TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T19433	Glutathione-dependent PGD synthase	D06TNL	Ethacrynic acid	Approved	3278	C13H12Cl2O4	303.13	CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl	IC50 = 122300 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B04BCQ	2-Phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole	Investigative	2763788	C12H9N3S	227.29	C1=CC=C(C=C1)C2=NC=C(S2)C3=CC=NN3	IC50 = 97700 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B05HOB	N-Benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	46899922	C24H19NO2S	385.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CC=C(S3)C4=CC(=CC=C4)O	IC50 = 79200 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B3A5KU	4-{[4-(4-Fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid	Investigative	695906	C17H13FN2O3S	344.4	CC1=C(C=CC(=C1)C2=CSC(=N2)NC3=CC(=C(C=C3)C(=O)O)O)F	IC50 = 94600 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B3L4BM	N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	46900244	C22H19N3O3S	405.5	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)N)NC(=O)C3=CC=C(S3)C4=CC(=CC=C4)O	IC50 = 72500 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B3LN1R	N-(1-Amino-4-methyl-1-oxopentan-2-yl)-4-(3-hydroxyphenyl)benzamide	Investigative	46900248	C19H22N2O3	326.4	CC(C)CC(C(=O)N)NC(=O)C1=CC=C(C=C1)C2=CC(=CC=C2)O	IC50 = 57600 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B4BP2U	2-Benzoylthiophene	Investigative	67262	C11H8OS	188.25	C1=CC=C(C=C1)C(=O)C2=CC=CS2	IC50 = 83500 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B4T7FG	N-(1-Amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	46900089	C17H20N2O3S	332.4	CC(C)CC(C(=O)N)NC(=O)C1=CC=C(S1)C2=CC(=CC=C2)O	IC50 = 66900 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B4W3LV	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-4-thiophen-2-ylbenzamide	Investigative	46900402	C20H18N2O2S	350.4	C1=CC=C(C=C1)CC(C(=O)N)NC(=O)C2=CC=C(C=C2)C3=CC=CS3	IC50 = 54000 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B67ODI	5-(3-Aminophenyl)-N-benzhydrylthiophene-2-carboxamide	Investigative	46899923	C24H20N2OS	384.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CC=C(S3)C4=CC(=CC=C4)N	IC50 = 76400 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B68DVR	N-[(1-Amino-1-oxo-3-phenylpropan-2-yl)carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	49864099	C21H19N3O4S	409.5	C1=CC=C(C=C1)CC(C(=O)N)NC(=O)NC(=O)C2=CC=C(S2)C3=CC(=CC=C3)O	IC50 = 89500 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	B8NMX6	N-[1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-(3-hydroxyphenyl)benzamide	Investigative	46900247	C24H21N3O3	399.4	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)N)NC(=O)C3=CC=C(C=C3)C4=CC(=CC=C4)O	IC50 = 91000 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BBUY48	n-(1-Amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide	Investigative	46900403	C19H17N3O2S	351.4	C1=CC=C(C=C1)CC(C(=O)N)NC(=O)C2=CN=C(C=C2)C3=CC=CS3	IC50 = 97000 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BF7ES8	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-2-hydroxy-4-(3-hydroxyphenyl)benzamide	Investigative	46900399	C22H20N2O4	376.4	C1=CC=C(C=C1)CC(C(=O)N)NC(=O)C2=C(C=C(C=C2)C3=CC(=CC=C3)O)O	IC50 = 61300 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BI2S6R	N-(2-Amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	46900088	C13H12N2O3S	276.31	C1=CC(=CC(=C1)O)C2=CC=C(S2)C(=O)NCC(=O)N	IC50 = 73900 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BIU35X	N-Benzhydryl-2-(3-hydroxyphenyl)thiazole-4-carboxamide	Investigative	46899925	C23H18N2O2S	386.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CSC(=N3)C4=CC(=CC=C4)O	IC50 = 71200 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BLR12Z	N-(1-Amino-3-methyl-1-oxobutan-2-yl)-4-(3-hydroxyphenyl)benzamide	Investigative	46900249	C18H20N2O3	312.4	CC(C)C(C(=O)N)NC(=O)C1=CC=C(C=C1)C2=CC(=CC=C2)O	IC50 = 53300 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BMUZ81	2-Phenyl-5-(2-phenylpyrimidin-5-yl)oxazole	Investigative	59252385	C19H13N3O	299.3	C1=CC=C(C=C1)C2=NC=C(C=N2)C3=CN=C(O3)C4=CC=CC=C4	IC50 = 125000 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BTD8R2	N-Benzhydryl-5-(1H-indol-4-yl)thiophene-2-carboxamide	Investigative	46900087	C26H20N2OS	408.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)C3=CC=C(S3)C4=C5C=CNC5=CC=C4	IC50 = 57900 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BTS56X	2-(4-Methoxybenzoyl)thiophene	Investigative	77812	C12H10O2S	218.27	COC1=CC=C(C=C1)C(=O)C2=CC=CS2	IC50 = 105000 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BVP2W3	N-(1-Amino-1-oxo-3-phenylpropan-2-yl)-3''-hydroxybiphenyl-4-carboxamide	Investigative	46900246	C22H20N2O3	360.4	C1=CC=C(C=C1)CC(C(=O)N)NC(=O)C2=CC=C(C=C2)C3=CC(=CC=C3)O	IC50 = 88500 nM	Poor binder
T19433	Glutathione-dependent PGD synthase	BZK49I	N-[[1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]-5-(3-hydroxyphenyl)thiophene-2-carboxamide	Investigative	49864100	C21H19N3O5S	425.5	C1=CC(=CC(=C1)O)C2=CC=C(S2)C(=O)NC(=O)NC(CC3=CC=C(C=C3)O)C(=O)N	IC50 = 91300 nM	Poor binder