TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T16987	Carbonic anhydrase XII	D0C8EU	Temozolomide	Approved	5394	C6H6N6O2	194.15	CN1C(=O)N2C=NC(=C2N=N1)C(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0V8QT	Chlorambucil	Approved	2708	C14H19Cl2NO2	304.2	C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D09XQU	Tirapazamine	Phase 3	135413511	C7H6N4O2	178.15	.	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0H6GI	VE-822	Phase 1	59472121	C24H25N5O3S	463.6	CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0F8XZ	PMID30074415-Compound-20	Patented	19890	C9H6OS	162.21	C1=CC=C2C(=C1)C=CC(=S)O2	Ki = 95200 nM	Poor binder
T16987	Carbonic anhydrase XII	D07XPE	Phenformin	Withdrawn from market	8249	C10H15N5	205.26	C1=CC=C(C=C1)CCN=C(N)N=C(N)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B01IQK	(1R,2S)-2-[(2,3-Dibromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid	Investigative	137645790	C13H14Br2O4	394.06	COC1=C(C(=C(C(=C1)C[C@@H]2C[C@H]2C(=O)O)Br)Br)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B09GXU	Benzyl 4-[2-[(4-sulfamoylphenyl)carbamoylamino]ethyl]piperazine-1-carboxylate	Investigative	137646223	C21H27N5O5S	461.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C(=O)OCC3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B0HA9F	2H-1-Benzothiopyran-2-thione	Investigative	640625	C9H6S2	178.3	C1=CC=C2C(=C1)C=CC(=S)S2	Ki = 96000 nM	Poor binder
T16987	Carbonic anhydrase XII	B0NYB5	(1R,2S)-2-[(2,6-Dibromo-3,4-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid	Investigative	137636130	C13H14Br2O4	394.06	COC1=CC(=C(C(=C1OC)Br)C[C@@H]2C[C@H]2C(=O)O)Br	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B0RC6Y	N-(4-Sulfamoylphenyl)-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]acetamide	Investigative	137633797	C19H21F3N4O3S	442.5	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B1G8LU	(1R,2R)-2-[(2,3,6-Tribromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid	Investigative	137659514	C13H13Br3O4	472.95	COC1=C(C(=C(C(=C1Br)C[C@H]2C[C@H]2C(=O)O)Br)Br)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B2RG5L	N-(N-Boc-sulfamoyl)glycine Methyl Ester	Investigative	44590306	C8H16N2O6S	268.29	CC(C)(C)OC(=O)NS(=O)(=O)NCC(=O)OC	Ki = 56300 nM	Poor binder
T16987	Carbonic anhydrase XII	B2VW7Y	2-[4-(4-Methylphenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide	Investigative	137655445	C19H24N4O3S	388.5	CC1=CC=C(C=C1)N2CCN(CC2)CC(=O)NC3=CC=C(C=C3)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B36OGI	Ethyl (1R,2S)-2-[(2,6-dibromo-3,4-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate	Investigative	137653361	C15H18Br2O4	422.11	CCOC(=O)[C@@H]1C[C@H]1CC2=C(C=C(C(=C2Br)OC)OC)Br	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B3C1UB	5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid	Investigative	1085887	C11H10N2O3	218.21	COC1=CC=C(C=C1)C2=NNC(=C2)C(=O)O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B3CF2B	Methyl 3-(Butylsulfamoylamino)Propanoate	Investigative	25258363	C8H18N2O4S	238.31	CCCCNS(=O)(=O)NCCC(=O)OC	Ki = 61200 nM	Poor binder
T16987	Carbonic anhydrase XII	B3DY2A	[(3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)amino] sulfamate	Investigative	137653170	C6H7N7O5S	289.23	CN1C(=O)N2C=NC(=C2N=N1)C(=O)NOS(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B4MYV1	N,N'-Dibenzylsulfamide	Investigative	1488548	C14H16N2O2S	276.36	C1=CC=C(C=C1)CNS(=O)(=O)NCC2=CC=CC=C2	Ki = 81500 nM	Poor binder
T16987	Carbonic anhydrase XII	B59AEJ	N-Methylsaccharin	Investigative	27290	C8H7NO3S	197.21	CN1C(=O)C2=CC=CC=C2S1(=O)=O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B59BND	2-[4-(4-Chlorophenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide	Investigative	5019114	C18H21ClN4O3S	408.9	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)Cl	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B59SMB	Ethyl (1R,2S)-2-[(2-bromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate	Investigative	137643203	C15H19BrO4	343.21	CCOC(=O)[C@@H]1C[C@H]1CC2=CC(=C(C=C2Br)OC)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B5E9YP	3-(3,4-Dimethylphenyl)-1H-pyrazole-5-carboxylic acid	Investigative	4598704	C12H12N2O2	216.24	CC1=C(C=C(C=C1)C2=NNC(=C2)C(=O)O)C	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B6N0FA	5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid	Investigative	738819	C10H7ClN2O2	222.63	C1=CC(=CC=C1C2=NNC(=C2)C(=O)O)Cl	Ki = 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B6Z4IJ	N,N'-Bis(2-aminoethyl)-1,3-propanediamine	Investigative	78479	C7H20N4	160.26	C(CNCCN)CNCCN	Ki = 68000 nM	Poor binder
T16987	Carbonic anhydrase XII	B79EKJ	1-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137641290	C19H24ClN5O3S	437.9	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)Cl	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B7SN0T	4-[[4-(Dimethylamino)phenyl]methylamino]benzenesulfonamide	Investigative	2755712	C15H19N3O2S	305.4	CN(C)C1=CC=C(C=C1)CNC2=CC=C(C=C2)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	B8TDZ9	Spermine(hbbh)	Investigative	389642	C20H42N4O4	402.6	CC(C)(C)OC(=O)N(CCCCN(CCCN)C(=O)OC(C)(C)C)CCCN	Ki = 165000 nM	Poor binder
T16987	Carbonic anhydrase XII	B9PUL1	(2S)-2-[[(Tert-Butyloxycarbonyl)sulfamoyl]amino]propionic acid methyl ester	Investigative	15014351	C9H18N2O6S	282.32	C[C@@H](C(=O)OC)NS(=O)(=O)NC(=O)OC(C)(C)C	Ki = 54500 nM	Poor binder
T16987	Carbonic anhydrase XII	B9RK1L	3-[(3-Bromophenyl)methoxy]-1,2-benzothiazole 1,1-dioxide	Investigative	76314550	C14H10BrNO3S	352.2	C1=CC=C2C(=C1)C(=NS2(=O)=O)OCC3=CC(=CC=C3)Br	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BB6OS5	6-(4-Methylsulfonylphenyl)-N-phenyl-3-(sulfamoylamino)pyrazine-2-carboxamide	Investigative	121382833	C18H17N5O5S2	447.5	CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)NS(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BC46IG	2beta-(2,3-Dibromo-4,5-dimethoxybenzyl)cyclopropane-1beta-carboxylic acid	Investigative	122367673	C13H14Br2O4	394.06	COC1=C(C(=C(C(=C1)C[C@H]2C[C@H]2C(=O)O)Br)Br)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BCY10H	Methyl 3-[[(2-methylpropan-2-yl)oxycarbonyl-(2-propylpentyl)sulfamoyl]amino]propanoate	Investigative	25258361	C17H34N2O6S	394.5	CCCC(CCC)CN(C(=O)OC(C)(C)C)S(=O)(=O)NCCC(=O)OC	Ki = 65400 nM	Poor binder
T16987	Carbonic anhydrase XII	BDG5B9	1-[2-(4-Benzylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137647845	C20H27N5O3S	417.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)CC3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BDQY18	1-(4-Sulfamoylphenyl)-3-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]urea	Investigative	137653309	C20H24F3N5O3S	471.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)C(F)(F)F	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BE9U8Z	3-(4-Isopropylphenyl)-1H-pyrazole-5-carboxylic acid	Investigative	975396	C13H14N2O2	230.26	CC(C)C1=CC=C(C=C1)C2=NNC(=C2)C(=O)O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BEB10N	2beta-(2,6-Dibromo-3,4-dimethoxybenzyl)cyclopropane-1beta-carboxylic acid	Investigative	122367675	C13H14Br2O4	394.06	COC1=CC(=C(C(=C1OC)Br)C[C@H]2C[C@H]2C(=O)O)Br	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BFJL25	1-[2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137659269	C21H27N5O5S	461.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)CC3=CC4=C(C=C3)OCO4	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BFU40J	Methyl 3-[(2-Hydroxyphenoxy)Sulfonylamino]Propanoate	Investigative	25258358	C10H13NO6S	275.28	COC(=O)CCNS(=O)(=O)OC1=CC=CC=C1O	Ki = 65000 nM	Poor binder
T16987	Carbonic anhydrase XII	BFZG13	Ethyl (1R,2R)-2-[(2,3-dibromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate	Investigative	137642233	C15H18Br2O4	422.11	CCOC(=O)[C@@H]1C[C@@H]1CC2=CC(=C(C(=C2Br)Br)OC)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BH8TK3	2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide	Investigative	137637767	C25H26F2N4O3S	500.6	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BH9TQ7	1-[2-[4-(4-Acetylphenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137631798	C21H27N5O4S	445.5	CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCNC(=O)NC3=CC=C(C=C3)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BHKO28	3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid	Investigative	818267	C11H10N2O2	202.21	CC1=CC=C(C=C1)C2=NNC(=C2)C(=O)O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BJ0UW1	1-[2-(4-Phenylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	55629711	C19H25N5O3S	403.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BJW8Q5	3-[4-(Methylaminomethyl)phenyl]-5-[6-(4-propan-2-ylsulfonylphenyl)-3-(sulfamoylamino)pyrazin-2-yl]-1,2-oxazole	Investigative	121382897	C24H26N6O5S2	542.6	CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)NS(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BKA09F	[(1R,2R)-2-[(3,4-Dimethoxyphenyl)methyl]cyclopropyl]methanol	Investigative	137641422	C13H18O3	222.28	COC1=C(C=C(C=C1)C[C@H]2C[C@H]2CO)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BM8Z9E	Methyl 3-[(3-methoxy-3-oxopropyl)sulfamoylamino]propanoate	Investigative	25258360	C8H16N2O6S	268.29	COC(=O)CCNS(=O)(=O)NCCC(=O)OC	Ki = 70800 nM	Poor binder
T16987	Carbonic anhydrase XII	BMU52N	1-[2-(4-Benzhydrylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137636981	C26H31N5O3S	493.6	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C(C3=CC=CC=C3)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BN31HQ	2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide	Investigative	137642180	C25H28N4O3S	464.6	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C(C3=CC=CC=C3)C4=CC=CC=C4	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BNB24V	1-[2-(4-Pyrimidin-2-ylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137662187	C17H23N7O3S	405.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=NC=CC=N3	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BNQ74S	Triethylenetetramine	Investigative	5565	C6H18N4	146.23	C(CNCCNCCN)N	Ki = 57000 nM	Poor binder
T16987	Carbonic anhydrase XII	BO01FG	2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide	Investigative	1277269	C20H24N4O5S	432.5	C1CN(CCN1CC2=CC3=C(C=C2)OCO3)CC(=O)NC4=CC=C(C=C4)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BOA31B	1-[2-[4-(4-Fluorophenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137640310	C19H24FN5O3S	421.5	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)F	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BP7QE0	1-[2-[4-(4-Methylphenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137646329	C20H27N5O3S	417.5	CC1=CC=C(C=C1)N2CCN(CC2)CCNC(=O)NC3=CC=C(C=C3)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BPD93A	(1R,2S)-2-[(3,4-Dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid	Investigative	137632898	C13H16O4	236.26	COC1=C(C=C(C=C1)C[C@@H]2C[C@H]2C(=O)O)OC	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BPFO04	2-[4-(4-Bromophenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide	Investigative	137643607	C18H21BrN4O3S	453.4	C1CN(CCN1CC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C3=CC=C(C=C3)Br	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BPO16U	3-(2,4-Dimethylphenyl)-1H-pyrazole-5-carboxylic acid	Investigative	4274816	C12H12N2O2	216.24	CC1=CC(=C(C=C1)C2=NNC(=C2)C(=O)O)C	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BR82NQ	4-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3h)-yl)butanenitrile	Investigative	239730	C11H10N2O3S	250.28	C1=CC=C2C(=C1)C(=O)N(S2(=O)=O)CCCC#N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BS58HU	N1,N3-Bis(2-(2,2,2-trifluoroacetamido)ethyl)-propane-1,3-diaminium trifluoroacetate	Investigative	46899573	C11H18F6N4O2	352.28	C(CNCCNC(=O)C(F)(F)F)CNCCNC(=O)C(F)(F)F	Ki = 112000 nM	Poor binder
T16987	Carbonic anhydrase XII	BTN45D	N,N'-Sulfonyl Bis-L-valine Dimethyl Ester	Investigative	12051191	C12H24N2O6S	324.4	CC(C)[C@@H](C(=O)OC)NS(=O)(=O)N[C@@H](C(C)C)C(=O)OC	Ki = 73000 nM	Poor binder
T16987	Carbonic anhydrase XII	BV0I2K	N1,N12-Bis(trifluoroacetyl)-N4,N8-bis(t-butoxycarbonyl)spermine	Investigative	389641	C24H40F6N4O6	594.6	CC(C)(C)OC(=O)N(CCCCN(CCCNC(=O)C(F)(F)F)C(=O)OC(C)(C)C)CCCNC(=O)C(F)(F)F	Ki = 175000 nM	Poor binder
T16987	Carbonic anhydrase XII	BVED64	2-(4-Benzylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide	Investigative	2196398	C19H24N4O3S	388.5	C1CN(CCN1CC2=CC=CC=C2)CC(=O)NC3=CC=C(C=C3)S(=O)(=O)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	BX71YW	1-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea	Investigative	137641425	C26H29F2N5O3S	529.6	C1CN(CCN1CCNC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0EJ9B	Phenyl Boronic acid	Investigative	66827	C6H7BO2	121.93	B(C1=CC=CC=C1)(O)O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0G0BJ	VE-821	Investigative	51000408	C18H16N4O3S	368.4	CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0G0ZI	Benzo[c][1,2]oxaborol-1(3H)-ol	Investigative	403788	C7H7BO2	133.94	B1(C2=CC=CC=C2CO1)O	Ki ~ 50000 nM	Poor binder
T16987	Carbonic anhydrase XII	D0Q2XB	3,5-difluorophenol	Investigative	75928	C6H4F2O	130.09	C1=C(C=C(C=C1F)F)O	Ki = 70220 nM	Poor binder