	C20H12N2O6	376.3	C1=CC(=CC(=C1)C2=CC(=NO2)C(=O)O)C3=CC(=CC=C3)C4=CC(=NO4)C(=O)O	Ki = 79432.82 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BYW7U8	(E)-2-Naphthalen-2-yl-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337402	C30H26N2O2S2	510.7	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC3=CC=CC=C3C=C2)C4=CC=C(C=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ0O2E	Atranorin	Investigative	68066	C19H18O8	374.3	CC1=CC(=C(C(=C1C(=O)OC2=C(C(=C(C(=C2)C)C(=O)OC)O)C)O)C=O)O	IC50 = 63500 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ0TX5	Abyssinoflavone V	Investigative	16737249	C20H18O5	338.4	CC1(C=CC2=C(O1)C=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ21GC	5-[4-Fluoro-3-[4-hydroxy-3-(3-hydroxy-2-methoxycarbonylphenoxy)butyl]phenyl]-1,2-oxazole-3-carboxylic acid	Investigative	45269583	C22H20FNO8	445.4	COC(=O)C1=C(C=CC=C1OC(CCC2=C(C=CC(=C2)C3=CC(=NO3)C(=O)O)F)CO)O	Ki = 125892.54 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ5QB3	(E)-2-Biphenyl-4-yl-ethenesulfonic acid (4,5-diphenyl-thiazol-2-yl)-amide	Investigative	44337597	C29H22N2O2S2	494.6	C1=CC=C(C=C1)C2=CC=C(C=C2)/C=C/S(=O)(=O)NC3=NC(=C(S3)C4=CC=CC=C4)C5=CC=CC=C5	IC50 = 90000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ6VF8	2-(2-(4-(Trifluoromethyl)benzyloxy)-4-bromo-6-hydroxyphenoxy)acetic acid	Investigative	44434672	C16H12BrF3O5	421.16	C1=CC(=CC=C1COC2=CC(=CC(=C2OCC(=O)O)O)Br)C(F)(F)F	IC50 = 73000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZ94VE	Phytyl acetate	Investigative	637195	C22H42O2	338.6	C[C@@H](CCC[C@@H](C)CCC/C(=C/COC(=O)C)/C)CCCC(C)C	IC50 = 50020 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZB02H	(E)-2-(4-Methylphenyl)-N-[4-(4-phenylphenyl)-5-propyl-1,3-thiazol-2-yl]ethenesulfonamide	Investigative	44337439	C27H26N2O2S2	474.6	CCCC1=C(N=C(S1)NS(=O)(=O)/C=C/C2=CC=C(C=C2)C)C3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 58000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZI57H	2-[4-[2-(1,3-Benzoxazol-2-yl)-2-[(4-methoxyphenyl)sulfamoyl]ethyl]anilino]-2-oxoacetic acid	Investigative	71602753	C24H21N3O7S	495.5	COC1=CC=C(C=C1)NS(=O)(=O)C(CC2=CC=C(C=C2)NC(=O)C(=O)O)C3=NC4=CC=CC=C4O3	Ki = 68800 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZKE25	Sulfuric acid mono-[2-(benzothiazol-2-yloxy)-1-benzyl-ethyl] ester	Investigative	44303489	C16H15NO5S2	365.4	C1=CC=C(C=C1)CC(COC2=NC3=CC=CC=C3S2)OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZL0O8	(2S)-5,7-Dihydroxy-2-[8-hydroxy-2-(hydroxymethyl)-2-methylchromen-6-yl]-2,3-dihydrochromen-4-one	Investigative	44589107	C20H18O7	370.4	CC1(C=CC2=C(O1)C(=CC(=C2)[C@@H]3CC(=O)C4=C(C=C(C=C4O3)O)O)O)CO	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	BZQ04U	(S)-5,7-Dihydroxy-2-(2,2,9,9-tetramethyl-2,9-dihydropyrano[3,2-h]chromen-5-yl)chroman-4-one	Investigative	44589108	C25H24O6	420.5	CC1(C=CC2=CC(=C3C=CC(OC3=C2O1)(C)C)[C@@H]4CC(=O)C5=C(C=C(C=C5O4)O)O)C	IC50 ~ 60000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D03BHQ	FORMYLCHROMONE	Investigative	45273571	C22H14O3	326.3	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC4=C(C=C3)C(=O)C(=CO4)C=O	Ki = 51000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D03KJL	1-Iodyl-4-nitro-benzene	Investigative	10107739	C6H4INO4	281	C1=CC(=CC=C1[N+](=O)[O-])I(=O)=O	IC50 = 130000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D08GDJ	ISOTHIAZOLIDINONE ANALOG	Investigative	9547915	C23H26N4O6S	486.5	CC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)[C@@H]3CC(=O)NS3(=O)=O)C(=O)N	IC50 ~ 100000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0F3QP	4-hydroxylonchocarpin	Investigative	5889042	C20H18O4	322.4	CC1(C=CC2=C(O1)C=CC(=C2O)C(=O)/C=C/C3=CC=C(C=C3)O)C	IC50 = 74100 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0G7HN	4-Iodyl-benzoic acid	Investigative	3718733	C7H5IO4	280.02	C1=CC(=CC=C1C(=O)O)I(=O)=O	IC50 = 200000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0K4PY	LIQUIRTIGENIN	Investigative	114829	C15H12O4	256.25	C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O	IC50 ~ 50000 nM	Poor binder
T16347	Protein-tyrosine phosphatase 1B	D0W1OR	3,5-dihydroxybenzoic acid	Investigative	7424	C7H6O4	154.12	C1=C(C=C(C=C1O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder